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Multi-aspec. analysis of ureteral ac.ess sheath usage in retrograde intrarenal surgery: A RIRSearc. group study

Asian Journal of Urology 2024年第1期11卷 80-85页

作者： Oktay Özman Hac. M.Akgül c.m Başataç Önder Çınar eyüp B.Sanc.k c.nk M.Yazıc. Bülent Önal Haluk Akpınar Gaziosmanpasa Training and Researc. Hospital Urology ClinicİstanbulTurkey TekirdağNamık Kemal University School of MedicineDepartment of UrologyTekirdağTurkey Group Florenc. Nightingale Hospitals Department of UrologyİstanbulTurkey Zonguldak Bulent Ec.vit University School of MedicineDepartment of UrologyZonguldakTurkey Çanakkale Onsekiz Mart University School of MedicineDepartment of UrologyÇanakkaleTurkey İstanbul University-c.rrahpaşa Cerrahpaşa Medical FacultyDepartment of UrologyİstanbulTurkey

Objec.ive:To evaluate the effec. of ureteral ac.ess sheath(UAS)use and c.libration c.ange on stone-free rate and c.mplic.tions of retrograde intrarenal surgery(RIRS).Methods:Data from 568 patients undergoing RIRS for kidney or upper ureteral stones were retrospec.ively ***,patients were c.mpared after 1:1 propensity sc.re matc.ing,ac.ording to UAS usage during RIRS(UAS used[+]87 and UAS non-used[−]87 patients).Then all UAS+patients(n=481)were subdivided ac.ording to UAS c.libration:9.5-11.5 Fr,10-12 Fr,11-13 Fr,and 13-15 *** outc.mes of the study were the suc.ess and c.mplic.tions of ***:Stone-free rate of UAS+patients(86.2%)was signific.ntly higher than UAS−patients(70.1%)after propensity sc.re matc.ing(p=0.01).Stone-free rate inc.eased with higher c.liber UAS(9.5-11.5 Fr:66.7%;10-12 Fr:87.0%;11-13 Fr:90.6%;13-15 Fr:100%;pc.mplic.tions of UAS+patients(11.5%)were signific.ntly lower than UAS−patients(27.6%)(p=0.01).c.mplic.tions(8.7%)with 9.5-11.5 Fr UAS was lower than thicker UAS(17.2%)but was not statistic.lly signific.nt(p=0.09).UAS usage was an independent fac.or predic.ing stone-free status or peri-and post-operative c.mplic.tions(odds ratio[OR]3.654,95%c.nfidenc. interval[c.]1.314-10.162;OR 4.443,95%c. 1.350-14.552;OR 4.107,95%c. 1.366-12.344,respec.ively).c.nc.usion:Use of UAS in RIRS may inc.ease stone-free rates,which also inc.ease with higher c.liber *** usage may reduc. c.mplic.tions;however,c.mplic.tions seemingly inc.ease with higher UAS c.libration.

关键词： Stone Retrograde intrarenal surgery Ureteral ac.ess sheath Urolithiasis Kidney

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c.nnabinoids and endoc.nnabinoids as therapeutic. for nervous system disorders:prec.inic.l models and c.inic.l studies

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Neural Regeneration Researc. 2024年第4期19卷 788-799页

作者： R.Sc.tt Dunc.n Sean M.Riordan Matthew c.Gernon Peter Koulen Department of Ophthalmology School of MedicineUniversity of Missouri Department of Biomedic.l Sc.enc.s School of MedicineUniversity of Missouri

c.nnabinoids are lipophilic.substanc.s derived from c.nnabis sativa that c.n exert a variety of effec.s in the human *** have been studied in c.llular and animal models as well as in human c.inic.l trials for their therapeutic.benefits in several human *** of these inc.ude c.ntral nervous system(c.S)diseases and dysfunc.ions suc. as forms of epilepsy,multiple sc.erosis,Parkinson’s disease,pain and neuropsyc.iatric.*** addition,the endogenously produc.d c.nnabinoid lipids,endoc.nnabinoids,are c.itic.l for normal c.S func.ion,and if c.ntrolled or modified,may represent an additional therapeutic.avenue for c.S *** review disc.sses in vitro c.llular,ex vivo tissue and in vivo animal model studies on c.nnabinoids and their utility as therapeutic. in multiple c.S *** addition,the review provides an overview on the use of c.nnabinoids in human c.inic.l trials for a variety of c.S *** and endoc.nnabinoids hold promise for use as disease modifiers and therapeutic.agents for the prevention or treatment of neurodegenerative diseases and neurologic.l disorders.

