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Diagnostic delay in inflammatory bowel diseases in a German population

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World Journal of Gastroenterology 2024年第29期30卷 3465-3478页

作者： Elisabeth Blüthner Annalena Dehe Carsten Büning Britta Siegmund Matthias Prager Jochen Maul Alexander Krannich Jan Preiß Bertram Wiedenmann Florian Rieder Raneem Khedraki Frank Tacke andreas Sturm Anja Schirbel Department of Hepatology and Gastroenterology Campus Virchow-Klinikum and Campus CharitéMitteCharité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Vivantes Klinikum im FriedrichshainBerlin 10249Germany Department of Internal Medicine Krankenhaus WaldfriedeBerlin 14163Germany Department of Gastroenterology Infectious Diseases and RheumatologyCharité-Universitätsmedizin BerlinBerlin 12203Germany Praxis für Gastroenterologie Berlin Zehlendorf Berlin 14195Germany Gastroenterologie am Bayrischen Platz Berlin 10825Germany Clinical Trial Office Charité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Diabetology and HepatologyVivantes Klinikum NeuköllnBerlin 10117Germany Department of Gastroenterology Hepatology and NutritionDigestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine DRK Kliniken Berlin WestendBerlin 14050Germany Gastroenterologie im Havelland Straße der EinheitFalkensee 14612Germany

BACKGROUND Early diagnosis is key to prevent bowel damage in inflammatory bowel disease(IBD).Risk factor analyses linked with delayed diagnosis in European IBD patients are scarce and no data in German IBD patients *** To identify risk factors leading to prolonged diagnostic time in a German IBD *** Between 2012 and 2022,430 IBD patients from four Berlin hospitals were enrolled in a prospective study and asked to complete a 16-item questionnaire to determine features of the path leading to IBD *** diagnostic time was defined as the time from symptom onset to consulting a physician(patient waiting time)and from first consultation to IBD diagnosis(physician diagnostic time).Univariate and multivariate analyses were performed to identify risk factors for each time *** The total diagnostic time was significantly longer in Crohn’s disease(CD)compared to ulcerative colitis(UC)patients(12.0 vs 4.0 mo;P<0.001),mainly due to increased physician diagnostic time(5.5 vs 1.0 mo;P<0.001).In a multivariate analysis,the predominant symptoms diarrhea(P=0.012)and skin lesions(P=0.028)as well as performed gastroscopy(P=0.042)were associated with longer physician diagnostic time in CD *** UC,fever was correlated(P=0.020)with shorter physician diagnostic time,while fatigue(P=0.011)and positive family history(P=0.046)were correlated with longer physician diagnostic *** We demonstrated that CD patients compared to UC are at risk of long diagnostic *** efforts should focus on shortening the diagnostic delay for a better outcome in these patients.

关键词： Diagnostic time Diagnostic delay Crohn’s disease Ulcerative colitis Germany

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食品工业中的协作机器人码垛

现代制造 2024年第9期 28-29页

作者： andreas Alboni 不详

食品工业企业面临着巨大的成本费用压力,而食品工业企业中使用的协作机器人则减轻了生产工人的工作量、承担了更加繁重的工作任务,例如码垛。因此,爱尔兰的乳制品供应商Ornua公司就用通用协作机器人(简称为UR)来高效地完成货物码垛和拆... 详细信息

食品工业企业面临着巨大的成本费用压力,而食品工业企业中使用的协作机器人则减轻了生产工人的工作量、承担了更加繁重的工作任务,例如码垛。因此,爱尔兰的乳制品供应商Ornua公司就用通用协作机器人(简称为UR)来高效地完成货物码垛和拆垛的工作任务。食品行业2024年预计的年营业额约为9.2万亿欧元,是全球增长速度最快、最重要的行业之一。工业企业与食品物流有着非常紧密的联系。

关键词：成本费用食品工业企业食品物流增长速度供应商食品行业欧元乳制品

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协作机器人码垛应用教程

现代制造 2024年第6期 28-30页

作者： andreas Schunkert 不详

利用协作机器人码垛时有哪些注意事项?本文“协作机器人应用教程”的摘录会告诉您一切。托盘码垛机是当今物流领域非常重要且不可替代的重要机械设备。多年来,工业机器人就一直被用于集装箱和周转箱的运输。传统的机器人工作单元能够在... 详细信息

