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小粒子，大效果

现代塑料 2010年第2期 46-48页

作者： andreas Eipper reinhard Stransky BSAF公司

含有纳米粒子的高流动性PBT树脂已被成功地用于结构复杂且精细的注塑制品中，且其应用领域不断扩大。这种材料正在得到不断完善且其品级越来越多，与此同时，聚酰胺类材料也呈现相似的趋势。

关键词：小粒子 PBT树脂注塑制品高流动性纳米粒子酰胺类材料

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小粒子，大功效

汽车制造业 2008年第23期 58-58页

作者： andreas EIPPER reinhard STRANSKY 巴斯夫公司

聚对苯二甲酸丁二醇酯（PBT）是一种工程塑料，得益于其主要应用领域——汽车舒适品和电子产品的需求正在日益增长，使得PBT的市场增长率高于平均水平——超过5％，PBT也成为了一种经济实用的材料。

关键词：聚对苯二甲酸丁二醇酯小粒子功效市场增长率工程塑料电子产品经济实用 PBT

Tomographic PIV investigation of coherent structures in a turbulent boundary layer flow

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Acta Mechanica Sinica 2012年第3期28卷 572-582页

作者： Zhan-Qi Tang Nan Jiang andreas Schroder reinhard Geisler Department of Mechanics Tianjin University300072 TianjinChina Tianjin Key Laboratory of Modern Engineering Mechanics 300072 TianjinChina Institute of Aerodynamics and Flow Technology Department of Experimental MethodsBunsenstrasse 1037073 GiSttingenGermany

Tomographic particle image velocimetry was used to quantitatively visualize the three-dimensional co- herent structures in the logarithmic region of the turbulent boundary layer in a water tunnel. The Reynolds number based on momentum thickness is Reo = 2 460. The in- stantaneous velocity fields give evidence of hairpin vortices aligned in the streamwise direction forming very long zones of low speed fluid, which is flanked on either side by high- speed ones. Statistical support for the existence of hairpins is given by conditional averaged eddy within an increasing spanwise width as the distance from the wall increases, and the main vortex characteristic in different wall-normal re- gions can be reflected by comparing the proportion of ejec- tion and its contribution to Reynolds stress with that of sweep event. The pre-multiplied power spectra and two-point cor- relations indicate the presence of large-scale motions in the boundary layer, which are consistent with what have been termed very large scale motions （VLSMs）. The three dimen-sional spatial correlations of three components of veloc- ity further indicate that the elongated low-speed and high- speed regions will be accompanied by a counter-rotating roll modes, as the statistical imprint of hairpin packet structures, all of which together make up the characteristic of coherent structures in the logarithmic region of the turbulent boundary layer （TBL）.

关键词： Tomographic particle image velocimetry Tur-bulent boundary layer Coherent structures Hairpin vortex Very large scale motion

Chronic Hyperinsulinism Induced Down-regulation of Insulin Post-Receptor Signaling Transduction in Hep G2 Cells

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第4期22卷 313-316页

作者：袁莉 reinhard Ziegler andreas Hamann DepartmentofEndocrinologyandMetabolism

To study the regulatory effect of acute and chronic insulin treatmenton insulin post- re- ceptor signaling transduction pathway in a human hepatom a cell line (Hep G2 ) ,Hep G2 cells were incubated in the presence or absence of insulin with different concentrations in serum free m edia for16 h and then stim ulated with10 0 nmol/ L insulin for1m *** levels of insulin receptor β- subunit(IRβ) ,insulin receptor substrate- 1(IRS- 1) and p85 subunit of phosphatidylinositol3- kinase(PI3- kinase) were determined in total cell lysates by Western- im ***- ed proteins IRβ,IRS- 1and interaction of PI3- kinase with IRS- 1were determ ined by im munopre- *** showed that 1- min insulin stimulation rapidly induced tyrosine phosphorylation of IRβ and IRS- 1,which in turn,resulting in association of PI 3- kinase with IRS- 1.1- 10 0 nm ol/ L chronic insulin treatment induced a dose- dependent decrease in the protein level of IRβ and a slight decrease in the protein level of IRS- *** was a m ore marked reduction in the phospho- rylation of IRβ,IRS- 1,reaching a nadir of2 2 % (P<0 .0 1) and15 % (P<0 .0 1) of control lev- els,respectively,after16 h treatment with 10 0 nm ol/ L *** association between IRS- 1 and PI3- kinase was decreased by6 6 % (P<0 .0 1) .There was no significant change in PI3- ki- nase protein levels. These data suggest that chronic insulin treatm ent can induce alterations of IRβ,IRS- 1and PI 3- kinase three early steps in insulin action,which contributes significantly to insulin resistance,and may account for desensitization of insulin action.

