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Role of second look endoscopy in endoscopic submucosal dissection and peptic ulcer bleeding:Meta-analysis of randomized controlled trials

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World Journal of Gastrointestinal Endoscopy 2024年第4期16卷 214-226页

作者： Gowthami Sai Kogilathota Jagirdhar Jose andres Perez Akshat Banga Rakhtan K Qasba Ruman K Qasba Harsha Pattnaik Muhammad Hussain Yatinder Bains Salim Surani Department of Medicine Saint Francis Health Science CenterNewarkNJ 07107United States Department of Medicine Saint Francis Health SystemsTulsaOK 74133United States Department of Internal Medicine Sawai Man Singh Medical CollegeJaipur 302004India Department of Medicine Green Life Medical College and HospitalDhaka 1205Bangladesh Department of Medicine Sher-i-kashmir Institute of Medical ScienceJammuSrinagar 190011India Department of Medicine Lady Hardinge Medical CollegeNew Delhi 110001India Department of Gastroenterology Saint Michaels Medical CenterNewarkNJ 07102United States Department of Medicine and Pharmacology Texas AM UniversityCollege StationTX 77843United States

BACKGROUND Second-look endoscopy(SLE)to prevent recurrent bleeding in patients with peptic ulcer disease(PUD)and those undergoing endoscopic submucosal dissection(ESD)is routinely being *** evidence exists regarding efficacy,risk,benefit,and *** To identify the role and effectiveness of SLE in ESD and PUD,associated rebleeding and PUD-related outcomes like mortality,hospital length of stay,need for endoscopic or surgical intervention and blood *** A systematic review of literature databases PubMed,Cochrane,and Embase was conducted from inception to January 5,*** controlled trials that compared patients with SLE to those who did not have SLE or evaluated the role of prophylactic hemostasis during SLE compared to other conservative interventions were *** study was conducted per PRISMA guidelines,and the protocol was registered in PROSPERO(ID CRD42023427555:).RevMan was used to perform meta-analysis,and Mantel-Haenszel Odds ratio(OR)were generated using random effect *** A total of twelve studies with 2687 patients were included in our systematic review and meta-analysis,of which 1074 patients underwent SLE after ESD and 1613 patients underwent SLE after PUD-related *** ESD,the rates of rebleeding were 7%in the SLE group compared to 4.4%in the non-SLE group with OR 1.65,95%confidence intervals(CI)of 0.96 to 2.85;P=0.07,whereas it was 11%in the SLE group compared to 13%in the non-SLE group with OR 0.895%CI:0.50 to 1.29;P=*** mean difference in the blood transfusion rates in the SLE and no SLE group in PUD was OR 0.01,95%CI:-0.22 to 0.25;P=*** SLE vs non-SLE groups with PUD,the OR for Endoscopic intervention was 0.29,95%CI:0.08 to 1.00;P=0.05 while it was OR 2.03,95%CI:0.95 to 4.33;P=0.07,for surgical *** mean difference in the hospital length of stay was-3.57 d between the SLE and no SLE groups in PUD with 95%CI:-7.84 to 0.69;P=0.10,denoting an average of

关键词： Endoscopy Endoscopic submucosal dissection Peptic ulcer Gastrointestinal bleeding

会计学课程教学研究现状与发展趋势可视化分析--基于CiteSpace

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西部素质教育 2024年第9期10卷 15-19页

作者：陆羽中孙彦琦 Guillermo andres Buitrago 苏州科技大学商学院江苏苏州215009 北京石油化工学院经济管理学院北京102617 上海杉达学院胜祥商学院上海201209

文章基于Citespace,对1993—2023年中国知网收录的核心期刊中的会计学课程教学研究相关文献进行了可视化分析,具体分析了发文机构、发文作者、热点及其演进趋势三方面的研究结果,并指出了值得深入研究的三大方向,包括以“思政引领”为核... 详细信息

