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Machine Intelligence Research 2025年第1期22卷 117-130页

作者： Aoxiang Dong andrew Starr Yifan Zhao School of Aerospace Transport and ManufacturingCranfield UniversityCranfield MK430ALUK

Traditional parametric system identification methods usually rely on apriori knowledge of the targeted system,which may not always be available,especially for complex *** neural networks(NNs)have been increasingly adopted in system iden-tification,most studies have failed to derive interpretable parametric models for further *** this paper,we propose a novel end-to-end autoregressive with exogenous input(ARX)model identification framework using *** order-wise neural network structure is introduced and trained using a multitask learning approach to simultaneously identify both the model terms and coefficients of the ARX *** testing with various neural network backbones and training data sizes in different scenarios,we empirically demonstrate that the proposed framework can effectively identify an arbitrary stable ARX model with finite simulation training *** study opens up a new research opportunity for parametric system identification by harnessing the power of deep learning.

关键词： Linear system identification and estimation learning systems model structure determination multivariable systems deep learning.

Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： andrew Gregory Chengyun Tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

hepatic artery infusion chemotherapy:A resurgence

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 299-303页

作者： andrew Kai-Yip Fung Kenneth Siu ho Chok Department of Surgery The Chinese University of Hong KongPrince of Wales HospitalHong Kong 999077China

In this manuscript,we comment on the article by Zhou et al,who assessed the efficacy of hepatic arterial infusion chemotherapy(hAIC)and its combination strategies for advanced hepatocellular carcinoma(hCC)using network metaanalysis *** focus specifically on the potential advantages and role of hAIC in the treatment algorithm for advanced ***,there remains numerous knowledge gaps before the role of hAIC can be *** is significant heterogeneity of hAIC regimes with difficult interpretation of the clinical ***,there is a lack of direct comparative data between hAIC,systemic chemotherapy,novel immunotherapies and targeted *** underlying biochemical mechanisms that might explain the efficacy of hAIC and its effect on the hCC microenvironment requires further *** the developing era of nanotechnology and targeted drug delivery systems,there is potential for integration of hAIC with novel technologies to effectively treat advanced hCC whilst minimising systemic complications.

关键词： hepatocellular carcinoma hepatic artery infusion chemotherapy Immunotherapy Targeted therapy Transarterial chemoembolisation

Experimental Study for Effect of Multi-Site Spark Ignition on Dedicated hybrid Engine Performance under high Dilution Condition

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Journal of Thermal Science 2025年第1期34卷 254-267页

作者： YAN Bowen WATERS Benjamin hAINES andrew MCGhEE Mike hU Tiegang DENG Wei PU Yongxian MA Tianyu Powertrain Engineering R&D Center Chongqing Changan Automobile Co.Ltd.Chongqing 400000China Changan UK R&D Centre Limited Birmingham B377YGUnited Kingdom

In this study,a triple spark ignition scheme was first designed on a three-cylinder 1.5-L dedicated hybrid engine(DhE).On this basis,the effect of different ignition modes on engine combustion and emission characteristics was studied,especially under high dilution *** results tested at 2000 r/min and 0.8 MPa BMEP(brake mean effective pressure)show that with highly increased in-cylinder flow intensity,using only passive prechamber(PPC)has a lower lean limit than that with single central spark plug(CSP),thereby leading to slightly higher minimum fuel consumption and nitrogen oxides(NO_(x))*** side spark plugs(SSP)based on PPC can result in improved capability of lean limit extension and engine performance than ***,the improvement level is lower than that with triple spark plugs(TSP).As the excess air ratio λ increases,the advantage of PPC and PPC with SSP in improving the combustion phasing compared with CSP gradually ***,the increasing tendency of their ignition delay and combustion duration is more *** added SSP based on PPC can effectively shorten the ignition delay of leaner mixture,but the combustion duration can be only slightly *** a result,under extremely lean condition,the advantage of PPC and PPC with SSP in terms of combustion characteristics over CSP becomes much *** contrast,the TSP ignition can achieve much shorter ignition delay and combustion duration simultaneously under this *** to the highest available dilution level,the TSP ignition achieves the lowest raw NO_(x)***,it can also reduce the raw carbon monoxide(CO)and hydrocarbons(hC)emissions compared to CSP due to a more thorough combustion of the end gas *** on the excellent performance of TSP,the highest engine brake thermal efficiency(BTE)was further *** results show that with normal RON 92 fuel,the engine finally achieved 43.69% and 45.02% BTE under stochiometric mode with exhaus

关键词： dedicated hybrid engine triple spark plug scheme passive prechamber high dilution condition thermal efficiency NO_(x)emissions

human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche andrew Chan Robert hoepner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(hERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation human

CO_(2)-mediated bicarbonate conversion to concentrated formate in a CEM-based electrolyzer

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Journal of Energy Chemistry 2025年第1期100卷 605-611页

作者： haocheng Xiong Donghuan Wu haonan Li andrew Li Qikun hu Siyao Song Bingjun Xu Qi Lu State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Ordos Laboratory Inner Mongolia 017000China

Renewable energy-driven bicarbonate conversion to valuable chemicals presents an attractive strategy for mitigating CO_(2)emissions,as bicarbonate can be efficiently generated from the capture of atmospheric CO_(2)using alkaline solutions with reactive *** this work,we present a CO_(2)-mediated bicarbonate conversion to pure formate using a cation exchange membrane-based electrolyzer with a 25 cm^(2)electrode *** electrolysis achieved selectivities exceeding 75%for formate at a total current of 2.5 A,achieving formate concentrations up to 1.2 M and yields as high as 95%over extended *** techno-economic assessment confirmed the economic viability of the process,highlighting the potential for bicarbonate electrolysis as a sustainable method for producing valuable chemicals.

