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Chemosensitizing Effect of Monk Fruit Extract on Human Bladder Cancer Cells

Journal of Cancer Therapy 2024年第6期15卷 250-264页

作者： Sensuke Konno Jonathan Wong andrew Penunuri Kelvin Zheng Muhammad Choudhury Department of Urology New York Medical College Valhalla New York USA

The outcomes of chemotherapy have been unsatisfactory with the palpable side effects. We hypothesized that natural products might help improve chemotherapy with few side effects. Recently, we came across the bioactive extracts of monk fruit (Siraitia grosvenori) with anticancer activity. We then investigated if these extracts might have chemosensitizing effect to improve the efficacy of drugs clinically used today. Four different drugs, cisplatin (CPL), carboplatin (CBL), mitomycin C (MMC), and gemcitabine (GEM), were used in this study. Human bladder cancer T24 cells were treated with each drug itself or drug combined with either LLE or MOG (two types of monk fruit extracts). Cell viability was determined to assess anticancer effect and also explored the anticancer mechanism of such combinations, focusing on the status of glycolysis, cell cycle, and chromatin structure. Cell viability test showed that all drugs had anticancer activity, reducing cell viability, but only CPL showed the enhanced anticancer effect when combined with LLE (not with MOG). The rest of three drugs had no such effects with LLE or MOG. The CPL/LLE combination was found to disrupt glycolysis, by inhibiting hexokinase activity, resulted in the decreased ATP synthesis. This combination also blocked the cell cycle progression, due to a G1 cell cycle arrest. Moreover, the two epigenetic regulators, DNA methyltransferase and histone deacetylase, were inactivated with the combination, indicating chromatin modifications. Ultimately, these treated cells were found to undergo apoptosis. In conclusion, anticancer activity of CPL can be significantly enhanced with LLE. This chemosensitizing effect is attributed to the glycolysis inhibition, a G1 cell cycle arrest, and chromatin modifications, ultimately leading to apoptosis. Thus, certain natural products such as LLE could be used as an adjuvant agent in current chemotherapy, improving the drug efficacy but minimizing side effects.

关键词： Monk Fruit Anticancer Bladder Cancer Chemosensitization Lakanto

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Enhancing performance and longevity of solid-state zinc-iodine batteries with fluorine-rich solid electrolyte interphase

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Materials Futures 2024年第3期3卷 121-131页

作者： Yongxin Huang Yiqing Wang Xiyue Peng Tongen Lin Xia Huang Norah S Alghamdi Masud Rana Peng Chen Cheng Zhang andrew K Whittaker Lianzhou Wang and Bin Luo Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandBrisbaneQLD4072Australia School of Chemical Engineering The University of QueenslandBrisbaneQLD4072Australia School of Chemistry and Molecular Biosciences Faculty of ScienceThe University of QueenslandBrisbaneQLD4072Australia Department of Chemistry Faculty of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh 11564Saudi Arabia

Rechargeable zinc-iodine(ZnI_(2))batteries have gained popularity within the realm of aqueous batteries due to their inherent advantages,including natural abundance,intrinsic safety,and high theoretical ***,challenges persist in their practical applications,notably battery swelling and vulnerability in aqueous electrolytes,primarily linked to the hydrogen evolution reaction and zinc dendrite *** address these challenges,this study presents an innovative approach by designing a solid-state ZnI_(2)battery featuring a solid perfluoropolyether based polymer *** results demonstrate the formation of a solid electrolyte interphase layer on zinc,promoting horizontal zinc growth,mitigating dendrite penetration,and enhancing battery cycle ***,the solid electrolyte hinders the iodine ion shuttle effect,reducing zinc foil *** batteries employing this electrolyte demonstrate excellent cycle performance,maintaining stability for approximately 5000 h at room temperature,while solid-state ZnI_(2)batteries exhibit over 7000 cycles with a capacity retention exceeding 72.2%.This work offers a promising pathway to achieving reliable energy storage in solid-state ZnI_(2)batteries and introduces innovative concepts for flexible and wearable zinc batteries.