利用协作机器人码垛时有哪些注意事项?本文“协作机器人应用教程”的摘录会告诉您一切。托盘码垛机是当今物流领域非常重要且不可替代的重要机械设备。多年来,工业机器人就一直被用于集装箱和周转箱的运输。传统的机器人工作单元能够在围栏内高效的工作,而它们的围栏也是完成托盘运输唯一的“人机接口”。近几年来,托盘码垛堆放技术有了很大进步,越来越多地出现了协作机器人码垛的解决方案。这些执行托盘码垛任务的协作机器人都高高地站在一个凸出地面的底座上。它也可以安装在其他码垛设备的悬伸轴上,完成最大工作范围2 m的高负载搬运。

关键词：工业机器人协作机器人人机接口工作单元托盘运输码垛机高负载周转箱

Development of a Web-Based GIS of Flood Zones in the Municipality of Ouagadougou in Burkina Faso

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Journal of Geographic Information System 2024年第1期16卷 32-43页

作者： Halidou Kafando Blaise Ouedraogo Vincent Nduka Ojeh andreas Rienow Aliou Gadiaga Ibrahim Elh Maman Garba WASCAL Graduate Research Programme on Climate Change and Education Department of Agriculture and Environment Science University of The Gambia Kanifing The Gambia Institute of Environment and Agricultural Research Ouagadougou Burkina Faso Department of Geography Faculty of Social Sciences Taraba State University Jalingo Nigeria Interdisciplinary Geographic Information Science Institute of Geography Ruhr-University Bochum Bochum Germany WASCAL Graduate Research Programme on Climate Change and Human Habitat University of Mina Mina Nigeria

This document describes the creation of an informative Web GIS aimed at mitigating the impacts of flooding in the municipality of Ouagadougou, in Burkina Faso, a region that is highly sensitive to climate change. Burkina Faso, which is undergoing rapid urbanization, faces major natural threats, particularly flooding, as demonstrated by the severe floods of 2009 that caused loss of life, injury, structural damage and economic losses in Ouagadougou. The aim of this research is to develop a web map highlighting the municipality’s flood-prone areas, with a view to informing and raising awareness of flood risk reduction. Using the Leaflet JavaScript mapping library, the study uses HTML, CSS and JavaScript to implement web mapping technology. Data on Ouagadougou’s flood zones is generated by a multi-criteria analysis combining Saaty’s AHP method and GIS in QGIS, integrating seven (7) parameters including hydrography, altitude, slope, rainfall, soil types, land use and soil moisture index. QGIS processes and maps the themes, PostgreSQL with PostGIS serves as the DBMS and GeoServer functions as the map server. The Web GIS platform allows users to visualize the different flood risks, from very low to very high, or the high-risk areas specific to Ouagadougou. The AHP calculations classify the municipality into five flood vulnerability zones: very low (24.48%), low (27.93%), medium (23.01%), high (17.11%) and very high (7.47%). Effective risk management requires communication and awareness-raising. This online mapping application serves as a tool for communication, management and flood prevention in Ouagadougou, helping to mitigate flood-related natural disasters.

关键词： Web GIS Flood Mapping Leaflet JavaScript Mapping Library Analysis Hierarchical Processes (AHP) Climate Change Adaptation Ouagadougou Municipality

Occupational physical activity, all-cause, cardiovascular disease, and cancer mortality in 349,248 adults: Prospective and longitudinal analyses of the MJ Cohort

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Journal of Sport and Health Science 2024年第4期13卷 579-589页

作者： Emmanuel Stamatakis Matthew N.Ahmadi Tiana-Lee Elphick Bo-Huei Huang Susan Paudel Armando Teixeira-Pinto Li-Jung Chen Borja del Pozo Cruz Yun-Ju Lai andreas Holtermann Po-Wen Ku Sydney School of Health Sciences Faculty of Medicine and HealthCharles Perkins CentreUniversity of SydneySydneyNSW 2006Australia Sydney School of Public Health Faculty of Medicine and HealthUniversity of SydneySydneyNSW 2006Australia Department of Exercise Health Science “National”Taiwan University of SportTaichung 40404China Department of Sports Science and Clinical Biomechanics University of Southern DenmarkOdense 5230Denmark Division of Endocrinology and Metabolism Department of Internal MedicinePuli Branch of Taichung Veterans General HospitalNantou 54552China National Research Centre for the Working Environment Copenhagen 2100Denmark Graduate Institute of Sports and Health Management “National”Chung Hsing UniversityTaichung 40227China

