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A proposed modulatory role of the endocannabinoid system on adipose tissue metabolism and appetite in periparturient dairy cows

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Journal of Animal Science and Biotechnology 2021年第3期12卷 995-1007页

作者： Madison N.Myers Maya Zachut Joseph Tam G.andres Contreras Department of Large Animal Clinical Sciences College of Veterinary MedicineMichigan State UniversityEast LansingMI 48824USA Department of Ruminant Science Institute of Animal SciencesAgricultural Research Organization/Volcani Center7505101 Rishon LeZionIsrael Obesity and Metabolism Laboratory The Institute for Drug ResearchSchool of PharmacyFaculty of MedicineThe Hebrew University of Jerusalem9112001 JerusalemIsrael

To sustain the nutrient demands of rapid fetal growth,parturition,and milk synthesis,periparturient dairy cows mobilize adipose tissue fatty acid stores through *** process induces an inflammatory response within AT that is resolved as lactation progresses;however,excessive and protracted lipolysis compounds the risk for metabolic and inflammatory *** suppression of lipolytic action and inflammation,along with amplification of adipogenesis and lipogenesis,serve as prospective therapeutic targets for improving the health of periparturient dairy ***,the activation of cannabinoid receptors by endocannabinoids enhances adipogenesis and lipogenesis,suppresses lipolysis,and increases appetite in *** biological effects of activating the endocannabinoid system open the possibility of harnessing the endocannabinoid system through nutritional intervention in dairy herds as a potential tool to improve dairy cows’health,although much is still to be revealed in this *** review summarizes the current knowledge surrounding the components of the endocannabinoid system,elaborates on the metabolic effects of its activation,and explores the potential to modulate its activity in periparturient dairy cows.

关键词： Adipogenesis Adipose tissue Dairy cow health Endocannabinoids Endocannabinoid system Lipogenesis Lipolysis

Electronic structure, optical properties, and lattice dynamics in atomically thin indium selenide flakes

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Nano Research 2014年第10期7卷 1556-1568页

作者： Juan F. Sanchez-Royo Suillermo Munoz-Matutano Mauro Brotons-Gisbert Juan P. martinez-Pastor Alfredo Segura andres Cantarero Rafael Mata Josep Canet-Ferrer Gerard Tobias Enric Canadell Jose Marques-Hueso Brian D. Gerardot ICMUV Instituto de Oencia de Materiales Universidad de Valencia P.O. Box 22085 46071 Valencia Spain MALTA-Consolider Team Institut de Ciencia dels Materials-Dpto. de Fisica Apficada Universitat de Valencia E-46100 Burjassot (Valencia) Spain Institut de Ciencia de Materials de Barcelona (ICMAB-CSIC) Campus de la UAB 08193 Bellaterra Barcelona Spain Institute of Photonics and Quantum Science SUPA Hefiot-Watt University Edinburgh EH14 4AS UK

chalcogenide 单身者层的进步的叠与能为新地效果晶体管和 photonic 设备被利用的悦耳的性质产生二维的半导体的材料。然而， chalcogenide 家庭的一些成员的性质仍然保持未经勘探。铟硒化物(InSe ) 由于它在近红外线的、可控制的 p 类... 详细信息

chalcogenide 单身者层的进步的叠与能为新地效果晶体管和 photonic 设备被利用的悦耳的性质产生二维的半导体的材料。然而， chalcogenide 家庭的一些成员的性质仍然保持未经勘探。铟硒化物(InSe ) 由于它在近红外线的、可控制的 p 类型并且 n 类型做和高化学稳定性的直接 bandgap 为应用是吸引人的。这里，我们揭示格子动力学，原子地薄的 InSe 薄片的光、电子的性质由 micromechanical 劈开准备了。拉曼活跃模式在取决于电子契约激动的薄片使硬或弄软。一进步光致发光山峰蓝移动为减少的薄片厚度被观察(象为三单个层的 0.2 eV 一样大) 。第一原则的计算在 bandgap 预言甚至更大的增加， 0.40 eV 为三单个层，并且为单个层的差不多 1.1 eV。这些结果与 Si 和 III-V 技术从为在纳米规模和兼容机的 optoelectronic 应用的这材料的通用性的观点是有希望的。

