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Reversibility of visual field defects through induction of brain plasticity: vision restoration, recovery and rehabilitation using alternating current stimulation

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Neural Regeneration Research 2020年第10期15卷 1799-1806页

作者： Bernhard A.Sabel Ying Gao andrea Antal Institute of Medical Psychology Medical FacultyOtto-von-Guericke University of MagdeburgMagdeburgGermany Center for Behavioral and Brain Sciences(CBBS) MagdeburgGermany Sabel Vision Restoration Center MagdeburgGermany Department of Clinical Neurophysiology University Medical Center GottingenGottingenGermany

For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is ***,there is always some potential for partial recovery of the visual field defect that can be achieved through induction of *** refers to the ability of the brain to change its own functional architecture by modulating synaptic *** is maintained throughout life and just as neurological rehabilitation can improve motor coordination,visual field defects in glaucoma,diabetic retinopathy or optic neuropathy can be improved by inducing *** ophthalmology many new treatment paradigms have been tested that can induce neuroplastic changes,including non-invasive alternating current *** with alternating current stimulation(e.g.,30 minutes,daily for 10 days using transorbital electrodes and^10 Hz)activates the entire retina and parts of the *** and functional magnetic resonance imaging studies revealed local activation of the visual cortex,global reorganization of functional brain networks,and enhanced blood flow,which together activate neurons and their *** future of low vision is optimistic because vision loss is indeed,partially reversible.

关键词： alternating current stimulation glaucoma low vision optic nerve rehabilitation recovery stress vision vision restoration therapy visual field

Simplified Wave Models Applicability to Shallow Mud Flows Modeled as Power-Law Fluids

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Journal of Mountain Science 2014年第6期11卷 1454-1465页

作者： Cristiana DI CRISTO Michele IERVOLINO andrea VACCA DICeM Università di Cassino e del Lazio Meridionale DICDEA Seconda Università di Napoli

Simplified wave models- such as kinematic,diffusion and quasi-steady- are widely employed as a convenient replacement of the full dynamic one in the analysis of unsteady open-channel flows,and especially for flood *** their use may guarantee a significant reduction of the computational effort,it is mandatory to define the conditions in which they may be confidently *** present paper investigates the applicability conditions of the kinematic,diffusion and quasisteady dynamic shallow wave models for mud flows of power-law *** power-law model describes in an adequate and convenient way fluids that at low shear rates fluids do not posses yield stress,such as clay or kaolin suspensions,which are frequently encountered in Chinese *** the framework of a linear analysis,the propagation characteristics of a periodic perturbation of an initial steady uniform flow predicted by the simplified models are compared with those of the full dynamic *** on this comparison,applicability criteria for the different wave approximations for mud flood of power-law fluids are *** presented results provide guidelines for selecting the appropriate approximation for a given flow problem,and therefore they may represent a useful tool for engineering predictions.

关键词： Power-law fluid Unsteady flows Shallow flows Simplified wave models

Neutrophils in chronic inflammatory diseases

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Cellular & Molecular Immunology 2022年第2期19卷 177-191页

作者： andrea Herrero-Cervera Oliver Soehnlein Ellinor Kenne Institute for Experimental Pathology Center for Molecular Biology of InflammationWestfälische Wilhelms-Universität MünsterMünsterGermany Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden.

Chronic inflammation is a component of many disease conditions that affect a large group of individuals *** inflammation is characterized by persistent,low-grade inflammation and is increased in the aging *** are normally the first responders to acute inflammation and contribute to the resolution of ***,in chronic inflammation,the role of neutrophils is less well understood and has been described as either beneficial or detrimental,causing tissue damage and enhancing the immune *** evidence suggests that neutrophils are important players in several chronic diseases,such as atherosclerosis,diabetes mellitus,nonalcoholic fatty liver disease and autoimmune *** review will highlight the interaction of neutrophils with other cells in the context of chronic inflammation,the contribution of neutrophils to selected chronic inflammatory diseases,and possible future therapeutic strategies.

