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Recurrence of hepatocellular carcinoma following deceased donor liver transplantation:case series

Hepatoma Research 2020年第3期6卷 31-40页

作者： Cem Simsek Amy Kim michelle ma Nilay Danis merve Gurakar andrew m.cameron Benjamin Philosophe Jacqueline Garonzik-Wang Shane Ottmann Ahmet Gurakar Behnam Saberi Johns Hopkins University School of medicine Division of Gastroenterology and Hepatology-Transplant HepatologyBaltimoreMD 21205USA Johns Hopkins University Bloomberg School of Public Health BaltimoreMD 21205USA Johns Hopkins University School of medicine Division of Transplant SurgeryBaltimoreMD 21205USA

Aim:We aimed to study the clinical and pathological characteristics of liver transplant recipients with hepatocellular carcinoma ***:We reviewed the data for 26 patients who had tumor recurrence after deceased donor liver transplant for hepatocellular carcinoma at the Johns Hopkins Hospital from January 2005 to December ***:In total,88%of recipients were *** mean age was 59 *** explant,poor differentiation was detected in 43%,while 73%had microvascular ***,62%were diagnosed to be outside of milan *** of these,15%met the criteria for ***(77%)patients had pre-transplant alpha fetoprotein levels≥20 ng/*** 54%of patients,the location of hepatocellular carcinoma(HCC)recurrence was extrahepatic,followed by intrahepatic in 31%and both intra-and extrahepatic in 15%.The post-transplant tumor recurrence was diagnosed at a mean of 427 days(range 34-1502).Fifty percent of HCC recurrences were diagnosed within one year following liver ***(77%)patients received treatment for their recurrent HCC:external radiation(n=10),surgical resections(n=8;brain 4,spine 2,bone 1,and Whipple surgery 1),sorafenib(n=7),locoregional therapy(n=5).Overall,24 out of 26(92%)recipients died within four years after the ***:HCC recurrence after liver transplant is *** than fifty percent of HCC recurrences following liver transplant are *** better recipient selection for liver transplant,the curative options are limited in recurrent cases and associated with extremely poor outcomes.

关键词： Hepatocellular carcinoma liver transplant liver resection locoregional therapy

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Antimicrobial usage and resistance in beef production

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Journal of Animal Science and Biotechnology 2017年第2期8卷 249-270页

作者： andrew cameron Tim A.mcAllister Faculty of Veterinary medicine University of CalgaryCalgaryABCanada Agriculture and Agri-Food Canada LethbridgeABCanada

Antimicrobials are critical to contemporary high-intensity beef production. many different antimicrobials are approved for beef cattle, and are used judiciously for animal welfare, and controversially, to promote growth and feed efficiency. Antimicrobial administration provides a powerful selective pressure that acts on the microbial community, selecting for resistance gene determinants and antimicrobial-resistant bacteria resident in the bovine flora. The bovine microbiota includes many harmless bacteria, but also opportunistic pathogens that may acquire and propagate resistance genes within the microbial community via horizontal gene transfer. Antimicrobial-resistant bovine pathogens can also complicate the prevention and treatment of infectious diseases in beef feedlots,threatening the efficiency of the beef production system. Likewise, the transmission of antimicrobial resistance genes to bovine-associated human pathogens is a potential public health concern. This review outlines current antimicrobial use practices pertaining to beef production, and explores the frequency of antimicrobial resistance in major bovine pathogens. The effect of antimicrobials on the composition of the bovine microbiota is examined, as are the effects on the beef production resistome. Antimicrobial resistance is further explored within the context of the wider beef production continuum, with emphasis on antimicrobial resistance genes in the food chain, and risk to the human population.

关键词： Antibiotics Antimicrobial resistance Antimicrobial usage Beef production Bovine pathogens Bovine microbiota Cattle Enteropathogens Fecal bacteria Resistome

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Phylogeny and Biogeography of Smilacaceae based on nuclear and chloroplast DNA sequences

Phylogeny and Biogeography of Smilacaceae based on nuclear a...

