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Assessment of risks, implications, and opportunities of waterborne neurotoxic pesticides

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Journal of Environmental Sciences 2023年第3期125卷 735-741页

作者： Delaram Dara andrei p.Drabovich Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaAlberta T6G 2G3Canada

pesticides are a well-known family of chemicals that have contaminated water systems globally. Four common subfamilies of pesticides include organochlorines, organophosphates, pyrethroids, and carbamate insecticides which have been shown to adversely affect the human nervous system. Studies have shown a link between pesticide exposure and decreased viability, proliferation, migration, and differentiation of murine neural stem cells. Besides human exposure directly through water systems, additional factors such as pesticide bioaccumulation, biomagnification and potential synergism due to co-exposure to other environmental contaminants must be considered. A possible avenue to investigate the molecular mechanisms and biomolecules impacted by the various classes of pesticides includes the field of-omics. Discovery of the precise molecular mechanisms behind pesticidemediated neurodegenerative disorders may facilitate development of targeted ***, discovery of pesticide biodegradation pathways may enable novel approaches for water system bioremediation using genetically engineered microorganisms. In this minireview, we discuss recently established harmful impacts of various categories of pesticides on the nervous system and the application of-omics field for discovery, validation, and mitigation of pesticide neurotoxicity.

关键词： Neurotoxic pesticides Water pollution Neural stem cells Omics approaches Drug discovery

Universal enzymatic numerical p systems with small number of enzymatic variables

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Science China(Information Sciences) 2018年第9期61卷 38-49页

作者： Zhiqiang ZHANG Tingfang WU andrei p■UN Linqiang pAN Key Laboratory of Image Information processing and Intelligent Control of Education Ministry of China School of Automation Huazhong University of Science and Technology School of Electric and Information Engineering Zhengzhou University of Light Industry Bioinformatics Department National Institute of Research and Development for Biological Sciences Department of Computer Science Faculty of Mathematics and Computer ScienceUniversity of Bucharest

Numerical p systems(for short, Np systems) are distributed and parallel computing models inspired from the structure of living cells and economics. Enzymatic numerical p systems(for short, ENp systems) are a variant of Np systems, which have been successfully applied in designing and implementing controllers for mobile robots. Since ENp systems were proved to be Turing universal, there has been much work to simplify the universal systems, where the complexity parameters considered are the number of membranes, the degrees of polynomial production functions or the number of variables used in the *** the number of enzymatic variables, which is essential for ENp systems to reach universality, has not been investigated. Here we consider the problem of searching for the smallest number of enzymatic variables needed for universal ENp systems. We prove that for ENp systems as number acceptors working in the all-parallel or one-parallel mode, one enzymatic variable is sufficient to reach universality; while for the one-parallel ENp systems as number generators, two enzymatic variables are sufficient to reach *** results improve the best known results that the numbers of enzymatic variables are 13 and 52 for the all-parallel and one-parallel systems, respectively.

关键词： bio-inspired computing numerical p system mobile robot membrane controller universality

Gasoline-derived methyl tert-butyl ether as a potential obesogen linked to metabolic syndrome

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Journal of Environmental Sciences 2020年第5期32卷 209-211页

作者： Yasmine Rais andrei pDrabovich Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonCanada

The power and efficiency of gasoline engines is often improved through the use of fuel with high octane *** octane rating of fuel could be further increased with oxygenate additives such as alcohols and ethers,with me... 详细信息

关键词： Methyl tert-butyl ether Gasoline additives Adipogenesis Metabolic syndrome Endocrine-disrupting chemicals Obesogens

Body Building on Diamonds

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Journal of Bionic Engineering 2009年第1期6卷 14-17页

作者： andrei p. Sommer Tim Scharnweber Hans-Joerg Fecht Institute of Micro and Nanomaterials University of UlmUlm 89081Germany Institute for Biological Interfaces Research Center KarlsruheKarlsruhe 76021Germany Institute for Nanotechnology Research Center Karlsruhe Karlsruhe 76021Germany