关键词：电子结构晶格动力学光学性质原子级硒化半导体材料场效应晶体管第一原理计算

Evidence-based biomaterials research

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Bioactive Materials 2022年第9期7卷 495-503页

作者： Kai Zhang Bin Ma Kaiyan Hu Bo Yuan Xin Sun Xu Song Zhonglan Tang Hai Lin Xiangdong Zhu Yufeng Zheng andres JGarcía Antonios GMikos James MAnderson Xingdong Zhang Institute of Regulatory Science for Medical Devices Sichuan UniversityChengdu610064PR China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu610064PR China College of Biomedical Engineering Sichuan UniversityChengdu610064PR China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou730000PR China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province Lanzhou730000PR China Chinese Evidence-based Medicine Centre West China HospitalSichuan UniversityChengdu610041PR China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871PR China Woodruff School of Mechanical Engineering Petit Institute for Bioengineering and BioscienceGeorgia Institute of TechnologyAtlantaGA30332-0363USA Departments of Bioengineering Chemical and Biomolecular EngineeringRice UniversityHoustonTX77251USA Departments of Pathology Biomedical Engineering and Macromolecular Science and EngineeringCase Western Reserve UniversityClevelandOH44106USA

The fast development of biomaterials science and engineering has generated significant number of studies and publications as well as tremendous amount of research data.A methodology is needed to translate such research data and results to validated scientific *** article for the first time proposes the concept and methodology of evidence-based biomaterials research,which is to use evidence-based research approach represented by systematic reviews to generate evidence for answering scientific questions related to *** briefly introducing the advancement of biomaterials since 1950s,the scientific and engineering nature of biomaterials are discussed along with the roadmap of biomaterials translation from basic research to commercialized medical products,and the needs of scientific *** information of the evidence-based approach such as its origination from evidence-based medicine,levels of evidence,systematic review and meta-analysis,differences between systematic and narrative reviews is then *** with a step-by-step procedure of conducting evidence-based biomaterials research,three examples of biomaterials research using evidence-based approach to generate scientific evidence,and opportunities and challenges of evidence-based biomaterials research are *** its notable impact on the practice of medicine,the evidence-based approach is also expected to make influential contributions to the biomaterials field.

关键词： Biomaterial Biomaterials research Evidence-based medicine Evidence-based approach Systematic review Meta-analysis

Therapies for patients with coexisting heart failure with reduced ejection fraction and non-alcoholic fatty liver disease

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World Journal of Cardiology 2023年第7期15卷 328-341页

作者： Jose Arriola-Montenegro Renato Beas Renato Cerna-Viacava andres Chaponan-Lavalle Karla Hernandez Randich Diego Chambergo-Michilot Herson Flores Sanga Pornthira Mutirangura Department of Internal Medicine University of MinnesotaMinneapolisMN 55455United States Department of Medicine Indiana University School of MedicineIndianaIN 46202United States Department of Medicine Henry Ford HospitalDetroitMI 48202United States Escuela de Medicina Universidad Peruana de Ciencias AplicadasLima 15067Peru Universidad Científica del Sur LimaPeru Department of Telemedicine CardiologyHospital Nacional Carlos Alberto Seguin EscobedoArequipa 8610Peru Department of Medicine University of MinnesotaMinneapolisMN 55415United States

Heart failure with reduced ejection fraction(HFrEF)and nonalcoholic fatty liver disease(NAFLD)are two common comorbidities that share similar pathophysiological *** is a growing interest in the potential of targeted therapies to improve outcomes in patients with coexisting HFrEF and *** manuscript reviews current and potential therapies for patients with coexisting HFrEF and *** therapies,including angiotensinconverting enzyme inhibitors/angiotensin receptor blockers,mineralocorticoids receptor antagonist,and sodium-glucose cotransporter-2 inhibitors,have been shown to reduce fibrosis and fat deposits in the ***,there are currently no data showing the beneficial effects of sacubitril/valsartan,ivabradine,hydralazine,isosorbide nitrates,digoxin,or beta blockers on NAFLD in patients with *** study highlights the importance of considering HFrEF and NAFLD when developing treatment plans for patients with these *** research is needed in patients with coexisting HFrEF and NAFLD,with an emphasis on novel therapies and the importance of a multidisciplinary approach for managing these complex comorbidities.