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中国植物学会七十五周年年会

作者： Kenneth m.cameron Department of Botany University of WisconsinMadison MadisonWI 53706-1381U.S.A.

Smilacaceae are a cosmopolitan family of liliales characterized by climbing habit,reticulate leaf venation,paired petiolar tendrils,and unisexual *** from this generalized morphology have lead to the division of Smilacaceae into at least seven different genera and five sections within the large genus *** particular,taxa with connate tepals (Heterosmilax),

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Levels and Patterns of Genetic Variation in the Endangered Species Changium smyrnioides (Umbelliferae) Using Inter-simple Sequence Repeats(ISSR) and Allozyme markers

Levels and Patterns of Genetic Variation in the Endangered S...

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第七届全国系统与进化植物学青年学术研讨会

作者： Kenneth m.cameron The Lewis B.and Dorothy Cullman Program for molecular Systematics Studies TheNew York Botanical GardenBronxNew York 10458-5126 USA

Changium smyrnioids(Umbelliferae)is an endangered plant endemic to Eastern China. This study investigates the levels of genetic variation and patterns of population structure to provide genetic information for the development of suitable conservation strategies. Four of the seven known populations were sampled and analyzed using starch gel electrophoresis of ten enzymes coded by 19 interpretable loci. Population-level values for *** (means: P =33.0%, I=0.13, He = 0.07) are slightly exceeded mean values for endemic species. Values of GST tended to be high (mean GST= 0.578), indicating substantial divergence and limited gene flow among populations. We further investigated genetic variation among and within 7 populations with ISSRs profiles. Of the 196ISSR loci scored,

关键词： Changium smyrnioides. Conservation genetics Allozymes ISSRs

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从下地壳寻找金

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地质地球化学 1990年第4期18卷 1-5,11页

作者： Eion m.cameron 石其光江西地质科学研究所

石英-碳酸盐矿脉是世界黄金生产的主要来源。沿上地壳中剪切带侵位的这种矿脉的来源迄今还是个谜。挪威南部班布勒(Bamble)带贫金,与地壳丰度相比要低一个数量级以上;金矿床中的其他元素也已丢失。在高级变质作用期间,金溶解,并在通过... 详细信息

石英-碳酸盐矿脉是世界黄金生产的主要来源。沿上地壳中剪切带侵位的这种矿脉的来源迄今还是个谜。挪威南部班布勒(Bamble)带贫金,与地壳丰度相比要低一个数量级以上;金矿床中的其他元素也已丢失。在高级变质作用期间,金溶解,并在通过广阔的韧性剪切带上升的氧化、富硫流体中迁移。与变质作用同时发生的变形作用使岩石增加了利于溶液渗透流动的渗透性。

关键词：下地壳金找矿金矿地球化学

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由深部韧性剪切带氧化变质作用衍生的金:理论模式

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地质科技情报 1990年第1期9卷 81-86页

作者： Eion m.cameron 石其光

石英-碳酸盐金矿床侵位于脆性-韧性过渡带或其上部的剪切带内,已知有些最大的矿床系沿主要长期活动的横推剪切带形成。这类剪切带向下在韧性范围内加宽,这是由于岩石粘度随深度残小的结果。有些剪切带在麻粒岩相变质作用带的深度宽达40k... 详细信息

