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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl james Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Role of cardiac magnetic resonance imaging in troponinemia syndromes

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World Journal of Cardiology 2022年第4期14卷 190-205页

作者： Nhung Nguyen Nguyen Joseph George Assad Giuseppe Femia andreas Schuster james Otton Tuan Le Nguyen Department of Cardiology Liverpool HospitalLiverpool 2170NSWAustralia Department of Cardiology Campbelltown HospitalCampbelltown 2560NSWAustralia Department of Cardiology and Pneumology University Medical CenterGöttingen 37075Germany

Cardiac magnetic resonance imaging(MRI)is an evolving technology,proving to be a highly accurate tool for quantitative *** recently,it has been increasingly used in the diagnostic and prognostic evaluation of conditions involving an elevation in troponin or *** an elevation in troponin is a nonspecific marker of myocardial tissue damage,it is a frequently ordered investigation leaving many patients without a specific ***,the advent of newer cardiac MRI protocols can provide additional *** this review,we discuss several conditions associated with an elevation in troponin such as myocardial infarction,myocarditis,Takotsubo cardiomyopathy,coronavirus disease 2019 related cardiac dysfunction and athlete’s heart syndrome.

关键词： Cardiac magnetic resonance imaging Troponin Myocardial infarction Myocarditis Takotsubo cardiomyopathy COVID-19 Athlete’s heart

Contributed papers:Microsporidia

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Contributed papers:Microsporidia

Supramolecular organization of the sperm plasma membrane during maturation and capacitation

9th International Colloquium on Invertebrate Pathology and Microbial Control & 39th Annual Meeting of the SIP & 8th International Conference on Bacillus Thuringiensis

作者： andreas Linde james Becnel

8:00 Discovery of an Encephalitozoon sp. (Fungi: Microsporidia) in an invertebrate host Carlos E. Lange, Leellen F. Solter, Michael D. Baker, S. Johny, Douglas W. Whitman and Ann Cali (Center for Parasitological Studies (CEPAVE), La Plata National University, CON1CET. La Plata, Argentina;Illinois Natural History Survey, 1816 S. Oak St., Champaign, IL 61820, USA;Iowa State University, 1184 Molecular Biology Bldg., Ames, 1A 50011 USA;Laboratory of Molecular Genetics Centre for DNA Fingerprinting and Diagnostics, EC1L Road, Nacharam, Hyderabad 500 076, India;Illinois State University, Department of Biology, Normal, IL 61790, USA;Rutgers University, Dept. of Biological Sciences, Smith Hall, 101 Warren St., Newark, NJ 07102. USA) We isolated an unusual microsporidium from wild lubber grasshoppers, Romalea microptera, collected from Weeks Island, Louisiana, USA. We initially observed that the development of the isolate in the grasshopper host was not characteristic of other common microsporidia infecting

关键词： Contributed papers:Microsporidia

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Asian Journal of Andrology 2007年第4期9卷 438-444页

作者： Roy Jones Peter S. james Liz Howes andreas Bruckbauer David Klenerman The Babraham Institute Cambridge CB2 4AT UK Department of Chemistry University of Cambridge Cambridge CB2 1EW UK

Aim： In the present study, a variety of high resolution microscopy techniques were used to visualize the organization and motion of lipids and proteins in the sperm＇s plasma membrane. We have addressed questions such as the presence of diffusion barriers, confinement of molecules to specific surface domains, polarized diffusion and the role of cholesterol in regulating lipid rafts and signal transduction during capacitation. Methods： Atomic force microscopy identified a novel region （EqSS） within the equatorial segment of bovine, porcine and ovine spermatozoa that was enriched in constitutively phosphorylated proteins. The EqSS was assembled during epididymal maturation. Fluorescence imaging techniques were then used to follow molecular diffusion on the sperm head. Results： Single lipid molecules were freely exchangeable throughout the plasma membrane and showed no evidence for confinement within domains. Large lipid aggregates, however, did not cross over the boundary between the post-acrosome and equatorial segment suggesting the presence of a molecular filter between these two domains. Conclusion： A small reduction in membrane cholesterol enlarges or increases lipid rafts concomitant with phosphorylation of intracellular proteins. Excessive removal of cholesterol, however, disorganizes rafts with a cessation of phosphorylation. These techniques are forcing a revision of long-held views on how lipids and proteins in sperm membranes are assembled into larger complexes that mediate recognition and fusion with the egg. （Asian JAndrol 2007 July; 9： 438-444）

关键词： cholesterol lipid rafts single molecules sperm membranes

Coulomb explosion of nanodroplets drives the conversion of laser energy to nuclear energy

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High Power Laser Science and Engineering 2013年第2期1卷 69-73页

作者： Isidore Last Shlomo Ron andreas Heidenreich Joshua Jortner School of Chemistry Tel Aviv University Kimika Fakultatea Euskal Herriko Unibertsitatea (UPV/EHU) and Donastia International Physics Center (DICP) IKERBASQUE Basque Foundation for Science

Theoretical–computational studies of table-top laser-driven nuclear fusion of high-energy(up to 15 MeV)deuterons with7Li,6Li,and D nuclei demonstrate the attainment of high fusion yields within a source–target reaction *** constitutes a source of Coulomb-exploding deuterium nanodroplets driven by an ultraintense femtosecond near-infrared laser and a solid hollow cylindrical target containing the second *** source–target reaction design attains the highest table-top fusion efficiencies(up to 4×109J 1per laser pulse)obtained to *** highest conversion efficiency of laser energy to nuclear energy(10 2–10 3)for table-top DD fusion attained in the source–target design is comparable to that for DT fusion currently accomplished for‘big science’inertial fusion setups.