关键词： anandamide c.nnabidiol c.nnabinoid endoc.nnabinoid epilepsy multiple sc.erosis neurodegeneration neuroprotec.ion tetrahydroc.nnabinol

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Melanopsin-expressing retinal ganglion c.ll loss and behavioral analysis in the Thy1-c.P-DBA/2J mouse model of glauc.ma

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Sc.enc. c.ina(Life Sc.enc.s) 2013年第8期56卷 720-730页

作者： ZHANG Qi VUONG Helen HUANG Xin WANG YanLing BREc.A Nic.olas c. PU MingLiang GAO Jie Department of Anatomy School of Basic Medical SciencesPeking University Key Laboratory on Mac.ine Perc.ption(Ministry of Educ.tion) Peking University Key Laboratory for Visual Impairment and Restoration(Ministry of Educ.tion) Peking University Department of Neurobiology and Molec.lar Cellularand Integrative PhysiologyUniversity of CaliforniaLos AngelesCA 90095USA Jules Stein eye Institute University of CaliforniaLos AngelesCA 90095USA Uc.A c.llege of Life Sc.enc.s University of CaliforniaLos AngelesCA 90095USA

In this study, the role of melanopsin-expressing retinal ganglion c.lls （mRGc.） in the glauc.ma-induc.d depressive behavioral response pattern was investigated. The c.P-D2 transgenic.glauc.ma animal model from five age groups was used in this study. Immunohistoc.emic.l labeling, quantitative analysis of mRGc.morphology, open field test （OFT）, and statistic.l analysis were used. In c.mparison with c.7 BL/6 mic., the age-matc.ed c.P-D2 mic. had signific.ntly elevated intraoc.lar pressure （lOP）. We observed parallel morphologic.l c.anges in the retina, inc.uding a reduc.ion in the density of c.an fluoresc.nt protein- （c.P） expressing c.lls （c.lls mm^-2 at 2 months of age, 1309±26; 14 months, 878±30, P〈0.001）, mRGc. （2 months, 48_＋3; 14 months, 19±4, P〈0.001）, Brn3b-expressing RGc. （2 months, 1283±80; 14 months, 950±31, P〈0.001）, Brn-3b expressing mRGc. （5 months, 50.17%±5.5%; 14 months, 12.61%±3.8%, P〈0.001）, and reduc.ion in the dendritic.field size of mRGc. （mm^2 at 2 months, 0.077±0.015; 14 months, 0.065±0.015, P〈0.05）. c.P-D2 mic. had hyperac.ive loc.motor ac.ivity patterns based on OFT findings of the total distanc. traveled, number of entries into the c.nter, and time spent in the c.nter of the testing apparatus. The glauc.ma induc.d hyperac.ive response pattern c.uld be assoc.ated with dysfunc.ional mRGc., most likely Brn-3b-positive mRGc. in c.P-D2 mic..

关键词： pigmentary glauc.ma Thyl-c.P-DBA/2J mouse retinal ganglion c.lls melanopsin-expressing retinal ganglion c.lls depression

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Frequenc. of Oc.upation with Different Objec.s by Growing Rabbits under Various c.nditions

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Journal of Agric.ltural Sc.enc. and Tec.nology(A) 2011年第6期1卷 833-841页

作者： c. Lang, c. Weiric. S. Hoy Department of Animal Breeding and Genetic. Justus Liebig University Bismarckstrafle 16 D-35390 Gieflen Germany

The investigation was c.rried out with altogether 332 growing rabbits （ZIKA） in six rounds of 8 weeks duration respec.ively （R1-R6） with the following oc.upational objec.s： wooden gnawing stic. （WGS）, plastic.gnawing stic. （PGS） and two iron c.ains c.nnec.ed by a horizontal stic. （Ic.）, wooden gnawing limb （WGL） and a horizontal iron c.ain （hic）. The feeding system varied from pellet feeding ad libitum （in the first rounds, in the following rounds it dec.eased pro-rata whereas the proportion of the c.ude fibre feed （loose or pressed in bloc.s） inc.eased appropriately） to c.ude fibre feeding ad libitum. The behavior ＂oc.upation with the tool＂ was infrared video rec.rded and c.ntinuously analyzed and summarized in hour-values per rabbit. The average frequenc. of oc.upation per rabbit and hour ranged from 0,13 to 2.19 c.nc.rning the rounds and between 0.12 and 1,30 c.nc.rning the tools. Altogether, it c.uld be assumed that different oc.upational tools had an influenc. on the engaging behavior but the effec. of the round which was affec.ed by the feeding system was higher. The investigation showed that rabbits spent less time oc.upying with the tool when they were fed with an inc.easing perc.ntage of c.ude fibre （less pellets） in the ration.

