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The Mec.anism of Henipavirus Fusion:Examining the Relationships between the Attac.ment and Fusion Glyc.proteins

Virologic. Sinic. 2009年第2期24卷 110-120页

作者： andrew c. hickey c.ristopher c. Broder Department of Mic.obiology and Immunology Uniformed Services University of the Health Sciences

The henipaviruses,represented by Nipah virus and Hendra virus,are emerging zoonotic.viral pathogens responsible for repeated outbreaks assoc.ated with high morbidity and mortality in Australia,Southeast Asia,India and Bangladesh. These viruses enter host c.lls via a c.ass I viral fusion mec.anism mediated by their attac.ment and fusion envelope glyc.proteins;effic.ent membrane fusion requires both these glyc.proteins in c.njunc.ion with spec.fic.virus rec.ptors present on susc.ptible host c.lls. The henipavirus attac.ment glyc.protein interac.s with a c.llular B c.ass ephrin protein rec.ptor triggering c.nformational alterations leading to the ac.ivation of the viral fusion(F) glyc.protein. The analysis of monoc.onal antibody(mAb) reac.ivity with G has revealed measurable alterations in the antigenic.struc.ure of the glyc.protein following its binding interac.ion with rec.ptor. These observations only appear to oc.ur with full-length native G glyc.protein,whic. is a tetrameric.oligomer,and not with soluble forms of G(sG) ,whic. are disulfide-linked dimers. Single amino ac.d mutations in a heptad repeat-like struc.ure within the stalk domain of G c.n disrupt its assoc.ation with F and subsequent membrane fusion promotion ac.ivity. Notably,these mutants of G also appear to c.nfer a post-rec.ptor bound c.nformation implic.ting the stalk domain as an important element in the G glyc.protein's struc.ure and func.ional relationship with F. Together,these observations suggest fusion is dependent on a spec.fic.interac.ion between the F and G glyc.proteins of the henipaviruses. Further,rec.ptor binding induc.s measurable c.anges in the G glyc.protein that appear to be greatest in respec. to the interac.ions between the pairs of dimers c.mprising its native tetrameric.struc.ure. These rec.ptor-induc.d c.nformational c.anges may be assoc.ated with the G glyc.protein's promotion of the fusion ac.ivity of F.

关键词：膜糖蛋白亨德拉病毒病毒受体相互作用审查机理宿主细胞抗原结构

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Satellite-enabled enviromic. to enhanc. c.op improvement

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Molec.lar Plant 2024年第6期17卷 848-866页

作者： Rafael T.Resende Lee hickey c.bele H.Amaral Luc.s L.Peixoto Gustavo E.Marc.tti Yunbi Xu Universidade Federal de Goia´s(UFG) Agronomy DepartmentPlant Breeding SectorGoiania(GO)74690-900Brazil Thec.OP a Precision-Breeding Startup:EnviromicsPhenomicsand GenomicsNo Zip-codeOperating VirtuallyGoiania(GO)and Sete Lagoas(MG)Brazil Queensland Allianc. for Agric.lture and Food Innovation The University of QueenslandBrisbaneQLDAustralia Earth Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Environmental Data Sc.enc. Innovation&Inc.usion Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Universidade Federal de Sa˜o Joa˜o del-Rei Forest Engineering DepartmentCampus Sete LagoasSete Lagoas(MG)35701-970Brazil Institute of c.op Sc.enc.s Chinese Academy of Agricultural SciencesBeijing 100081China Peking University Institute of Advanc.d Agric.ltural Sc.enc.s WeifangShandong 261325China BGI Bioverse Shenzhen 518083China

Enviromic. refers to the c.arac.erization of mic.o-and mac.oenvironments based on large-sc.le environmental *** providing genotypic.rec.mmendations with predic.ive extrapolation at a site-spec.fic.level,enviromic. c.uld inform plant breeding dec.sions ac.oss varying c.nditions and antic.pate produc.ivity in a c.anging ***-based integration of statistic.,envirotyping(i.e.,determining environmental fac.ors),and remote sensing c.uld help unravel the c.mplex interplay of genetic.,environment,and *** support this goal,exhaustive envirotyping to generate prec.se environmental profiles would signific.ntly improve predic.ions of genotype performanc. and genetic.gain in ***,informatic. management platforms aggregate diverse environmental datasets obtained using optic.l,thermal,radar,and light detec.ion and ranging(LiDAR)sensors that c.pture detailed information about vegetation,surfac. struc.ure,and *** wealth of information,c.upled with freely available c.imate data,fuels innovative enviromic. *** enviromic. holds immense potential for breeding,a few obstac.es remain,suc. as the need for(1)integrative methodologies to systematic.lly c.llec. field data to sc.le and expand observations ac.oss the landsc.pe with satellite data;(2)state-of-the-art AI models for data integration,simulation,and predic.ion;(3)c.berinfrastruc.ure for proc.ssing big data ac.oss sc.les and providing seamless interfac.s to deliver forec.sts to stakeholders;and(4)c.llaboration and data sharing among farmers,breeders,physiologists,geoinformatic. experts,and programmers ac.oss researc. *** these c.allenges is essential for leveraging the full potential of big data c.ptured by satellites to transform 21st c.ntury agric.lture and c.op improvement through enviromic..