关键词： Non-alcoholic fatty liver disease Heart Failure Heart failure reduced ejection fraction Novel therapies Cardiovascular disease

仿射死亡率模型长期预测的优化与分析——考虑非完整近期队列数据

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保险研究 2023年第9期 61-70页

作者：李玉龙 Michael Sherris andres M.Villegas Jonathan Ziveyi 中国精算师协会国际部澳大利亚新南威尔士大学商学院风险精算系

死亡率建模与预测是精算科学的重要基础,而仿射死亡率模型作为一种经典的连续时间随机模型被大量地应用于评估系统性死亡率的发展,其中模型构建的一种常用方法是卡尔曼滤波算法。本文针对传统卡尔曼滤波算法在建模过程中自动忽略近期非... 详细信息

死亡率建模与预测是精算科学的重要基础,而仿射死亡率模型作为一种经典的连续时间随机模型被大量地应用于评估系统性死亡率的发展,其中模型构建的一种常用方法是卡尔曼滤波算法。本文针对传统卡尔曼滤波算法在建模过程中自动忽略近期非完整队列数据的情况,借鉴机器学习和贝叶斯算法中迭代学习的理念,对传统算法进行了拓展,从而将近期非完整队列数据应用于模型拟合与预测中。通过量化分析对比证明了基于拓展算法的模型在预测方面,尤其是长期预测中,有两方面的优势:更好地捕捉了系统性死亡率风险的变动,避免了对长期长寿风险的低估;在预测精度方面有了较大的提升,特别是在长期预测时优势更为明显。

关键词：非完整数据应用卡尔曼滤波算法模型长期预测养老产品定价

Rupture area analysis of the Ecuador (Musine) Mw = 7.8 thrust earthquake on April 16, 2016, using GOCE derived gradients

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Geodesy and Geodynamics 2017年第1期8卷 49-58页

作者： Orlando Alvarez andres Folguera Mario Gimenez lnstituto Geofisico y Sismologico lng Volponi Universidad Nacional de San Juan Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas Argentina indean-instituto de Estudios Andinos "Don Pablo Groeber" Departamento de Cs. Geologicas FCEN Universidad de Buenos Aires Argentina

The Ecuador Mw - 7.8 earthquake on April 16, 2016, ruptured a nearly 200 km long zone along the plate interface between Nazca and South American plates which is coincident with a seismic gap since 1942, when a Mw - 7.8 earthquake happened. This earthquake occurred at a margin characterized by moderately big to giant earthquakes such as the 1906 （Mw 8.8）. A heavily sedimented trench explains the abnormal lengths of the rupture zones in this system as inhibits the role of natural barriers on the propagation of rupture zones. High amount of sediment thickness is associated with tropical climates, high erosion rates and eastward Pacific dominant winds that provoke orographic rainfalls over the Pacific slope of the Ecuatorian Andes. Offshore sediment dispersion off the oceanic trench is controlled by a close arrangement of two aseismic ridges that hit the Costa Rico and South Ecuador margin respectively and a mid ocean ridge that separates the Cocos and Nazca plate trapping sediments. Gravity field and Ocean Circulation Explorer （GOCE） satellite data are used in this work to test the possible relationship between gravity signal and earthquake rupture structure as well as registered aftershock seismic activity. Reduced vertical gravity gradient shows a good correlation with rupture structure for certain degrees of the harmonic expansion and related depth of the causative mass; indicating, such as in other analyzed cases along the subduction margin, that fore-arc structure derived from density heterogeneities explains at a certain extent propagation of the rupture zones. In this analysis the rupture zone of the April 2016 Ecuador earthquake developed through a relatively low density zone of the fore-arc sliver. Finally, aftershock sequence nucleated around the area of maximum slips in the rupture zone, suggesting that heterogeneous density structure of the fore-arc determined from gravity data could be used in forecasting potential damaged zones associated with big rupture

关键词： Gravity field and Ocean Circulation Explorer(GOCE)Vertical gravity gradientEcuador earthquakeTrench sedimentsRupture zone

