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Association of donor hepatectomy time with liver transplantation outcomes: A multicenter retrospective study

World Journal of Transplantation 2024年第1期14卷 130-140页

作者： Geisiane Custodio andrew Maykon Massutti Aline Caramori Taynara Gonçalves Pereira Augusto Dalazen Gabriela Scheidt Ludmilla Thomazini Cristiane Bauermann Leitão Tatiana Helena Rech Department of Intensive Care Unit Hospital Santa IsabelBlumenau-Santa Catarina CEP-89010906Brazil Transplant Division Hospital Santa IsabelBlumenau-Santa Catarina CEP-89010906Brazil School of Medicine Universidade Regional de Blumenau(FURB)Blumenau-Santa Catarina CEP-89010906Brazil School of Medicine Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Brazil Departement of Endocrinology Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Rio Grande do SulBrazil Department of Internal Medicine Hospital de Clínicas de Porto AlegreDivision of Intensive Care MedicinePorto Alegre 90035-903Brazil

BACKGROUND Prolonged donor hepatectomy time may be implicated in early and late complications of liver *** To evaluate the impact of donor hepatectomy time on outcomes of liver transplant recipients,mainly early allograft *** This multicenter retrospective study included brain-dead donors and adult liver graft ***-recipient matching was obtained through a crossover *** and laboratory data were recorded for both donors and *** hepatectomy,cold ischemia,and warm ischemia times were *** outcome was early allograft *** outcomes included need for retransplantation,length of intensive care unit and hospital stay,and patient and graft survival at 12 *** From January 2019 to December 2021,a total of 243 patients underwent a liver transplant from a brain-dead *** these,57(25%)developed early allograft *** median donor hepatectomy time was 29(23–40)*** with early allograft dysfunction had a median hepatectomy time of 25(22–38)min,whereas those without it had a median time of 30(24–40)min(P=0.126).CONCLUSION Donor hepatectomy time was not associated with early allograft dysfunction,graft survival,or patient survival following liver transplantation.

关键词： Brain death Hepatectomy Liver transplantation Early allograft dysfunction Graft survival

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CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKM supports antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling Colin A.Chavel Anand P.Sharda Mackenzie M.Lieberman Caitlin M.James Shivana M.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou andrew M.Intlekofer Richard M.Higashi Teresa W.M.Fan andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:Massachusetts Institute of Technology BostonMA 02139USA Present address:Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of PKM2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKM alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 PKM2

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Survey of international experts on research priorities to improve care for healthy ageing

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Family Medicine and Community Health 2024年第3期12卷 36-39页

作者： Matteo Cesari Yuka Sumi Hyobum Jang Jotheeswaran Amuthavalli Thiyagarajan Yejin Lee Rachel Albone Marco Canevelli Monica R Perracini andrew M Briggs Anshu Banerjee Department of Maternal NewbornChild and Adolescent Health and AgeingWorld Health OrganizationGenevaSwitzerland Department of Clinical Sciences and Community Health University of MilanMilanItaly Department of Human Neuroscience Universitàdegli Studi di Roma La SapienzaRomeItaly Department of Neurobiology Care Sciences and SocietyStockholm UniversityStockholmSweden National Center for Disease Prevention and Health Promotion Italian National Institute of HealthRomeItaly Master's and Doctoral Program in Physical Therapy Universidade Cidade de São PauloSão PauloBrazil Curtin School of Allied Health Curtin enAble InstituteCurtin UniversityPerthWAAustralia

INTRODUCTION The United Nations(UN)Decade of Healthy Ageing(2021–2030),coordinated by the World Health Organization(WHO),1 is a global collaborative initiative aimed at improving the lives of older people,their families and the communities.23 The Action Areas 3(ie,‘deliver person-centred,integrated care and primary health services responsive to older people’)and 4(ie,‘provide access to long-term care(LTC)for older people who need it’)of the Decade’s work programme focus on reorienting health and care systems to promote‘ageing in place’and the delivery of personalised interventions in a seamless continuum of care.

