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Evidence-based biomaterials research

Bioactive Materials 2022年第9期7卷 495-503页

作者： Kai Zhang Bin Ma Kaiyan Hu Bo Yuan Xin Sun Xu Song Zhonglan Tang Hai Lin Xiangdong Zhu Yufeng Zheng andres jgarcía Antonios GMikos James MAnderson Xingdong Zhang Institute of Regulatory Science for Medical Devices Sichuan UniversityChengdu610064PR China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu610064PR China College of Biomedical Engineering Sichuan UniversityChengdu610064PR China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou730000PR China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province Lanzhou730000PR China Chinese Evidence-based Medicine Centre West China HospitalSichuan UniversityChengdu610041PR China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871PR China Woodruff School of Mechanical Engineering Petit Institute for Bioengineering and BioscienceGeorgia Institute of TechnologyAtlantaGA30332-0363USA Departments of Bioengineering Chemical and Biomolecular EngineeringRice UniversityHoustonTX77251USA Departments of Pathology Biomedical Engineering and Macromolecular Science and EngineeringCase Western Reserve UniversityClevelandOH44106USA

The fast development of biomaterials science and engineering has generated significant number of studies and publications as well as tremendous amount of research data.A methodology is needed to translate such research data and results to validated scientific *** article for the first time proposes the concept and methodology of evidence-based biomaterials research,which is to use evidence-based research approach represented by systematic reviews to generate evidence for answering scientific questions related to *** briefly introducing the advancement of biomaterials since 1950s,the scientific and engineering nature of biomaterials are discussed along with the roadmap of biomaterials translation from basic research to commercialized medical products,and the needs of scientific *** information of the evidence-based approach such as its origination from evidence-based medicine,levels of evidence,systematic review and meta-analysis,differences between systematic and narrative reviews is then *** with a step-by-step procedure of conducting evidence-based biomaterials research,three examples of biomaterials research using evidence-based approach to generate scientific evidence,and opportunities and challenges of evidence-based biomaterials research are *** its notable impact on the practice of medicine,the evidence-based approach is also expected to make influential contributions to the biomaterials field.

关键词： Biomaterial Biomaterials research Evidence-based medicine Evidence-based approach Systematic review Meta-analysis

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Endotoxin-induced alterations of adipose tissue function:a pathway to bovine metabolic stress

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1391-1407页

作者： Miguel Chirivi G.andres Contreras Department of Large Animal Clinical Sciences Michigan State UniversityEast LansingMIUSA

During the periparturient period, dairy cows exhibit negative energy balance due to limited appetite and increased energy requirements for lactogenesis. The delicate equilibrium between energy availability and expenditure puts cows in a state of metabolic stress characterized by excessive lipolysis in white adipose tissues(AT), increased production of reactive oxygen species, and immune cell dysfunction. Metabolic stress, especially in AT, increases the risk for metabolic and inflammatory diseases. Around parturition, cows are also susceptible to endotoxemia. Bacterial-derived toxins cause endotoxemia by promoting inflammatory processes and immune cell infiltration in different organs and systems while impacting metabolic function by altering lipolysis, mitochondrial activity, and insulin sensitivity. In dairy cows, endotoxins enter the bloodstream after overcoming the defense mechanisms of the epithelial barriers, particularly during common periparturient conditions such as mastitis, metritis, and pneumonia, or after abrupt changes in the gut microbiome. In the bovine AT, endotoxins induce a pro-inflammatory response and stimulate lipolysis in AT, leading to the release of free fatty acids into the bloodstream. When excessive and protracted, endotoxin-induced lipolysis can impair adipocyte's insulin signaling pathways and lipid synthesis. Endotoxin exposure can also induce oxidative stress in AT through the production of reactive oxygen species by inflammatory cells and other cellular components. This review provides insights into endotoxins' impact on AT function, highlighting the gaps in our knowledge of the mechanisms underlying AT dysfunction, its connection with periparturient cows' disease risk, and the need to develop effective interventions to prevent and treat endotoxemia-related inflammatory conditions in dairy cattle.