文章基于Citespace,对1993—2023年中国知网收录的核心期刊中的会计学课程教学研究相关文献进行了可视化分析,具体分析了发文机构、发文作者、热点及其演进趋势三方面的研究结果,并指出了值得深入研究的三大方向,包括以“思政引领”为核心,更加注重课堂思政;与新兴数字技术融合,更加注重智能财会;围绕业财融合,更加注重复合型财会人员培养。

关键词：会计学课程教学 CiteSpace 可视化分析

Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu Shishir Dube Norman Gellada So Yung Choi Susan Win Yoo Jin Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal andres J Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi SY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win S,Lee YJ and Yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

Phylogenetic framework for coevolutionary studies： a compass for exploring jungles of tangled trees

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Current Zoology 2016年第4期62卷 393-403页

作者： andres martinez-AQUINO Division Zoologfa Invertebrados Museo de La Plata FCNyM UNLP Paseo del Bosque s/n 1900 La Plata Argentina

Phylogenetics is used to detect past evolutionary events, from how species originated to how their ecological interactions with other species arose, which can mirror cophylogenetic patterns. Cophylogenetic reconstructions uncover past ecological relationships between taxa through inferred coevolutionary events on trees, for example, codivergence, duplication, host-switching, and loss. These events can be detected by cophylogenetic analyses based on nodes and the length and branching pattern of the phylogenetic trees of symbiotic associations, for example, host-parasite. In the past 2 decades, algorithms have been developed for cophylogetenic analyses and implemented in different software, for example, statistical congruence index and event-based methods. Based on the combination of these approaches, it is possible to integrate temporal information into cophylogenetical inference, such as estimates of lineage divergence times between 2 taxa, for example, hosts and parasites. Additionally, the advances in phylogenetic biogeography applying methods based on parametric process models and combined Bayesian approaches, can be useful for interpreting coevolutionary histories in a scenario of biogeographical area connectivity through time. This article briefly reviews the basics of parasitology and provides an overview of software packages in cophylogenetic methods. Thus, the objective here is to present a phylogenetic framework for coevolutionary studies, with special emphasis on groups of parasitic organisms. Researchers wishing to undertake phylogeny-based coevolutionary studies can use this review as a "compass" when "walking" through jungles of tangled phylogenetic trees.

关键词： coevolution cophylogenetic analyses host–parasite molecular systematics parametric biogeography symbiosis

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一种更高的生活

十月 2024年第1期 45-68页

作者： [西班牙]安德烈斯·伊巴涅斯杨玲(译) 不详

译者序。亲爱的读者,如果你关注西班牙当代文学,那么你一定听说过安德烈斯·伊巴涅斯·塞古拉(Andrés Ibanez Segura)的名字。这位1961年生于马德里的作家,被认为是西班牙当代最富有个性的小说家之一,作品风格独特,自成一体。今天,我... 详细信息

译者序。亲爱的读者,如果你关注西班牙当代文学,那么你一定听说过安德烈斯·伊巴涅斯·塞古拉(Andrés Ibanez Segura)的名字。这位1961年生于马德里的作家,被认为是西班牙当代最富有个性的小说家之一,作品风格独特,自成一体。今天,我们要阅读的就是这样一位曾获得过西班牙文学批评奖的原创性小说家的作品。然而,如果你认为你即将读到的仅仅是一部小说,那么你错了。

关键词：当代文学安德烈斯文学批评风格独特译者序巴涅斯原创性马德里

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Topological circuit of a versatile non-Hermitian quantum system

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Science China(Physics,Mechanics & Astronomy) 2022年第1期65卷 53-60页

作者： David-andres Galeano Xiao-Xiao Zhang Jorge Mahecha Instituto de F´ısica Facultad de Ciencias Exactas y NaturalesUniversidad de AntioquiaMedell´ın 050010Colombia Unidad Transacciones T&D Energ´ıa Gerencia Comercial T&D Energ´ıaV.P.T&D Energ´ıaEPMMedell´ın 050015Colombia Department of Physics and Astronomy&Stewart Blusson Quantum Matter Institute University of British ColumbiaVancouver V6T 1Z4Canada RIKEN Center for Emergent Matter Science(CEMS) Saitama 351-0198Japan Department of Chemistry University of British ColumbiaVancouver V6T 1Z4Canada