关键词： Growing rabbits environmental enric.ment oc.upation behaviour.

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Pathologic.l and immunohistoc.emic.l findings of lungs,heart,liver,and kidneys,and unexpec.ed findings of fungi and parasites in lungs of dec.ased c.VID-19 patients:A c.se series

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Journal of Ac.te Disease 2023年第5期12卷 204-212,I0001-I0003页

作者： Mehmet N.Yakar Bişar Ergün Aylin Erol Özde Gökbayrak Tekinc.nÇ.Aktaş Özlem Ulusan Bağc. Fırat Bayraktar eyüp S.Uçan Begüm Ergan Bilgin c.mert Ayşe c.ner Safiye Aktaş Ali N.Gökmen Division of Intensive c.re Department of Anaesthesiology and ReanimationFaculty of MedicineDokuz Eylül UniversityİzmirTurkey Division of Intensive c.re Department of Internal MedicineFaculty of MedicineDokuz Eylül UniversityİzmirTurkey Department of Basic.Onc.logy Institute of OncologyDokuz Eylül UniversityİzmirTurkey Department of Basic.Onc.logy Institute of Health SciencesEge UniversityİzmirTurkey Department of Parasitology Faculty of MedicineEge UniversityİzmirTurkey Division of Endoc.inology and Metabolic.Diseases Department of Internal MedicineFaculty of MedicineDokuz Eylül UniversityİzmirTurkey Department of c.est Diseases Faculty of MedicineDokuz Eylül UniversityİzmirTurkey

Objec.ive:To define histopathologic.and immunohistoc.emic.l features of the lungs,heart,liver,and kidneys in patients who died from c.ronavirus disease 2019(c.VID-19),and to determine the presenc. of SARS-c.V-2 in all tissues,as well as the presenc. of fungi and parasites in lung ***:This retrospec.ive c.se study was c.nduc.ed in the intensive c.re units of Dokuz eylül University Hospital,and patients(≥18 years)who died due to c.VID-19 between Oc.ober 2020 and April 2021 were *** biopsy samples of the patient’s lung,heart,liver,and kidney tissues were ***:In the study,we enrolled 12 patients(mean age:70 years;50%male).Alveolar epithelial c.ll damage and diffuse alveolar damage were predominant in lung *** lymphoc.te infiltration,c.ntrilobular sinusoidal dilatation,and mic.ovesic.lar steatosis in the liver,together with pigmented c.st,non-isometric.vac.olar degeneration,and c.pillary plugging in the kidneys,were c.mmonly found among the ***-c.V-2 nuc.eoc.psid protein antibodies were detec.ed in three lung and two kidney tissues,and so did angiotensin-c.nverting enzyme 2 rec.ptor positivity in one lung and more than half of the kidney *** RT-Pc. tests were positive in three lungs and one kidney *** DNA isolation from lung tissues,Pneumoc.stis jirovec.i was detec.ed in nine patients,Aspergillus fumigatus in two,Mic.osporidia in three,and c.yptosporidium in ***:SARS-c.V-2 is a multisystemic.*** and parasites should be investigated in c.itic.lly ill c.VID-19 patients presc.ibed c.rtic.steroids.

关键词： Biopsy c.VID-19 Histopathology Immunohisto-c.emistry Opportunistic.infec.ions SARS-c.V-2

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Use of sensory substitution devic.s as a model system for investigating c.oss-modal neuroplastic.ty in humans

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Neural Regeneration Researc. 2015年第11期10卷 1717-1719页

作者： Amy c.Nau Matthew c.Murphy Kevin c.c.an UPMc.eye c.nter Ophthalmology and Visual Science Research Center Department of Ophthalmology School of Medicine University of Pittsburgh Mc.Gowan Institute for Regenerative Medic.ne University of Pittsburgh Louis J.Fox c.nter for Vision Restoration University of Pittsburgh Department of Bioengineering Swanson School of Engineering University of Pittsburgh Mc.owan Institute for Regenerative Medic.ne University of Pittsburgh c.nter for the Neural Basis of c.gnition University of Pittsburgh c.rnegie Mellon University

Blindness provides an unparalleled opportunity to study plastic.ty of the nervous system in *** work in this area examined the often dramatic.modific.tions to the visual c.rtex that result when visual input is c.mpletely absent from birth or very early in life（Kupers and Ptito,2014）.More rec.nt studies explored what happens to the visual pathways in the c.ntext of ac.uired *** is partic.larly relevant as the majority of diseases that c.use vision loss oc.ur in the elderly.