Background:Evidence on the health benefits of occupational physical activity(OPA)is *** examined the associations of baseline OPA and OPA changes with all-cause,cardiovascular disease(CVD),and cancer mortality and survival ***:This study included prospective and longitudinal data from the MJ Cohort,comprising adults over 18 years recruited in 1998-2016,349,248 adults(177,314 women)with baseline OPA,of whom 105,715(52,503 women)had 2 OPA measures at 6.3±4.2 years(mean±SD)*** were baseline OPA,OPA changes,and baseline leisure-time physical ***:Over a mean mortality follow-up of 16.2±5.5 years for men and 16.4±5.4 years for women,11,696 deaths(2033 of CVD and 4631 of cancer causes)in men and 8980 deaths(1475 of CVD and 3689 of cancer causes)in women *** moderately heavy/heavy baseline OPA was beneficially associated with all-cause mortality in men(multivariable-adjusted hazard ratio(HR)=0.93,95%confidence interval(95%CI):0.89-0.98 compared to light OPA)and women(HR=0.86,95%CI:0.79-0.93).Over a mean mortality follow-up of 12.5±4.6 years for men and 12.6±4.6 years for women,OPA decreases in men were detrimentally associated(HR=1.16,95%CI:1.01-1.33)with all-cause mortality,while OPA increases in women were beneficially(HR=0.83,95%CI:0.70-0.97)associated with the same *** or changes in OPA showed no associations with CVD or cancer ***:Higher baseline OPA was beneficially associated with all-cause mortality risk in both men and *** longitudinal OPA analyses partly confirmed the prospective findings,with some discordance between sex groups.

关键词： Cancer Cardiovascular disease Epidemiology Mortality

Manipulating the Gut Microbiome to Alleviate Steatotic Liver Disease:Current Progress and Challenges

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Engineering 2024年第9期40卷 51-60页

作者： Ernesto Saenz Nathally Espinosa Montagut Baohong Wang Christoph Stein-Thöringer Kaicen Wang Honglei Weng Matthias Ebert Kai Markus Schneider Lanjuan Li andreas Teufel Division of Hepatology Division of Clinical BioinformaticsDepartment of Medicine IIMedical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Clinical Cooperation Unit Healthy Metabolism Center for Preventive Medicine and Digital HealthMedical Faculty MannheimHeidelberg UniversityMannheim 68167Germany School of Medicine Universidad de Los AndesBogotá111711Colombia State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Internal MedicineⅠ University Clinic Tuebingen&CoE CMFI(Controlling Microbes to Fight Infections)Tuebingen 72074Germany Department of MedicineⅡ Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany DKFZ Hector Cancer Institute at the University Medical Center Mannheim 69120Germany Molecular Medicine Partnership Unit European Molecular Biology LaboratoryHeidelberg 69117Germany Department of MedicineⅢ University Hospital RWTH AachenAachen 52074Germany

The prevalence of metabolic-dysfunction-associated steatotic liver disease(MASLD)is alarmingly high;it is estimated to affect up to a quarter of the global population,making it the most common liver disorder *** is characterized by excessive hepatic fat accumulation and is commonly associated with comorbidities such as obesity,dyslipidemia,and insulin resistance;however,it can also manifest in lean ***,it is crucial to develop effective therapies for this complex ***,there are no approved medications for MASLD treatment,so there is a pressing need to investigate alternative *** research has characterized MASLD as a multifaceted disease,frequently linked to metabolic disorders that stem from dietary *** suggests that changes in the gut microbiome play a fundamental role in the development and progression of MASLD from simple steatosis to steatohepatitis and even hepatocellular carcinoma(HCC).In this review,we critically examine the literature on the emerging field of gut-microbiota-based therapies for MASLD and metabolicdysfunction-associated steatohepatitis(MASH),including interventions such as fecal microbiota transplantation(FMT),probiotics,prebiotics,short-chain fatty acids,antibiotics,metabolic pathway targeting,and immune checkpoint kinase blockade.

