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Medical management of symptomatic severe aortic stenosis in patients non-eligible for transcatheter aortic valve implantation

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Journal of Geriatric Cardiology 2020年第11期17卷 704-709页

作者： Gabriela Silvia gheorghe Andreea Simona Hodorogea andrei cristian dan gheorghe Ioan Tiberiu Nanea Ana Ciobanu University of Medicine and Pharmacy Carol Davila BucharestProf.Dr.Th.Burghele HospitalBucharestRomania

1 Transcatheter aortic valve implantation in symptomatic severe aortic stenosis: where do we stand? Aortic stenosis occurs in 2%-9% of patients over the age of 65, the most common cause being degenerative.^([1,2]) The preferred treatment in symptomatic severe aortic stenosis(SAS) is surgical aortic valve replacement(SAVR), but in the elderly, the surgical risk can be greater than the benefit.([3]).

关键词： Angiotensin-converting enzyme inhibitors Beta-blockers Calcium channel blockers Diuretics Symptomatic severe aortic stenosis Transcatheter aortic valve implantation

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Endoscopic ultrasound-guided fine-needle aspiration pancreatic adenocarcinoma samples yield adequate DNA for next-generation sequencing:A cohort analysis

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World Journal of Gastroenterology 2023年第18期29卷 2864-2874页

作者： Stefania Bunduc Bianca Varzaru Razvan andrei Iacob andrei Sorop Ioana Manea Andreea Spiridon Raluca Chelaru Adina Emilia Croitoru Gabriel Becheanu Mona Dumbrava Simona Dima Irinel Popescu cristian gheorghe Faculty of Medicine Carol Davila University of Medicine and PharmacyBucharest 020021Romania Digestive Diseases and Liver Transplantation Center Fundeni Clinical InstituteBucharest 022328Romania Center of Excellence in Translational Medicine Fundeni Clinical InstituteBucharest 022328Romania

BACKGROUND Genetic tests are increasingly performed for the management of unresectable pancreatic *** genotyping aimed samples current guidelines recommend using core specimens,although based on moderate quality ***,in clinical practice among the endoscopic ultrasound(EUS) guided tissue acquisition methods,fine needle aspiration(FNA) is the most widely *** To assess the adequacy for next generation sequencing(NGS) of the DNA yielded from EUS-FNA pancreatic adenocarcinoma(PDAC) *** Between November 2018 and December 2021,105 patients with PDAC confirmed by EUS-FNA were included in the study at our tertiary gastroenterology *** 22 gauge(G) or 19G FNA needles were *** pass was dedicated to DNA *** concentration and purity(A260/280,A260/230) were assessed by *** assessed the differences in DNA parameters according to needle size and tumor characteristics(size,location) and the adequacy of the extracted DNA for NGS(defined as A260/280 ≥ 1.7,and DNA yield:≥ 10 ng for amplicon based NGS,≥ 50 ng for whole exome sequencing [WES],≥ 100 ng for whole genome sequencing [WGS]) by analysis of variance and ttest ***,we compared DNA purity parameters across the different DNA yield *** Our cohort included 49% male patients,aged 67.02 ± 8.38 *** 22G needle was used in 71%of the *** DNA parameters across our samples varied as follows:DNA yield:1289 ng(inter quartile range:534.75-3101),A260/280 = 1.85(1.79-1.86),A260/230 = 2.2(1.72-2.36).DNA yield was > 10 ng in all samples and > 100 ng in 93% of them(one sample < 50 ng).There were no significant differences in the concentration and A260/280 between samples by needle *** size was the only independent predictor of A260/230 which was higher in the 22G samples(P =0.038).NGS adequacy rate was 90% for 19G samples regardless of NGS type,and for 22G samples it reached 89% for WGS adequacy and 91% for WES and

关键词： Pancreatic adenocarcinoma Endoscopic ultrasound guided fine needle aspiration Next generation sequencing DNA yield Needle size Genetic testing

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LC-MS Phytochemical Profiles of Phenolic Compounds and Antimicrobial, Antioxidant, and Antiplasmodial Activities of Ethanol Extracts of Pycnostachys erici-rosenii *** and Leucas martinicensis (Jack.) *** (Lamiaceae)

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Advances in Biological Chemistry 2023年第6期13卷 209-227页