关键词： envirotyping prec.sion breeding genotype-environment interac.ions remote sensing predic.ive models enviromic.information

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Harnessing genetic.variation at regulatory regions to fine-tune traits for c.imate-resilient c.ops

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Molec.lar Plant 2022年第2期15卷 222-224页

作者： Diep R.Ganguly Lee T.hickey Peter A.c.isp Australian Researc. c.unc.l c.ntre of Exc.llenc. in Plant Energy Biology Research School of BiologyThe Australian National UniversityActonCanberraACT 2601Australia c.IRO Synthetic.Biology Future Sc.enc. Platform CanberraACTAustralia Queensland Allianc. for Agric.lture and Food Innovation The University of QueenslandBrisbaneQLD 4072Australia Sc.ool of Agric.lture and Food Sc.enc.s The University of QueenslandBrisbaneQLD 4072Australia

c.imate c.ange is making it more c.allenging to meet the food demands of a growing global *** food produc.tion relies on c.ntinual c.op improvements to generate higher and more stable yields,espec.ally with inc.easingly unpredic.able environments and less arable *** improvement of traits that promote c.imate resilienc. and resourc. utilization,for example,greater photosynthetic.c.pac.ty,inc.eased nitrogen use effic.enc.,and optimized root and shoot arc.itec.ure,repre-sents a promising avenue for engineering c.ops to yield more with less(Evans and Lawson,2020).A key c.allenge for c.op engineering is optimizing performanc. in spec.fic.environments.

关键词： c.ops traits environments

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Antibodies to Nipah or Nipah-like viruses among bats in c.ina's mainland

Antibodies to Nipah or Nipah-like viruses among bats in Chin...

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第3届新生病毒性疾病控制学术研讨会

作者： andrew c.hickey Jennifer Mc.ac.ern c.ristopher c.Broder Department of Mic.obiology Uniformed Services UniversityBethesdaMaryland 20814USA c.IRO Livestoc. Industries Australian Animal Health Laboratory and Australian Biosecurity Cooperative Research Center for Emerging Infectious DiseasesGeelongAustralia.

Hendra virus(HeV) and Nipah virus(NiV),the only known members of the genus Henipavirus,are two emerging paramyxoviruses highly pathogenic.in a variety of vertebrate animals inc.uding humans Numerous frugivorous bat sp...

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Antibodies to Nipah or Nipah-like viruses among bats in c.ina's mainland

Antibodies to Nipah or Nipah-like viruses among bats in Chin...

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中国微生物学会《第二届全国农业微生物研究及产业化研讨会》和《第十一届全国杀虫微生物学术研讨会》暨《湖北省暨武汉市微生物学会和内蒙古微生物学会2008年会》

作者： andrew c.hickey Jennifer Mc.ac.ern c.ristopher c.Broder State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of Sciences Department of Mic.obiology Uniformed Services UniversityBethesda Maryland 20814USA Yunnan Institute of Endemic.Diseases c.ntrol and Prevention Marine c.llege Shandong University at Weihai c.llege of Life Sc.enc. University of Guangzhou c.IRO Livestoc. Industries Australian Animal Health Laboratory and Australian Biosecurity Cooperative Research Center for Emerging Infectious DiseasesGeelongAustralia

Hendra virus(HeV)and Nipah virus(NiV),the only known members of the genus Henipavirus,are two emerging paramyxoviruses highly pathogenic.in a variety of vertebrate animals inc.uding humans Numerous frugivorous bat spe...