关键词： Microbiome Fecal microbiota transplantation Metabolic-dysfunction-associated steatotic liver disease Fatty liver

Effects of combined aerobic,resistance and inspiratory training in patients with pulmonary hypertension:A systematic review

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World Journal of Critical Care Medicine 2024年第2期13卷 168-179页

作者： Christos Kourek Antonia Zachariou Eleftherios Karatzanos Michalis Antonopoulos Theodora Soulele andreas Karabinis Serafim Nanas Stavros Dimopoulos Department of Clinical Ergospirometry Exercise and Rehabilitation Laboratory1^(st)Department of Critical Care MedicineEvangelismos HospitalNational and Kapodistrian University of AthensAthens 10676Greece Department of Cardiology 417 Army Share Fund Hospital of AthensAthens 11521Greece Cardiac Surgery ICU Onassis Cardiac Surgery centerAthens 17674AtticaGreece Cardiac Surgery ICU Onassis Cardiac Surgery CenterAthens 17674Greece Cardiac Surgery Intensive Care Unit Onassis Cardiac Surgery CenterAthens 17674Greece Department of Clinical Ergospirometry Exercise and Rehabilitation LaboratoryNational and Kapodistrian University of AthensAthens 10676Greece

BACKGROUND Pulmonary hypertension(PH)is a serious progressive disorder of the modern world,characterized by endothelial dysfunction and impaired *** with PH usually present exercise intolerance from the very early stages and reduced exercise *** training has been shown to have beneficial effects in patients with cardiovascular ***,data regarding the effects of combined exercise training programs in patients with PH still remains *** To investigate the effects of combined exercise training programs on exercise capacity and quality of life in patients with *** Our search included all available randomized controlled trials(RCTs)regarding combined aerobic,resistance and inspiratory training programs in patients with PH in 4 databases(Pubmed,PEDro,Embase,CINAHL)from 2012 to *** RCTs were included in the final *** capacity,assessed by peak VO_(2)or 6-min walking test(6MWT),as well as quality of life,assessed by the SF-36 questionnaire,were set as the primary outcomes in our *** Peak VO_(2)was measured in 4 out of the 5 RCTs while 6MWT was measured in all *** indices of functional capacity were significantly increased in patients with PH who underwent combined exercise training compared to the controls in all of the included RCTs(P<0.05).Quality of life was measured in 4 out of 5 *** patients improved their quality of life in each group,however,only 2 RCTs demonstrated further improvement in patients performing combined training compared to *** By this systematic review,we have demonstrated that combined aerobic,resistance and inspiratory exercise training is safe and has beneficial effects on aerobic capacity and quality of life in patients with *** exercise training regimen may be part of the therapeutic strategy of the syndrome.

关键词： Pulmonary hypertension Exercise training Peak VO2 Functional capacity Quality of life

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基于GQFD的手持工具人机工程设计研究

湖北工业大学学报 2024年第3期39卷 86-92页

作者：程文婷李慧 andreas Papenfuss 湖北工业大学工业设计学院湖北武汉430068 Atelier Papenfuss设计公司魏玛99423

为优化手持工具的用户使用体验,提出一种将基于灰色关联分析的质量功能展开(GQFD)与人机工程相结合的设计方法,并将其应用于手持工具的产品研发中。首先采用非参与式观察法观察用户行为并获取用户需求,并依据手持工具的人机工程设计原... 详细信息

为优化手持工具的用户使用体验,提出一种将基于灰色关联分析的质量功能展开(GQFD)与人机工程相结合的设计方法,并将其应用于手持工具的产品研发中。首先采用非参与式观察法观察用户行为并获取用户需求,并依据手持工具的人机工程设计原则将用户需求转化为对应的设计要素;再运用GQFD构建设计质量屋,对用户需求与设计要素的相关关系度进行量化评价,分析设计要素重要度,从而明确重点设计目标;最后根据人机工程学的原理和方法,对重点设计目标进行分析设计,得到最终的设计方案。将该方法应用于德国Prym公司的手工钳改良设计项目,设计结果不仅满足了用户使用需求,而且提升了用户体验,为手持工具类产品的创新设计提供一种新的研究思路。

关键词：手持工具质量功能展开人机工程灰色关联分析用户需求

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管道清洁机器人的创新应用

现代制造 2024年第1期 27-29页

作者： andreas Seegen Ellen-Christine Rei 不详

地下排水管道需要定期的维护保养,而且最好是在不挖开地面的情况下进行维护保养。为此,Pipetronics公司开发了一种可对地下管道进行维护保养的机器人。这款机器人由Faulhaber公司研发生产的无刷直流电机来驱动机器人车轮运转,驱动机器... 详细信息

地下排水管道需要定期的维护保养,而且最好是在不挖开地面的情况下进行维护保养。为此,Pipetronics公司开发了一种可对地下管道进行维护保养的机器人。这款机器人由Faulhaber公司研发生产的无刷直流电机来驱动机器人车轮运转,驱动机器人的清洁工具完成地下管道的清洁。

关键词：机器人地下管道维护保养 Pipe 无刷直流电机创新应用清洁工具