关键词： Adipose tissue dysfunction Endotoxin Inflammation Insulin resistance

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Carbon stock estimation in halophytic wooded savannas of Uruguay:An ecosystem approach

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Forest Ecosystems 2024年第4期11卷 580-589页

作者： andres Baietto andres Hirigoyen Carolina Toranza Franco Schinato Maximiliano Gonzalez Rafael Navarro Cerrillo Forest Department Faculty of AgronomyUniversity of the RepublicMontevideoPO 12900Uruguay National Research Program of Forest Production National Agriculture Research InstituteTacuaremboPO 97000Uruguay Soil and Water Department Faculty of AgronomyUniversity of the RepublicMontevideoPO 12900Uruguay Department of Forestry Engineering University of CordobaCordobaPO 14014Spain

Savannas constitute a mixture of trees and shrub patches with a more continuous herbaceous *** contribution of this biome to the soil organic carbon(SOC)and above-ground biomass(AGB)carbon(C)stock globally is ***,they are frequently subjected to land use changes,promoting increases in CO_(2) *** Uruguay,subtropical wooded savannas cover around 100,000 ha,of which approximately 28%is circumscribed to sodic soils(i.e.,subtropical halophytic wooded savannas).Nevertheless,there is little background about the contribution of each ecosystem component to the C stock as well as site-specific allometric *** study was conducted in 5 ha of subtropical halophytic wooded savannas of the national protected area Esteros y Algarrobales del Rio *** work aimed to estimate the contribution of the main ecosystem components(e.g.,soil,trees,shrubs,and herbaceous plants)to the C ***-specific allometric equations for the most frequent tree species and shrub genus were fitted based on basal diameter(BD)and total height(H).The fitted equations accounted for between 77%and 98%of the aerial biomass variance of Netuma affinis and Vachellia *** shrubs(Baccharis sp.),the adjusted equation accounted for 86%of total aerial biomass.C stock for the entire system was 116.71±11.07 Mg·ha^(-1),of which 90.7%was allocated in the soil,8.3%in the trees,0.8%in the herbaceous plants,and 0.2%in the *** results highlight the importance of subtropical halophytic wooded savannas as C sinks and their relevance in the mitigation of global warming under a climate change scenario.

关键词： Carbon stock Climate change Biomass modeling Sodic soils

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A Distributionally Robust Optimization Scheduling Model for Regional Integrated Energy Systems Considering Hot Dry Rock Co-Generation

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1387-1404页

作者： Hao Qi Mohamed Sharaf andres Annuk Adrian Ilinca Mohamed A.Mohamed College of Electrical and New Energy China Three Gorges UniversityYichang443002China Department of Industrial Engineering College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia Institute of Forestry and Engineering Estonian University of Life SciencesTartu51006Estonia Department of Mechanical Engineering école de Technologie SupérieureMontréalQC H3C 1K3Canada Electrical Engineering Department Faculty of EngineeringMinia UniversityMinia61519Egypt

Hot dry rock(HDR)is rich in reserve,widely distributed,green,low-carbon,and has broad development potential and *** this paper,a distributionally robust optimization(DRO)scheduling model for a regionally integrated energy system(RIES)considering HDR co-generation is ***,the HDR-enhanced geothermal system(HDR-EGS)is introduced into the ***-EGS realizes the thermoelectric decoupling of combined heat and power(CHP)through coordinated operation with the regional power grid and the regional heat grid,which enhances the system wind power(WP)feed-in ***,peak-hour loads are shifted using price demand response guidance in the context of time-of-day ***,the optimization objective is established to minimize the total cost in the RIES scheduling cycle and construct a DRO scheduling model for RIES with *** simulating a real small-scale RIES,the results show that HDR-EGS can effectively promote WP consumption and reduce the operating cost of the system.

关键词： Energy harvesting integrated energy systems optimum scheduling time-of-use pricing demand response geothermal energy

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A review of torsional vibration mitigation techniques using active control and machine learning strategies

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Petroleum 2024年第3期10卷 411-426页

作者： Aditya Sharma Khizar Abid Saket Srivastava andres Felipe Baena Velasquez Catalin Teodoriu The University of Oklahoma NormanOKUSA

Drilling is one of the most challenging and expensive processes in hydrocarbon extraction and geothermal well *** faced during drilling can increase the non-productive time(NPT)greatly,resulting in inflating the drilling cost and also pose a safety *** of the main problems faced during drilling that limits the life of drilling equipment and tools and decreases the overall productivity of the system is drilling *** vibrations can be categorized into three modes:axial,lateral,and ***-slip vibrations are a type of torsional vibration in which the bottom hole assembly(BHA)periodically stops to rotate followed by a spike in the bottom hole *** paper provides a comprehensive review of techniques used to control and mitigate torsional vibration with an emphasis on stick-slip.A brief introduction to drillstring and friction modeling is presented followed by a concise summary of passive control techniques to control *** the focus is shifted to an up-to-date review of active control and machine learning for stick-slip control and *** paper ultimately highlights the importance of adapting novel control and mitigation concepts to improve stick slip detection and improve the overall drilling process.A unique solution is insufficient to control a complex process such as drilling,but integration of various techniques has been found promising.

