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Secretome of polarized macrophages:potential for targeting inflammatory dynamics in spinal cord injury

Neural Regeneration Research 2025年第11期20卷 3231-3232页

作者： andreia monteiro Susana monteiro Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabBraga/GuimaraesPortugal

Spinal cord injury(SCI)involves an initial traumatic phase,followed by secondary events such as ischemia,increased blood-spinal cord barrier permeability,ionic disruption,glutamate excitotoxicity,and metabolic alterations.A pe rsistent and exagge rated inflammato ry response within the spinal cord accompanies these events(Lima et al.,2022).The complexity and interplay of these mechanisms exacerbate the initial injury,leading to a degenerative process at the injury *** the initial trauma is unavoidable,the secondary injury begins within minutes and can last for months,creating an optimal window for therapeutic intervention.

关键词： alterations injury companies

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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa andreia monteiro António J.Salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

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Bread enriched with resveratrol:Influence of the delivery vehicles on its bioactivity

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Food Bioscience 2022年第5期49卷 428-435页

作者： andreia F.R.Silva Mariana monteiro Rute Nunes Ana Baiao Susana S.Braga Bruno Sarmento Manuel A.Coimbra Artur M.S.Silva Susana M.Cardoso LAQV-REQUIMTE Department of ChemistryUniversity of Aveiro3810-193AveiroPortugal i3S Instituto de Investigaçao e Inovaçao em SaúdeUniversidade do PortoPortoPortugal CESPU Instituto de Investigaçao e Formaçao Avançada em Ciencias e Tecnologias da SaúdeGandraPortugal

Trans-resveratrol(RSV)is recognised as a bioactive ingredient in the development of functional *** stability,solubility,and bioavailability constraints can be overcome by delivery systems,not yet tested in *** study aims at evaluating the impact of two delivery systems on the stability,antioxidant activity,bioaccessibility and bioavailability of RSV integrated into a bread matrix:an inclusion complex of RSV andγ-cyclodextrin(γCD⋅RSV)and RSV loaded zein nanoparticles(nZ-RSV).Wheat bread was supplemented with 0.5%of pure RSV(RSV-bread)and equivalent amounts ofγ-CD⋅RSV and *** amount of RSV recovered from the hydroethanolic extracts ofγ-CD⋅RSV-and nZ-RSV-bread was 70.3%and 62.8%of the initial amount,respectively,lower than RSV-bread extract,89.0%,indicating lower degradability during bread *** vehicles helped to retain RSV antioxidant activity but did not increase RSV bioaccessibility(c.a.40%for free RSV andγCD⋅RSV,and 29%for nZ-RSV).In vitro tests on intestinal cell monolayers showed that,after 4 h of contact,only 5.0%of the initially available amount of RSV was able to permeate the intestinal barrier in all ***,bread itself is a vehicle for RSV integration into our daily diet,without the need for an additional delivery system.

关键词： Stilbenes Loaf γ-Cyclodextrin Zein nanoparticle Bioaccessibility Permeability assay

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Characterization of Virulence Factors in Enteroaggregative and Atypical Enteropathogenic Escherichia coli Strains Isolated from Children with Diarrhea

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Advances in Infectious Diseases 2012年第4期2卷 135-142页

作者： Thiago Azevedo Feitosa Ferro Francyelle Costa Moraes andreia Meneses da Silva Claude Porcy Leandro Amorim Soares Cristina Andrade monteiro Nyla Thyara Melo Lobao Francisco Amazonas Assis de Mello Valério monteiro-Neto Patrícia de Maria Silva Figueiredo Research Group of Endemic and Parasitic Diseases CEUMA UniversitySao LuisBrazil Federal Institute of Maranhao Sao LuisBrazil Health and Biological Sciences Center Federal University of MaranhaoSao LuísBrazil

Enteroaggregative (EAEC) and atypical enteropathogenic (EPEC) Escherichia coli are important bacterial etiologic agents causing diarrhea among children. The aim of the present study was to examine the impact of virulence factors predisposes to diarrhea. In this study some virulence properties were examined on 11 EAEC and 8 EPEC strains identified by Polymerase Chain Reaction (PCR), isolated from stool samples of children were analyzed genotypically and phenoltypically for the prevalence of virulence factors. The most frequently detected factor was resistance to serum (94%), followed by curli fimbriae (78%), biofilm production (73%), and gene coding for Extended-Spectrum Beta-Lactamase (ESBL) (68%). EPEC isolates showed at least three of the evaluated properties, while EAEC isolates showed at least two. The prevalence of these virulence factors between the two strains showed no statistical difference. This study showed the heterogeneity of the virulence profile of the isolates of EAEC and atypical EPEC strains and suggests that this diversity may influence in the disease severity.

关键词： E.coli Diarrhea Virulence Factors

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