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Genomic and functional evaluation of TNFSF14 in multiple sclerosis susceptibility

Journal of Genetics and Genomics 2021年第6期48卷 497-507页

作者： Miriam Zuccala Nadia Barizzone Elena Boggio Luca Gigliotti Melissa Sorosina Chiara Basagni Roberta Bordoni Ferdinando Clarelli Santosh Anand Eleonora Mangano Domizia Vecchio Elena Corsetti Serena Martire Simona perga Daniela Ferrante Alberto Gajofatto andrei Ivashynka Claudio Solaro Roberto Cantello Vittorio Martinelli Giancarlo Comi Massimo Filippi Federica Esposito Maurizio Leone Gianluca De Beilis Umberto Dianzani Filippo Martinelli-Boneschi Sandra D’Alfonso Department of Health Sciences Center on Autoimmune and Allergic Diseases(CAAD)UPOUniversity of Eastern PiedmontA.AvogadroNovara 28100Italy Consorzio Interuniversitario di Biotecnologie(CIB) Trieste 34149Italy Laboratory of Human Genetics of Neurological Disorders Institute of Experimental NeurologyDivision of NeurosciencesIRCCS San Raffaele Scientific InstituteMilan 20132Italy National Research Council of Italy Institute for Biomedical TechnologiesSegrateMilan 20090Italy Department of Genetic Medicine and Development(GEDEV) Faculty of MedicineUniversity of Geneva Medical SchoolGeneva 1211Switzerland Department of Informatics Systems and Communications(DISCo)University of Milano-BicoccaMilan 20126Italy MS Centre SCDU NeurologyAOU Maggiore della CaritàNovara 28100Italy Department of Translational Medicine Interdisciplinary Research Center of Autoimmune Diseases(IRCAD)University of Eastern PiedmontNovaraAvogadro UniversityNovara 28100Italy Neuroscience Institute Cavalieri Ottolenghi OrbassanoTurin 10043Italy Neurobiology Unit Neurology-CReSM(Regional Referring Center of Multiple Sclerosis)AOU San Luigi GonzagaOrbassanoTurin 10043Italy Department of Neuroscience‘Rita Levi Montalcini’ University of TurinTurin 10126Italy Department of Neuroscience Biomedicine and Movement SciencesUniversity of VeronaVerona 37134Italy UO Neurologia Fondazione IRCCS Casa Sollievo della Sofferenza San Giovanni RotondoFoggia 71013Italy Centro Recupero e Rieducazione Funzionale“Mons L Novarese” Moncrivello(VC)13040Italy Department of Neurology IRCCS San Raffaele Scientific InstituteMilan 20132Italy Neuroimaging Research Unit Institute of Experimental NeurologyDivision of NeuroscienceIRCCS San Raffaele Scientific InstituteMilan 20132Italy Vita-Salute San Raffaele University Milan 20138Italy Neurophysiology Unit IRCCS San Raffaele Scientific InstituteMilan 20138Italy Dino Ferrari Centre Neuroscience SectionDepartment of Pathophysiology and Transplantation(DEPT)University of MilanMilan 20122

Among multiple sclerosis(MS)susceptibility genes,the strongest non-human leukocyte antigen(HLA)signal in the Italian population maps to the TNFSF14 gene encoding LIGHT,a glycoprotein involved in dendritic cell(DC)*** fine-mapping in a large Italian dataset(4,198 patients with MS and3,903 controls),we show that the TNFSF14 intronic SNp rs1077667 is the primarily MS-associated variant in the *** quantitative trait locus(e QTL)analysis indicates that the MS risk allele is significantly associated with reduced TNFSF14 messenger RNA levels in blood cells,which is consistent with the allelic imbalance in RNA-Seq reads(ppression(ppatients with MS and 80 healthy controls(HCs).Interestingly,patients with MS are lower expressors of TNFSF14 compared to HC(pplay an increased percentage of LIGHT-positive peripheral blood myeloid DCs(CD11 c+,p=0.035)in 37 HCs,as well as in in vitro monocyte-derived DCs from 22 HCs(p=0.04).Our findings suggest that the intronic variant rs1077667 alters the expression of TNFSF14 in immune cells,which may play a role in MS pathogenesis.