All-optical switching in silicon photonic waveguides with an epsilon-near-zero resonant cavity [Invited]

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Photonics Research 2018年第5期6卷 I0026-I0030页

作者： andres D.NEIRA GREGORY A.WURTZ ANATOLY V.ZAYATS Department of Physics King's College London

Strong nonlinearity of plasmonic metamaterials can be designed near their effective plasma frequency in the epsilon-near-zero(ENZ) regime. We explore the realization of an all-optical modulator based on the Au nonlinearity using an ENZ cavity formed by a few Au nanorods inside a Si photonic waveguide. The resulting modulator has robust performance with a modulation depth of about 30 dB/μm and loss less than 0.8 dB for switching energies below 600 fJ. The modulator provides a double advantage of high mode transmission and strong nonlinearity enhancement in the few-nanorod-based design.

关键词： All-optical switching in silicon photonic waveguides with an epsilon-near-zero resonant cavity

Platelet rich plasma(PRP)induces autophagy in osteoblast precursor 3T3-L1

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BIOCELL 2018年第1期42卷 13-16页

作者： SERGIO andres CARMINATI MARÍA CAROLINA BARBOSA CLAUDIO MARCELO FADER Universidad Nacional de Cuyo Facultad de OdontologíaMendozaArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET).Instituto de Histología y Embriología(IHEM) Facultad de Ciencias MédicasUniversidad Nacional de CuyoMendozaArgentina

Autophagy is an essential cellular homeostatic mechanism by which intracellular components are delivered into the lysosomes for degradation and *** has been related with a diversity of pathological or physiological dentary processes such as bone remodeling,skeletal aging,osteoclastogenesis,osteoblastogenesis and different types of oral ***-rich plasma(PRP),isolated from autologous blood,is a plasma preparation containing a higher concentration of platelets which contains numerous different growth factors and cytokines that activate several cellular signaling *** purpose of this study is to investigate the effect of PRP on autophagy stimulation in both osteoblast precursor 3T3-L1 and non-related osteoblastic *** results showed that PRP can increase the number of autophagic structures in 3T3-L1 and HeLa(cervical cancer cells)***,we have determined by Western blot a rise in the lipidated form of the autophagic protein LC3(***3-II)upon PRP *** together,our results suggest that PRP is able to induce a strongly autophagy response in osteoblast precursor and,to a lesser extent,in non-related osteoblastic cells,suggesting that PRP could be a potential therapeutic tool for some autophagy-related diseases associated with bone homeostasis.

关键词： Autophagy 3T3-L1 Platelet rich plasma Odontology

Hyponatraemia and cirrhosis

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Gastroenterology Report 2014年第1期2卷 21-26页

作者： Robert J.Gianotti andres Cardenas Department of Gastroenterology Beth Israel Deaconess Medical CenterBoston MA GI Unit Institut Clinic de Malalties Digestives i MetaboliquesHospital ClinicUniversity of Barcelona

Hyponatraemia is a common complication of advanced cirrhosis related to an impairment in the renal capacity for eliminating solute-free water,causing a retention of water that is disproportionate to the retention of sodium,thus leading to a reduction in serum sodium concentration and *** main pathogenic factor responsible for hyponatraemia is a non-osmotic hypersecretion of arginine vasopressin(AVP)or antidiuretic hormone from the neurohypophysis,related to circulatory *** in cirrhosis is associated with increased morbidity and *** is also associated with increased morbidity and impaired short-term survival after *** current standard of care based on restricting fluids to 1-1.5 L/day is rarely *** approaches,such as albumin infusion and the use of vaptans—which act by specifically antagonizing the effects of AVP on the V2 receptors located in the kidney tubules—have been evaluated for their role in the management of *** short-term treatment with vaptans is associated with a marked increase in renal solute-free water excretion and improvement of hyponatraemia;however their use in patients with end-stage liver disease is limited by hepatotoxic effects of some of these *** administration of vaptans seems to be effective in maintaining the improvement of serum sodium concentration,but the available information is still limited.

关键词： hyponatraemia cirrhosis end-stage liver disease vaptans