关键词： services ageing centre

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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman Jason Lynch Christopher E.Stevens Christopher Munley Chentao Li Jin Hou Hao Zhang andrew Torma Thomas Darlington Francis Coen Kevin Li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into E–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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卫星编队实现人造小型日食

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科技纵览 2024年第7期 10-11页

作者： andrew Jones 不详

欧洲航天局在未来几个月内将执行一项发射任务,使用两艘航天器编队在轨道上以精确的形式定位,形成一次人造日食。欧洲航天局的普罗巴3号(机载自主项目)包括一对航天器:300公斤的Coronagraph和250公斤的Occulter。按计划,这两艘航天器将... 详细信息

欧洲航天局在未来几个月内将执行一项发射任务,使用两艘航天器编队在轨道上以精确的形式定位,形成一次人造日食。欧洲航天局的普罗巴3号(机载自主项目)包括一对航天器:300公斤的Coronagraph和250公斤的Occulter。按计划,这两艘航天器将由印度空间研究组织开发的极轨卫星运载火箭发射,进入最近距离600公里、最远距离60350公里的高度椭圆的轨道,这两艘航天器相距约144米。

关键词：欧洲航天局空间研究组织最近距离极轨卫星日食卫星编队形式定位自主项目

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Generation of Eco-Friendly and Disease-Resistant Channel Catfish(Ictalurus punctatus)Harboring the Alligator Cathelicidin Gene via CRISPR/Cas9 Engineering

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Engineering 2024年第8期39卷 273-286页

作者： Jinhai Wang Baofeng Su De Xing Timothy J.Bruce Shangjia Li Logan Bern Mei Shang andrew Johnson Rhoda Mae C.Simora Michael Coogan Darshika U.Hettiarachchi Wenwen Wang Tasnuba Hasin Jacob Al-Armanazi Cuiyu Lu Rex A.Dunham School of Fisheries Aquacultureand Aquatic SciencesAuburn UniversityAuburnAL 36849USA

As a precise and versatile tool for genome manipulation,the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)platform holds promise for modifying fish traits of *** the aim of reducing transgene introgression and controlling reproduction,upscaled disease resistance and reproductive intervention in catfish species have been studied to lower the potential environmental risks of the introgression of escapees as transgenic *** advantage of the CRISPR/Cas9-mediated system,we succeeded in integrating the cathelicidin gene(As-Cath)from an alligator(Alligator sinensis)into the target luteinizing hormone(lh)locus of channel catfish(Ictalurus punctatus)using two delivery systems assisted by double-stranded DNA(dsDNA)and single-stranded oligodeoxynucleotides(ssODNs),*** this study,high knock in(KI)efficiency(22.38%,64/286)but low ontarget events was achieved using the ssODN strategy,whereas adopting a dsDNA as the donor template led to an efficient on-target KI(10.80%,23/213).The on-target KI of As-Cath was instrumental in establishing the lh knockout(LH^(–)_As-Cath^(+))catfish line,which displayed heightened disease resistance and reduced fecundity compared with the wild-type(WT)sibling ***,administration of human chorionic gonadotropin(HCG)and luteinizing hormone-releasing hormone analogue(LHRHa)can restore the reproduction of the transgenic fish ***,we replaced the lh gene with an alligator cathelicidin transgene and then administered hormone therapy to move towards complete reproductive control of diseaseresistant transgenic catfish in an environmentally responsible *** strategy not only effectively improves consumer-valued traits but also guards against unwanted introgression,providing a breakthrough in aquaculture genetics to confine fish reproduction and prevent the establishment of transgenic or domestic genotypes in the natural environment.

关键词： Genome editing ssODN dsDNA Antimicrobial peptide Reproductive confinement Aquaculture

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支撑中国探月工程的五架航天器

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科技纵览 2024年第5期 10-11页

作者： andrew Jones 不详

嫦娥六号登月之旅并非易事。在2024年3月,鹊桥二号中继星成功发射升空,开启了一项复杂多级项目的第一步。该项目最快将于今年夏季在月球背面采集样本,并将珍贵的样本送回地球,这是一项前所未有的壮举。

关键词：中继星中国探月工程月球背面航天器登月

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重返月球,即将就绪

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科技纵览 2024年第1期 50-53,4页

作者： andrew Jones 不详

在2024年年底之前,将有4人登上航天器,飞往月球、绕月之后再返回地球。是的,曾经去过,曾经做过。但那已经过去50多年了。美国国家航空航天局的“阿尔忒弥斯二号”任务是2025年登月计划的热身,这将标志着自1972年“阿波罗17号”任务以来... 详细信息