Whereas conservative therapies aim to stall the advance of disease,regenerative medicine strives to reverse *** capacity of most tissues to regenerate derives from stem cells,but there are a number of barriers which have to be circumvented before it will be possible to use stem-cell-based *** therapies,however,are expected to improve human health enormously, and knowledge gained from studying stem cells in culture and in model organisms is now laying the groundwork for a new era of regenerative *** of the most prominent methods to study stem cell differentiation is to let them to form embryoid *** favourable conditions any stem cell line will form embryoid ***,the mechanism of the formation of embryoid bodies is not very well understood,and to produce them in the laboratory is in no way trivial-an important technical barrier in stem cell ***,the embryoid body cultivation step has been successfully circumvented for the derivation of osteogenic cultures of embryonic stem *** we report on a simple and reusable system to cultivate embryoid bodies in extremely short *** method is inspired by the principles that lead to the establishment of the biomimetic triangle.

关键词： biomimetic triangle stem cells embryoid bodies nanobionics nanocrystalline diamond

Seminal biomarkers for the evaluation of male infertility

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Asian Journal of Andrology 2016年第3期18卷 426-433,I0009页

作者： Jared M Bieniek andrei p Drabovich Kirk C Lo Department of Urology Hartford Hospital Hartford CT USA Department of Clinical Biochemistry University Health Network Toronto ON Canada Department ofLaboratory Medicine and pathobiology University of Toronto Toronto ON Canada Department of Surgery Division of Urology Mount Sinai Hospital Toronto ONCanada.

For men struggling to conceive with their partners, diagnostic tools are limited and often consist of only a standard semen analysis. This baseline test serves as a crude estimation of male fertility, leaving patients and clinicians in need of additional diagnostic biomarkers. Seminal fluid contains the highest concentration of molecules from the male reproductive glands, therefore, this review focuses on current and novel seminal biomarkers in certain male infertility scenarios, including natural fertility, differentiating azoospermia etiologies, and predicting assisted reproductive technique success. Currently available tests include antisperm antibody assays, DNA fragmentation index, sperm fluorescence in situ hybridization, and other historical sperm functional tests. The poor diagnostic ability of current assays has led to continued efforts to find more predictive biomarkers. Emerging research in the fields of genomics, epigenetics, proteomics, transcriptomics, and metabolomics holds promise for the development of novel male infertility biomarkers. Seminal protein-based assays of TEXI01, ECM 1, and ACRV1 are already available or under final development for clinical use. Additional panels of DNA, RNA, proteins, or metabolites are being explored as we attempt to understand the pathophysiologic processes of male infertility. Future ventures will need to continue data integration and validation for the development of clinically useful infertility biomarkers to aid in male infertility diagnosis, treatment, and counseling.

关键词： assisted reproductive techniques diagnosis male infertility, semen

It is Time for a Change： opetri Dishes Weaken Cells

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Journal of Bionic Engineering 2012年第3期9卷 353-357页

作者： andrei p. Sommer Mike Kh. Haddad Hans-Joerg Fecht Institute of Micro and Nanomaterials University of Ulm 89081 Ulm Germany Institute for Nanotechnology Karlsruhe Institute for Technology 76344 Eggenstein-Leopoldshafen Germany

We wish to draw the attention to a potential deficiency in the biocompatibility of polystyrene cell culture dishes which is caused by a softening of the material under relevant culture conditions. The finding confirms the central hypothesis of our previous model study. In it we assumed a local increase in pH at the interface between the hydrophilic polymer and liquid. The finding is of considerable biological interest. polystyrene tissue culture dishes are now in use for 50 years. To the best of our knowledge their biocompatibility has never been challenged. Here we report the first experimental proof that exposure to water softens the surface of polystyrene petri dishes. We expect that our results will stimulate the development of a new generation of cell culture devices, including petri dishes and culture flasks, and the establishment of improved biomimetic settings for tissue engineering and stem cell research. New non-swelling biomaterials or nanocoatings designed to reduce the swelling of polymer ct, lture dishes could improve cell performance. The need for further study is clear.

