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steatosis and insulin resistance in hepatitis C: A way out for the virus?

World Journal of gastroenterology 2009年第40期15卷 5014-5019页

作者： José A Del Campo Manuel Romero-gómez Unit for The Clinical Management of Digestive Diseases and CIBERehd Hospital Universitario de Valme

The hepatitis C virus (HCV) induces lipid accumulation in vitro and in vivo. The pathogenesis of steatosis is due to both viral and host factors. Viral steatosis is mostly reported in patients with genotype 3a, whereas meta-bolic steatosis is often associated with genotype 1 and metabolic syndrome. several molecular mechanisms responsible for steatosis have been associated with the HCV core protein, which is able to induce gene expres-sion and activity of sterol regulatory element binding protein 1 (sREBP1) and peroxisome proliferator-activat-ed receptor γ (PPARγ), increasing the transcription of genes involved in hepatic fatty acid synthesis. steatosis has been also implicated in viral replication. In infected cells, HCV core protein is targeted to lipid droplets which serve as intracellular storage organelles. These studies have shown that lipid droplets are essential for virus assembly. Thus, HCV promotes steatosis as an eff icient mechanism for stable viral replication. Chronic HCV in-fection can also induce insulin resistance. In patients with HCV, insulin resistance is more strongly associated with viral load than visceral obesity. HCV seems to lead to insulin resistance through interference of intracellular insulin signalling by HCV proteins, mainly, the serine phosphorylation of insulin receptor-1 (IRs-1) and im-pairment of the downstream Akt signalling pathway. The HCV core protein interferes with in vitro insulin signal-ling by genotype-specif ic mechanisms, where the role of suppressor of cytokine signal 7 (sOCs-7) in genotype 3aand mammalian target of rapamycin (mTOR) in geno-type 1 in IRs-1 downregulation play key roles. steatosis and insulin resistance have been associated with f ibrosis progression and a reduced rate of sustained response to peginterferon plus ribavirin.

关键词： steatosis Insulin resistance Hepatitis Cvirus

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Cobalamin deficiency as an extra intestinal manifestation of Helicobacter pylori infection

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World Journal of gastroenterology 2015年第11期21卷 3447-3448页

作者： Emmanuel andrès Department of Internal Medicine University Hospital of Strasbourg

We read with great interest the excellent review by Wong et al on extra intestinal manifestations of Helicobacter pylori(***) infection published in the *** is a well-documented and structured ***,I believe that Wong ... 详细信息

关键词： Cobalamin deficiency Helicobacter pylori Food-coba

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sampling lattices in semi-grand canonical ensemble with autoregressive machine learning

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npj Computational Materials 2022年第1期8卷 588-597页

作者： James Damewood Daniel schwalbe-Koda Rafael gómez-Bombarelli Department of Materials science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA02319USA

Calculating thermodynamic potentials and observables efficiently and accurately is key for the application of statistical mechanics simulations to materials ***,naive Monte Carlo approaches,on which such calculations are often dependent,struggle to scale to complex materials in many state-of-the-art disciplines such as the design of high entropy alloys or multi-component *** address this issue,we adapt sampling tools built upon machine learning-based generative modeling to the materials space by transforming them into the semi-grand canonical ***,we show that the resulting models are transferable across wide ranges of thermodynamic conditions and can be implemented with any internal energy model U,allowing integration into many existing materials *** demonstrate the applicability of this approach to the simulation of benchmark systems (AgPd,CuAu) that exhibit diverse thermodynamic behavior in their phase ***,we discuss remaining challenges in model development and promising research directions for future improvements.

关键词： canonical thermodynamic directions

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Elevation transition of aquatic insects closely matches a thermal feature in the Yungas of Northwestern Argentina

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Journal of Mountain science 2024年第2期21卷 433-448页

作者： Alexandra BUITRAgO-gUACANAME Carlos MOLINERI andrés LIRA-NORIEgA Daniel andrés DOs sANTOs Neotropical Biodiversity Institute(CONICET-UNT) UNT-DomesHorco Molle S/N4107 TucumánArgentina CONACYT Research Fellow Network of Advanced Molecular StudiesInstitute of Ecology A.COld Road to Coatepec 351El HayaCP 91073XalapaVeracruzMexico Biostatistics Chair Faculty of Natural Sciences and IMLNational University of TucumánSan Miguel de TucumánMiguel Lillo 2054000 TucumánArgentina

