检索结果-南通市图书馆

Machine learning-guided accelerated discovery of structure-property correlations in lean magnesium alloys for biomedical applications

引用

j.urnal of Magnesium and Alloys 2024年第6期12卷 2267-2283页

作者： Sreenivas Raguraman Maitreyee Sharma Priyadarshini Tram Nguyen Ryan McGovern andrew Kim Adam j.Griebel Paulette Clancy Timothy P.Weihs Department of Materials Science and Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Hopkins Extreme Materials Institute Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Department of Chemical and Biomolecular Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Translational Tissue Engineering Center Johns Hopkins School of Medicine400 N BroadwayBaltimore21231MDU.S.A Department of Biomedical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Research and Development Fort Wayne Metals Research ProductsLLC9609 Ardmore AveFort Wayne46809INU.S.A Department of Mechanical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A

Magnesium alloys are emerging as promising alternatives to traditional orthopedic implant materials thanks to their biodegradability,biocompatibility,and impressive mechanical ***,their rapid in-vivo degradation presents challenges,notably in upholding mechanical integrity over *** study investigates the impact of high-temperature thermal processing on the mechanical and degradation attributes of a lean Mg-Zn-Ca-Mn alloy,*** rapid,cost-efficient characterization methods like X-ray diffraction and optical microscopy,we swiftly examine microstructural changes post-thermal *** Pearson correlation coefficient analysis,we unveil the relationship between microstructural properties and critical targets(properties):hardness and corrosion ***,leveraging the least absolute shrinkage and selection operator(LASSO),we pinpoint the dominant microstructural factors among closely correlated *** findings underscore the significant role of grain size refinement in strengthening and the predominance of the ternary Ca_(2)Mg_(6)Zn_(3)phase in corrosion *** suggests that achieving an optimal blend of strength and corrosion resistance is attainable through fine grains and reduced concentration of ternary *** thorough investigation furnishes valuable insights into the intricate interplay of processing,structure,and properties in magnesium alloys,thereby advancing the development of superior biodegradable implant materials.

关键词： Magnesium alloys Machine learning Corrosion Mechanical properties Rapid characterization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Editorial for the Special Issue on Emerging Technology and Advanced Application of Nondestructive Detection for Power Equipment

引用

Chinese j.urnal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li j. Mei H. Li S. Tianj.n University China Tsinghua Shenzhen International Graduate School China Lanzhou j.aotong University China

The rapid development of clean and renewable energy technologies represented by wind and solar energy,as well as the continuous growth of load demand,have put forward higher requirements for the safe operation of the power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,which cannot meet the reliability requirements of power systems in the new *** detection is an essential technical method in industrial development,which can detect and evaluate the defect and damage status of in-service equipment,key components,and materials without damaging the obj.ct.

关键词： service Application operation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development of novel 5-FU modified siRNA against BCL-2 with enhanced efficacy and vehicle-free cellular uptake

引用

Genes & Diseases 2024年第1期11卷 23-25页

作者： andrew Fesler Ga-Ram Hwang j.ngfang j. Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA The Northport Veteran's Administration Medical Center NorthportNY 11768USA Curamir Therapeutics Inc. WoburnMA 01801USA

One of the maj.r obstacles for nucleic acid-based medicine is cellular uptake due to the concern of efficiencyand potential toxicity of the *** this work,we developed a novel approach to eliminate the need for a vehicle to allow for the cellular uptake of siRNA-based therapy with a unique modification strategy that also further enhances therapeutic *** discovery may be of great importance for the development of siRNA-based therapeutics as cellular uptake remains a critical *** this study,we have tested the potential of this modification strategy for siRNA using a siRNA that targets B-cell lymphoma-2(BCL-2).