石英-碳酸盐金矿床侵位于脆性-韧性过渡带或其上部的剪切带内,已知有些最大的矿床系沿主要长期活动的横推剪切带形成。这类剪切带向下在韧性范围内加宽,这是由于岩石粘度随深度残小的结果。有些剪切带在麻粒岩相变质作用带的深度宽达40km。韧性剪切带是可渗透的,由于渗透是沿微裂隙进行的,流体的流动范围广,为广泛的化学反应提供了条件,其反应速率由于剪切热、矿物变形诱发的应力梯度和颗粒的减小而提高。因为进入剪切带的脆性部分压力下降使溶液流动趋于向上。已知韧性剪切带为楔形轮廓,通过广阔下地壳的流体集中在脆性-韧性过渡带,因此,如果当溶液流动通过下地壳时,存在有选择迁移的活动元素,则这些元素也会集中在过渡带。石英-碳酸盐脉最常见的特点之一是碳酸盐蚀变,它们可延伸于主要矿床千米之外。~13C特征与幔源的CO_2相似,可能为地幔成因的CO_2向上运移。这已被角闪岩相脱水变为麻粒岩相岩石及伴有大离子亲石元素(LILE)的亏损所证明。CO_2对下地壳的改变在主要剪切带表现最明显,在深部,CO_2排出只能出现在比石墨稳定性更加氧化的条件之下,这样有利于金的溶解,(a)使Au~。氧化为Au^+;(b)使Au^+与从岩石中溶解的硫化物络合,最近工作表明有些主要的太古代金矿床由相对氧化的溶液形成。至少对有些石英-

关键词：金矿金氧化变质作用剪切带

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Ischemic cholangiopathy after livertransplantation

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Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 495-501页

作者： andrew m. cameron Ronald W. Busuttil Division of Liver and Pancreas Transplantation Department of SurgeryDavid Geffen School of Medicine at UCLALos AngelesCalifornia 90095-7054USA

Orthotopic liver transplantation ( OLT) has evolved over the last forty years from an experimental endeavor to standard of care therapy for many patients with end stage hepatic disease. many technical advances have contributed to the current success of OLT, but surgical complications, especially involving the biliary reconstruction, remain a morbid problem. Biliary complications after OLT include leaks and strictures. Strictures may be anastoinotic or intrahepatic and diffuse, as seen in cases of hepatic artery thrombosis. Current efforts to expand the limited donor pool include the use of non-heart beating donors. The organ procurement process in these donors entails an increased period of warm ischemia and results with non-heart beating donor grafts have been mixed. It is now appreciated that there is an increased incidence of subsequent diffuse biliary stricturing or ' ischemic cholangiopathy' in recipients of these organs. Animal models of this phenomenon and potential therapeutic strategies targeted at ischemic cholangiopathy are being developed with potential applicability to non-heart beating donation and will be the focus of this review.

关键词： orthotopic liver transplantation biliary strictures non-anastoinotic strictures ischemic cholangiopathy non-heart beating donor

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In-service performance of emergency shutdown valves and dependent operational relationships in the offshore oil and gas industry

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Petroleum 2023年第4期9卷 613-620页

作者： Keith cameron andrew Lewis Diogo montalvao mohammad Reza Herfatmanesh School of Physics Engineering and Computer ScienceUniversity of HertfordshireUnited Kingdom Department of Design and Engineering Faculty of Science and TechnologyBournemouth UniversityUnited Kingdom

Industrial process plants use emergency shutdown valves(ESDVs)as safety barriers to protect against hazardous events,bringing the plant to a safe state when potential danger is *** ESDVs are used extensively in offshore oil and gas processing plants and have been mandated in the design of such systems from national and international standards and *** paper has used actual ESDV operating data from four mid/late life oil and gas production platforms in the North Sea to research operational relationships that are of interest to those responsible for the technical management and operation of *** first of the two relationships is between the closure time(CT)of the ESDV and the time it remains in the open position,prior to the close *** has been hypothesised that the CT of the ESDV is affected by the length of time that it has been open prior to being closed(Time since the last stroke).In addition to the general analysis of the data series,two sub-categories were created to further investigate this possible relationship for CT and these are“above mean”and“below mean”.The correlations(Pearson's based)resulting from this analysis are in the“weak”and“very weak”*** second relationship investigated was the effect of very frequent closures to assess if this improves the *** operational records for six subjects were analysed to find closures that occurred within a 24 h period of each ***,no discriminating trend was apparent where CT was impacted positively or negatively by the frequent closure *** was concluded that the variance of ESDV closure time cannot be influenced by the technical management of the ESDV in terms of scheduling the operation of the ESDV.

