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Microbiome and colorectal carcinogenesis:Linked mechanisms and racial differences

World Journal of Gastrointestinal Oncology 2022年第2期14卷 375-395页

作者： Sofia C Tortora Vimal M Bodiwala andrew quinn Laura A Martello Shivakumar Vignesh Department of Medicine and Division of Gastroenterology&Hepatology SUNY Downstate Health Sciences UniversityBrooklynNY 11203United States

Various studies have shown the interplay between the intestinal microbiome,environmental factors,and genetic changes in colorectal cancer(CRC)*** this review,we highlight the various gut and oral microbiota associated with CRC and colorectal adenomas,and their proposed molecular mechanisms in relation to the processes of“the hallmarks of cancer”,and differences in microbial diversity and abundance between race/*** with CRC showed increased levels of Bacteroides,Prevotella,Escherichia coli,enterotoxigenic Bacteroides fragilis,Streptococcus gallolyticus,Enterococcus faecalis,Fusobacterium nucleatum(***)and Clostridium *** levels of Bacteroides have been found in African American(AA)compared to Caucasian American(CA)***-inflammatory bacteria such as *** and Enterobacter species were significantly higher in ***,AA patients have been shown to have decreased microbial diversity compared to CA *** studies have shown that using microbiome profiles in conjunction with certain risk factors such as age,race and body mass index may help predict healthy colon vs one with adenomas or *** is one of the most common bacterial infections in humans and is more prevalent in Non-Hispanic-Blacks as compared to Non-Hispanic *** condition causes increased systemic inflammation,immune dysregulation,gut microbiota dysbiosis and thereby possibly influencing colorectal ***-associated bacteria such as Fusobacterium,Prevotella,Bacteroides and Porphyromonas have been found in CRC tissues and in feces of CRC ***,a deeper understanding of the association between oral and gastrointestinal bacterial profile,in addition to identifying prevalent bacteria in patients with CRC and the differences observed in ethnicity/race,may play a pivotal role in predicting incidence,prognosis,and lead to the development of new treatments.

关键词： Colorectal cancer Oral microbiome Gut microbiome Hallmarks of cancer Racial/ethnic microbial diversity

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Bottled Water Not Always As Clean As Advertised

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当代外语研究 1999年第6期 13-16页

作者： andrew quinn 雷根泉

美国是世界上为数不多的可直接饮用自来水的国家之一。美国市场上销售的瓶装饮用水更应该洁净而令消费者放心,可是,本文让读者大吃一惊！

关键词：瓶装饮用水 Bottled Water Not Always As Clean As Advertised As

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Scientists Plot Search For Earth--Like Planets

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当代外语研究 1999年第6期 2-4页

作者： andrew quinn 金月芹

1999年5月22日清晨,在Internet上读到此文,兴奋异常。遥望那无垠的、群星闪烁的夜空,人类很早就在思考:Are we alone in the universe?许多科幻小说中描写的外星人,更点燃了人类的想象。人们在无法解开金字塔的建造之谜时,仰望太空,猜... 详细信息

1999年5月22日清晨,在Internet上读到此文,兴奋异常。遥望那无垠的、群星闪烁的夜空,人类很早就在思考:Are we alone in the universe?许多科幻小说中描写的外星人,更点燃了人类的想象。人们在无法解开金字塔的建造之谜时,仰望太空,猜测那是外星人在地球上留下的杰作;人们在惊叹UFO的神秘行踪时,也翘首天际,设想那是外星人在向我们暗递的“秋波”！今天,人类的科技终于驶入了一个新时代,能够更精确更清晰更自信地去探求茫茫宇宙里的奥秘。这篇报道的第一句就足以让我们欣喜: Somewhere,in a star system porhaps not so far away,lies a″ pale bluedot″which could be a planet much like Earth. 在这个淡蓝色的小点(pale blue dot)上也许就生活着人类的邻居。美国的一群科学家们上周就聚首在位于加州的NASA(国家航空和航天局)researchcenter,这次科学聚会就被称为The″Pale Blue Dot″Conference！再过10年,一个名为Terrestrial Planet Finder的宇宙望远镜将投入使用,届时,它将提供比目前的哈勃望远镜清晰100倍的图象。美国亚利桑那州的的一位天文学家这样断言: Life on earth is by no means the only kind of life that can exist. 在即将过去的20世纪,人类登上了月球,失望地发现,那里除了环形山?