关键词： Multiple sclerosis TNFSF14 LIGHT Fine-mapping analysis SNV

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LC-MS phytochemical profiles of phenolic Compounds and Antimicrobial, Antioxidant, and Antiplasmodial Activities of Ethanol Extracts of pycnostachys erici-rosenii *** and Leucas martinicensis (Jack.) *** (Lamiaceae)

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Advances in Biological Chemistry 2023年第6期13卷 209-227页

作者： Uwikunda Serondo Héritier Nizigiyimana Libérata pius Tshimankinda Mpiana Nyamangyoku Ishibwela Obedi Ngezahayo Jérémie Dan Cristian Vodnar Daniela Hanganu Ioana Matei Sanda andrei Department of Chemistry Faculty of Sciences Institut Supérieur Pédagogique de Bukavu Bukavu Democratic Republic of Congo Centre de Recherche en Sciences Naturelles et de l’Environnement (CRSNE) Faculté des Sciences Université du Burundi Bujumbura Burundi Department of preclinical Sciences Faculty of Veterinary Medicine University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Cluj-Napoca Romania Ecole Doctorale de l’Université du Burundi Bujumbura Burundi Department of Chemistry Faculty of Sciences Université de Kinshasa Kinshasa Democratic Republic of Congo Faculty of Agriculture Université Catholique de Bukavu Bukavu Democratic Republic of Congo Department of Food Science Faculty of Food Science and Technology University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Cluj-Napoca Romania Department of pharmacognosy Faculty of Pharmacy University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca Romania Department of Microbiology Mycology and Immunology Faculty of Veterinary Medicine University of Agricultural Science and Veterinary Medicine Cluj-Napoca Romania

This study has been conducted to analyze the chemical composition and antimicrobial, antioxidant and antiplasmodial properties of ethanol extracts of pycnostachys erici-rosenii *** and Leucas martinicensis (Jack.) *** that are not yet well known. The HpLC-DAD-MS-ESIp>+p> method was used to investigate the chemical profile, the disc diffusion and microdilution method for the antimicrobial activities, the DppH and FRAp assays for antioxidant property and SYBR Green I-based growth inhibition assay on pf 3D7 (CQ-sensitive) strain for antiplasmodial properties. The results indicated significant amounts of hydroxybenzoic acid, flavonol and hydroxycinnamic acid in the two species. The total polyphenols analysis gave 209.0 ± 16.1 mg GAE/100g DW for p. erici-rosenii and 175.3 ± 1.6 mg GAE/100g DW for L. martinicensis while for total flavonoids analysis 33.4 ± 1.8 mg TE/100g DW was found for p. erici-rosenii and 39.6 ± 0.6 mg TE/100g DW for L. martinicensis. Moreover, antimicrobial tests revealed 0.125 mg/mL on E. faecalis ATCC25922 for ethanol extracts p. erici-rosenii and L. martinicensis. The antioxidant assays revealed IC50 56.17 μg/mL and 78.43 μg/mL for DppH assay, and 112.03 μM TE/100mL and 90.46 μM TE/100mL) for FRAp assay for ethanol extracts of p. erici-rosenii and L. martinicensis respectively. Finally, for Antiplasmodial activity, IC50 was 4.07 μg/mL for p. erici-rosenii and 12.29 μg/mL for L. martinicensis. Therefore, the antimicrobial, the antioxidant, and the antiplasmodial results suggest that the ethanolic extracts of the aerial parts of p. erici-rosenii and L. martinicensis contain compounds with antimicrobial, antioxidant, and antiplasmodial properties, which can be searched in new drug discovery for treatment of infectious diseases.

关键词： pycnostachys erici-rosenii Leucas martinicensis phytochemical profile Antimicrobial Activity Antioxidant Activity Antiplasmodial Activity

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Quantum Supercurrent Transistors in Silicon Quantum Wells Confined by Superconductor Barriers

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Journal of Modern physics 2011年第4期2卷 256-273页

作者： Nikolay T. Bagraev Edward Yu. Danilovsky Leonid E. Klyachkin andrei A. Kudryavtsev Roman V. Kuzmin Anna M. Malyarenko Wolfgang Gehlhoff Vladimir V. Romanov 不详