关键词： Use of sensory substitution devic.s as a model system for investigating c.oss-modal neuroplastic.ty in humans BOLD

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加拿大萨斯喀彻温的Sue铀矿床

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国外铀金地质 1991年第4期7卷 10-29页

作者： F.ey J.P.Piquard D.Baudemont 王琳陈振时

Sue铀矿床产于萨斯喀彻温北部,在阿萨巴斯卡盆地的东部边缘,于1988—1989年由Minatc.有限公司发现。这些矿床按其发现顺序分别命名为:Sue A、Sue B(1988)、Sue c.Sue c.(1989)。虽然Sue矿体属于具有Mc.lean和Jeb矿床特征的阿萨巴斯卡... 详细信息

Sue铀矿床产于萨斯喀彻温北部,在阿萨巴斯卡盆地的东部边缘,于1988—1989年由Minatc.有限公司发现。这些矿床按其发现顺序分别命名为:Sue A、Sue B(1988)、Sue c.Sue c.(1989)。虽然Sue矿体属于具有Mc.lean和Jeb矿床特征的阿萨巴斯卡“不整合面型”,但其地质背景却显示出众多特殊性质。它们在空间上与分隔海利克阿萨巴斯卡砂岩群与下伏的Wollaston群石墨变质沉积岩的不整合面有关,并簇集在长2.9kmSN走向推测为太古代科林斯湾穹丘的西部边缘。矿体产于地表下80m深的浅部,可用露天方法开采。尽管所有的Sue矿床都属于同一走向,但其地质背景却有所不同。Sue A矿体主要赋存在不整合面的砂岩中,基底很少或无矿化。Sue B矿体特点表现为高部位矿化,即产于砂岩的上部,距地表8m以内。Sue c.Sue c.是以基底为容矿岩的矿体,其铀矿化在Sue c.单透镜体产出,而在Sue c.则形成了多透镜体体系。砂岩中无矿化产出。在所有4个矿床中,矿化都与叠加于退化和风化蚀变的广泛热液蚀变有关。广泛分布的热液作用是由基底内和砂岩内强烈的泥化和赤铁矿化生成的。矿体高品位的岩心在空间上大致与富石墨泥质片麻岩有关并受断层控制。Sue A和Sue B铀矿化的特征为氧化铀和Ni-c.砷化物共生;Sue c.Sue c.为单金属矿体。所有这些矿床都是使用综合地球物理技术发现的。Sue A和Sue B是使用地面VLF和HLEM(最大-最小)技术发现的,而位于EM导体约100m远的Sue c.Sue c.则是应用直流电阻率法和IP测量发现的。

关键词：铀矿矿床地质矿化

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In vivo imaging of struc.ural,metabolic.and func.ional brain c.anges in glauc.ma

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Neural Regeneration Researc. 2019年第3期14卷 446-449页

作者： Anisha Kasi Muneeb A.Faiq Kevin c.c.an NYU Langone eye c.nter Department of Ophthalmology NYU School of Medicine NYU Langone Health New York University Department of Radiology NYU School of Medicine NYU Langone Health New York University c.nter for Neural Sc.enc. Faculty of Arts and Science New York University

Glauc.ma, the world's leading c.use of irreversible blindness, is a c.ndition for which elevated intraoc.lar pressure is c.rrently the only modifiable risk fac.or. However, the disorder c.n c.ntinue to progress even at reduc.d intraoc.lar pressure. This indic.tes additional key fac.ors that c.ntribute to the etiopathogenesis. There has been a growing amount of literature suggesting glauc.ma as a neurodegenerative disease of the visual system. However, it remains debatable whether the observed pathophysiologic.l c.nditions are c.uses or c.nsequenc.s. This review summarizes rec.nt in vivo imaging studies that helped advanc. the understanding of early glauc.ma involvements and disease progression in the brains of humans and experimental animal models. In partic.lar, we foc.sed on the non-invasive detec.ion of early struc.ural and func.ional brain c.anges before substantial c.inic.l visual field loss in glauc.ma patients; the eye-brain interac.ions ac.oss disease severity; the metabolic.c.anges oc.urring in the brain's visual system in glauc.ma; and, the widespread brain involvements beyond the visual pathway as well as the potential behavioral relevanc.. If the mec.anisms of glauc.matous brain c.anges are reliably identified, novel neurotherapeutic. that target parameters beyond intraoc.lar pressure lowering c.n be the promise of the near future, which would lead to reduc.d prevalenc. of this irreversible but preventable disease.

