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Cats Infected by Feline Leukemia Virus—Morpho-Quantitative Evaluation of the Thymus

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Open Journal of Animal Sciences 2015年第3期5卷 277-282页

作者： Flávia Azevedo Cavalcanti de Melo Anna Clara dos Santos Kaique Nogueira andré rodrigues da cunha barreto-vianna Eduardo Maurício Mendes de Lima Faculty of Agronomy and Veterinary Medicine University of Brasilia Brasília Brazil

The feline leukemia virus (FeLV) is a complex disease that affects mainly the immune and hematological systems of cats. And because the thymus was closely associated with the immune system, the aim of this study was to quantify the morphological changes in the thymus of naturally infected and uninfected animals. Thymus morphological changes were evaluated by quantifying the following parameters: thymocytes, fat tissue, thymic corpuscles, connective tissue, and type I and III collagen. This study analyzed a total of seven cats, five in the negative group (Fn) and two in the positive (Fp) group. The areas occupied by thymocytes in FeLV negative (Fn) and positive (Fp) animals were, respectively, 55.16% ± 6.15% and 44.81% ± 6.15% (p = 0.39);adipocytes, 42.14% ± 5.97% (Fn) and 53.42% ± 11.3% (Fp) (p = 0.34);blood vessels, 0.85% ± 0.24% (Fn) and 1.75% ± 0.52% (Fp) (p = 0.15). Whereas thymic corpuscles occupied an area of 0.68% ± 0.19% in negative animals (Fn) only. The connective tissue covered area varied between 12.05% ± 0.68% (Fn) and 10.34% ± 0.62% (Fp) (p = 0.009). Collagen type I (p = 0.30) and type III (p = 0.59) were present in, respectively, 1.73% ± 0.3% and 0.44% ± 0.09% in Fn, and 1.44% ± 0.36 and 0.44% ± 0.13% in Fp. The FeLV virus was not able to completely modify the thymus structure of infected animals, considering the areas occupied by thymocytes, adipose tissue, blood vessels and also type I and III collagens. However, the connective tissue underwent a certain degree of remodeling since less connective tissue area was observed in FeLV infected animals. The absence of thymic corpuscles in immunosuppressed animals suggests a possible connection to thymopoiesis.

关键词： Domestic Cats Morphology Lymphoid Organ FeLV

Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer

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World Journal of Gastroenterology 2016年第35期22卷 7951-7962页

作者： Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto rodrigues Mello Junior andré Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith danielle Queiroz Calcagno Núcleo de Pesquisas em Oncologia Universidade Federal do Pará Hospital Universitário Joao de Barros Barreto Disciplina de Genética Departamento de Morfologia e Genética Universidade Federal de Sao Paulo Laboratório de Citogenética Humana Instituto de Ciências Biológicas Universidade Federal do Pará

Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity.

关键词： Gastric cancer Epigenetic Diagnostic biomarkers miRNAs Prognostic biomarkers

Temporomandibular Disorder in University Students of the Parque das Rosas Campus, Universidade Estácio de SáThat Practice Sports

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Health 2016年第1期8卷 18-23页

作者： Rosineli Paz Cabral Manuel Eduardo Moiolli-rodrigues Flávia Lima Kleinsorgen Motta Francisco Carlos Kleinsorgen de Souza Motta Juliana Rocha da Silva Larissa Malheiros Neide Martins Leonardo Trepte andré Luiz G. Abrão Adalgisa Maiworm Luiz Carlos Oliveira Raphael Lemgruber Cardoso Adriano Arnóbio Giuseppe Antonio Presta danúbia da cunha de Sá Caputo Sebastião david Santos Filho Éric Heleno F. F. Frederico Mario Bernardo-Filho Severo de Paoli Universidade Estácio de Sá—Campus R9—GEPS R9 Rio de Janeiro Brasil Universidade Estácio de Sá—Campus Parque das Rosas Rio de Janeiro Brasil Departamento de Biofísica e Biometria Instituto de Biologia Roberto Alcantara Gomes Universidade do Estado de Rio de Janeiro Rio de Janeiro Brasil Programa de Pós-Graduacao em Fisiopatologia Clínica e Experimental Faculdade de Ciências Médicas Universidade do Estado do Rio de Janeiro Rio de Janeiro Brasil UniFacex—Centro Universitário do Facex Natal Brasil Programa de Pós-Graduacao em Biociências Instituto de Biologia Roberto Alcantara Gomes Universidade do Estado do Rio de Janeiro Rio de Janeiro Brasil

The stomatognathic system (SS) is a functional unit of the body that depends on the balance of several tissues. It consists of various structures, including the temporomandibular joint. Temporomandibular disorder (TMD) can occur due to alterations in the SS. The Fonseca Anamnestic Index (FAI) is a scale used to evaluate and to characterize the TMD Type: no DTM, mild, moderate and severe. The aim is to evaluate the prevalence of signs and symptoms related to TMD in university students of the Parque das Rosas Campus, Universidade Estácio de Sá that practice sports. This investigation was approved (CAAE number 325678413.9.0000.5284). Two hundred eighth students (110 male and 98 female, aged 19 - 35 years) accepted to be in this investigation. All the participants answered a General Questionnaire (GQ) and the FAI. The GQ had questions about the age, sex and the presence of TMD. The FAI was used. A statistical difference (p > 0.05) was not found about the presence of TMD. Among the female, an elevated number of the students with signal or symptoms related to the temporomandibular with statistic significance (p < 0.05) was observed. In the population without TMD, the prevalence of this disorder is higher between male than female. Considering the FAI, among the female students, there is a prevalence of the Mild Type. Considering the evaluation of the type of TMD among the male and female students no difference was found between male and female to the types mild and moderate, however, the prevalence of the severe Type is higher in female than in male with statistical significance. In conclusion, TMD is a relevant clinical condition with an important prevalence among the university students. Moreover, the type of the TMD could be considered due to prevalence of the Type Severe among the women.