关键词： Drilling vibrations Controllers Mitigations strategies Stick slip Torsional vibrations Machine Learning

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Interactions between maternal parity and feed additives drive the composition of pig gut microbiomes in the post‑weaning period

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1241-1257页

作者： Kayla Law Eduardo Rosa Medina Garcia Chad Hastad Deborah Murray Pedro E.Urriola andres Gomez Department of Animal Science University of Minnesota1364 Eckles AvenueSaint PaulMN 55108USA New Fashion Pork 164 Industrial ParkwayJacksonMN 56143USA

Background Nursery pigs undergo stressors in the post-weaning period that result in production and welfare *** challenges disproportionately impact the offspring of primiparous sows compared to those of mul-tiparous *** is known regarding potential interactions between parity and feed additives in the post-weaning period and their effects on nursery pig ***,the objective of this study was to investigate the effects of maternal parity on sow and offspring microbiomes and the influence of sow parity on pig fecal microbi-ome and performance in response to a prebiotic *** weaning,piglets were allotted into three treat-ment groups:a standard nursery diet including pharmacological doses of Zn and Cu(Con),a group fed a commercial prebiotic only(Preb)based on an Aspergillus oryzae fermentation extract,and a group fed the same prebiotic plus Zn and Cu(Preb+ZnCu).Results Although there were no differences in vaginal microbiome composition between primiparous and mul-tiparous sows,fecal microbiome composition was different(R^(2)=0.02,P=0.03).The fecal microbiomes of primiparous offspring displayed significantly higher bacterial diversity compared to multiparous offspring at d 0 and d 21 post-weaning(P<0.01),with differences in community composition observed at d 21(R^(2)=0.03,P=0.04).When analyzing the effects of maternal parity within each treatment,only the Preb diet triggered significant microbiome distinc-tions between primiparous and multiparous offspring(d 21:R^(2)=0.13,P=0.01;d 42:R^(2)=0.19,P=0.001).Composi-tional differences in pig fecal microbiomes between treatments were observed only at d 21(R^(2)=0.12,P=0.001).Pigs in the Con group gained significantly more weight throughout the nursery period when compared to those in the Preb+ZnCu *** Nursery pig gut microbiome composition was influenced by supplementation with an Aspergillus oryzae fermentation extract,with varying effects on performance

关键词： Aspergillus prebiotic Copper Feed additives Maternal Nursery pig microbiome Parity Swine microbiome Trace minerals Zinc

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SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C

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World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： andres F.Moreno Rojas Emelia Bainto Helen Harvey Adriana H.Tremoulet Jane C.Burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑CoV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-C).SARS‑CoV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-C at Rady Children’s Hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-C waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to C,20G,21C(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22C).MIS-C presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-CoV-2 triggered MIS-C with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： Complications COVID-19 MIS-C SARS-CoV-2 variants

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Hepatic rupture secondary to HELLP syndrome: outcomes in three cases

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World Journal of Emergency Medicine 2024年第1期15卷 56-58页

作者： Salvador Gomez-Carro Ruben R.Lozano-Salazar Kassandra Santos-Zaldívar Victor andres Villasuso-Alcocer Nina Méndez-Domínguez O'Horan General Hospital Merida 97000Mexico Highly Specialized Hospital of the Yucatan Peninsula Merida 97134Mexico National Institute of Perinatology.Mexico City 11000 Mexico

Hypertensive disorders of pregnancy,including chronic hypertension,gestational hypertension,and preeclampsia,are the most common complications in pregnant women,affecting approximately 15%of pregnancies.[1,2]Hemolysis,elevated liver enzymes,and low platelet count(HELLP syndrome)can occur in 0.2%-0.6%of all pregnancies,and 10%-15%of patients are diagnosed with preeclampsia.[3,4]Among its severe complications,liver hematoma is remarkable and may lead to liver *** identification of HELLP syndrome is crucial for proper therapeutic management and to avoid fatal outcomes[4,5]since when a hepatic hematoma occurs,the risk of rupture increases to 12%.[3,5]

关键词： rupture HELLP hypertension pregnancy

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Harnessing photosynthetic microorganisms for enhanced bioremediation of microplastics:A comprehensive review

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Environmental Science and Ecotechnology 2024年第4期20卷 63-78页