关键词： zinc-iodine battery solid electrolyte zinc metal anode electrolyte interphase shuttle effect

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Insights into upper blepharoplasty: Conservative volume-preserving techniques

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World Journal of Clinical Cases 2024年第27期12卷 6129-6131页

作者： andrew Gorgy Rawan Al Hashemi Johnny Ionut Efanov Plastic Reconstructiveand Aesthetic SurgeryMcGill UniversityMontreal H4A3J1QuebecCanada Plastic and Reconstructive Surgery Jaber Al Ahmad HospitalKuwait CityKuwait Plastic and Reconstructive Surgery Centre Hospitalier de l’Universitéde MontréalMontreal H2X 3E4QuebecCanada

This editorial commentary critically examines the systematic review by Miotti et al,which discusses the evolving trends in upper lid blepharoplasty towards a conservative,volume-preserving *** review emphasizes the shift from traditional tissue resection to techniques that maintain anatomical integrity,paralleling broader trends in panfacial *** et al delve into the nuances of fat pad management,advocating for conservation over reduction to sustain natural contours and improve long-term aesthetic *** perspective is supported by comparative studies and empirical data,such as those from Massry and Alghoul et al,highlighting the benefits of conservative approaches in terms of patient satisfaction and aesthetic *** review also stresses the importance of surgeon discretion in adapting procedures to diverse patient demographics,particularly in addressing distinct features such as the Asian upper ***,it identifies a significant gap in long-term comparative research,underscoring the need for future studies to substantiate the safety and efficacy of these minimalist ***,Miotti et al.'s work contributes profoundly to the discourse on personalized,conservative cosmetic surgery,urging ongoing research to refine and validate surgical best practices in upper eyelid blepharoplasty.

关键词： Upper lid blepharoplasty Volume preservation Panfacial rejuvenation Aesthetic longevity,Blepharoplasty

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Information Security in the Cloud: Emerging Trends and Challenges

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International Journal of Communications, Network and System Sciences 2024年第5期17卷 69-80页

作者： Keerthana Chitreddy andrew Mikhl Anthony Chinna Manikanta Bandaru Olatunde Abiona Department of Computer Information Systems Indiana University Northwest Gary IN USA

This article explores the evolution of cloud computing, its advantages over traditional on-premises infrastructure, and its impact on information security. The study presents a comprehensive literature review covering various cloud infrastructure offerings and security models. Additionally, it deeply analyzes real-life case studies illustrating successful cloud migrations and highlights common information security threats in current cloud computing. The article concludes by offering recommendations to businesses to protect themselves from cloud data breaches and providing insights into selecting a suitable cloud services provider from an information security perspective.

关键词： Cloud Computing Information Security Cloud Infrastructure Offerings Cloud Migration Security Measures Data Breaches Cloud Service Providers Cybersecurity Cloud Security Case Studies Cloud Threat Landscape Data Encryption Compliance Cloud Security Tools

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Emerging probing perspective of two-dimensional materials physics:terahertz emission spectroscopy

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Light(Science & Applications) 2024年第7期13卷 1278-1298页

作者： Yifei Wu Yuqi Wang Di Bao Xiaonan Deng Simian Zhang Lin Yu-chun Shengxian Ke Jianing Liu Yingjie Liu Zeli Wang Pingren Ham andrew Hanna Jiaming Pan Xinyue Hu Zhengcao Li Ji Zhou Chen Wang State Key Laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua University100084 BeijingChina Beijing Advanced Innovation Center for Integrated Circuits 100084 BeijingChina

