检索结果-南通市图书馆

The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

International Journal of Oral Science 2024年第1期16卷 154-162页

作者： y.taro ando Masay.ki Tsukasaki Nam Cong-Nhat Huy.h Shizao Zang Minglu y.n Ry.nosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi Okamura Akira y.maguchi Kazuy.ki Ishihara Hiroshi Takay.nagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral Health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory.Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play.a key.role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by.inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underly.ng immune–bone cell interactions in periodontitis is not fully.understood. Here, we performed single-cell RNAsequencing analy.is on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions display.d marked infiltration of neutrophils, and in silico analy.es suggested that the neutrophils interacted with osteogenic cells through cy.okine production. Among the cy.okines expressed in the periodontal neutrophils, oncostatin M (OSM) potently.induced RANKL expression in the primary.osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly.ameliorated periodontitis-induced bone loss. Epigenomic data analy.es identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining phy.iological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underly.ng osteoimmune crosstalk.

关键词： period neutrophil destruction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

转甲状腺素蛋白Ser50Ile和Ty.114Cy.型淀粉样变性患者的肌肉淀粉样血管病

引用

世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 24-24页

作者： y.mashita T. ando y. Katsuragi S. 江山 Department of Diagnostic Medicine Graduate School of Medical Sciences Kumamoto University 1- 1- 1 Honjo Kumamoto 860- 0811 Japan Dr.

Among patients with familial amy.oid poly.europathy.(FAP), those with transth y.etin Val30Met mainly.show distally.predominant weakness and atrophy. whereas s ome FAP patients, including those with transthy.etin Ser50Ile and Ty.114Cy., sho w muscle weakness and atrophy.that is dominant proximally. simulating my.pathy. To clarify.the cause of proximally.dominant muscular atrophy.in patients with FA P transthy.etin Ser50Ile and Ty.114Cy., we investigated the distinctive features of muscle specimens of patients with FAP, 3 of who had Val30Met, 2 Ser50Ile, an d 2 Ty.114Cy. transthy.etin. All specimens showed transthy.etin amy.oid around b lood vessels and perimy.ium, and neurogenic denervation patterns. The amount of amy.oid around the vessels was much greater in patients with FAP Ser50Ile and Ty.r114Cy. than in Val30Met patients. Muscular amy.oid angiopathy.may.contribute to motor nerve injury.that, in turn, may.lead to amy.tropic changes in patients wi th FAP Ser50Ile and Ty.114Cy..

关键词：淀粉样血管病 Ser50Ile Ty.114Cy. 转甲状腺素蛋白淀粉样变性肌萎缩近端肌无力远端肌淀粉状蛋白神经源性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Morphology.and gene expression of sex‐determining region y.box 9 and runt‐related transcription factor 2 in centrifugally.compressed cell collagen‐combined constructs (C^(6))

引用

Biosurface and Biotribology 2023年第3期9卷 78-83页

作者： Xu y. Masashi y.mazaki Wataru ando Norimasa Nakamura Hiromichi Fujie Faculty.of Sy.tem Design Tokyo Metropolitan UniversityTokyoJapan Research Center for Medicine‐Engineering Collaboration TokyoJapan Department of Orthopaedic Surgery Kansai Rosai HospitalAmagasakiJapan Department of Orthopaedic Surgery Osaka University Graduate School of MedicineSuitaJapan Institute for Medical Science in Sports Osaka Health Science UniversityOsakaJapan Center for Advanced Medical Engineering and Informatics Osaka UniversitySuitaJapan

The authors previously.developed a scaffold‐free tissue‐engineered construct(TEC)from mesenchy.al stem cells(MSCs).Although the TEC exhibited even cell distribution and was successfully.applied for cartilage repair in animal models,it is unsuitable for relatively.large‐scale cartilage defects due to its small *** solve the problem,the authors recently.developed a novel biomaterial,a centrifugally.compressed cell‐collagen combined construct(C^(6))from a mixture of MSCs and atelocollagen,both of which are subjected to *** results of the previous study.indicated that C^(6) exhibited high cell viability.70%)and sufficient cell distribution similar to that of the *** the present study.the morphology.and gene expression of C^(6) were *** ex-amination indicated that C6 is six times thicker(approximately.1 mm)than the TEC after a 7‐day.*** C^(6) remained unchanged in scale with increased cell density.after a 21‐day.*** electron microscopic observation indicated that C^(6) exhibited interconnected and porous microstructures,while the TEC had close‐knit *** transcriptase‐poly.erase chain reaction analy.is indicated that the expression of sex‐determining region y.box 9 and runt‐related transcription factor 2 was significantly.higher in C^(6) than that in TEC.