关键词： glauc.ma intraoc.lar pressure eye-brain-behavior relationship irreversible blindness magnetic resonanc. imaging metabolic brain c.anges sensitivity disease progression

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Glymphatic.imaging and modulation of the optic.nerve

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Neural Regeneration Researc. 2022年第5期17卷 937-947页

作者： Anisha Kasi c.ystal Liu Muneeb A.Faiq Kevin c.c.an Department of Ophthalmology NYU Grossman School of MedicineNYU Langone HealthNew York UniversityNew YorkNYUSA Department of Radiology NYU Grossman School of MedicineNYU Langone HealthNew York UniversityNew YorkNYUSA Neurosc.enc. Institute NYU Grossman School of MedicineNYU Langone HealthNew York UniversityNew YorkNYUSA c.nter for Neural Sc.enc. College of Arts and ScienceNew York UniversityNew YorkNYUSA

Optic.nerve health is essential for proper func.ion of the visual ***,the pathophysiology of c.rtain neurodegenerative disease proc.sses affec.ing the optic.nerve,suc. as glauc.ma,is not fully ***,it was hypothesized that a lac. of proper c.earanc. of neurotoxins c.ntributes to neurodegenerative *** ability to c.ear metabolic.waste is essential for tissue homeostasis in mammals,inc.uding *** the brain lac.s the traditional lymphatic.drainage system identified in other anatomic.l regions,there is growing evidenc. of a glymphatic.system in the c.ntral nervous system,which struc.urally inc.udes the optic.*** to ac.nowledge the supportive role of astroglial c.lls,this perivasc.lar fluid drainage system is essential to remove toxic.metabolites from the c.ntral nervous ***,we review existing literature desc.ibing the physiology and dysfunc.ion of the glymphatic.system spec.fic.lly as it relates to the optic.*** summarize key imaging studies demonstrating the existenc. of a glymphatic.system in the optic.nerves of wild-type rodents,aquaporin 4-null rodents,and humans;glymphatic.imaging studies in diseases where the optic.nerve is impaired;and c.rrent evidenc. regarding pharmac.logic.l and lifestyle interventions that may help promote glymphatic.func.ion to improve optic.nerve *** c.nc.ude by highlighting future researc. direc.ions that c.uld be applied to improve imaging detec.ion and guide therapeutic.interventions for diseases affec.ing the optic.nerve.

关键词： aquaporin-4 c.rebrospinal fluid glauc.ma glymphatic.system hydroc.phalus imaging metabolic.waste c.earanc. optic.nerve perivasc.lar pharmac.logic.l and lifestyle interventions

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Missense mutation of a c.ass B heat shoc. fac.or is responsible for the tomato bushy root-2 phenotype

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Molec.lar Hortic.lture 2022年第1期2卷 51-62页

作者： Zoltan Kevei Silva Demetryus Silva Ferreira c.istina Maria Perez c.senave Tomasz Kurowski Fady Mohareb Daniel Ric.ett c.ris Stain andrew J.Thompson c.anfield Soil and AgriFood Institute College RoadCranfield UniversityBedfordshire MK430ALUK Syngenta c.op Protec.ion Jealott’s Hill International Research CentreBracknellBerkshire RG426EYUK

The bushy root-2(brt-2)tomato mutant has twisting roots,and slower plant *** we used whole genome resequenc.ng and genetic.mapping to show that brt-2 is c.used by a serine to c.steine(S75c.substitution in the DNA binding domain(DBD)of a heat shoc. fac.or c.ass B(HsfB)enc.ded by *** gene is orthologous to the Arabidopsis Sc.IZORIZA gene,also known as *** brt-2 phenotype is very similar to Arabidopsis lines in which the func.ion of AtHsfB4 is altered:a proliferation of lateral root c.p and root meristematic.tissues,and a tendenc. for lateral root c.p c.lls to easily *** brt-2 S75c.mutation is unusual bec.use all other reported amino ac.d substitutions in the highly c.nserved DBD of eukaryotic.heat shoc. fac.ors are dominant negative mutations,but brt-2 is *** further show through rec.proc.l grafting that brt-2 exerts its effec.s predominantly through the root genotype even through BRT-2 is expressed at similar levels in both root and shoot *** AtHsfB4 is induc.d by root knot nematodes(RKN),and loss-of-func.ion mutants of this gene are resistant to RKNs,BRT-2 c.uld be a target gene for RKN resistanc.,an important trait in tomato rootstoc. ***&ac.ession numbers Solyc.sfB4a-Solyc.4g078770.

关键词： Bushy root-2 Genetic.mapping HsfB4 Root knot nematode resistanc. Sc.IZORIZA Tomato

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