关键词： eliminate uptake modified

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The impact of sarcopenia on patients undergoing treatment for pancreatic ductal adenocarcinoma

引用

j.urnal of Pancreatology 2020年第2期3卷 59-71页

作者： Amundson j.lia R. Williams j.lani K. Benj.min andrew j. Witmer Hunter D.D. Roggin Kevin K. Department of Surgery University of Chicago Medical CenterChicagoILUSA

Introduction:Pancreatic ductal adenocarcinoma(PDAC)is a deadly cancer that disproportionately affects geriatric *** therapy with surgery and chemotherapy is associated with longer survival than medical treatment or supportive *** selection of patients for surgical treatment,based on patient-specific factors such as sarcopenia,may help risk-stratify patients and improve *** paper aims to review the current literature on the impact of sarcopenia and sarcopenic obesity on patients undergoing treatment for ***:The impact of sarcopenia and sarcopenia obesity on perioperative and long-term outcomes after treatment for PDAC is *** has been associated with high-grade complications,longer length of hospital,and intensive care unit stays,more frequent discharge to skilled nursing facilities and decreased utilization of adj.vant therapy in patients treated with curative intent *** obesity has been associated with more complications,high-grade complications,and hematologic *** with sarcopenic obesity may have even lower overall survival than sarcopenic ***:The effect of a pre-treatment diagnosis of sarcopenia or sarcopenic obesity on outcomes for patients undergoing treatment for PDAC remains unknown,in part due to the heterogeneity of studies and *** programs including resistance exercise and nutritional supplementation have shown benefit in sarcopenic ***:PDAC remains a deadly disease and patient-specific factors such as sarcopenia and sarcopenic obesity identified at the time of cancer diagnosis offer potential as risk stratification measures and points of ***,a paucity of standardized measurement tools,definitions,and prehabilitation regimens limits the clinical implementation of such knowledge.

关键词： Frailty Pancreatic ductal adenocarcinoma Sarcopenia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Some Mean Convergence Theorems for the Maximum of Normed Double Sums of Banach Space Valued Random Elements

引用

Acta Mathematica Sinica,English Series 2024年第7期40卷 1727-1740页

作者： andrew ROSALSKY Le Van THANH Nguyen Thi THUY Department of Statistics University of FloridaGainesvilleFL 32611-8545USA Department of Mathematics Vinh UniversityVinhNghe AnViet Nam High School for Gifted Students Vinh UniversityVinhNghe AnViet Nam

In this correspondence,we establish mean convergence theorems for the maximum of normed double sums of Banach space valued random *** of the results pertain to random elements which are *** expand and improve a number of particular cases in the literature on mean convergence of random elements in Banach *** of the main contributions of the paper is to simplify and improve a recent result of Li,Presnell,and Rosalsky[j.urnal of Mathematical Inequalities,16,117–126(2022)].A new maximal inequality for double sums of M-dependent random elements is proved which may be of independent *** sharpness of the results is illustrated by four examples.

关键词： Double sum mean convergence Rademacher type p Banach space Banach space valued random element M-dependent random elements

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

《SHOCK》2019年第3期新观点

引用

实用休克杂志（中英文） 2019年第2期3卷 114-116页

作者： Hongkuan Fan andrew j. Goodwin 朱浙祥(译) 不详湖南省人民医院(湖南师范大学附属第一医院)急诊科急危重症代谢组学湖南省重点实验室

2019年3月期的《休克》杂志将临床和基础科学研究有力结合,填补了创伤、脓毒症和炎症领域的重要知识空白。该期共16篇文章,重点讨论凝血疾病、输血、生物标志物、内皮功能、巨噬细胞极化和细胞治疗。这些文章的作者们给大家带来了精彩... 详细信息

2019年3月期的《休克》杂志将临床和基础科学研究有力结合,填补了创伤、脓毒症和炎症领域的重要知识空白。该期共16篇文章,重点讨论凝血疾病、输血、生物标志物、内皮功能、巨噬细胞极化和细胞治疗。这些文章的作者们给大家带来了精彩的研究成果。纤维蛋白溶解关闭是创伤死亡率增加的一个独立危险因素。第一篇文章来自务实优秀的最优血小板和血浆比率(PROPPR)研究小组,是一篇关于创伤后血栓弹力图(TEG)纤维蛋白溶解关闭的继发性研究。

关键词：纤维蛋白溶解独立危险因素生物标志物血栓弹力图创伤后科学研究内皮功能细胞治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Increased proportion of alcohol-related trauma in a South London maj.r trauma centre during lockdown:A cohort study