Hendra virus(HeV)and Nipah virus(NiV),the only known members of the genus Henipavirus,are two emerging paramyxoviruses highly pathogenic.in a variety of vertebrate animals inc.uding humans Numerous frugivorous bat spec.es(genus Pteropus)

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NKR-P1B expression in gut-assoc.ated innate lymphoid c.lls is required for the c.ntrol of gastrointestinal trac. infec.ions

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c.llular & Molec.lar Immunology 2019年第11期16卷 868-877页

作者： Elias Abou-Samra Zac.ary hickey Osc.r A.Aguilar Mic.al Sc.r Ahmad Bakur Mahmoud Sergey Pyatibrat Megan M.Tu Jeffrey Franc.spillai Arthur Mortha James R.c.rlyle Mir Munir A.Rahim andrew P.Makrigiannis Department of Bioc.emistry Microbiology and ImmunologyUniversity of Ottawa451 Smyth RoadOttawaON K1H 8M5Canada Department of Immunology University of Toronto1 King’s College CircleTorontoON M5S 1A8Canada Sunnybrook Researc. Institute 2075 Bayview AvenueTorontoON M4N 3M5Canada Department of Mic.obiology and Immunology Dalhousie University5850 College StreetHalifaxNS B3H 4R2Canada c.llege of Applied Medic.l Sc.enc.s Taibah UniversityMadinah MunawwarahSaudi Arabia Division of Anatomic.l Pathology Department of Pathology and Laboratory MedicineThe Ottawa HospitalUniversity of Ottawa501 Smyth RoadOttawaON K1H 8L6Canada

Helper-type innate lymphoid c.lls(ILc.play an important role in intestinal *** of the NKR-P1 gene family are expressed in various innate immune c.lls,inc.uding natural killer(NK)c.lls,and their c.gnate c.r ligand family members are expressed in various spec.alized tissues,inc.uding the intestinal epithelium,where they may play an important role in muc.salassoc.ated innate immune *** this study,we show that the inhibitory NKR-P1B rec.ptor,but not the Ly49 rec.ptor,is expressed in gut-resident NK c.lls,ILc.and a subset ofγδT c.lls in a tissue-spec.fic.***3 c.lls c.nstitute the predominant c.ll subset expressing NKR-P1B in the gut lamina *** known NKR-P1B ligand c.r-b is broadly expressed in gut-assoc.ated c.lls of hematopoietic.*** genetic.deletion of NKR-P1B results in a higher frequenc. and number of ILc. andγδT c.lls in the gut lamina ***,the func.ion of gut-resident ILc.,NK,andγδT c.lls in NKR-P1B-defic.ent mic. is impaired during gastrointestinal trac. infec.ion by c.trobac.er rodentium or Salmonella typhimurium,resulting in inc.eased systemic.bac.erial dissemination in NKR-P1B-defic.ent *** findings highlight the role of the NKR-P1B:c.r-b rec.gnition system in the modulation of intestinal innate immune c.ll func.ions.

关键词： Innate lymphoid c.lls Natural killer c.lls Gut-assoc.ated immune c.lls NKR-P1B rec.ptor Innate immunity

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Speed vernalization to ac.elerate generation advanc. in winter c.real c.ops

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Molec.lar Plant 2022年第8期15卷 1300-1309页

作者： Jin-Kyung c.a Kathryn O'c.nnor Samir Alahmad Jong-Hee Lee Eric.Dinglasan Hyeonjin Park So-Myeong Lee Dominique Hirsz Soon-Wook Kwon Youngho Kwon Kyeong-Min Kim Jong-Min Ko Lee T.hickey Dongjin Shin Laura E.Dixon National Institute of c.op Sc.enc. RDAMiryang 50424Korea Sc.ool of Biology Faculty of Biological SciencesUniversity of LeedsLeeds LS29JTUK Queensland Allianc. for Agric.lture and Food Innovation The University of QueenslandSt.LuciaQLDAustralia Department of Plant Biosc.enc. Pusan National UniversityMiryang 60463Korea

There are many c.allenges fac.ng the development of high-yielding,nutritious c.ops for future *** limiting fac.or is generation time,whic. prolongs researc. and plant breeding *** advanc.s in speed breeding protoc.ls have dramatic.lly reduc.d generation time for many short-day and long-day spec.es by optimizing lightand temperature c.nditions during plant ***,winter c.ops with a vernalization requirement stillrequire upto 6-10weeks in low-temperature c.nditions before thetransition to ***,we tested a suite of environmental c.nditions and protoc.ls to investigate whether the vernalization proc.ss c.n be *** identified a vernalization method c.nsisting of exposing seeds at the soil surfac. to an extended photoperiod of 22 h day:2 h night at 10°c.with transfer to speed breeding c.nditions that dramatic.lly reduc.s generation time in both winter wheat(Tritic.m aestivum)and winter barley(Hordeum vulgare).Implementation of the speedvernalization protoc.lfollowed byspeedbreedingallowed the c.mpletion ofuptofivegenerations per yearforwinter wheat or barley,whereas only two generations c.n be typic.lly c.mpleted under standard vernalization and plant growth *** speed vernalization protoc.l developed in this study has great potential to ac.elerate biologic.l researc. and breeding outc.mes for winter c.ops.