Terahertz(THz)emission spectroscopy(TES)has emerged as a highly effective and versatile technique for investigating the photoelectric properties of diverse materials and nonlinear physical processes in the past few ***,research on two-dimensional(2D)materials has experienced substantial growth due to their atomically thin structures,exceptional mechanical and optoelectronic properties,and the potential for applications in flexible electronics,sensing,and ***,these materials offer advantages such as tunable bandgap,high carrier mobility,wideband optical absorption,and relatively short carrier *** applying TES to investigate the 2D materials,their interfaces and heterostructures,rich information about the interplay among photons,charges,phonons and spins can be unfolded,which provides fundamental understanding for future *** it is timely to review the nonlinear processes underlying THz emission in 2D materials including optical rectification,photon-drag,high-order harmonic generation and spin-to-charge conversion,showcasing the rich diversity of the TES employed to unravel the complex nature of these *** applications based on THz emissions,such as THz lasers,ultrafast imaging and biosensors,are also *** further,we analyzed the unique advantages of spintronic terahertz emitters and the future technological advancements in the development of new THz generation mechanisms leading to advanced THz sources characterized by wide bandwidth,high power and integration,suitable for industrial and commercial *** continuous advancement and integration of TES with the study of 2D materials and heterostructures promise to revolutionize research in different areas,including basic materials physics,novel optoelectronic devices,and chips for post-Moore’s era.

关键词： optoelectronic versatile exceptional

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Music alters heart rate and psychological responses but not muscle activation during light-intensity isometric exercise

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Sports Medicine and Health Science 2024年第4期6卷 394-401页

作者： andrew R.Moore Jasmin C.Hutchinson Christa Winter Paul C.Dalton Lori A.Bolgla Vincent J.Paolone Department of Kinesiology Augusta University112015th St.AugustaGA30912USA Department of Exercise Science&Athletic Training Springfield College263 Alden St.SpringfieldMA01109USA Department of Psychology Springfield College263 Alden St.SpringfieldMA01109USA Heart&Vascular Institute Penn State College of MedicinePenn State University500 HMC Crescent RoadNorth Lobby HersheyPA17033USA Department of Physical Therapy Augusta University112015th St.AugustaGA30912USA

Listening to music manipulates attention to be more externally focused,which has the potential to improve muscular *** study aimed to determine the effect of listening to music on muscle activation during an isometric exercise task,and compare this effect to those of other attentional focus *** healthy subjects(n=35;16 men/19 women)completed an isometric elbow flexion task for 1 min in three randomized and counterbalanced conditions:internal focus(INT),external focus with a simple distraction task(EXT),or listening to music(MUS).Muscle activation of the biceps and triceps brachii and heart rate(HR)were recorded throughout the exercise *** of perceived exertion(RPE),affective valence,and motivation were measured at the end of each *** was no difference in muscle activation measures among the three *** during MUS was lower than EXT at 15 s([89.4±11.8]beats/min vs.[93.1±12.9]beats/min;p=0.018)and 30 s([90.6±12.4]beats/min vs.[94.2±12.5]beats/min;p=0.026),and lower than INT at 60 s([93.3±13.3]beats/min vs.[96.7±12.0]beats/min;p=0.016).Overall RPE was higher for INT(13.4±2.2)than for MUS([12.6±2.0];p=0.020)and EXT([11.94±2.22];p<0.001).Affective valence was higher for MUS than for INT([2.7±1.4]vs.[2.1±1.5];p=0.011).Manipulating attentional focus did not alter muscle activation for a light-intensity isometric muscular endurance task,though MUS was reported as more positive and requiring less exertion to complete than *** music can therefore be recommended during light-intensity isometric exercise based on the psychological benefits observed.

关键词： Electromyography Attentional focus Rating of perceived exertion Elbow flexion

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Non-steroidal anti-inflammatory drugs in postoperative hand fracture management:Do they positively or negatively impact recovery?