关键词： Electrocatalysis Techno-economic assessments Electrochemistry Flow electrolyzer

ENSO-induced Latitudinal Variation of the Subtropical Jet Modulates Extreme Winter Precipitation over the Western himalaya

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Advances in Atmospheric Sciences 2025年第3期42卷 427-437页

作者： Priya BhARATI Pranab DEB Kieran M.R.hUNT andrew ORR Mihir Kumar DASh Centre for Ocean RiverAtmosphere and Land Sciences(CORAL)Indian Institute of Technology KharagpurKharagpur 721302India Department of Meteorology University of ReadingReadingRG66ETUK National Centre for Atmospheric Science University of ReadingRG66ETUK British Antarctic Survey CambridgeCB30ETUK

In this study,we investigate the complex relationship between western disturbances(WDs),the El Ni?o–Southern Oscillation(ENSO),and extreme precipitation events(EPEs) in the western himalaya(Wh) during the extended winter season(November–March).WDs west of Wh coincide with 97% of recorded EPEs,contributing substantially(32% in winter,11% annually) to total precipitation within *** are 6% less frequent and 4% more intense during El Ni?o than La Ni?a to the west of *** El Ni?o(compared to La Ni?a) years,WDs co-occurring with EPEs are significantly more intense and associated with 17% higher moisture transport over “Wh box”(the selected region where most of the winter precipitation over Wh occurs).This results in twice the EPE frequency during El Ni?o periods than La Ni?a periods.A substantial southward shift(~180 km) of the subtropical jet(STJ) axis during El Ni?o brings WD tracks further south towards their primary moisture sources,especially the Arabian *** have shown that WDs that are both more intense and pass to the south of their typical latitudes have higher levels of vertically integrated moisture flux(VIMF)within *** convergence in the most intense pentile of WDs is 5.7 times higher than in the weakest,and is 3.4 times higher in the second lowest latitude pentile than in the ***,this study demonstrates a direct link between changes in the latitudinal position and intensity of WDs associated with the winter STJ,and moisture convergence,which leads to the occurrence of EPEs over Wh during ENSO phases.

关键词： western himalaya extreme precipitation western disturbances ENSO moisture flux winter

The effect of adsorbent textural and functional properties on model naphthenic acid adsorption

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Journal of Environmental Sciences 2025年第2期148卷 27-37页

作者： Tyler M.Roy Elmira Nazari Oliver K.L.Strong Paul R.Pede andrew J.Vreugdenhil Material Science Department of ChemistryTrent University1600 West BankPeterboroughOntario K9L 0G2Canada Carbonix 690 Mountain RdSuite 200Fort William First NationOntario P7J 1G8Canada

Naphthenic acids,NAs,are a major contaminant of concern and a focus of much research around remediation of oil sand process affected waters,*** activated carbon adsorbents are an attractive option given their low cost of fabrication and implementation.A deeper evaluation of the effect NA structural differences have on uptake affinity is *** we provide an in-depth exploration of NA adsorption including many more model NA species than have been assessed previously with evaluation of adsorption kinetics and isotherms at the relevant alkaline ph of OSPW using several different carbon adsorbents with ph buffering to simulate the behaviour of real *** for the NA varied considerably regardless of the activated carbon used,ranging from 350 mg/g to near zero highlighting recalcitrant *** equilibrium data was explored to identify structural features of these species and key physiochemical properties that influence *** found that certainNAwill be resistant to adsorptionwhen hydrophobic adsorbents are *** isotherm modelling helped explore interactions occurring at the interface between NA and adsorbent *** identified the importance of NA hydrophobicity for activated carbon *** is also presented that indicates favorable hydrogen bonding between certain NA and surface site hydroxyl groups,demonstrating the importance of adsorbent surface functionality for NA *** research highlights the challenges associated with removing NAs from OSPW through adsorption and also identifies howadsorbent surface chemistry modification can be used to increase the removal efficiency of recalcitrant NA species.

关键词： Adsorption Activated carbon Model naphthenic acids Isotherm modelling

Innovative approaches in predicting outcomes for rectal neuroendocrine tumors

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World Journal of Gastroenterology 2025年第6期31卷 126-131页

作者： Mahmoud Nassar Bahaaeldin Baraka andrew h Talal Department of Internal Medicine Jacobs School of Medicine and Biomedical SciencesUniversity of BuffaloBuffaloNY 14221United States Department of Research American Society for InclusionDiversityand Equity in HealthcareLewesDE 19958United States Medical Oncologist OncologyNottingham University HospitalsCity HospitalNottingham NG51PBUnited Kingdom Department of Medicine University at BuffaloState University of New YorkBuffaloNY 14203United State

Rectal neuroendocrine neoplasms pose significant challenges due to their varied presentations and *** prognostic models,while useful,often fall short of accurately predicting clinical outcomes for these *** article discusses the development and implications of a novel prognostic tool,the GATIS score,which aims to enhance predictive accuracy and guide treatment strategies more effectively than current *** data from a large cohort and employing sophisticated statistical models,the GATIS score integrates clinical and pathological markers to provide a nuanced assessment of *** evaluate the potential of this score to transform clinical decision-making processes,its integration into current medical practices,and future directions for its *** integration of genetic markers and other biomarkers could further refine its predictive power,highlighting the ongoing need for innovation in the management of rectal neuroendocrine neoplasms.

关键词： Rectal neuroendocrine tumors GATIS score Tumor staging Rectal neuroendocrine neoplasms Survival prediction Prognostic assessment Biomarkers Neuroendocrine carcinoma