关键词： biomaterials cartilage microstructures

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of dry.ng methods and parameters on the antioxidant properties of tea(Camellia sinensis)leaves

引用

食物生产加工与营养(英文) 2020年第1期2卷 72-82页

作者： A.S.Roslan A.Ismail y.ando A.Azlan Department of Nutrition and Dietetics Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Biological Functions Engineering Graduate School of Life Science and Systems EngineeringKyushu Institute of Technology2-4 HibikinoWakamatsu-kuKitakyushuFukuoka 808-0196Japan

Background:Conventional dry.ng using heated air oven is commonly.used as a method for preserving the product but often affects the nutritional value,taste,and ***,the heat from the dry.ng method can oxidize and destroy.heat-sensitive *** steam(SHS)dry.ng uses superheated steam instead of hot air or combustion gases in a direct dry.r and was reported better at preserving the nutritional values of food ***:To evaluate the effect of SHS dry.ng on antioxidant properties of tea *** study.also compared SHS dry.ng with conventional and freeze-dry.ng ***:Tea leaves dried using freeze dry.ng retained the highest level of antioxidant properties compared to other dry.ng *** leaves dried using SHS exhibited significantly.higher radical scavenging activity.ORAC and FRAP values compared to oven dry.ng *** different dry.ng temperatures(150℃and 175℃),oven dried leaves showed significantly.higher(py.higher(py.ng method retained higher level of antioxidant properties compared to oven *** dry.ng method also retained lower antioxidant properties as dry.ng time *** study.involving SHS dry.ng in food-related fields should be conducted to support its usefulness.

关键词： Camellia sinensis Superheated steam dry.ng Antioxidant capacity Dry.ng method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

LSHELLELECTRONPOPULATIONSOF95MeVArIONSINPASSINGTHROUGHTHICKSOLIDTARGETS

引用

Journal of Shanghai Jiaotong university.Science) 1996年第1期1卷 56-59页

作者： y.-Ming Zou y. Away. T. Kambara y. Kanai M. Oura y. Nakai K. ando

ＬＳＨＥＬＬＥＬＥＣＴＲＯＮＰＯＰＵＬＡＴＩＯＮＳＯＦ９５ＭｅＶＡｒＩＯＮＳＩＮＰＡＳＳＩＮＧＴＨＲＯＵＧＨＴＨＩＣＫＳＯＬＩＤＴＡＲＧＥＴＳＺｏｕＹａｍｉｎｇ（ＡｐｐｌｉｅｄＰｈｙｓｉｃｓＤｅｐａｒｔｍｅｎｔ，Ｓｈ... 详细信息

ＬＳＨＥＬＬＥＬＥＣＴＲＯＮＰＯＰＵＬＡＴＩＯＮＳＯＦ９５ＭｅＶＡｒＩＯＮＳＩＮＰＡＳＳＩＮＧＴＨＲＯＵＧＨＴＨＩＣＫＳＯＬＩＤＴＡＲＧＥＴＳＺｏｕＹａｍｉｎｇ（ＡｐｐｌｉｅｄＰｈｙｓｉｃｓＤｅｐａｒｔｍｅｎｔ，ＳｈａｎｇｈａｉＪｉａｏｔｏｎｇＵｎｉ...

关键词： shell electron Ar ions solid targets fast heavy ions electron populations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Production of a High-Mach-Number Plasma Flow for an Advanced Plasma Space Thruster

引用

Plasma Science and Technology 2004年第6期6卷 2541-2545页

作者： M.Inutake K.y.shino S.Fujimura H.Tobari T.y.gai y.Hosokawa R.Sato K.Hattori A.ando Department of Electrical Engineering Tohoku University Sendai 980-8579 Japan

A higher specific impulse and a larger thrust are required for a mannedinterplanetary.space thruster. Prior to a realization of a fusion-plasma thruster, amagneto-plasma-dy.amic arcjet (MPDA) powered by.a fission reactor is one of the promising candidatesfor a manned Mars space thruster. The MPDA plasma is accelerated axially.by.a self-induced j x Bforce. Thrust performance of the MPDA is expected to increase by.apply.ng a magnetic nozzle insteadof a solid nozzle. In order to get a much higher thruster performance, two methods have beeninvestigated in the HITOP device, Tohoku University. One is to use a magnetic Laval nozzle in thevicinity.of the MPDA muzzle for converting the high ion thermal energy.to the axial flow energy. Theother is to heat ions by.use of an ICRF antenna in the divergent magnetic nozzle. It is found thatby.use of a small-sized Laval-ty.e magnetic nozzle, the subsonic flow near the muzzle is convertedto be supersonic through the magnetic Laval nozzle. A fast-flowing plasma is successfully.heated by.se of an ICRF antenna in the magnetic beach configuration.

关键词： electric propulsion MPD thruster magnetic nozzle RF ion heating

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-infectious pulmonary.complication after stem cell transplantation and genetic background

Non-infectious pulmonary complication after stem cell transp...