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World Journal of Clinical Cases 2024年第21期12卷 4856-4858页

作者： andrew Gorgy Jacqueline Dalfen Natasha Barone Johnny Ionut Efanov Department of Plastic Reconstructiveand Aesthetic SurgeryMcGill UniversityMontreal H4A 3J1QCCanada Faculty of Medicine and Health Sciences McGill UniversityMontreal H4A 3J1QCCanada Department of Plastic and Reconstructive Surgery University of TorontoToronto M5S 1A1ONCanada Department of Plastic and Reconstructive Surgery Centre Hospitalier de l’Universitéde MontréalMontreal H2X 3E4QCCanada

This editorial explores the impact of non-steroidal anti-inflammatory drugs(NSAIDs)on postoperative recovery in hand fracture patients,amidst shifting pain management strategies away from opioids due to their adverse *** hand fractures being significantly common and postoperative pain management crucial for recovery,the potential of NSAIDs offers a non-addictive pain control ***,the controversy over NSAIDs'effects on bone healing—stemming from their Cyclooxygenase-2 inhibition and associated risks of fracture non-union or delayed union—necessitates further *** a comprehensive literature search,the study finds a lack of specific research on NSAIDs in postoperative hand fracture management,highlighting an urgent need for future studies to balance their benefits against possible risks.

关键词： Hand fracture Post operative management Non-steroidal anti-inflammatory drugs Non-union Bone healing Cyclooxygenase-2 inhibitors Opioid alternatives

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Outcomes following minimally invasive dorsal cheilectomy for hallux rigidus:A systematic review

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World Journal of Orthopedics 2024年第6期15卷 585-592页

作者： Katherine Esser James J Butler Mackenzie Roof Nathaniel P Mercer Michael C Harrington Alan P Samsonov andrew J Rosenbaum John G Kennedy Department of Orthopaedic Surgery University of Toledo Medical Center University of Toledo College of Medicine and Life SciencesToledoOH 43614United States Department of Orthopedic Surgery NYU Langone HealthNew YorkNY 10002United States Department of Orthopedic Surgery Albany Medical CenterAlbanyNY 12208United States

BACKGROUND Cheilectomy of the 1^(st)metatarsophalangeal joint(MTPJ)is one of the most common procedures for the management of hallux ***,there is no consensus regarding outcomes following minimally invasive dorsal cheilectomy(MIDC)for the management of hallux *** To evaluate outcomes following MIDC for the management of hallux *** During November 2023,the PubMed,EMBASE and Cochrane Library databases were systematically reviewed to identify clinical studies examining outcomes following MIDC for the management of hallux *** Six studies were *** total,348 patients(370 feet)underwent MIDC for hallux rigidus at a weighted mean follow-up of 37.9±16.5 *** distribution of patients by Coughlin and Shurna's classification was recorded in 4 studies as follows:Ⅰ(58 patients,27.1%),Ⅱ(112 patients,52.3%),Ⅲ(44 patients,20.6%).Three studies performed an additional 1^(st)MTPJ arthroscopy and debridement following *** intra-articular bone debris was observed in 100%of patients in 1 *** weighted mean American orthopedic foot and ankle society score improved from a preoperative score of 68.9±3.2 to a postoperative score of *** complication rate was 8.4%,the most common of which was persistent joint pain and ***-two failures(8.7%)were ***-three secondary procedures(8.9%)were performed at a weighted mean time of 8.6±3.2 months following the index *** This systematic review demonstrated improvements in subjective clinical outcomes together with a moderate complication rate following MIDC for the management of hallux rigidus at short-term follow-up.A moderate reoperation rate at short-term follow-up was *** marked heterogeneity between included studies and paucity of high quality comparative studies limits the generation of any robust conclusions.