在2024年年底之前,将有4人登上航天器,飞往月球、绕月之后再返回地球。是的,曾经去过,曾经做过。但那已经过去50多年了。美国国家航空航天局的“阿尔忒弥斯二号”任务是2025年登月计划的热身,这将标志着自1972年“阿波罗17号”任务以来,美国首次有宇航员离开近地轨道。“这表明,美国正在恢复已失去几十年的技术能力,正在计划让宇航员重返月球。”英国莱斯特大学副教授布莱丁·鲍文(Bleddyn Bowen)说,“经过几十年的概念艺术、含糊其词的承诺、总统和国会的犹豫不决,现在看到一次真正的载人绕月任务,确实令人振奋。”

关键词：登月计划近地轨道概念艺术宇航员英国莱斯特大学阿波罗阿尔忒弥斯

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Imaging the western boundary of the Sichuan Craton from multiple geophysical observations

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Journal of Earth Science 2024年

作者： Qihang Yin Xi Xu Xiaodong Yang Xuhua Shi Lei Wu andrew V.Zuza Liu Yang Hefeng Tian Yuanhai Shu Shufeng Yang Nevada Bureau of Mines and Geology， University of Nevada China Aero Geophysical Survey and Remote Sensing Center for Natural Resources，China Geological Survey School of Earth Sciences， Zhejiang University Research Center for Structures in Oil and Gas Bearing Basins， Ministry of Education Key Laboratory of Ocean and Marginal Sea Geology， South China Sea Institute of Oceanology， Innovation Academy of South China Sea Ecology and Environmental Engineering， Chinese Academy of Sciences School of Mechanical and Electrical Engineering， Hubei Open University

The boundary between the cratonic and orogenic lithospheres is one of the most significant seismogenic zones characterized by strong lithospheric deformation. As the essential tectonic block bounding the eastern Tibetan Plateau， the Sichuan Craton (SCC) resists the eastward escape of Plateau’s crustal materials， resulting in the uplift of the Songpan-Ganzi Block (SGB) and the crustal deformation of the Longmenshan tectonic belt (LMTB). To uncover the compressional structures and deformational mode of the LMTB and SCC， it is crucial to determine the precise location and geometry of the western boundary of the SCC. To address this issue， the lithospheric properties of the obduction SGB， the underthrusting SCC， and the LMTB were analyzed using a series of geophysical data， including seismic reflection profiles， magnetotellurics， aeromagnetics， gravity， and seismic tomography. The crust of the SGB is characterized by low magnetism， low seismic velocity， low resistivity and low Bouguer gravity， while that of the SCC features non-uniform high magnetism， high seismic velocity， high resistivity and high Bouguer gravity. The LMTB， as the boundary between the SGB and SCC， shows the geophysical characteristics similar to the SCC along the southern and central segments. The integration of all these geophysical observations suggests that the SCC’s western boundary follows the Yingxiu-Beichuan fault along the northern segment， without obvious underthrust. However， this boundary is located west of the Wenchuan-Maoxian fault zone along the southern and central segments， with distinct westward wedging/underthrusting. The irregular geometry of the SCC’s western boundary can further explain the variation in structural deformation along the LMTB. By comparing the differences in crustal thickness and lithospheric strength between the SGB and SCC， this study suggests that the varying crustal strength between tectonic blocks may be the controlling factor for the irregular geometry of the

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Correction to:Advancing the Disaster and Development Paradigm

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International Journal of Disaster Risk Science 2024年第1期15卷 178-178页

作者： andrew E.Collins Department of Geography and Environmental Sciences/Disaster and Development Network(DDN) Northumbria UniversityNewcastle upon Tyne NE18STUK

Correction to:International Journal of Disaster Risk Science(2018)9:486–495 https://***/10.1007/s13753-018-0206-5 In this article the reference to Lewis(2012)was incorrect;it should have read Lewis and Kelman(2012),with the following details:Lewis,J.,and *** good,the bad and the ugly:Disaster Risk Reduction(DRR)versus Disaster Risk Creation(DRC).PLoS Currents:***://***/10.1371/4f8d4eaec6af8.

关键词： details Creation Lewis

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