We present the findings of spin-dependent single-hole and pair-hole transport in plane and across the p-type high mobility silicon quantum wells (Si-QW), 2 nm, confined by the superconductor δ-barriers on the n-type Si (100) surface. The oscillations of the conductance in normal state and the zero-resistance supercurrent in superconductor state as a function of the top gate voltage are found to be correlated by on- and off-resonance tuning the two-dimensional levels of holes in Si-QW with the Fermi energy in the superconductor δ-barriers. The SIMS and STM studies have shown that the δ-barriers heavily doped with boron, 5 × 1021 cm–3, represent really alternating arrays of silicon empty and doped dots, with dimensions restricted to 2 nm. This concentration of boron seems to indicate that each doped dot located between empty dots contains two impurity atoms of boron. The EpR studies show that these boron pairs are the trigonal dipole centres, B+ - B–, that contain the pairs of holes, which result from the negative -U reconstruction of the shallow boron acceptors, 2B0 => B+ - B–. The electrical resistivity, magnetic susceptibility and specific heat measurements demonstrate that the high density of holes in the Si-QW (> 1011 cm–2) gives rise to the high temperature superconductor properties for the δ-barriers. The value of the superconductor energy gap obtained is in a good agreement with the data derived from the oscillations of the conductance in normal state and of the zero-resistance supercurrent in superconductor state as a function of the bias voltage. These oscillations appear to be correlated by on- and off-resonance tuning the two-dimensional subbands of holes with the Fermi energy in the superconductor δ-barriers. Finally, the proximity effect in the S-Si-QW-S structure is revealed by the findings of the quantization of the supercurrent and the multiple Andreev reflection (MAR) observed both across and along the Si-QW plane thereby identifying the spin transis

关键词： Silicon Quantum Well Superconductor δ-barrier ESR Dipole Boron Center Multiple Andreev Reflection Supercurrent Conductance EDESR Silicon Microcavity

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Spencer’s曲线：经典血流动力学模型的临床意义

Spencer’s曲线：经典血流动力学模型的临床意义

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第七届全国颅脑及颈动脉超声学术会议

作者： andrei V.Alexandrov 杨洁李秋萍华扬首都医科大学宣武医院超声诊断科

Merrill p Spencer 和 John M Reid 应用 Hagen-poiseville 法则,连续波原理和脑血管阻力来描述关于流速、流量和残余管腔大小之间关系的理论模型。这个模型被描绘成曲线图即众所周知的 Spencer’s 曲线。尽管此模型推导的是一小段没有... 详细信息

Merrill p Spencer 和 John M Reid 应用 Hagen-poiseville 法则,连续波原理和脑血管阻力来描述关于流速、流量和残余管腔大小之间关系的理论模型。这个模型被描绘成曲线图即众所周知的 Spencer’s 曲线。尽管此模型推导的是一小段没有分叉而具有稳定的动脉压和血粘度的光滑和对称的狭窄动脉,它仍然代表了长期以来在实践和研究应用中我们理解脑血流动力学的里程碑。这篇综述总结了几个影响流速与流量变化的血流动力学原理,解释了此模型是如何帮助我们理解脑血管超声,并描述了它在临床实践和研究中的作用。

关键词：血流动力学超声颈动脉经颅多普勒

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*** trends in adult strabismus surgery

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Annals of Eye Science 2018年第1期 481-481页

作者： andrei-Alexandru Szigiato Meggie Caldwell Yvonne M.Buys Stephen p.Kraft Kamiar Mireskandari Departement d'Ophtalmologie Universitéde MontréalMontréalQuebecCanada Department of Ophthalmology and Visual Sciences Hospital for Sick Children and University of TorontoTorontoOntarioCanada Department of Ophthalmology and Vision Sciences University of TorontoTorontoOntarioCanada

Background:To review the trends in adult strabismus procedures in Ontario from ***:A population based,retrospective data analysis was *** Health Insurance plan billing claims for strabismus procedures were collected and subdivided by number of muscles repaired,the use of adjustable sutures and repeat procedures,adjusted by the total adult *** number of Ophthalmologists performing adult strabismus surgery was also analyzed,subdivided by high volume and low volume ***:From 2000-2014,per 100,000 adult population,the number of total strabismus surgeries in Ontario increased 29.1%;single muscle surgery increased 25.0%,two muscle surgery increased 46.3%,and three or more muscle surgeries increased 8.3%.During the study period,strabismus procedures using adjustable sutures increased 26.1%and repeat procedures increased 65.1%.The number of surgeons performing adult strabismus surgery decreased 21.7%from *** 2014,88.4%of surgeries were performed by 29.8%of all of surgeons who performed adult strabismus ***:From 2000-2014,more strabismus surgery was performed in adults by fewer surgeons from *** number of adult strabismus surgeries in Ontario increased since 2000,including procedures using adjustable sutures and repeat *** changes may be due to increases in healthcare funding and an increased awareness of the functional and psychosocial benefits of strabismus surgery.