关键词： Coulomb explosion nanodroplets and clusters source-target design table top nuclear fusion ultraintense lasers

Handbook of Stem Cells

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Prognostic factors in periodontal therapy and their association with treatment outcomes

丛书名： v. 1

2004年

作者： Robert Lanza John Gearhart Brigid Hogan Douglas Melton Roger pedersen james Thomson Michael West

ISBN: (数字)9780080533735

ISBN: (纸本)9780124366435

New discoveries in the field of stem cell research have frequently appeared in the news and in scientific literature. Research in this area promises to lead to new therapies for cancer, heart disease, diabetes, and a wide variety of other diseases. This two-volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system. The editors of the Handbook of Stem Cells include: Robert Lanza, Helen Blau, John Gearhart, Brigid Hogan, Douglas Melton, Malcolm Moore, Roger pedersen, E. Donnall Thomas, james Thomson, Catherine Verfaillie, Irving Weissman, and Michael West. The Editorial Board includes: W. French Anderson, Peter Andrews, Anthony Atala, Jose Cibelli, Giulio Cossu, Robert Edwards, Martin Evans, Elaine Fuchs, Margaret Fuller, Fred Gage, Richard Gardner, Margaret Goodell, Ronald Green, William Haseltine, Joseph Itskovitz-Eldor, Rudolf Jaenisch, Ihor Lemischka, Dame Anne McLaren, Richard Mulligan, Stuart Orkin, Martin Pera, Benjamin Reubinoff, Janet Rossant, Hans Scholer, Austin Smith, Evan Snyder, Davor Solter, Alan Trounson, and Leonard Zon. This comprehensive set should be a much-needed addition to the library of students and researchers alike.

关键词： Stem cells.

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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World Journal of Clinical Cases 2014年第12期2卷 822-827页

作者： andreas L Ioannou Georgios A Kotsakis james E Hinrichs Advanced Education in Periodontology Division of Periodontology University of Minnesota Minnesota MN 55455 United States

During the incipient steps of periodontal treatment, clinicians are usually asked to predict the prognosis of teeth with compromised periodontium. The aim of this literature review was to investigate the association between periodontal Prognosis, Tooth Loss and risk indicators, such as smoking and genetics. Results showed that the definition of good prognosis has much higher predictability than the one for questionable prognosis. Several risk indicators for periodontal prognosis and tooth loss are discussed as well as different definitions of questionable prognosis and their success in predicting tooth loss. In conclusion, the major focus of future studies should be to construct simplified prognostic models with high predictability that will increase the confidence of dentists and periodontists when assigning teeth prognosis.

关键词： Periodontal prognosis Tooth loss Risk indicators Periodontitis

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协调流程从创新到创收的捷径

IT时代周刊 2006年第18期16卷 78-79页

作者： james P.Andrew andreas Maurer (美)波士顿咨询公司芝加哥办公室杜塞尔多夫办公室

对习惯于独立进行新产品开发和市场化过程的公司而言,如果能够考虑协调模式的巨大优势。

关键词：协调模式创新新产品开发市场化业绩

土壤中有机肥源抗生素抗性基因环境归趋与风险管理研究进展

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农业环境科学学报 2022年第12期41卷 2563-2576页

作者：王芳豆庆圆付玉豪梅芝相雷雷刘雨蒋新 SCHAEFFER andreas 朱永官 TIEDJE james M 中国科学院南京土壤研究所土壤与农业可持续发展国家重点实验室中国科学院土壤环境与污染修复重点实验室南京210008 中国科学院大学北京100049 亚琛工业大学环境研究所德国亚琛52074 中国科学院城市环境研究所福建厦门361021 中国科学院生态环境研究中心北京100085 密歇根州立大学植物、土壤和微生物学系美国东兰辛48824

抗生素抗性基因——一类新型污染物,已对人类健康和环境安全构成威胁,如何有效应对日益严峻的耐药性危机已成为一项全球性挑战。有机肥源抗生素抗性基因是土壤抗生素抗性基因的主要来源,而土壤参与并主导不同环境单元中抗生素抗性基因... 详细信息

抗生素抗性基因——一类新型污染物,已对人类健康和环境安全构成威胁,如何有效应对日益严峻的耐药性危机已成为一项全球性挑战。有机肥源抗生素抗性基因是土壤抗生素抗性基因的主要来源,而土壤参与并主导不同环境单元中抗生素抗性基因演化的多元交互作用,因此,有必要厘清有机肥源抗生素抗性基因在土壤和其他环境介质中的命运、归趋与风险。本文综述了近年来有机肥源抗生素抗性基因在土壤中的分布特征、环境归趋、人体暴露风险以及风险管理方面的研究进展,并提出建议与展望,以期为有效减轻抗生素抗性基因在环境中的危害,遏制抗生素抗性基因的增殖与传播提供理论依据与决策参考。

关键词：土壤有机肥抗生素抗性基因环境归趋阻控技术风险评估