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对斑贴试验致敏性结果的回顾性评估

世界核心医学期刊文摘（皮肤病学分册） 2006年第9期2卷 44-45页

作者： Jensen C.D. Paulsen e. andersen k.e. 张路坤 Department of Dermatology Odense University Hospital Sdr. Boulevard 29 5000 Odense C Denmark

The risk of actively sensitizing a patient in connection with diagnostic patch tests exists. This risk, however, is extremely low, especially from standard allergens, and if the test is carried out according to internationally accepted guidelines. This retrospective study investigates the clinical consequences in cases of possible patch test sensitization. Among 7619 consecutively tested eczema patients in a 14- year period 26 (0.3% ) were identified in the database as having had a late patch test reaction, which may be an indication of patch test sensitization. 9 of these cases were not suitable or available for the follow-up investigation and 3 patients were not traceable. Among the 14 remaining patients 1 had a reaction to gold sodiumthiosulphate, which was assessed to be a persistent reaction and not a late reaction, and in 2 patients a clear relevance for the late reacting allergen was found. For the remaining 11 patients we could not rule out that they were patch test sensitized, and they were investigated further. 1 was diseased and 10 were interviewed regarding the possible consequences of the alleged patch test sensitization. 9 had not experienced any dermatitis problems, and 1 could not exclude the possibility that the alleged patch test sensitization had aggravated her dermatitis problems, although we find it unlikely based on the full clinical history. even though the patient material is small and the limitations inherent in such a retrospective study, the results and the literature indicate that development of clinical contact dermatitis following patch test sensitization is very rare.

关键词：回顾性调查斑贴试验致敏性评估接触性皮炎试验反应晚期反应临床结果

对二甲基溴戊二腈接触性过敏:每天1次与每天多次接触的结果

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 47-48页

作者： Jensen C.D. Johansen J.D. Menné T. andersen k.e. 惠海英 Department of Dermatology Odense University Hospital Sdr. Boulevard 29 5000 Odense C Denmark

Some types of cosmetic products such ashand soaps and creams are commonly used several times a day, especially in occupational use situations. Little has experimentally been shown of how the daily frequency of the application of an allergen in a product influences the allergic response. This study investigates the allergic responses elicited in presensitized individuals when exposed to a specific amount of allergen applied either in 1 application per day or distributed over 4 applications per day. As model allergen, the cosmetic preservative methyldibromo glutaronitrile (MDBGN) is used. 19 contact allergic individuals and 12 controls participated in a double- blind, randomized use test. To areas on the forearms were applied 2 drops either once daily of a solution containing 0.04% MDBGN or 4 times a day of a solution containing 0.01% MDBGN. 14 of 19 patients developed dermatitis following the application of approximately equal amounts of MDBGN on both arms. Controls were negative. In this experiment, applications of 0.04% MDBGN once daily or 0.01% MDBGN 4 times daily had, in a use test, approximately equal capabilities of provoking allergic contact dermatitis. This adds new knowledge to the risk assessment and regulation of cosmetic allergens. However, these results may be highly allergen dependent, and further studies are needed before more general conclusions can be made.

关键词：戊二腈性过敏甲基溴护手霜双盲随机试验研究一般性结论阴性反应致敏

松香和菊科混合物作为芳香物过敏的标记物:在芳香萜、松香及菊科植物提取物间的交叉反应

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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 43-43页

作者： Paulsen e. andersen k.e. 潘敏 Dept. of Dermatology Odense University Hospital Sdr. Boulevard 29 DK- 5000OdenseCDenmark

