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Resection of a rapid-growing 40-cm giant liver hemangioma

World Journal of Hepatology 2010年第7期2卷 292-294页

作者： andreas jm koszka Fabio G Ferreira Caio GG de Aquino Maurício A Ribeiro André S Gallo Elisa MC Aranzana Luiz A Szutan Department of Surgery Liver and Portal Hypertension GroupSanta Casa School of Medical Sciences

Hemangiomas are the most frequent benign tumors of the liver. Most hemangiomas are asymptomatic and therefore largely diagnosed only in routine screening tests. Usually they are small and require no specific treatment. In some situations they can reach great dimensions, causing some discomfort to the patient. Resection of liver hemangioma is indicated in cases of great dimension tumors causing symptoms such as pain, nausea or bloating caused by compression of adjacent organs. We report a case of a rare giant hemangioma with rapid growth in short time:a 50 year old female reported to our institution with a 40 cm giant liver hemangioma and then underwent a left hepatectomy.

关键词： Liver benign neoplasms Giant liver Hemangioma Liver surgery

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Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism

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World Journal of Gastroenterology 2011年第26期17卷 3117-3125页

作者： Jesper AB Strickertsson Kristina BV DΦssing Anna jm Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge andreas Kjr Torkel Wadstrm Lennart Friis-Hansen Genomic Medicine Department of Clinical BiochemistryRigshospitaletUniversity of Copenhagen Department of Basic Animal and Veterinary Sciences Faculty of Life SciencesUniversity of Copenhagen Department of Microbiology University of Lund Department of Gastro-Intestinal Surgery RigshospitaletUniversity of Copenhagen Department of Clinical Physiology RigshospitaletUniversity of Copenhagen

AIM- To investigate if and how the proinflammatory cytokine interferon γ （IFNγ） affects ghrelin expression in mice. METHODS： The plasma concentration of ghrelin, and gastric ghrelin and somatostatin expression, were ex- amined in wild-type mice and mice infected with Helico- bacter pylori （H. pylorO. Furthermore, ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth. To study the effect of IFNγ, alone, mice were given a subcutaneous infusion of IFNγ, for 7 d. Finally, the influ- ence of IFNγ, and somatostatin on the ghrelin promoter was characterized. RESULTS： H. py/ori infection was associated with a 50% reduction in ghrelin expression and plasma concentration. Suppression of ghrelin expression was in- versely correlated with gastric inflammation in achlorh- dyric mouse models. Subcutaneous infusion of IFNγ, suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations. Finally, we showed that the ghrelin promoter operates under the control of soma- tostatin but not under that of IFNγ. CONCLUSION： Gastric infection and inflammation is associated with increased IFNγ, expression and reduced ghrelin expression. IFNγ, does not directly control ghre- lin expression but inhibits it indirectly via somatostatin.

关键词： Ghrelin Interferon-γ Somatostatin Inflam-matory diseases He/icobacterpy/ori

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Deformation and phase transformation behaviors of a high Nb-containing TiAl alloy compressed at intermediate temperatures

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Journal of Materials Science & Technology 2022年第7期102卷 89-96页

作者： Xu Liu Lin Song andreas Stark Uwe Lorenz Zhanbing He Junpin Lin Florian Pyczak Tiebang Zhang State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Institute of Materials Research Helmholtz-Zentrum GeesthachtMax Planck-Str.1Geesthacht 21502Germany State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

In modernβ-solidified TiAl alloys,the decomposition of α_(2) phase is frequently observed during heat treatment or high-temperature deformation of the *** this study,high-temperature deformation and decomposition mechanisms of α_(2) phase in a Ti-45Al-8.5Nb-0.2B-0.2W-0.02Y alloy are *** a sample deformed at 800℃,the precipitation ofβ_(o)(ω_(o))phase is observed within the equiaxed α_(2) *** nucleation ofω_(o) particles within theβ_(o) matrix indicates the α_(2)→β_(o)→ω_(o) *** addition,numerous y phase precipitates form within theβ_(o)(ω)*** α_(2) lamellae decompose into ultrafine( α_(2)+γ)lamellae and coarsened y lamellae via α_(2)→ α_(2)+γand α_(2)→γtransformation,***,theω_(o) phase nucleates within the ultrafine lamellae via α_(2)→ω_(o) ***,in a sample deformed at 1000℃,the nucleation ofβ_(o) particles is sluggish,which is caused by the efficient release of the internal stress via dynamic recrystallization(DRX).These results indicate that complex phase transformations can be introduced by the decomposition of α_(2) phase in TiAl alloys with a high amount ofβ-stabilizing elements.

关键词： TiAl alloys Phase transformation Microstructure Electron microscopy

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On the reversibility of the α_(2)/ω_(o) phase transformation in a high Nb containing TiAl alloy during high temperature deformation

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Journal of Materials Science & Technology 2021年第34期93卷 96-102页

作者： Lin Song Fritz Appel andreas Stark Uwe Lorenz Junyang He Zhanbing He Junpin Lin Tiebang Zhang Florian Pyczak State Key Laboratory of Solidification Processing Northwestern Poly technical University.Xi'an 710072China Institute of Materials Research Helmholtz-Zentrum GeesthachtMax Planck-Str.1Geesthacht 21502Germany Department of Microstructure Physics and Alloys Design Max-Planck-lnsdtut fiir Eisenforschung GmbHDusseldorf 40237Germany State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

The transformations between the phasesα_(2)(Ti_(3)Al)andω_(o)were investigated in a lamellar multiphase titanium aluminide alloy based onγ(TiAl).The paper complements an earlier investigation performed on the same material in which the importance of deformation-induced twin structures for theα_(2)→ω_(o) transformation was *** present study shows that the reverse transformationω_(o)→α_(2) can also occur during high-temperature *** transformation is probably triggered by constraint stresses,which exist between the different constituents due to the crystalline *** combined operation of mechanical twinning of theα_(2) phase and the reversible transformation fully converts theα_(2) lamellae into a mixture ofα_(2) andω_(o).This conversion greatly reduces the mechanical anisotropy existing in formerα_(2) *** the technical use of the alloy,the stability of the converted structure with respect to further annealing was also *** reported processes occur at the nano-meter and sub nano-meter scale,thus,advanced characterization techniques were applied,such as high-resolution transmission electron microscopy(HRTEM)and atom probe tomography(APT).

关键词： TiAl alloys Phase transformation Electron microscopy Microstructure

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