关键词： insulin insulin signaling transduction insulin resistance

Listen to the sound of moving sediment in a small gravel-bed river

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International Journal of Sediment Research 2016年第3期31卷 271-278页

作者： andreas Krein Reimar Schenkluhn andreas Kurtenbach reinhard Bierl Julien Barrière Luxembourg Institute of Science and Technology Environmental Research and Innovation Department Department of Hydrology University of Trier National Museum of Natural History(Mnhn) European Center for Geodynamics and Seismology

In order to assess the dynamics of rivers,a reliable characterization of bedload transport particularly during unsteady flow regimes is *** contrast to highly energetic cases in hillslope areas,we aim to answer the question whether the usage of acoustic measurements can improve the characterization of bedioad in small rivers draining low land mountains with comparatively low water discharge and *** addition to the investigation of natural flood events,controlled floods were generated by releasing water from a reservoir into a small gravel-bed *** controlled releases allow for an evaluation of bedioad solely from channel storage or bank *** acoustical in-situ characterization of bedioad transport,hydrophones were mounted onto the bottom side of steel plates,thus recording the impacts of sediments via the acoustic vibrations on the surface of the plates while at the same time minimizing the disturbing noise resulting from water *** bedioad traps are removable boxes with open lids fixed in the riverbed so that bedioad material registered by the hydrophone is *** acoustic signals correlate well with the quantity of the transported *** summer flood events the highest transport rates occur at the beginning of the rising limb featuring clockwise *** is due to the rising transport energy of the flow and the presence of loose,unconsolidated *** typical winter flood events bedioad shows anticlockwise *** intensification of bedioad conveyance after the runoff peak can be explained by a decreasing stability of the bed material from the beginning to the end of a transport *** behavior also results from a combination of bedioad exhaustion in the vicinity of the monitoring station with a delayed arrival of new material from distal sources later in the hydrograph.

关键词： Bedload Gravel-bed Hydroacoustic Hysteresis Plate system

二甲双胍在慢性高胰岛素处理的Hep G2细胞对胰岛素受体后信号转导的调节作用(英文)

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Acta Pharmacologica Sinica 2003年第1期24卷 57-62页

作者：袁莉,reinhard ZIEGLER,andreas HAMANN 德国海德堡大学医院内分泌代谢科德国海德堡大学医院内分泌代谢科德国海德堡大学医院内分泌代谢科海德堡 69115 德国 Department of Endocrindlogy in Union Hospital of tongji Medical Colege Huazhong University of Science and Technology Wuhan 430022 China 海德堡 69115 德国海德堡 69115 德国

目的:研究慢性高胰岛素对胰岛素受体后信号转导的影响及其与胰岛素抵抗的关系,并探讨二甲双胍治疗胰岛素抵抗是否通过胰岛素信号转导途径的介导。方法:人类肝癌细胞系(Hep G2)在无血清条件下首先与100nmol/L高浓度胰岛素预温育16h以产... 详细信息

目的:研究慢性高胰岛素对胰岛素受体后信号转导的影响及其与胰岛素抵抗的关系,并探讨二甲双胍治疗胰岛素抵抗是否通过胰岛素信号转导途径的介导。方法:人类肝癌细胞系(Hep G2)在无血清条件下首先与100nmol/L高浓度胰岛素预温育16h以产生胰岛素抵抗细胞模型,并观察不同浓度(0.01-10mmol/L)的二甲双胍对胰岛素受体后磷酯酰肌醇3激酶(PI3K)途径信号转导的影响。结果:高浓度胰岛素100nmol/L慢性处理引起了IRβ、IRS1和IRS2的酪氨酸磷酸化和蛋白表达水平的下调,p85与IRS的相互作用也有显著降低。生理治疗浓度的(0.01-0.1mmol/L)二甲双胍逆转了这种慢性高胰岛素引起的信号下调,细胞用0.1mmol/L二甲双胍预温育后,IRB、IRS1和IRS2的磷酸化反应水平分别增加了2.7倍(P<0.01),6.8倍(P<0.01)和2.3倍(P<0.01),p85与IRS1的相互作用从34％增加至86％(P<0.01),与IRS2的相互作用从30％增加至92％(P<0.01)。相反,药物浓度(1-10mmol/L)的二甲双胍进一步抑制了IRB、IRS的磷酸化及IRS与p85的相互作用。结论:高浓度胰岛素慢性处理可引起胰岛素受体后PI3K途径信号转导的下调,二甲双胍对胰岛素信号转导的作用可能是其治疗胰岛素抵抗的主要分子机制。