关键词： Chronic Inflammation Disease Neutrophil Neutrophil extracellular traps

Add on the next level—the time point of the type I IFN response orchestrates the immune response

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Cellular & Molecular Immunology 2020年第8期17卷 791-793页

作者： Angela Wedekind David Fritzsch andrea Kröger Research Group Molecular Microbiology Institute of Microbiology and Hospital HygieneOtto von Guericke University39120MagdeburgGermany Research Group Innate Immunity and Infection Helmholtz Centre for Infection Research38124BraunschweigGermany

The directed control of an effective cellular or adaptive immune response is the aim of vaccine strategies and tumor *** antibodies prevent the spread of pathogens,while efficient cellular immunotherapy is used to overcome T-cell exhaustion and unresponsiveness toward *** such settings,the type I interferon(IFN)system mediates pleiotropic effects of the immune system that can be either immunostimulating or *** a recent work,De Giovanni et *** a novel regulatory checkpoint by which type I IFN regulates CD4^(+)T-cell *** study dissects the time point of type I IFN induction as a central regulator of the adaptive immune response that determines the balance between humoral and cellular *** findings identify an intriguing and previously undescribed checkpoint that can potentially be manipulated for ***,the authors demonstrate that CD4^(+)T-cell polarization could be influenced by manipulating the IFN response during infection.

关键词： al. vaccine interferon

Model-driven engineering for multi-party business processes on multiple blockchains

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Blockchain(Research and Applications) 2021年第3期2卷 31-45页

作者： Flavio Corradini Alessandro Marcelletti andrea Morichetta andrea Polini Barbara Re Emanuele Scala Francesco Tiezzi Universita degli Studi di Camerino Camerino62032Italy

As a disruptive technology,the blockchain is continuously finding novel application contexts,bringing new opportunities and radical *** this paper,we use blockchain as a communication infrastructure to support multi-party business *** particular,through smart contracts specifically generated by the mentioned business process,it is possible to derive a trustable infrastructure enabling the interaction among ***,the emergence of different blockchain technologies,satisfying different characteristics,gives the possibility to support the same business process dealing with different non-functional *** this paper,we propose a novel engineering methodology supported by a practical framework called *** permits to derive,using a model-driven strategy,a blockchain-based infrastructure,that can be deployed over a specific blockchain technology(e.g.,Ethereum or Hyperledger Fabric).The objective is to permit the single definition and multiple deployments of the business process,to deliver the same functionalities,but satisfying different nonfunctional *** such a way,organisations willing to cooperate can select the multi-party business process and the blockchain technology they would like to use to satisfy their *** Multi-Chain,they will be able to automatically derive from a Business Process Modelling Notation(BPMN)choreography diagram a blockchain infrastructure ready to be *** overcomes the need to get acquainted with many details of the specific technology.

关键词： Blockchain Model-driven Multi-party Choreography

AQUEOUS STABLE FREE RADICAL POLYMERIZATION PROCESSES

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Chinese Journal of Polymer Science 2004年第4期22卷 309-312页

作者： andrea R. Szkurhan Michael K. Georges University of Toronto at Mississauga 3359 Mississauga Road North South Building Mississauga Ontario L5L 1C6University of Toronto at Mississauga 3359 Mississauga Road North South Building Mississauga Ontario L5L 1C6

An overview of aqueous polymerizations, which include emulsion, miniemulsion and suspension polymerizations, under stable free radical polymerization (SFRP) conditions is presented. The success of miniemulsion and suspension SFRP polymerizations is contrasted with the difficulties associated with obtaining a stable emulsion polymerization. A recently developed unique microprecipitation technique is referenced as a means of making submicron sized particles that can be used to achieve a stable emulsion SFRP process.

关键词： Stable free radical polymerization Living-radical polymerization Aqueous polymerization Miniemulsion polymerization Emulsion polymerization Suspension polymerization

Towards very high RAP content asphalt mixes:A comprehensive performance-based study of rejuvenated binders

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第6期8卷 1022-1035页

作者： Marco Pasetto andrea Baliello Giovanni Giacomello Emiliano Pasquini Department of Civil Environmental and Architectural Engineering(ICEA)University of PaduaPaduaItaly

