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Nutrition in alcohol-related liver disease:Physiopathology and management

World Journal of Gastroenterology 2020年第22期26卷 2916-2930页

作者： Umair Kamran Jennifer Towey Amardeep Khanna Abhishek Chauhan Neil Rajoriya andrew holt The Liver Unit Queen Elizabeth Hospital BirminghamBirmingham B152GWUnited Kingdom Department of Dietetics Queen Elizabeth Hospital BirminghamBirmingham B152GWUnited Kingdom Centre for Liver Research Institute of Immunology and Inflammationand National Institute for Health Research(NIHR)Birmingham Biomedical Research CentreThe Medical SchoolUniversity of BirminghamBirmingham B152TTUnited Kingdom

Malnutrition encompassing both macro-and micro-nutrient deficiency,remains one of the most frequent complications of alcohol-related liver disease(ArLD).Protein-energy malnutrition can cause significant complications including sarcopenia,frailty and immunodepression in cirrhotic *** reduces patient’s survival and negatively affects the quality of life of individuals with ***,nutritional deficit increases the likelihood of hepatic decompensation in *** recognition of at-risk individuals,early diagnosis and treatment of malnutrition remains a key component of ArLD *** this review,we describe the pathophysiology of malnutrition in ArLD,review the screening tools available for nutritional assessment and discuss nutritional management strategies relevant to the different stages of ArLD,ranging from acute alcoholic hepatitis through to decompensated end stage liver disease.

关键词： Malnutrition Sarcopenia Alcohol-related liver disease Nutritional assessment Nutrition support Micronutrients

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Suppressing tawny crazy ant (Nylanderia fulva) by RNAi technology

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Insect Science 2020年第1期27卷 113-121页

作者： Jia Meng Jiaxin Lei andrew Davitt Jocelyn Rholt Jian Huang Roger Gold Edward L Vargo Aaron MTarone Keyan Zhu-Salzman College of Plant Protection Fujian Agricultural and Forestry UniversityFuzhouFujianChina Department of Entomology Texas A&M UniversityCollege StationTexasUSA Institute for Plant Genomics&Biotechnology Texas A&M UniversityCollege StationTexasUSA

A bstract The tawny crazy ant(Nylanderia fulva)is a new invasive pest in the United *** present,its management mainly relies on the use of synthetic insecticides,which are generally ineffective at producing lasting control of the pest,necessitating alternative environmentally friendly *** this study,we evaluated the feasibility of gene silencing to control this ant *** housekeeping genes encoding actin(NfActin),coatomer subunit β (NfCOPP),arginine kinase(NfArgK),and V-type proton ATPase subunits A(NfvATPaseA),B(NfvATPaseB)and E(NfvATPaseE)were *** analysis revealed high sequence similarity to homologs from other ant species,particularly the Florida carpenter ant(Camponotus floridanus).To silence these genes,vector L4440 was used to generate six specific RNAi constructs for bacterial ***-inactivated,dsRNA-expressing Escherichia coli were incorporated into artificial *** ants exhibited reduced endogenous gene expression after feeding on such diet for 9 ***,only ingestion of dsRNAs of NfCOPfi(a gene involved in protein trafficking)and NfArgK(a cellular energy reserve regulatory gene in invertebrates)caused modest but significantly higher ant mortality than the *** results suggest that bacterially expressed dsRNA can be orally delivered to ant cells as a mean to target its *** efficacy is necessary for the RNAi-based approach to be useful in tawny crazy ant management.

关键词： artificial diet gene silencing housekeeping gene Nylanderia fulva RNAi survival rate

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Femoro Patella Vialla patellofemoral arthroplasty: An independent assessment of outcomes at minimum 2-year follow-up

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World Journal of Orthopedics 2016年第8期7卷 487-493页

作者： Mansur Halai andrew Ker Iain Anthony Graeme holt Bryn Jones Mark Blyth Department of Trauma and Orthopaedics Glasgow Royal Infirmary Department of Trauma and Orthopaedics University Hospital Crosshouse

AIM: To determine outcomes using the Femoro-Patella Vialla(FPV) arthroplasty and if there is an ideal patient for this implant. METHODS: A total of 41 FPV patellofemoral joint replacements were performed in 31 patients(22 females, 9 males, mean age 65 years). Mean followup was 3.2 years(minimum 2 years). Radiographs were reviewed preoperatively and postoperatively. We assessed whether gender, age, previous surgery, patella atla or trochlear dysplasia influenced patient satisfaction or patient functional ***: The median Oxford Knee Score was 40 and the median Melbourne Patellofemoral Score was 21 postoperatively. Seventy-six percent of patients were satisfied, 10% unsure and 14% dissatisfied postoperatively. There was no radiological progression of tibiofemoral joint arthritis, using the Ahlback grading,in any patient. One patient, who was diagnosed with rheumatoid arthritis postoperatively, underwent revision to total knee replacement. There were no intraoperative lateral releases and no implant failures. Gender, age, the presence of trochlear dysplasia, patella alta or bilateral surgery did not influence patient outcome. Previous surgery did not correlate with outcome. CONCLUSION: In contrast to the current literature, the FPV shows promising early results. However, we cannot identify a subgroup of patients with superior outcomes.

关键词： Patellofemoral Arthritis Femoro-Patella Vialla Outcomes Arthroplasty

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