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含水层层状非均质对地下水流系统的影响

中国地质 2020年第6期47卷 1715-1725页

作者：张俊刘天罡董佳秋王晓勇查元源唐小平尹立河 andrew j.love 中国地质调查局干旱半干旱区地下水与生态重点实验室陕西西安710054 中国地质调查局西安地质调查中心陕西西安710054 河北省众联能源环保科技有限公司河北石家庄050056 武汉大学水资源与水电工程科学国家重点实验室湖北武汉430072 School of the Environment/National Centre for Groundwater Research and Trainning Flinders UniversityAdelaide SA 5001Australia

区域尺度上含水层非均质具有复杂的结构性和随机性,难以准确刻画,造成非均质对区域地下水流系统的影响机制研究不够深入。本文以鄂尔多斯盆地白垩系地下水流系统为研究实例,选择典型剖面,采用剖面二维随机数值模拟方法,通过对比不同非... 详细信息

区域尺度上含水层非均质具有复杂的结构性和随机性,难以准确刻画,造成非均质对区域地下水流系统的影响机制研究不够深入。本文以鄂尔多斯盆地白垩系地下水流系统为研究实例,选择典型剖面,采用剖面二维随机数值模拟方法,通过对比不同非均质刻画方法下地下水流场的变化,探讨含水层层状非均质对地下水流系统的影响机制。结果显示,均质条件下模型各向异性(含水层水平和垂向渗透系数比值Kh/Kv)取值为1000时,地下水流场与实际条件较为接近;非均质条件下,渗透系数方差取值0.91,水平相关长度取值5000 m,Kh/Kv取值150时,接近实际条件。研究表明,在大尺度地下水流模拟研究中,采用水平相关长度、渗透系数方差和各向异性值三个变量生成的随机场能很好地刻画含水层的层状非均质特征及其对水流系统的影响控制作用。由于含水层不同尺度层状非均质的叠加效应,采用均质各向异性介质等效概化含水层层状非均质性会造成等效各向异性值偏大失真的效应。

关键词：地下水流系统含水层非均质各向异性数值模拟水文地质调查工程鄂尔多斯盆地

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer C.Munoz Pareja andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Validation of Zebrafish (Danio rerio) Reference Genes for Quantitative Real-time RT-PCR Normalization

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Acta Biochimica et Biophysica Sinica 2007年第5期39卷 384-390页

作者： andrew DODD Daniel LA Warren C. MCNABB Donald R. love School of Biological Sciences University of Auckland Private Bag 92019 Auckland 1142 New Zealand Food and Health Group AgResearch Grasslands Private Bag 11008 Tennant Drive Palmerston North New Zealand

The normalization of quantitative real time RT-PCR (qRT-PCR) is important to obtain accurate gene expression data. The most common method for qRT-PCR normalization is to use reference, or house- keeping genes. However, there is emerging evidence that even reference genes can be regulated under different conditions, qRT-PCR has only recently been used in terms of zebrafish gene expression studies and there is no validated set of reference genes. This study characterizes the expression of nine possible reference genes during zebrafish embryonic development and in a zebrafish tissue panel. All nine reference genes exhibited variable expression. The β-actin, EF1α and Rp113α genes comprise a validated reference gene panel for zebrafish developmental time course studies, and the EF1α, Rp113α and 18S rRNA genes are more suitable as a reference gene panel for zebrafish tissue analysis. Importantly, the zebrafish GAPDH gene appears unsuitable as reference gene for both types of studies.

关键词： zebrafish quantitative real-time RT-PCR housekeeping genes GAPDH gene GeNorm

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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加拿大华人癌肿死亡率研究(摘要)

中山大学学报(医学科学版) 1990年第1期 23-26页

作者：王志瑾,Savitri Ramcharan,Edgar j.love 中山医科大学流行病学教研室加拿大卡尔加里大学公共卫生系加拿大卡尔加里大学公共卫生系

本文比较加拿大华人与加拿大人的癌肿死亡率。结果显示加拿大华人癌肿死亡率无论男、女均高于加拿大人,男标化死亡比(SMR)为141;女SMR为116,其差异在统计学上有极显著意义。各部位癌肿死亡情况与美国华人极为相似。加拿大华人无论男、... 详细信息

本文比较加拿大华人与加拿大人的癌肿死亡率。结果显示加拿大华人癌肿死亡率无论男、女均高于加拿大人,男标化死亡比(SMR)为141;女SMR为116,其差异在统计学上有极显著意义。各部位癌肿死亡情况与美国华人极为相似。加拿大华人无论男、女其鼻咽癌、肝癌死亡率明显高于加拿大人。肺、胃、肠癌死亡率亦高于加拿大人。加拿大华人男性前列腺癌低于加拿大人;加拿大华人女性肺癌、子宫颈癌均高于加拿大人;但乳腺癌、卵巢癌明显低于加拿大人。加拿大华人男、女皮肤癌死亡率均明显低于加拿大人。这对进一步研究加拿大华人癌肿病因提供一可靠依据。

关键词：加拿大华人死亡率标化死亡比

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Bio-Imitation of Mexican Migration Routes to the USA with Slime Mould on 3D Terrains

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journal of Bionic Engineering 2013年第2期10卷 242-250页

作者： andrew Adamatzky Genaro j Martinez Department of Computer Sciences University of the West of England Bristol BS16 1QY UK Escuela Superior de Computo Instituto Politecnico Nacional Mexico

Plasmodium ofPhysarum polycephalum （P. polycephalum） is a large single cell visible by an unaided eye. It shows sophisticated behavioural traits in foraging for nutrients and developing an optimal transport network of protoplasmic tubes spanning sources of nutrients. When placed in an environment with distributed sources of nutrients the cell computes＇ an optimal graph spanning the nutrients by growing a network of protoplasmic tubes. P. polycephalum imitates development ofman-made transport networks of a country when configuration of nutrients represents major urban areas, We employed this feature of the slime mould to imitate mexican migration to USA. The Mexican migration to USA is the World＇s larger migration system. We bio-physically imitated the migration using slime mould P. poIycephalum. In laboratory experiments with 3D Nylon terrains of USA we imitated development of migratory routes from Mexico-USA border to ten urban areas with high concentration of Mexican migrants. From results of laboratory experiments we extracted topologies of migratory routes, and highlighted a role of elevations in shaping the human movement networks.

关键词： biomimetics bio-inspired computing migration routes slime mould