We propose a resistors,inductors and capacitors(RLC)electrical circuit to theoretically analyze and fully simulate a new type of non-Hermitian Su-Schrieffer-Heeger(SSH)model with complex *** formulate its construction and investigate its properties by taking advantage of the circuit’s *** physical properties can be identified in this system from the normal modes of oscillation of the RLC circuit,including the highly tunable bulk-edge correspondence between topological winding numbers and edge states and the non-Hermitian skin phenomenon originating from a novel complex energy plane *** present study is able to show the wide and appealing topological physics inherent to electric circuits,which is readily generalizable to a plenty of both Hermitian and non-Hermitian nontrivial systems.

关键词： topolectric circuit SSH model non-Hermitian topology skin effect

Biaxial versus uniaxial strain tuning of single-layer MoS_(2)

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Nano Materials Science 2022年第1期4卷 44-51页

作者： Felix Carrascoso Riccardo Frisenda andres Castellanos-Gomez Materials Science Factory Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)28049Madrid Spain

Strain engineering has arisen as a powerful technique to tune the electronic and optical properties of twod imensional semiconductors like molybdenum disulfide(MoS_(2)).Although several theoretical works predicted that biaxial strain would be more effective than uniaxial strain to tune the band structure of MoS_(2),a direct experimental verification is still missing in the *** we implemented a simple experimental setup that allows to apply biaxial strain through the bending of a cruciform polymer *** used the setup to study the effect of biaxial strain on the differential reflectance spectra of 12 single-layer MoS_(2)flakes finding a redshift of the excitonic features at a rate between-40 meV/%and-110 meV/%of biaxial *** also directly compare the effect of biaxi al and uniaxial strain on the same single-layer MoS_(2)finding that the biaxial strain gauge factor is 2.3 times larger than the uniaxial strain one.

关键词： finding layer gauge

Analysis and Validation for an Inverter-side Current Controller in LCL Grid-connected Power Systems

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Journal of Modern Power Systems and Clean Energy 2020年第2期8卷 387-398页

作者： Jose MSosa Panfilo R.martinez-Rodriguez Gerardo Escobar Gerardo Vazquez andres A.Valdez-Fernandez Juan F.martinez-Garcia the Tecnologico Nacional de Mexico/ITS de Irapuato(TecNM/ITESI) IrapuatoGTO 36821Mexico the School of Sciences Autonomous University of San Luis Potosi(UASLP)San Luis PotosiSLP 78290Mexico Tecnologico de Monterrey N.L.64849Mexico

Transformerless grid-connected inverters offer greater efficiencies when transferring power from renewable energy sources to the electrical *** the grid-inverter connection is done with an LCL filter,high attenuation of switching harmonics is achieved while preserving a small-size output ***,damping must be included in the controller to assure closed-loop *** paper proposes a reference computation methodology for the inverter-side current feedback in a photovoltaic(PV)generation system connected to the grid through an LCL *** analysis of the closed-loop system stability and of the steady-state performance are presented as well as experimental validation of the closed-loop *** feedback controller includes active damping and relies on a resonant control structure which improves the ability of dealing with grid harmonic *** controller uses a reduced set of measurements,which requires the inverter-side current and grid voltage only,and assures a power factor close to unity.

关键词： LCL filter transformerless inverter grid connection inverter-side current feedback

Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： Javier Martin-Broto Jeronimo martinez-Garcia David SMoura andres Redondo Antonio Gutierrez Antonio Lopez-Pousa Javier martinez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio Carnero Marco Perez David Marcilla Jesus Garcia-Foncillas Pablo Romero Javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de Sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 *** median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRNA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4