作者： Giovanni Davide Barone andres Rodríguez-Seijo Mattia Parati Brian Johnston Elif Erdem Tomislav Cernava Zhi Zhu Xufeng Liu Ilka MAxmann Peter Lindblad Iza Radecka Institute of Biology University of GrazUniversitatsplatz 28010GrazAustria Area de Edafoloxía Departamento de Bioloxía Vexetal e Ciencia Do SoloFacultade de CienciasUniversidade de Vigo32004OurenseSpain Agroecology and Food Institute(IAA) University of Vigo e Campus Auga32004OurenseSpain School of Life Sciences Faculty of Science and EngineeringUniversity of WolverhamptonWolverhamptonWV11LYUnited Kingdom FlexSea Ltd. LondonEC2A4NEUnited Kingdom Department of Chemical and Biochemical Engineering Technical University of Denmark2800Kongens LyngbyDenmark Institute of Environmental Biotechnology Graz University of Technology8010GrazAustria The Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province School of Life SciencesJiangsu Normal University221116XuzhouChina Department of ChemistrydÅngstrom Laboratory Uppsala UniversitySE-75120UppsalaSweden Synthetic Microbiology Department of BiologyHeinrich Heine University Düsseldorf40225DüsseldorfGermany Cluster of Excellence on Plant Sciences(CEPLAS) Heinrich HeineUniversity DüsseldorfD-40001DüsseldorfGermany

Mismanaged plastics,upon entering the environment,undergo degradation through physicochemical and/or biological *** process often results in the formation of microplastics(MPs),the most prevalent form of plastic debris(<1 mm).MPs pose severe threats to aquatic and terrestrial ecosystems,necessitating innovative strategies for effective *** photosynthetic microorganisms can degrade MPs but there lacks a comprehensive *** we examine the specific role of photoautotrophic microorganisms in water and soil environments for the biodegradation of plastics,focussing on their unique ability to grow persistently on diverse polymers under ***,these cells utilise light and CO_(2) to produce valuable compounds such as carbohydrates,lipids,and proteins,showcasing their multifaceted environmental *** address key scientific questions surrounding the utilisation of photosynthetic microorganisms for MPs and nanoplastics(NPs)bioremediation,discussing potential engineering strategies for enhanced *** review highlights the significance of alternative biomaterials and the exploration of strains expressing enzymes,such as polyethylene terephthalate(PET)hydrolases,in conjunction with microalgal and/or cyanobacterial ***,we delve into the promising potential of photo-biocatalytic approaches,emphasising the coupling of plastic debris degradation with sunlight *** integration of microalgal-bacterial consortia is explored for biotechnological applications against MPs and NPs pollution,showcasing the synergistic effects in wastewater treatment through the absorption of nitrogen,heavy metals,phosphorous,and *** conclusion,this review provides a comprehensive overview of the current state of research on the use of photoautotrophic cells for plastic *** underscores the need for continued investigation into the engineering of these microorganisms and the development of innovative approaches

关键词： Environmental biotechnology Microplastic Nanoplastic Microalgae Cyanobacteria

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Exercise-induced hypoalgesia in chronic neck pain: A narrative review

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Sports Medicine and Health Science 2024年第1期6卷 37-47页

作者： Fernando Rojas-Galleguillos Cecilia Clark-Hormazabal Eduardo Mendez-Fuentes Francisco Guede-Rojas Cristhian Mendoza andres Riveros Valdes Claudio Carvajal-Parodi Universidad San Sebastian Programa Magíster en Kinesiología MusculoesqueleticaLientur#1457ConcepcionChile Exercise and Rehabilitation Sciences Laboratory School of Physical TherapyFaculty of Rehabilitation SciencesUniversidad Andres BelloSantiago7591538Chile Universidad San Sebastian Laboratoriode NeurobiologíFacultad de Odontologíay Ciencias dela RehabilitacionLientur#1457ConcepcionChile Universidad San Sebastian Departamento de Ciencias MorfologicasFacultad de MedicinaCienciaLientur#1457ConcepcionChile Universidad San Sebastian Escuelade KinesiologíaFacultad de OdontologíaCiencias dela RehabilitacionLientur#1457ConcepcionChile

Chronic neck pain(CNP)is a worldwide health problem with several risk *** of the most widely used treatments for managing this condition is therapeutic exercise,which could generate a response called exerciseinduced hypoalgesia(EIH).There is no consensus on the best exercise modality to induce ***,this review aims to analyze and synthesize the state-of-the-art about the hypoalgesic effect of exercise in subjects with *** included articles on EIH and CNP in patients older than 18 years,with pain for more than three months,where the EIH response was *** that studied CNP associated with comorbidities or measured the response to treatments other than exercise were *** studies reviewed reported variable *** in healthy subjects has been shown to reduce indicators of pain sensitivity;however,in people with chronic pain,the response is *** investigations reported adverse effects with increased pain intensity and decreased pain sensitivity,others found no clinical response,and some even reported EIH with decreased pain and increased *** is an identifiable,stimulable,and helpful therapeutic response in people with *** research is still needed on subjects with CNP to clarify the protocols and therapeutic variables that facilitate the EIH *** addition,it is necessary to deepen the knowledge of the intrinsic and extrinsic factors that influence EIH in people with CNP.

关键词： Exercise-induced hypoalgesia Neck pain Chronic pain Neck exercise therapy

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