关键词：国家航空 Scientists Plot Search For Earth Like Planets 航天局外星人

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Huge New Telescope to Boost Hunt for Alien Life

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当代外语研究 2000年第9期 4-6页

作者： andrew quinn 陈国凝

微软公司的创始人之一Paul Allen和前微软公司的技术总监NathanMyhrvold慷慨出手,献出巨资,筹建大型的新望远镜Allen Telescope Array,对人类探索地球以外的智能生命助一臂之力。本文并未对两位捐助者歌功颂德,而对人类目前寻找地球以... 详细信息

微软公司的创始人之一Paul Allen和前微软公司的技术总监NathanMyhrvold慷慨出手,献出巨资,筹建大型的新望远镜Allen Telescope Array,对人类探索地球以外的智能生命助一臂之力。本文并未对两位捐助者歌功颂德,而对人类目前寻找地球以外的高级动物的探索作了详尽的介绍。许多信息鲜活感人。人类探索地球外的高级动物的努力已经进行了四十余年,英语甚至收入了SETI(=search for extraterrestrial intelligence)这样的专用名词及其相应的组织。以下两段文字值得注意: While the best scientific estimates tell us the probability of intelligent lifeelsewhere in the universe is fairly high, there is great uncertainty and somecontroversy in the calculation. One thing however, is beyond dispute. That is, if we don't continuesupporting projects like the Allen Telescope Array, our chances of discovery willremain at zero. 预计在2005,Allen Telescope Array将投入使用。我们翘首盼望这一天的到来,更翘首盼望人类有朝一日能够发现人类并非茫茫宇宙之唯一,并能彻底揭开UFO一类的谜团。

关键词：高级动物 Huge New Telescope to Boost Hunt for Alien Life

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美国遭遇世纪突袭死亡人数成千上万

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大学英语 2001年第10期 3-5页

作者： Alan Elsner andrew quinn 朱凤莲

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Monitoring permeable paver runoff with an open-innovation geospatial sensor network

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International Journal of Digital Earth 2016年第1期9卷 30-46页

作者： andrew J.Rettig Sumit Khanna Richard A.Beck quinn Wojcik Carmen A.McCane Department of Geography University of CincinnatiCincinnatiOHUSA College of Engineering and Computer Science University of Tennessee at ChattanoogaChattanoogaTNUSA

Sensor networks are an essential tool for environmental *** scientists and engineers are beginning to utilize these new methods and devices in their fieldwork,they need to be actively involved in the future of sensor-networking *** sensor network innovation is important for improved standardization,affordability,and *** article uses a storm water case study to outline an end-to-end open-innovation sensor *** innovation by scientists,engineers,and entities is the collaborative process of creating value for this project in permeable paver runoff data and advances within sensor *** article focuses on the technical implementation of the near–real-time location and temporally aware sensor *** are streamed in near–real-time with subliter precision to the cloud using common off-the-shelf *** sensors use Maxim’s 1-wire™protocol,and the unique digital serial numbers confirm the *** data retrieved compare residence times within the permeable paver catchment basins and the control *** network advances are made by bridging the gap between sensor protocols and communication *** advances enable the development of open-source representational state transfer web *** successful implementation serves as an example for others to study and expand upon for a variety of monitoring solutions.

关键词： sensor networks Internet of things open geospatial consortium open innovation permeable pavers

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Holobricks:modular coarse integral holographic displays

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Light(Science & Applications) 2022年第4期11卷 580-594页

作者： Jin Li quinn Smithwick Daping Chu Centre for Photonic Devices and Sensors University of Cambridge9 JJ Thomson AvenueCambridge CB30FAUK Disney Research 521 Circle 7GlendaleCA 91201USA

Here,we propose and demonstrate a modular holographic display system that allows seamless spatial tiling of multiple coarse integral holographic(CIH)displays called"holobricks".A holobrick is a self-contained CIH module enclosing a spatial light modulator(SLM),a scanner,and periscopic coarse integral *** CIH uses a coarse pitch and small area but high-bandwidth SLM in conjunction with periscopic coarse integral optics to form the angularly tiled 3D holograms with large viewing areas and fields of *** creation of periscopic coarse integral optics prevents the optical system from being larger than the holographic image and allows the holographic fringe pattern to fill the entire face of the ***,multiple holobricks can be seamlessly abutted to form a scalable spatially tiled holographic image display capable of both wide feld-of-view angle and arbitrary large-size *** demonstrate an initial prototype that seamlessly tiles two holobricks each with 1024×768 pixels,40°FOV,full color,24 fps,displaying 2D,3D holographic stereograms,and full parallax 3D CGI Fresnel holograms.