关键词： petri dish polystyrene biomimetic triangle nanoindentation stem cells diamond

The Top of the Biomimetic Triangle

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Journal of Bionic Engineering 2008年第2期5卷 91-94页

作者： andrei p. Sommer Dan Zhu Matthias Wiora Hans-Joerg Fecht Institute of Micro and Nanomaterials University of Ulm Ulm 89081 Germany Institute for Nanotechnology Forschungszentrum Karlsruhe Karlsruhe 76021 Germany

There is increasing observational evidence indicating that crystalline interfacial water layers play a central role in evolution and biology. For instance in cellular recognition processes, in particular during first contact events, where cells decide upon survival or entering apoptosis. Understanding water layers is thus crucial in biomedical engineering, specifically in the design of biomaterials inspired by biomimetic principles. Whereas there is ample experimental evidence for crystalline interfacial water layers on surfaces in air, their subaquatic presence could not be verified directly, so far. Analysing a polarity dependent asym- metry in the surface conductivity on hydrogenated nanocrystalline diamond, we show that crystalline interfacial water layers persist subaquatically. Nanoscopic interfacial water layers with an order different from that of bulk water have been identified at room temperature on both hydrophilic and hydrophobic model surfaces - in air and subaquatically. Their generalization and systematic inclusion into the catalogue of physical and chemical determinants of biocompatibility complete the biomimetic triangle.

关键词： biomimetic triangle crystalline interfacial water layers nanobionics diamond

Silica-Metal Spherules in Ignimbrites of Southern primorye,Russia

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Journal of Earth Science 2011年第1期22卷 20-31页

作者： andrei V Grebennikov Far East Geological Institute Prospect Stoletia 159 690022 Vladivostok Russia

A comprehensive mineralogical-geochemical and petrological study of ignimbrites from the Yakut-Gora volcanic depression （primorye, Far Eastern Russia） revealed a wide distribution of silica-metal spherules （＂globules＂） that are typical liquid immiscibility resultant. The metallic portion of a spherule （composition varies from low-carbon iron to cohenite） borders gas pores and is rimmed by symplectite that consists of quartz, magnetite, and silica-potassic glass. This allows us to consider that the whole formation formed through reduction of the enclosing silicate melt. Abundant evidence of high reduction states of ignimbrite melts and the presence of iron carbides suggest an H2-CH4 composition of the fluidal phase in ignimbrite magmas.

关键词： spherule native iron ignimbrite tektite primorye Russia.

Influence of Bottom Inclination on the Flow Structure in a Rotating Convective Layer

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Fluid Dynamics & Materials processing 2024年第4期20卷 739-748页

作者： andrei Vasiliev andrei Sukhanovskii Elena popova Laboratory of Turbulence Institute of Continuous Media Mechanics UB RASPerm614013Russia

The formation of convective flows in a rotating cylindrical layer with an inclined bottom and free surface is *** is driven by localized cooling at the center of the upper free surface and by rim heating at the bottom near the *** horizontal temperature difference in a rotating layer leads to the formation of a convective flow with a complex *** mean meridional circulation,consisting of three cells,provides a strongly non-uniform differential *** a result of the instability of the main cyclonic zonal flow,the train of baroclinic waves appears in the upper *** baroclinic waves provide most of the heat transfer in the middle radii and are responsible for strong temperature and velocity *** is shown that the inclination of the bottom is a crucial factor for the structure of the convective cells and the dynamics of the baroclinic *** increase in the inclination angle leads to a significant increase in the energy of the *** obtained results may be important for heat and mass transfer in various geophysical and industrial systems,including transport of various additives and impurities in rotating crucibles,and crystallization processes.

关键词： Laboratory modeling global atmospheric circulation baroclinic waves beta-effect