引用

第十届亚太国际骨髓移植会议

作者： Onizuka M Kishi K ando K Hotta T Miy.mura K Kodera y.Suy.n Li Inoko H Department of Hematology.and Rheumatology.Tokai University.School of Medicine Kanagawa Japan Department of Hematology.and Rheumatology.Tokai University.School of Medicine Kanagawa Japan Department of Hematology.and Rheumatology.Tokai University.School of Medicine Kanagawa Japan Department of Hematology.and Rheumatology.Tokai University.School of Medicine Kanagawa Japan Bone Marrow Transplantation Center Japanese Red Cross Nagoy. First Hospital AichiJapan Bone Marrow Transplantation Center Japanese Red Cross Nagoy. First Hospital AichiJapan Department of Molecular Life Sciences Tokai University.School of Medicine KanagawaJapan Department of Molecular Life Sciences Tokai University.School of Medicine KanagawaJapan

＜正＞Objectives: Non-infectious pulmonary.dy.function （NIPD） represents a common and often fatal complication of hematopoietic stem cell transplantation （HSCT）. In order to predict the risk factor of developing NIPD before transplantation, we investigated genetic poly.orphisms of some candidate genes and compared the frequency.of developing NIPD with the allele frequency.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Manipulating Hy.oxia in Solid Tumors Has the Potential to Influence Lung Metastases in vivo

Manipulating Hypoxia in Solid Tumors Has the Potential to In...

引用

作者： S.Masunaga y.Matsumoto R.Hiray.ma G.Kashino y.Sakurai H.Tanaka M.Suzuki y.Kinashi y.Liu K.ando K.Ono National Institute of Radiological Sciences Heavy.Ion Medical Center Gunma University

BACKGROUNDS AND PURPOSES:Many.cells in solid tumors are quiescent in situ but are still clonogenic .Quiescent(Q) tumor cells are more resistant to low-LET radiation because of their larger hy.oxic fraction and greater capacity.to recover from radiation -induced DNA damage than proliferating(P) tumor *** original method for selectively.detecting the response of intratumor Q cells has made it possible to evaluate the usefulness of various modalities for cancer therapy.in terms of effectiveness against intratumor Q

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Progress in Phy.ics and Technology.Developments for the Modification of JT-60

引用

Plasma Science and Technology 2004年第1期6卷 2141-2150页

作者： H.Tamai M.Matsukawa G.Kurita N.Hay.shi K.Urata y.M.Miura K.Kizu K.Tsuchiy. A.Morioka y.Kudo S.Sakurai K.Masaki T.Suzuki M.Takechi y.Kamada A.Sakasai S.Ishida K.Abe A.ando T.Cho T.Fujii T.Fujita S.Goto K.Hananda A.Hatay.ma T.Hino H.Horiike N.Hosogane M.Ichimura Tsuji-Iio S.Itoh M.Katsurai M.Kikuchi A.Kohy.ma H.Kubo M.Kuriy.ma M.Matsuoka y.Miura N.Miy. T.Mizuuchi K.Nagasaki H.Ninomiy. N.Nishino y.Ogawa K.Okano T.Ozeki M.Saigusa M.Sakamoto M.Satoh M.Shimada R.Shimada M.Shimizu T.Takagi y.Takase T.Tanabe K.Toi y.Ueda y.Uesugi K.Ushigusa y.y.gi T.y.mamoto K.y.tsu K.y.shikawa Japan Atomic Energy.Research Institute Naka Ibarahi 311-0193 Japan Tohoku University University.of Tsukuba Osaka University Ky.shu University Keio University Hokkaido University Toky. Institute of Technology the University.of Toky. Ky.to University Mie University Hiroshima University Central research Institute of Electric Power Industry Ibaraki University ITER JCT Nagoy. University National Institute for Fusion Science Kanazawa University National Institute of Advanced Industrial Science and Technology

Recent progress in the phy.ics and engineering design study.for themodification programme of JT-60 is presented. In order to achieve a steady.state high-βplasmaoperation, which is the dominant issue of this programme, phy.ics design for the MHD control and thestability.analy.is is investigated. Engineering design and the R & D for the superconducting coils,irradiation shield are performed well towards the mission of programme.

关键词： modification of JT-60 phy.ics design technology.developments

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

日本职业性过敏性肺炎

引用

中华结核和呼吸杂志 1997年第Z1期20卷 89-89页

作者： Nishiura y.Nakagawa K Suga M Arima K y.neda R Tamura M ando M 沈玲(译) FirstDepartmentofInternalMedicine KuamotoUniversitySchoolofMedicineLumamoto FirstDepartmentofInternalMedicine KumamotoUniversitySchoolofMedicineLumamoto Toky.NationalChestHospital Tokyo ThirdDepartmentofInternalMedicine IwateUniversityIwateJapan

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：