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WNT/β-catenin-M2 macrophage interplay as a target for therapy against hepatocellular carcinoma:Role of Calculus bovis

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World Journal of Gastroenterology 2025年第3期31卷 130-133页

作者： Tryfonas Mpektsis Anastasios Manolakis andreas Kapsoritakis Department of Gastroenterology University Hospital of LarisaLarisa 41100Greece

Liver cancer,and in particular hepatocellular carcinoma(HCC)is a disease of rising prevalence and *** date,definitive treatment options include either surgical excision or ablation of the affected *** increasing research on several pathways that could be involved in the progression of HCC,new elements within these pathways emerge as potential targets for novel *** WNT/β-catenin pathway favors the presence of M2 tumor-associated macrophages which in turn promote tumor growth and *** inhibition of this pathway is considered a good candidate for such targeted therapeutic ***,as Huang et al show in their recently published article,Calculus bovis which is used in traditional Chinese medicine can exert an inhibitory effect on theβ-catenin pathway and become a potential candidate for targeted pharmacotherapy against liver cancer.

关键词： Hepatocellular carcinoma Calculus bovis WNT/β-catenin pathway Tumorassociated macrophages

Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng Thomas Skutella Karl Kiening andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

Tunable structural colors on display

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Light(Science & Applications) 2022年第6期11卷 1036-1037页

作者： andreas Tittl Chair in Hybrid Nanosystems Nanoinstitute MunichFaculty of PhysicsLudwig-Maximilians-Universitat MünchenKoniginstraβe 1080539 MünchenGermany

Structural coloration takes inspiration from the bright hues found in nature to control the reflection and transmission of light from artificially structured *** them with active electrical tuning heralds breakthrough... 详细信息

关键词： materials tuning breakthrough

Geoscience material structures prediction via CALYPSO methodology

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Chinese Physics B 2019年第10期28卷 38-49页

作者： andreas Hermann Centre for Science at Extreme Conditions and SUPA School of Physics and Astronomy The University of Edinburgh

Many properties of planets such as their interior structure and thermal evolution depend on the high-pressure properties of their constituent materials. This paper reviews how crystal structure prediction methodology can help shed light on the transformations materials undergo at the extreme conditions inside planets. The discussion focuses on three areas:(i) the propensity of iron to form compounds with volatile elements at planetary core conditions(important to understand the chemical makeup of Earth's inner core),(ii) the chemistry of mixtures of planetary ices(relevant for the mantle regions of giant icy planets), and(iii) examples of mantle minerals. In all cases the abilities and current limitations of crystal structure prediction are discussed across a range of example studies.

关键词： crystal structure prediction core materials planetary ices hydrous minerals

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Plasma optics improving plasma accelerators

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Light(Science & Applications) 2022年第9期11卷 1954-1955页

作者： andreas Dopp Ludwig-Maximilians-Universit?t Munchen GarchingGermany

Plasma accelerators driven by high-power lasers can provide high-energy electron beams on a dramatically smaller scale than conventional radio-frequency ***,the performance of these accelerators is fundamentally limited by the diffraction of the ***-generated plasma waveguides can mitigate this problem and,combined with a controlled injection method for electrons,highlight the potential of novel laser-plasma optics.

关键词： optics Plasma conventional

Numerical micro-texture optimization for lubricated contacts-A critical discussion

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Friction 2022年第11期10卷 1772-1809页

作者： Max MARIAN andreas ALMQVIST andreas ROSENKRANZ Michel FILLON Department of Mechanical and Metallurgical Engineering Pontificia Universidad Católica de ChileSantiago 690411Chile Division of Machine Elements LuleåUniversity of TechnologyLuleåSE-97187Sweden Department of Chemical Engineering Biotechnology and MaterialsFCFMUniversity of ChileSantiago 8370456Chile Institut Pprime CNRSUniversity of PoitiersPoitiers Cedex TSA 4112386073France

Despite numerous experimental and theoretical studies reported in the literature,surface micro-texturing to control friction and wear in lubricated tribo-contacts is still in the trial-and-error *** tribological behaviour and advantageous micro-texture geometries and arrangements largely depend on the contact type and the operating *** scale implementation is hampered by the complexity of numerical *** substantiates the urgent need to numerically design and optimize micro-textures for specific *** these aspects have not been covered by other review articles yet,we aim at summarizing the existing state-of–the art regarding optimization strategies for micro-textures applied in hydrodynamically and elastohydrodynamically lubricated *** analysis demonstrates the great potential of optimization strategies to further tailor micro-textures with the overall aim to reduce friction and wear,thus contributing toward an improved energy efficiency and sustainability.

关键词： micro-texturing hydrodynamics elastohydrodynamics tribo-simulation optimization

SMRs-overview,international developments,safety features and the GRS simulation chain

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Frontiers in Energy 2021年第4期15卷 793-809页

作者： andreas SCHAFFRATH andreas WIELENBERG Robert KILGER Armin SEUBERT Gesellschaft für Anlagen-und Reaktorsicherheit gGmbH Boltzmannstrasse 1485748 Garching near MunichGermany

The Gesellschaft für Anlagen-und Reaktorsicherheit(GRS)gGmbH as the main technical support organization for the German Federal Government in nuclear safety has been dealing with small modular reactors(SMRs)for about one decade since SMRs are one interesting option for new builds in most countries worldwide which continue to use nuclear energy for commercial electricity *** four different SMR designs are in operation,four in construction,one is licensed,and further 12 are in a licensing *** this paper,definitions,history,and current developments of SMRs are ***,selected trends of SMR development such as factory fabrication and transport,compactness and modularity,core design,improved core cooling,exclusion of accidents,features for preventing and limiting the impact of severe accidents,economic viability,competitiveness and licensing are *** gaps of the GRS simulation chain programs with a view to applications in nuclear licensing procedures are identified and a strategy for closing these gaps is ***,selected work on the extension and improvement of the simulation chain and first generic test analyses are presented.

关键词： small modular reactors(SMRs) history recent developments safety aspects simulation chain of the Gesellschaft für Anlagen-und Reaktorsicherheit(GRS)

Dependence of impact regime boundaries on the initial temperatures of projectiles and targets

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Defence Technology（防务技术） 2024年第1期31卷 49-57页

作者： Stefano Signetti andreas Heine Fraunhofer-Institut für Kurzzeitdynamik Ernst-Mach-InstitutEMIErnst-Zermelo-Str.479104 Freiburg im BreisgauGermany

Towards higher impact velocities,ballistic events are increasingly determined by the material *** effects might range from moderate thermal softening to full phase *** particular,it is of great interest to quantify the conditions for incipient or full melting of metals during impact interactions,which result in a transition from still strength-affected to hydrodynamic material *** this work,we investigate to which extent the respective melting thresholds are also dependent on the initial,and generally elevated,temperatures of projectiles and targets before *** is studied through the application of a model developed recently by the authors to characterize the transition regime between high-velocity and hypervelocity impact,for which the melting thresholds of materials were used as the defining *** obtained results are expected to be of general interest for ballistic application cases where projectiles or targets are *** conditions might result,for example,from aerodynamic forces acting onto a projectile during atmospheric flight,explosive shapedcharge-jet formation or armor exposure to environmental *** performed analyses also broaden the scientific understanding of the relevance of temperature in penetration events,generally known since the 1960s,but often not considered thoroughly in impact studies.

关键词： Ballistic impact Thermal effects Metallic targets Energy partitioning Homologous temperature