关键词： Strabismus adult strabismus surgery epidemiology workforce

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philippine retinoblastoma initiative multi-eye center study 2010-2020

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph D.Tan Gary John V.Mercado patricia E.Cabrera paulita pamela p.Astudillo Rolando Enrique D.Domingo Josept Mari S.poblete Charmaine Grace M.Cabebe Adriel Vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria M.Castro Mara Augustine S.Galang Aldous Dominic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo Michael Maniwan andrei p.Martin Calvin Y.Martinez John Alfred H.Lim Rena Ivy Bascuna Rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz M.prieto Department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines Department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Department of Ophthalmology Manila Doctors HospitalManila 1000Philippines Department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines Department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines Department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines Department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines Department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and Mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the philippines namely Luzon,Vizayas and Mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(pppatients had Stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).Delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma philippines clinical profile

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Thymidine Glycol: The Effect on DNA Structure and DNA Binding by Site-Specific proteins

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Natural Science 2015年第11期7卷 491-509页

作者： Elena A. Kubareva Fan Yang Alexandra Yu. Ryazanova Nina G. Dolinnaya andrei V. Golovin Nikolai V. Molochkov Elena A. Romanova Elizaveta A. Karpova Timofei S. Zatsepin Tatiana S. Oretskaya Belozersky Institute of physico-Chemical Biology Lomonosov Moscow State University Moscow Russia Chemistry Department Lomonosov Moscow State University Moscow Russia Faculty of Bioengineering and Bioinformatics Lomonosov Moscow State University Moscow Russia Institute of Theoretical and Experimental Biophysics Russian Academy of Science Moscow Region Pushchino Russia

Thymidine glycol (5,6-dihydroxy-5,6-dihydrothymidine, Tg) is a major type of oxidative damage in DNA. During chemical oligonucleotide synthesis, Tg residue was incorporated in the different positions of 17 b.p. DNA duplexes, which differ in one base pair in the internal part. According to UV-melting curves, Tg destabilizes the double helix in a sequence independent manner. In contrast, the localized alterations in duplex structure were shown by CD spectroscopy to depend on the type of base pairs flanking the Tg lesion. Molecular dynamics simulations demonstrate that Tg is partially out of the double helix. For the first time, Tg impact on several site-specific DNA-binding proteins is studied, namely p50 and p65 subunits of nuclear factor kappa-B (NF-κB) and DNA methyltransferase SsoII (***). Our results show that p50/p50 and p65/p65 homodimers of NF-κB can tolerate a single Tg residue in the binding site quite well. Nevertheless the homodimers have different affinities to the oxidized κB site depending on the Tg position. *** can act as a transcription repressor when bound to the regulatory site. *** demonstrates decreased affinity and lowered methylation efficiency when its methylation site contains Tg in the central position. Single Tg in one half of the regulatory site decreases *** affinity to the oxidized DNA, whereas Tg presence in both half-sites prevents *** binding to such ligand.

关键词： Thymidine Glycol Oxidative Damage Molecular Dynamics Simulations Nuclear Factor Kappa-B DNA Methyltransferase SsoII

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冷刺激对细颗粒物致气道上皮炎症反应的增敏效应及冷诱导RNA结合蛋白的转录后调控机制

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中国呼吸与危重监护杂志 2021年第3期20卷 195-202页

作者：曾曼李琪周向东维克多·科罗索夫尤立·皮尔曼安德列·斯帕科海南医学院第一附属医院海南海口570102 海南医学院急救与创伤研究教育部重点实验室海南海口570102 中国医学科学院海岛急救医学创新单元海南海口570102 俄罗斯医学科学院远东呼吸生理与病理研究中心俄罗斯布拉戈维申斯克675000 白俄罗斯国立杨卡˙库帕拉大学运动与康复医学系白俄罗斯格罗德诺州230023