关键词： Temporomandibular Disorder University Student Fonseca Anamnestic Index Prevalence

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巴西BCG卡痕阅读的敏感性与特异性

国际结核病与肺部疾病杂志 2002年第1期 35-37页

作者： S.M.Pereira I.Dourado M.L.barreto S.S.cunha M.Y.T.Ichiara M.A.Hijjar J.C.L.Goes L.C.rodrigues 安燕生 Instituto de Saude Coletiva Salvador Bahia Brazil Infectious Disease and Epidemiology Unit London School of Hygiene and Tropical Medicine London England Coordenaco Regional da Fundaco Nacional de Sade Salvador Bahia Centro de Referência Hélio Fraga/Cenepi/FUNASA Rio de Janeiro Brazil Instituto de Saúde Coletiva Salvador Bahia Brazil Infectious Disease and Epidemiology Unit London School of Hveiene and Tropical Medicine London England

在巴西社区的一个BCG效果评价试验的横断面调查中,培训过的人员检查儿童的上臂,同时从监护人的来信及儿童接种卡上获得信息。随后护士再对样本进行双盲抽查。两组卡痕阅读有高度的一致性(Kappa=0.839)。以监护人和卡片记录的信息作为金... 详细信息

在巴西社区的一个BCG效果评价试验的横断面调查中,培训过的人员检查儿童的上臂,同时从监护人的来信及儿童接种卡上获得信息。随后护士再对样本进行双盲抽查。两组卡痕阅读有高度的一致性(Kappa=0.839)。以监护人和卡片记录的信息作为金标准获得高敏感性和低特异性。当监护人与接种卡片一致时敏感性仍然高,而当两者不一致时,敏感性仍然高,而特异性非常低。(BCG)卡痕是已接种BCG的好指标。

关键词：确认敏感性特异性 BCG疫苗 BCG卡痕

Development of Psychic Pain in the Context of Microcephaly and Abortion: Systematic Review and Meta-Analysis

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Health 2017年第2期9卷 376-391页

作者： Uilna Naté rcia Soares Feitosa danilo Ferreira de Sousa Poliana Moreira de Medeiros Carvalho Raquel Guimarã es Kanda Joaquim Alves Diniz Luis Clescivan Ferreira Nobre dayse Christina rodrigues Pereira Luz Wilma José Santana Cí cera Jaqueline Sobreira andriola Né lio barreto Vieira Antonio Souto Gouveia Alberto Olavo Advincula Reis Caio Parente Barbosa Modesto Leite Rolim Neto Programa de Pó s-Graduaç ã o em Ciê ncias da Saú de Faculdade de Medicina do ABC-FMABC Santo Andr&eacute S&atilde o Paulo Brazil Faculdade de Juazeiro do Norte FJN Juazeiro do Norte Cear&aacute Brazil Faculdade de Medicina Est&aacute cio/FMJ Juazeiro do Norte Cear&aacute Brazil Faculdade de Medicina Universidade Federal do Cariri-UFCA Barbalha Cear&aacute Brazil Programa de Pó s-Graduaç ã o em Saú de Pú blica Universidade de S&atilde o Paulo-USP S&atilde o Paulo Brazil

Background: In the year of 2015, evidence of a relation between Zika virus and the development of microcephaly in pregnant women who acquired the infection started to come up. Thus, it is extremely necessary that the analysis of the affliction affects these women in a biopsychosocial context, in order to discuss and comprehend in a more reliable manner the affection from the perception of the disease, origin, and psychic pain mechanisms. Methods: Systematic review with meta-analysis, using the PRISMA protocol. The study period was 2016 and the keywords included “microcephaly” and “abortion”, one at a time and then combined with the Boolean operator “AND.” The statistical analysis was done using the BioEstat 5.0 program. Calculation was based on an adjustment of Mantel-Haenszel random effect. Results: 41,046 registrations were found. Of this total, 40,992 articles were excluded because they only mentioned the fact or referred to spontaneous abortion, did not analyze abortion on the eyes of microcephaly, only treated with Zika virus, or were repeated. Limitations: Psychic pain and suffering need studies in the mother/son/disease relation, which were not found in the databases. The article was based on other sources. Conclusions: The pains vary in different areas of the female life, since internal conflicts, gender violence, stress, fear, insecurity, psychologic torture, grieve, loneliness, among other kinds of psychic suffering. More studies on psycho-emotional themes need to be promoted to discuss the female suffering on a wider vision, closer to the reality faced by these women.

关键词： Abortion Microcephaly Psychic Pain