Hot recycling of reclaimed asphalt pavement(RAP)from replacement of deteriorated asphalt pavements is a widespread technique,and able to ensure clear economic and environmental *** this reason,paving industries,agencies and researchers are spending significant efforts in order to maximize such advantages by increasing the amount of RAP within new asphalt ***,adequate performance of recycled mixtures must be guaranteed despite the re-use of high amounts of RAP which involves the presence of aged,oxidized and stiffened *** this perspective,the present study aimed at evaluating the rheological properties at mid-service and high-service temperatures of bituminous blends composed by 40%of virgin binder and 60%of aged rejuvenated bitumen(simulating the aged hard bitumen coming from the RAP).Such proportion was selected to represent a high recycling rate of RAP(about 60%of the total weight of aggregates,RAP included).A chemical commercial additive at the liquid state was selected as rejuvenator;it was dosed at the optimum content based on empirical and rheological preliminary *** performance of the recycled blend was then compared to that of a virgin reference *** shear rheometer tests were carried out to determine the master curves and the failure characteristics(at mid and high service temperatures)of the selected *** effect of aging(related to the durability over the material lifetime)was also studied analyzing binders’responses in unaged,shortterm and long-term aged ***,experimental findings demonstrated the efficacy of the rejuvenation of recycled binders containing very high amount of aged bitumen.

关键词： Pavement engineering Hot recycling Reclaimed asphalt Rejuvenation DSR Rheology

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Linking temporal records

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Frontiers of Computer Science 2012年第3期6卷 293-312页

作者： Pei LI Xin Luna DONG andrea MAURINO Divesh SRIVASTAVA Department of Informatics Systems and Communication University of Milan-Bicocca Milan 20126 Italy Data Management Department AT&T Labs-Research Florham Park NJ 07932 USA

Many data sets contain temporal records which span a long period of time; each record is associated with a time stamp and describes some aspects of a real-world en- tity at a particular time （e.g., author information in DBLP）. In such cases, we often wish to identify records that describe the same entity over time and so be able to perform interest- ing longitudinal data analysis. However, existing record link- age techniques ignore temporal information and fall short for temporal data. This article studies linking temporal records. First, we ap- ply time decay to capture the effect of elapsed time on entity value evolution. Second, instead of comparing each pair of records locally, we propose clustering methods that consider the time order of the records and make global decisions. Ex- perimental results show that our algorithms significantly out- perform traditional linkage methods on various temporal data sets.

关键词： temporal data record linkage data integration

Mechanisms of immune checkpoint inhibitormediated liver injury

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3727-3739页

作者： Layla Shojaie Myra Ali andrea Iorga Lily Dara Division of Gastrointestinal and Liver Diseases Department of MedicineKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Research Center for Liver Disease Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Keck School of Medicine University of Southern CaliforniaLos AngelesCA 90033USA U.S.Food and Drug Administration Center for Devices and Radiological HealthSilver SpringMD 20993USA UMBC Center for Accelerated Real Time Analytics University of MarylandBaltimore CountyBaltimoreMD 21250USA

The immune checkpoints,cytotoxic T-lymphocyte-associated antigen 4(CTLA-4) and programmed cell death protein-1/ligand-1(PD-1/PD-L1) are vital contributors to immune resulation and *** immune checkpoint inhibitors(ICIs) have revolutionized cancer therapy;however,they come with the cost of immune related adverse events involving multiple organs such as the *** to its constant expo sure to foreign antigens,the liver has evolved a high capacity for immune tolerance,therefore,blockade of the immune checkpoints can result in aberrant immune activation affecting the liver in up to 20% of patients depending on the agent(s) used and underlying *** type of hepatotoxicity is termed immune mediated liver injury from checkpoint inhibitors(ILICI) and is more common when CTLA4 and PD-1/PDL1 are used in *** underlying mechanisms of this unique type of hepatotoxicity are not fully understood;however,the contribution of CD8^(+) cytotoxic T lymphocytes,various CD4^(+) T cells populations,cytokines,and the secondary activation of the innate immune system leading to liver injury have all been *** review summarizes our current understanding of the underlying mechanisms of liver injury in immunotherapy using animal models of ILICI and available patient data from clinical studies.

关键词： Hepatotoxicity DILI Immunotherapy Cell death Hepatocyte CTLA-4 PD-1 PD-L1 Necrosis Apoptosis