目的探讨冷刺激对细颗粒物(pM2.5)致气道上皮炎症反应的增敏效应及冷诱导RNA结合蛋白(CIRp)可能的转录后调控机制。方法采用在体、离体实验,并结合人体手术切除肺组织标本的观察,将动物模型和气道上皮细胞16HBE各分为4组(每组n=8),即空... 详细信息

目的探讨冷刺激对细颗粒物(pM2.5)致气道上皮炎症反应的增敏效应及冷诱导RNA结合蛋白(CIRp)可能的转录后调控机制。方法采用在体、离体实验,并结合人体手术切除肺组织标本的观察,将动物模型和气道上皮细胞16HBE各分为4组(每组n=8),即空白对照组、5℃/18℃组、pM2.5组、5℃/18℃+pM2.5组,分别以酶联免疫吸附试验、实时荧光定量聚合酶链反应、蛋白印迹检测各组气道上皮细胞和大鼠支气管/肺组织的代表性炎症因子及CIRp mRNA和蛋白的表达规律,并进一步采用细胞免疫荧光技术观察CIRp变化的时相动力学规律。同时采用免疫组织化学的方法观察各组大鼠及人体支气管/肺组织CIRp的定位和表达规律。结果在体实验中,相较于对照组,5℃组和pM2.5组CIRp、白细胞介素-6、肿瘤坏死因子-α的mRNA及蛋白均呈现表达水平增高的现象(均ppM2.5组相应的mRNA及蛋白表达则最为显著(均pp主要定位于胞核内,相较于对照组,18℃组和pM2.5组均出现CIRp胞内移位趋势,而18℃+pM2.5组CIRp胞内移位现象最为明显。在大鼠支气管/肺组织的免疫组织化学中,5℃组CIRp的表达高于对照组,pM2.5组CIRp的表达量相较于对照组也有所增加,而5℃+pM2.5组CIRp的表达量变化最为显著。此外,CIRp在正常人群和慢性阻塞性肺疾病(简称慢阻肺)患者支气管上皮黏膜中均有表达,且主要位于气道黏膜上皮细胞胞核内。其中慢阻肺患者CIRp的表达量较正常人群显著升高。结论冷刺激对pM2.5所致的气道上皮炎症反应有增敏效应,而CIRp由胞核移位至胞浆形成的转录后调控可能是其重要机制。

关键词：冷诱导RNA结合蛋白气道炎症细颗粒物冷刺激

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自主神经过反射对脊髓损伤者高级脑功能影响的初步研究

自主神经过反射对脊髓损伤者高级脑功能影响的初步研究

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第25届全国脊柱脊髓学术会议暨2013年贵州省骨科年会

作者：高峰李建军 Chetwyn Chan andrei Krassioukov Melissa pak 杨明亮杜良杰王玉明李军陈亮顾蕊褚宏宇中国康复研究中心脊柱脊髓神经功能重建科首都医科大学康复医学院香港理工大学康复科学系 ICORD Division of Physical Medicine and RehabilitationDepartment of MedicineUniversity of British Columbia

脊髓损伤不仅导致感觉运动和自主神经功能障碍,也会对高级脑功能带来一定的影响。自主神经过反射是脊髓损伤者常见的并发症之一,通过心脑血管系统的一系列生理变化,给脊髓损伤者的高级脑功能带来更大的危害。本研究探讨脊髓损伤者自主... 详细信息