作者： Uwikunda Serondo Héritier Nizigiyimana Libérata Pius Tshimankinda Mpiana Nyamangyoku Ishibwela Obedi Ngezahayo Jérémie dan cristian Vodnar daniela Hanganu Ioana Matei Sanda andrei Department of Chemistry Faculty of Sciences Institut Supérieur Pédagogique de Bukavu Bukavu Democratic Republic of Congo Centre de Recherche en Sciences Naturelles et de l’Environnement (CRSNE) Faculté des Sciences Université du Burundi Bujumbura Burundi Department of Preclinical Sciences Faculty of Veterinary Medicine University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Cluj-Napoca Romania Ecole Doctorale de l’Université du Burundi Bujumbura Burundi Department of Chemistry Faculty of Sciences Université de Kinshasa Kinshasa Democratic Republic of Congo Faculty of Agriculture Université Catholique de Bukavu Bukavu Democratic Republic of Congo Department of Food Science Faculty of Food Science and Technology University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Cluj-Napoca Romania Department of Pharmacognosy Faculty of Pharmacy University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca Romania Department of Microbiology Mycology and Immunology Faculty of Veterinary Medicine University of Agricultural Science and Veterinary Medicine Cluj-Napoca Romania

This study has been conducted to analyze the chemical composition and antimicrobial, antioxidant and antiplasmodial properties of ethanol extracts of Pycnostachys erici-rosenii *** and Leucas martinicensis (Jack.) *** that are not yet well known. The HPLC-DAD-MS-ESI+ method was used to investigate the chemical profile, the disc diffusion and microdilution method for the antimicrobial activities, the DPPH and FRAP assays for antioxidant property and SYBR Green I-based growth inhibition assay on Pf 3D7 (CQ-sensitive) strain for antiplasmodial properties. The results indicated significant amounts of hydroxybenzoic acid, flavonol and hydroxycinnamic acid in the two species. The total polyphenols analysis gave 209.0 ± 16.1 mg GAE/100g DW for P. erici-rosenii and 175.3 ± 1.6 mg GAE/100g DW for L. martinicensis while for total flavonoids analysis 33.4 ± 1.8 mg TE/100g DW was found for P. erici-rosenii and 39.6 ± 0.6 mg TE/100g DW for L. martinicensis. Moreover, antimicrobial tests revealed 0.125 mg/mL on E. faecalis ATCC25922 for ethanol extracts P. erici-rosenii and L. martinicensis. The antioxidant assays revealed IC50 56.17 μg/mL and 78.43 μg/mL for DPPH assay, and 112.03 μM TE/100mL and 90.46 μM TE/100mL) for FRAP assay for ethanol extracts of P. erici-rosenii and L. martinicensis respectively. Finally, for Antiplasmodial activity, IC50 was 4.07 μg/mL for P. erici-rosenii and 12.29 μg/mL for L. martinicensis. Therefore, the antimicrobial, the antioxidant, and the antiplasmodial results suggest that the ethanolic extracts of the aerial parts of P. erici-rosenii and L. martinicensis contain compounds with antimicrobial, antioxidant, and antiplasmodial properties, which can be searched in new drug discovery for treatment of infectious diseases.

关键词： Pycnostachys erici-rosenii Leucas martinicensis Phytochemical Profile Antimicrobial Activity Antioxidant Activity Antiplasmodial Activity

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新型数字结构集成化设计过程

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时代建筑 2014年第5期57卷 34-37页

作者：安德烈·盖奥格罗丹张朔炯维也纳应用艺术大学哥伦比亚大学英国建筑联盟

参数化结构设计技术与数字设计、数字建造工具的结合,改变并重新定义了当代建筑设计的过程。研究尝试探索一种新的数字设计教育模式,将建筑设计过程与数字结构设计技术相结合,并且在各种国际教育机构中讨论实验性工作坊的成果。研究的... 详细信息

参数化结构设计技术与数字设计、数字建造工具的结合,改变并重新定义了当代建筑设计的过程。研究尝试探索一种新的数字设计教育模式,将建筑设计过程与数字结构设计技术相结合,并且在各种国际教育机构中讨论实验性工作坊的成果。研究的目的在于挖掘这一系列课程在启发建筑实践创新方面的潜力。

关键词：数字设计与建造数字建筑设计数字建筑设计教育数字结构设计

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