引用

Chinese j.urnal of Traumatology 2022年第5期25卷 277-282页

作者： Oliver S.Brown Toby O.Smith andrew j.Gaukroger Prodromos Tsinaslanidis Caroline B.Hing St George's University Hospitals NHS Foundation Trust LondonUnited Kingdom Faculty of Medicine and Health Sciences University of East AngliaNonwvichUnited Kingdom

Purpose:Alcohol has been associated with 10%—35%trauma admissions and 40%trauma-related deaths *** response to the COVID-19 pandemic,the United Kingdom entered a state of"lockdown"on March 23,*** were most significantly eased on j.ne 1,2020,when shops and schools *** purpose of this study was to quantify the effect of lockdown on alcohol-related trauma ***:All adult patients admitted as"trauma calls"to a London maj.r trauma centre during April 2018 and April 2019(pre-lockdown,n=316),and 1st April—31st May 2020(lockdown,n=191)had electronic patient records analysed ***’blood alcohol level and records of intoxication were used to identify alcohol-related *** admissions from pre-lockdown and lockdown cohorts were compared using multiple regression ***:Alcohol-related trauma was present in a significantly higher proportion of adult trauma calls during lockdown(lockdown 60/191(31.4%),***-lockdown 62/316(19.6%);(odds ratio(OR):0.83,95%CI:0.38—1.28,p0.05).Conclusions:The United Kingdom lockdown was independently associated with an increased proportion of alcohol-related *** admissions were increased during the weekend when staffing levels are *** the possibility of further global"waves"of COVID-19,the long-term repercussions of dangerous alcohol-related behaviour to public health must be addressed.

关键词： Trauma Alcohol Lockdown COVID-19 Maj.r trauma centre

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

这书让你不烦躁

引用

作者： (美)安德鲁·伯恩斯坦(andrew j. Bernstein)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Is VATS Bullectomy and Pleurectomy an Effective Method for the Management of Spontaneous Pneumothorax?

引用

Open j.urnal of Thoracic Surgery 2016年第3期6卷 25-31页

作者： Ramzi A. Addas Farid M. Shamj. Sudhir R. Sundaresan Patrick j.mes Villeneuve andrew j. E. Seely Sebastien Gilbert Donna E. Maziak Department of Thoracic Surgery General Hospital Ottawa Canada

Spontaneous pneumothorax, primary or secondary, is a common medical emergency for which specific indications for surgical intervention are well defined in selected patients. The traditional surgical approach has been by limited thoracotomy using axillary or posterolateral incision. With the advent of video-assisted minimally invasive technique in the last 20 years the traditional approach is infrequently used. The definitive operation to prevent recurrent pneumothorax by surgical approach requires bullectomy and parietal pleurectomy. The recurrence rate after the traditional open surgical approach has been low at <2%. On the other hand, video-assisted thoracoscopic surgery, although better tolerated has a higher recurrence rate at 5% [1]. Information on post-operative morbidity and mortality are lacking. For this reason, we have reviewed our experience at one institution on the outcome of the VATS approach. We found that prolonged post- operative air leak is the most common complication and cigarette smoking remains an important associated factor.

关键词： Bullectomy Pleurectomy Thoracoscopic Morbidity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hard Paternalism and Confucian Familism

引用

Fudan j.urnal of the Humanities and Social Sciences 2024年第3期17卷 455-478页

作者： andrew Tsz Wan Hung Division of Social Sciences Humanities and DesignCollege of Professional and Continuing EducationThe Hong Kong Polytechnic University9 Hoi Ting RoadYau Ma TeiKowloonHong KongChina

In this paper,I criticize j.el Feinberg's argument of soft paternalism,which stands against hard paternalism,as being *** assessing one's voluntariness is very difficult and controversial,paternalistic measures would be preferable to be implemented by hard paternalism rather than soft paternalism.I then examine four usual criticisms of hard paternalism from the perspective of utilitarianism and the principle of autonomy.I argue that these criticisms are unsound and unfounded,and I defend hard paternalism from the perspective of Confucian familism.I argue that as one's life and identity are inseparable from one's family,“self-regarding”actions,traditionally understood,do not only affect the self,but also one's family ***,paternalistic measures to protect individuals from self-harming are also aimed to protect their family members which are indeed compatible with Mill's harm principle.

关键词： Paternalism Feinberg j.hn S.Mill-Confucian familism Autonomy:Voluntariness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：