脊髓损伤不仅导致感觉运动和自主神经功能障碍,也会对高级脑功能带来一定的影响。自主神经过反射是脊髓损伤者常见的并发症之一,通过心脑血管系统的一系列生理变化,给脊髓损伤者的高级脑功能带来更大的危害。本研究探讨脊髓损伤者自主神经过反射对高级脑功能的影响及其关系。方法:2010年5月至2012年3月,在加拿大GF Strong Rehabilitation Centre门诊病人中选取两组脊髓损伤患者,研究组为伴自主神经过反射的脊髓损伤患者13例(32.15+18.97岁),对照组为不伴自主神经过反射脊髓损伤患者11例(35.26+21.03岁),脊髓损伤后时间为2-26年,两组在教育水平、年龄、性别比、脊髓损伤后时间、康复训练等无统计学差异(p>0.05)。自主神经过反射的强度通过回顾性问卷的形式进行采集,采用的神经心理学评估手段有雷伊听觉言语学习测验(RAVLT),符号数字模式测试(SDMT),口头路径制作测试A和B(Oral Trails Making Test A and B),斯楚普试验(Stroop Test)和言语流畅性测验(Verbal Fluency Test)。结果:研究组与对照组在认知处理速度(符号数字模拟测验)上具有显著性差异(p=0.038)。对于伴有自主神经过反射的脊髓损伤组患者,自主神经过反射的严重程度与执行控制(口头路径制作测试B)和执行功能(言语流畅性测试)呈正相关(r=0.628,p=0.009;r=0.508,p=0.044)。结论:本研究结果表明对于伴有自主神经过反射的脊髓损伤患者,自主神经过反射越严重,大脑高级脑功能(尤其是执行功能)越差。因而,在临床实践中,有效控制自主神经过反射的发生对于维持现有高级脑功能具有重要意义。同时,要及时关注脊髓损伤者(尤其是伴有自主神经过反射的脊髓损伤者)的大脑认知功能变化,在临床实践中,要适时加以评估。本研究由于样本量较小,对实验结果有一定的影响,今后应进一步进行大样本量研究,并选择适当的评估工具和手段,探讨潜在的病理生理机制。

关键词：脊髓损伤自主神经过反射高级脑功能执行功能

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自主神经过反射对脊髓损伤者高级脑功能影响的初步研究

自主神经过反射对脊髓损伤者高级脑功能影响的初步研究

引用

第七届北京国际康复论坛

目的:脊髓损伤不仅导致感觉运动和自主神经功能障碍,也会对高级脑功能带来一定的影响。自主神经过反射是脊髓损伤者常见的并发症之一,通过心脑血管系统的一系列生理变化,给脊髓损伤者的高级脑功能带来更大的危害。本研究探讨脊髓损伤者... 详细信息

目的:脊髓损伤不仅导致感觉运动和自主神经功能障碍,也会对高级脑功能带来一定的影响。自主神经过反射是脊髓损伤者常见的并发症之一,通过心脑血管系统的一系列生理变化,给脊髓损伤者的高级脑功能带来更大的危害。本研究探讨脊髓损伤者自主神经过反射对高级脑功能的影响及其关系。方法:2010年5月至2012年3月,在加拿大GF Strong Rehabilitation Centre门诊病人中选取两组脊髓损伤患者,研究组为伴自主神经过反射的脊髓损伤患者13例（32.15+18.97岁）,对照组为不伴自主神经过反射脊髓损伤患者11例（35.26+21.03岁）,脊髓损伤后时间为2-26年,两组在教育水平、年龄、性别比、脊髓损伤后时间、康复训练等无统计学差异（p﹥0.05）。自主神经过反射的强度通过回顾性问卷的形式进行采集,采用的神经心理学评估手段有雷伊听觉言语学习测验（RAVLT）,符号数字模式测试（SDMT）,口头路径制作测试A和B（Oral Trails Making Test A and B）,斯楚普试验（Stroop Test）和言语流畅性测验（Verbal Fluency Test）。结果:研究组与对照组在认知处理速度（符号数字模拟测验）上具有显著性差异（p=0.038）。对于伴有自主神经过反射的脊髓损伤组患者,自主神经过反射的严重程度与执行控制（口头路径制作测试B）和执行功能（言语流畅性测试）呈正相关（r=0.628,p=0.009;r=0.508,p=0.044）。结论:本研究结果表明对于伴有自主神经过反射的脊髓损伤患者,自主神经过反射越严重,大脑高级脑功能（尤其是执行功能）越差。因而,在临床实践中,有效控制自主神经过反射的发生对于维持现有高级脑功能具有重要意义。同时,要及时关注脊髓损伤者（尤其是伴有自主神经过反射的脊髓损伤者）的大脑认知功能变化,在临床实践中,要适时加以评估。本研究由于样本量较小,对实验结果有一定的影响,今后应进一步进行大样本量研究,并选择适当的评估工具和手段,探讨潜在的病理生理机制。

关键词：脊髓损伤自主神经过反射高级脑功能执行功能

来源： cnki会议评论

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