关键词： Emergency Shutdown Valve Safety instrumented systems Closure time IEC-61511

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Phylogenomics and integrative taxonomy reveal two new species of Amana(Liliaceae)

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Plant Diversity 2023年第1期45卷 54-68页

作者： mei-Zhen Wang Xiao-Kai Fan Yong-Hua Zhang Jing Wu Li-mi mao Sheng-Lu Zhang min-Qi Cai ming-Hong Li Zhang-Shi-Chang Zhu ming-Shui Zhao Lu-Xian Liu Kenneth m.cameron Pan Li Laboratory of Systematic&Evolutionary Botany and Biodiversity College of Life SciencesZhejiang UniversityHangzhou 310058ZhejiangChina College of Life and Environmental Sciences Wenzhou UniversityWenzhou325035China Nanjing Institute of Geology and Palaeontology Chinese Academy of SciencesNanjing 210008JiangsuChina Shanghai Science and Technology museum Shanghai200127China Nanyue Hengshan National Nature Reserve Administration Hengyang 421900HunanChina Zhejiang Tianmushan National Nature Reserve management Bureau Hangzhou311311China Key Laboratory of Plant Stress Biology School of Life SciencesHenan UniversityKaifeng 475001HenanChina Department of Botany University of WisconsinMadisonWI53706USA

Until now the genus Amana(Liliaceae),known as ’East Asian tulips’,has contained just seven *** this study,a phylogenomic and integrative taxonomic approach was used to reveal two new species,Amana nanyueensis from Central China and *** from East *** resembles Amana edulis in possessing a densely villous-woolly bulb tunic and two opposite bracts,but differs in its leaves and *** tianmuensis resembles Amana erythronioides in possessing three verticillate bracts and yellow anthers,but differs in aspects of its leaves and *** four species are clearly separated from each other in principal components analysis based on *** analyses based on plastid CDS further support the species delimitation of *** and *** and suggests they are closely related to *** analysis shows that *** and A tianmuensis are both diploid(2n=2x=24),different from A edulis,which is either diploid(northern populations) or tetraploid(southern populations,2n=4x=48).The pollen morphology of *** is similar to other Amana species(single-groove germination aperture),but *** is quite different because of the presence of a sulcus membrane,which creates the illusion of double *** niche modelling also revealed a niche differentiation between ***,*** and ***.

关键词： Amana edulis Parallel evolution Phylogeny Species concept Taxonomy Tulip

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Diagnosis of Vocal Cord Paralysis in Anaesthesia

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Journal of Donghua University(English Edition) 2011年第1期28卷 5-9页

作者：余炜曾孝平 HAmID GholamHosseini andrew cameron mICHAEL Harrison J Faculty of Information Engineering and Automation Kunming University of Science and Technology College of Communication Engineering Chongqing University Institute of Biomedical Technologies(IBTec) Auckland University of Technology middlemore Hospital(Otahuhu) Auckland 1640New Zealand School of medicine University of AucklandAuckland 1142New Zealand

Vocal cord paralysis can occur as a complication o surgery or anaesthesia,if permanent is a significant clinica *** detection is important to optimize the chance o repair,and avoid complications associated with an impaired *** algorithm to detect altered vocal cord function was presented based on wavelet packet analysis(WPA) and suppor vector machines(SVm),and compared with the Hoarseness Diagram method(HDm),which was reported as an objective voice quality evaluation approach and could be used for pathological voice *** using voice signals recorded from subjects before and after the procedure show high classification accuracy with the new algorithm,whereas HDm fails in the detection of a hoarse *** finding would help to develop a screening tool to detect the vocal structure damage during surgery.

关键词： vocal cord paralysis wavelet packet analysis(WPA) support vector machine(SVm) anaesthesia

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