关键词：二甲双胍胰岛素受体信号传递

Spinel Castables for Steel Ladle Lining:In-Situ Versus Preformed

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China's Refractories 2012年第3期21卷 7-15页

作者： andreas BUHR Marion SCHNABEL LONG Bin reinhard EXENBERGER Christian RAMPITSCH Jerry DUTTON Almatis GmbH Frankfurt Germany Qingdao Almatis Co. Ltd. Qingdao 266071 China Voestalpine Stahl GmbH Linz Austria Stourbridge United Kingdom

The paper discusses the difference in the formulation concepts of alumina - spinel （spinel containing ） and alumina - magnesia （ spin, el forming） castables and the influence on their physical properties. The individual property profile is discussed with respect to the requirements of refactory lining materials for the different zones of a steel ladle.

关键词： in-situ spinel preformed spinel steel ladle lining

Comparison of the Clinical Efficacy of Four Different Liposomal Sprays for the Treatment of Dry Eye

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Open Journal of Ophthalmology 2017年第2期7卷 103-116页

作者： andreas Hueck reinhard Wehrmann Private Ophthalmology Practice Holzkirchen Germany Private Ophthalmology Practice Miesbach Germany

Purpose: To compare the clinical efficacy of four different liposomal sprays for dry eye treatment. Methods: Prospective randomized consecutive intraindividual comparison enrolling 166 patients (age, 18 - 93 years). Patients were randomly assigned to one of 4 groups, receiving one spray in their right eye and another one in their left eye: Ocuvers Hyaluron (OH) (87 eyes) and Ocuvers Lipostamin (OL) (80 eyes) (Innomedis AG), and Tears Again (TA) (80 eyes) and Tears Again Sensitive (TAS) (85 eyes) (Optima Pharmaceutical). Symptomatology was evaluated with the OSDI (Ocular Surface Disease Index) questionnaire. Subjective comfort, tear break up time (TBUT), redness, tear meniscus, application comfort and smell were evaluated during a 30-minute follow-up. Results: Smell for TA and TAS was significantly fattier compared to OH and OL (p Conclusions: The four evaluated liposome sprays may be useful for dry eye treatment, with higher subjective comfort and less dry eye signs using the Ocuvers sprays. The use of OL may be a better treatment option for severe dry eye.

关键词： Liposomal Spray Dry Eye Ocuvers Tears Again Tear Break Up Time Redness Smell

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一种新数值工具在车辆气动声学开发中的应用

同济大学学报（自然科学版） 2021年第S1期49卷 20-27页

作者： PERUGINI Carlo Alberto ARZILLI Gilberto TORLUCCIO Antonio BLUMRICH reinhard WAGNER andreas Research Institute of Automotive Engineering and Vehicle Engines Stuttgart-FKFS 德国斯图加特70596 Automobili LamborghiniS.p.A. 意大利圣亚加塔·波隆尼40019

为了优化车辆开发过程的有效性,数值气动声学分析法的实施和应用对汽车制造商来说变得越来越重要。提出了一种结合延迟分离涡流模拟和基于Lighthill方程及声学扰动方程的有限元模型混合数值工具,应用OpenFOAM和Actran软件实现了基于声... 详细信息

为了优化车辆开发过程的有效性,数值气动声学分析法的实施和应用对汽车制造商来说变得越来越重要。提出了一种结合延迟分离涡流模拟和基于Lighthill方程及声学扰动方程的有限元模型混合数值工具,应用OpenFOAM和Actran软件实现了基于声学有限元法的近场声源区提取及声学压力脉动计算,并尝试应用于车顶扰流板及后视镜区域的气动噪声计算及分析。在兰博基尼Urus车型上,研究了不同车顶扰流板设计的气动声学行为,将仿真结果与斯图加特大学气动声学全尺寸风洞的实验结果进行比较,发现了令人信服的相关性。此外,探讨了扰流板上的主要噪声产生机制,研究了汽车表面压力波动水平随几何形状改变的变化情况。

关键词：车辆气动声学计算气动声学风噪车辆舒适性