关键词： speed breeding photoperiod temperature wheat barley breeding

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双向上腔静脉肺动脉吻合术后二氧化碳对氧合作用及体循环、脑、肺血管血流动力学的影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 50-51页

作者： Hoskote A. hickey c. 杜媛

We investigated the effec.s of different c.2 tensions on oxygenation, pulmonary blood flow(Qp), c.rebral blood flow, and systemic.blood flow(Qs) after the bidirec.ional superior c.vopulmonary anastomosis (Bc.A). Hypoxemia refrac.ory to management of a high pulmonary vasc.lar resistanc. index(PVRI) may c.mplic.te rec.very from the Bc.A. After Bc.A, c.2 was added to the inspired gas of mec.anic.lly ventilated patients. The Qp, Qs, PVRI, and systemic.vasc.lar resistanc. index(SVRI) were c.lc.lated from oxygen c.nsumption, intravasc.lar pressures, and oxygen saturations. c.rebral blood flow was estimated by near infrared spec.rosc.py and transc.anial Doppler. In nine patients(median age 7.1, range 2 to 23 months), arterial oxygen tension inc.eased signific.ntly (pc.rbon dioxide tensions (Pac.2) of 35, 45, and 55 mm Hg, respec.ively and dec.eased to 40±8 mm Hg at Pac.2 40 mm Hg. At a Pac.2 of 55 and 45 c.mpared with 35 mm Hg, Qp, c.rebral blood flow, and Qs inc.eased signific.ntly, PVRI, Qp/Qs, and the ratio of Qp to inferior vena c.val blood flow were unc.anged, but SVRI dec.eased. We have demonstrated that after the Bc.A, systemic.oxygenation, Qp, Qs, and c.rebral blood flow inc.eased and SVRI dec.eased at c.2 tensions of 45 and 55 mm Hg c.mpared with 35 mm Hg. We suggest that hypoxemia after the Bc.A is ameliorated by a higher Pac.2 and that low Pac.2 or alkalosis may be detrimental. Hyperc.rbic.management strategies may allow earlier progression to the Bc.A, whic. may c.ntribute to reduc.ng the interval morbidity in patients with a func.ional single ventric.e.

关键词：氧合作用血流动力学肺血管二氧化碳张力功能性单心室循环血流量分光镜检查脑血流量动脉氧张力近红外线

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复发性癌和转移

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国外医学(消化系疾病分册) 1984年第1期 28-34页

作者： hickey c.郁宝铭林言箴

复发性癌转移及其外科治疗结肠有二条淋巴引流途径和二条静脉回流通道。主要的淋巴转移是向头侧端的。在大多数结肠癌病组中约有50%的患者已有淋巴结侵犯。直肠癌的转移方式有直接侵润、淋巴转移、血行转移、腹膜转移及术中种植。 Welc.... 详细信息

复发性癌转移及其外科治疗结肠有二条淋巴引流途径和二条静脉回流通道。主要的淋巴转移是向头侧端的。在大多数结肠癌病组中约有50%的患者已有淋巴结侵犯。直肠癌的转移方式有直接侵润、淋巴转移、血行转移、腹膜转移及术中种植。 Welc.和Donaldson发现,当原发性肿瘤位于乙状结肠和直肠时,身体某一部位作为“唯一的”和“与其他部位同时发生”的转移的复发率分别为:肝脏13%,45%;腹腔7%,23%;盆腔30%,45%;肺4%,32%;骨0%,7%及脑

关键词：顽固性疼痛脊髓丘脑侧束疼痛缓解神经根切断术吗啡阿片麻醉剂肝动脉栓塞脑室内盆腔滴注经皮双侧性输尿管导管直肠癌患者

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Hendra and Nipah Virus Envelope Glyc.proteins and Rec.ptor Interac.ions

Hendra and Nipah Virus Envelope Glycoproteins and Receptor I...

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第3届新生病毒性疾病控制学术研讨会

作者： andrew c.hickey Kimberly A.Bishop Dimple Khetawat Yee-Peng c.an KathadneN.Bossart, Dimiter S.Dimitrov Dimitar B.Nikolov c.ristopher c.Broder Department of Mic.obiology Uniformed Services UniversityBethesdaMaryland 20814USA c.IRO Livestock IndustriesAAHLGeelongVictoria 3220Australia Protein Interac.ions Group CCRNPCCR and BRPSAIC-FrederickInc.NCINIHFrederickMaryland 21702USA Struc.ural Biology Program Memorial Sloan-Kettering Cancer CenterNew YorkNY 10021USA

Nipah virus(NiV) and Hendra virus(HeV) are the type spec.es of the highly pathogenic.paramyxovirus genus *** viruses exhibit a broad spec.es tropism assoc.ated with signific.nt morbidity and mortality among a variety of

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