关键词： holographic integral optics

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Testing development of different surface treatments on pervious concrete

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Frontiers of Structural and Civil Engineering 2016年第4期10卷 385-393页

作者： Mina YEKKALAR Liv HASELBACH quinn LANGFITT Civil and Environmental Engineering Washington State University Pullman WA 99164-2910 USA

Pervious concrete systems are developing stormwater management technologies which also have wintertime benefits as melting snow may percolate into the system instead of refreezing on the surface. Enhancing the surface microtexture of pervious concrete may also be beneficial in preventing icing or slipping by pedestrians. This research explored different surface treatments on pervious concrete specimens both qualitatively from personal judgements, and quantitatively through static friction measurements with a spring balance with respect to ＂slipperiness＂. The tests were performed on both dry and wet specimens. One aim was to determine whether the spring balance method may be a simple test for comparing surface treatments on pavement samples with little surface area such as laboratory specimens or sidewalk sections. The other purpose was to make a preliminary decision of which surface treatments to use for a sidewalk installation for future studies on wintertime performance. The reliability analysis of the spring balance results showed that there was high operator consistency. In addition, there was a high level of consistency on average results between the quantitative and qualitative methods. This implies that the spring balance test may be an acceptable methodology for comparative analyses with respect to static friction.

关键词： pervious concrete static coefficient of friction pedestrian

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Stress responses of plants through transcriptome plasticity by mRNA alternative polyadenylation

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Molecular Horticulture 2023年第1期3卷 127-140页

作者： Jiawen Zhou Qingshun quinn Li Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystem College of the Environment and EcologyXiamen UniversityXiamen 361102FujianChina Biomedical Sciences College of Dental MedicineWestern University of Health SciencesPomonaCA 91766USA

The sessile nature of plants confines their responsiveness to changing environmental *** expression regulation becomes a paramount mechanism for plants to adjust their physiological and morphological *** polyadenylation(APA)is known for its capacity to augment transcriptome diversity and plasticity,thereby furnishing an additional set of tools for modulating gene *** has also been demonstrated to exhibit intimate associations with plant stress *** this study,we review APA dynamic features and consequences in plants subjected to both biotic and abiotic *** stresses include adverse environmental stresses,and pathogenic attacks,such as cadmium toxicity,high salt,hypoxia,oxidative stress,cold,heat shock,along with bacterial,fungal,and viral *** analyzed the overarching research framework employed to elucidate plant APA response and the alignment of polyadenylation site transitions with the modulation of gene expression levels within the ambit of each stress *** also proposed a general APA model where transacting factors,including poly(A)factors,epigenetic regulators,RNA m6A modification factors,and phase separation proteins,assume pivotal roles in APA related transcriptome plasticity during stress response in plants.

关键词： Alternative polyadenylation RNA processing Transcriptome diversity Biotic and abiotic stress Stress response

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Habitat suitability and herbivores determine reintroduction success of an endangered legume

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Plant Diversity 2019年第2期41卷 109-117页

作者： Matthew A.Albrecht quinn G.Long Center for Conservation and Sustainable Development Missouri Botanical Garden Shaw Nature Reserve Missouri Botanical Garden

Reintroductions of rare plants require detailed knowledge of habitat requirements, species interactions,and restoration techniques. Thus, incremental experimentation over many years may be required to develop adequate knowledge and techniques for successful reintroduction. To determine drivers of extinction in historical reintroductions of a federally endangered perennial(Astragalus bibullatus), we developed a reintroduction experiment to disentangle the relative importance of habitat quality, herbivores, and restoration technique on reintroduction success. In a factorial design, we manipulated access to vertebrate herbivores across different habitat types(mesic ecotone vs. xeric barren), and used founder populations comprised of more transplants and genetic sources than previous reintroduction *** mesic ecotones where historical reintroductions failed, excluding herbivores, thinning woody encroachment to improve habitat quality, outplanting across a greater array of microhabitats, and increasing founder population size did not improve demographic rates over previous *** to mesic ecotones, transplant survival rates and cumulative fruit production were more than two and ten times greater, respectively, in a xeric barren ecotone characterized by open, grassy, and dry microenvironmental conditions. Across all sites, herbivores decreased probabilities of survival and flowering of larger adult plants. Flowering rates were 80% greater inside relative to outside herbivore exclusion cages. Over a four-year period, only a single uncaged plant produced fruit. Our study demonstrates that habitat quality and vertebrate herbivory are key drivers of long-term persistence in rare plant reintroductions. Using incremental experiments that build on previous knowledge gained from long-term monitoring can improve reintroduction outcomes.

关键词： Astragalus bibullatus Translocation Rare plant Conservation Founder size Grassland

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