Temperature is a key factor that shapes the distribution of *** knowledge about how species respond to temperature is relevant to devise strategies for addressing the impacts of climate *** insects are particularly vulnerable to climate change,yet there is still much to learn about their ecology and *** the Yungas ecoregion of Northwestern Argentina,cold-and warm-adapted species of the orders Ephemeroptera,Plecoptera,and Trichoptera(EPT)are segregated by *** modeled the ecological niche of south American EPT species in this region using available data and projected their potential distribution in geographic *** were grouped based on their ecogeographic similarity,and we analyzed their replacement pattern along elevation gradients,focusing on the ecotone where opposing thermal preferences *** this interface,we identified critical points where the combined incidence of cold and warm assemblages maximizes,indicating a significant transition *** found that the Montane Cloud Forest holds the interface,with a particularly greater suitability at its lower *** main axis of the interface runs in a N-s direction and falls between 14°C-16°C mean annual *** probability of a particular location within a basin being classified as part of the interface increases as Kira’s warmth index approaches a score around *** the interface is critical for defining the thermal limits of species distribution and designing biomonitoring *** in the location of thermal constants related to mountainous ecotones may cause vertical displacement of aquatic insects and vegetation *** have recognized significant temperature thresholds that serve as indicators of suitability for the *** global warming is anticipated to shift these indicators,we suggest using them to monitor the imprints of climate change on mountain ecosystems.

关键词： Austral Yungas Ecological Niche Model Ephemeroptera Kira’s warmth index Plecoptera Trichoptera

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Wide QRs complex tachycardia in a patient with wide QRs complex sinus rhythm due to left bundle branch block pattern

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Journal of geriatric Cardiology 2020年第8期17卷 530-532页

作者： andrás Vereckei Katalin Vadász andrás Zsáry 3^rd Department of Medicine Semmelweis UniversityBudapestHungary 2^nd Department of Medicine Semmelweis UniversityBudapestHungary

A 58-year-old man with hypertension and half a year ago documented left bundle branch block(LBBB)in his past history presented with progressive dyspnea.A pre-admission echocardiography showed severely depressed systolic left ventricular function[ejection fraction(EF)=27%],diffuse hypokinesis and dilated heart chambers consistent with dilated cardiomyopathy(DCM).

关键词： Dilated cardiomyopathy Electrocardiogram supraventricular tachycardia Ventricular tachycardia Wide QRs complex tachycardia

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Magnetic field assisted fluidization:A modified Richardson-Zaki equation

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China Particuology 2007年第1期5卷 61-70页

作者： Jose Manuel Valverde Antonio castellanos Faculty of Physics Universidad de Sevilla Avenida Reina Mercedes s/n 41012 Sevilla Spain

Magnetic particles can be uniformly fluidized by coupling the gas flow with an externally imposed magnetic field. Interparticle forces generated by the magnetic field cause aggregation of the particles in chain-like structures preferentially oriented along the magnetic field lines. In the present paper, we study the implications of the formation of these special types of aggregates on the empirical Richardson-Zaki （RZ） equation, originally proposed to describe the expansion of fluidized beds of non-aggregated particles. We have addressed two important issues, namely the flow regime, which is a function of the size of the aggregates, and the effect of shape and orientation of the chain-like aggregates with respect to gas flow on fluid drag. We propose a modified RZ equation （MRZE） in which the velocity scale, given by the terminal settling velocity of the individual aggregates, and the RZ exponent are predetermined as a function of the chain length. The chain length depends on the ratio of the magnetic energy to gravitational energy, and is estimated from the magnetic field intensity, and particle magnetization, size and density. Predictions of the MRZE are successfully compared with published results in the literature on the expansion of magnetic particles in the presence of externally applied magnetic fields.