关键词： Minimally invasive dorsal cheilectomy Hallux rigidus The first metatarsophalangeal joint Cheilectomy Minimally invasive surgery

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Increasing the Efficiency and Level of Environmental Safety of Pro-Environmental City Heat Supply Technologies by Low Power Nuclear Plants

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World Journal of Nuclear Science and Technology 2024年第2期14卷 107-117页

作者： Vladimir Kravchenko Igor Kozlov Volodymyr Vashchenko Iryna Korduba andrew Overchenko Serhii Tsybytovskyi Department of Nuclear Power Plants Odesa Polytechnic National University Odesa Ukraine Interdepartmental Scientific Center for Fundamental Research on Energy and Ecology of the National Academy of Sciences of Ukraine &#8220Odesa Polytechnic&#8221 and Ministry of Ecology of Ukraine Odesa Ukraine Department of Environmental Protection and Labor Protection Technologies Kyiv National University of Construction and Architecture Kyiv Ukraine

In connection with the current prospect of decarbonization of coal energy through the use of small nuclear power plants (SNPPs) at existing TPPs as heat sources for heat supply to municipal heating networks, there is a technological need to improve heat supply schemes to increase their environmental friendliness and efficiency. The paper proves the feasibility of using the heat-feeding mode of ASHPs for urban heat supply by heating the network water with steam taken from the turbine. The ratio of electric and thermal power of a “nuclear” combined heat and power plant is given. The advantage of using a heat pump, which provides twice as much electrical power with the same heat output, is established. Taking into account that heat in these modes is supplied with different potential, the energy efficiency was used to compare these options. To increase the heat supply capacity, a scheme with the use of a high-pressure heater in the backpressure mode and with the heating of network water with hot steam was proposed. Heat supply from ASHPs is efficient and environmentally friendly even in the case of significant remoteness of heat consumers.

关键词： Low-Capacity Nuclear Power Plants Environmental Friendliness of the Thermal Power Generation Mode Heat Generation Condensation Mode Heat Supply

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Temperate Stutzerimonas Phage Encoding Toxin-Antitoxin System Genes Represents a Novel Genus

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Journal of Ocean University of China 2024年第4期23卷 1087-1101页

作者： ZHANG Hong GUO Ruizhe GAO Chen ZHENG Kaiyang XIONG Yao DONG Yue LIU Yundan WANG Ziyue CHEN Ying WANG Hongmin SHAO Hongbing SUNG Yeong Yik MOK Wen Jye WONG Li Lian MCMINN andrew WANG Min LIANG Yantao College of Marine Life Sciences Institute of Evolution and Marine BiodiversityMOE Laboratory of Evolution and Marine BiodiversityFrontiers Science Center for Deep Ocean Multispheres and Earth SystemCenter for Ocean Carbon NeutralityOcean University of ChinaQingdao 266003China UMT-OUC Joint Center for Marine Studies Qingdao 266003China Institute of Marine Biotechnology Universiti Malaysia Terengganu21030 Kuala TerengganuMalaysia Institute for Marine and Antarctic Studies University of TasmaniaHobartTAS 7001Australia Haide College Ocean University of ChinaQingdao 266100China The Affiliated Hospital of Qingdao University Qingdao 266001China

Stutzerimonas have been extensively studied due to their remarkable metabolic and physiological ***,research on its phages is currently *** this study,we isolated a novel double-stranded DNA(dsDNA)phage,vB_SstM-PG1,from the marine environment that infects Stutzerimonas stutzeri *** dsDNA genome is 37204 bp long with a G/C content of 64.14%and encodes 54 open reading *** phage possesses a tail packaging structure that is different from known Stutzerimonas stutzeri phages and exhibits structural protein characteristics similar to those of temperate *** addition,two genes of toxin-antitoxin system,including YdaS_antitoxin and HEPN_SAV_6107,were found in the vB_SstM-PG1 genome and play important roles in regulating host growth and *** phylogenetic tree and comparative genomic analysis,it has been determined that vB_SstM-PG1 is not closely related to any phages previously identified in the GenBank ***,it has a connection with enigmatic,uncultured ***,the vB_SstM-PG1 virus exhibits an average nucleotide identity of over 70%with six uncultivated viruses identified in the IMG/VR v4 *** significant finding has resulted in the identification of a novel viral genus known as Metabovirus.

关键词： Stutzerimonas vB_SstM-PG1 Metabovirus temperate phage genomic and phylogenetic analysis

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