关键词： Fluidization geldart B Magnetic particles Aggregation Richardson-Zaki equation

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streamflow prediction in ungauged catchments by using the grunsky method

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International soil and Water Conservation Research 2023年第4期11卷 700-712页

作者： Bruno K.Marchezepe andréAlmagro andrés.Ballarin Paulo Tarso s.Oliveira Department of Hydraulics and sanitary Engineering São Carlos School of EngineeringUniversity of São PauloSão CarlosSPBrazil Faculty of Engineering Architecture and Urbanism and GeographyFederal University of Mato Grosso do SulMS79070-900Brazil

Establish a reliable rainfall-runoff relation capable of predicting runoff in ungauged basins is a matter of interest across the world for a long time and has been taking importance during the past *** approaches,hydrological models and machine learning techniques have been used to estimate ***,returning some simplicity to the predictions might be necessary for practical *** this paper,we re-introduce *** approach,developed in the early 1900s to predict runoff from values of precipitation on a two-equations ***,we analyze the grunsky generalized method applied for 716 Brazilian catchments,on an interannual and monthly ***,we established the best method to find the rainfall-runoff relation coefficient for each ***,we evaluate the performance of the method on a local scale,i.e.,catchment by ***,we analyze the method of regionalization,by grouping the catchments into six hydrologically similar *** local scale,the Kling-gupta Efficiency(KgE)values range from 0.87 to 0.93 on the interannual scale and is greater than 0.50 on the monthly *** the regionalized approach,KgE varies from 0.60 to 0.84 on an interannual *** also found suitable KgE values on a monthly scale,with more than 22%of catchments with KgE greater than 0.50,being the best performances in the Non-seasonal and Extremely-wet groups,and the worst performance in the Dry *** findings indicate that grunsky approach is suitable to predict streamflow for Brazilian catchments on interannual and monthly *** simple and easy-to-use equation presents a reliable alternative to more complex methods to compute runoff by only using rainfall data.

关键词： Regionalization Hydrological group Temporal scale Tropical basins

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glutaminolysis-ammonia-urea Cycle Axis,Non-alcoholic Fatty Liver Disease Progression and Development of Novel Therapies

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 356-362页

作者： Ángela Rojas María Rosario garcía-Lozano Antonio gil-gómez Manuel Romero-gómez Javier Ampuero Department of Unit of Digestive Diseases Virgen del Rocío University HospitalSevilleSpain seLiver group at the Insti-tute of Biomedicine of seville(IBIs) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Center for the study of Liver and gastrointestinal Diseases(CIBERehd) Carlos III National Institute of HealthMadridSpain De-partment of Organic and Medicinal Chemistry Faculty of PharmacyUniversity of SevilleE-41071SevilleSpain

The prevalence of non-alcoholic fatty liver disease(NAFLD)is increasing worldwide,reflecting the current epidemics of obesity,insulin resistance,type 2 diabetes mellitus,and metabolic *** is characterized by the accumulation of fat in the liver,and is known to be a cause of *** many pathways have been proposed,the cause of NAFLD-linked fibrosis progression is still unclear,which posed challenges for the development of new therapies to prevent NAsH-related cirrhosis and hepatocellular *** is associated with activation of hepatic stellate cells(HsC)and accumulation of excess extracellular matrix proteins,and inhibiting the activation of HsCs would be expected to slow the progression of *** molecular signals and pathways such as oxidative stress and glutaminolysis have been reported to promote HsC *** mechanisms are plausible antifibrotic targets in NAsH,as the activation of HsCs the proliferation of myofibroblasts depend on those *** review summarizes the role of the glutaminolysis-ammonia-urea cycle axis in the context of NAFLD progression,and shows how the axis could be a novel therapeutic target.

关键词： Non-alcoholic fatty liver disease Cirrhosis Fibrosis glutaminoly-sis Ammonia Urea

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stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

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Magnetic imaging-assisted colonoscopy vs conventional colonoscopy: A randomized controlled trial

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World Journal of gastroenterology 2014年第36期20卷 13178-13184页

作者： Christopher W Teshima sergio Zepeda-gómez suliman H Alshankiti gurpal s sandha Division of gastroenterology University of Alberta Edmonton Alberta T6G 2X8 Canada

AIM: To compare magnetic imaging-assisted colonoscopy (MIC) with conventional colonoscopy (CC).

关键词： Colonoscopy Conscious sedation Magnetic endoscope imaging Pain measurement Randomized controlled trial

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