The aim of this study was to assess the strength of any association between sensitization to ‘ new’ fragrance compounds and sensitization to Compositae, fragrance mix, Myroxylon pereirae resin and colophonium, respectively. Consecutive eczema patients were tested with a series of essential oils and selected fragrance compounds and another series of oxidized terpenes in connectionwith european multicentre fragrance projects. Contact allergy to either series was frequently detected, in 5% of 318 and 4.6% of 262 persons tested, and both had a statistically significant association with Compositae, colophonium and fragrance mix sensitization. The individual results indicated that simultaneously occurring positive reactions to essential oils, colophonium and Compositae were based on cross- reactivity rather than concomitant sensitization. Thus, all patients with positive reaction to the rare fragrance sensitizer β - caryophyllene had positive colophonium reactions, and cross- reactivity between essential oils and Compositae was related to the Compositae plant extracts of the Compositae mix and not the pure sesquiterpene lactones of the standard series. The implication is that Compositae mix and colophonium may be markers of fragrance allergy, which is important to know when assessing the relevance of positive reactions to Compositae plant extracts and colophonium.

关键词：植物提取物交叉反应湿疹患者丁香烯倍半萜内酯阳性反应致敏物秘鲁香脂性过敏芳香化合物

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腋臭剂:异丁子香酚的实验性激发研究

世界核心医学期刊文摘（皮肤病学分册） 2005年第9期1卷 41-41页

作者： Bruze M. Johansen J.D. andersen k.e. 潘敏 Department of Occupational and environmental Dermatology University Hospital S205 02 Malm Sweden

Axillary dermatitis is common and overrepresented in people with contact allergy to fragrances. Many people suspect their deodorants to be the incriminating products. In order to investigate the significance of isoeugenol in deodorants for the development of axillary dermatitis when used by people with and without contact allergy to isoeugenol, patch tests with deodorants and ethanol solutions with isoeugenol, as well as repeated open application tests (ROAT) with roll-on deodorants with and without isoeugenol at various concentrations, were performed in 35 dermatitis patients, 10 without and 25 with contact allergy to isoeugenol. A positive ROAT was observed only in patients hypersensitive to isoeugenol (P e axilla to which the deodorants containing isoeugenol had been applied (P eodorants containing isoeugenol in the concentration range of 0.0063-0.2%used 2 times daily on healthy skin can thus elicit axillary dermatitis within a few weeks in people with contact allergy to isoeugenol.

关键词：异丁子香酚接触性变态反应腋部斑贴试验接触性过敏反应致病物质走珠酒精溶液

金黄色葡萄球菌定植动力学和儿童特应性皮炎致病因子

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世界核心医学期刊文摘（皮肤病学分册） 2006年第8期2卷 22-22页

作者： Lomholt H. andersen k.e. kilian M. 朱国兴 Department of Dermatology and Venerology Aarhus University Hospital P. P. Oerumsgade 11 8000 Aarhus C Denmark

A prospective cohort study was undertaken to determine the clonal dynamics of Staphylococcus aureus colonization and infection during 1 y in children with atopic dermatitis, and to correlate specific clones, accessory gene regulator (agr) groups, and production of virulence factors with eczema activity. eleven children were examined every 6 wk with swaps taken from active eczema, anterior nose, axillae and perineum, and scoring of eczema activity by severity scoring of atopic dermatitis (SCORAD). Individual S. aureus clonal types were identified and examined for production of superantigens, toxins, and were assigned to agr groups. S. aureus colonization patterns ranged from rare colonization over transient colonization to persistent colonization by a single clone or a dynamic exchange of up to five clones. Production of no single virulence factor including superantigens and toxins was significantly associated with exacerbation of eczema. In four children there was a shift between visits in agr group of colonizing clones. These shifts were associated with an increased SCORAD value of 19 (Se = 7, p = 0.009). Change of clones belonging to the same agr group was not associated with a higher SCORAD value. In 11 of 12 cases with two different clones co-colonizing a child the clones belonged to the same agr group. In conclusion, this limited group of children with atopic dermatitis showed highly variable colonization patterns of S. aureus, and communication between strains by use of agr encoded octa peptides appeared to be active in vivo. Increased severity of eczema was related to a change in agr group and may have been because of inflammation triggered by the takeover of an antigenically different clone, as agr groups represent ancient phylogenetic lineages.

关键词：金黄色葡萄球菌特应性皮炎致病因子动力学前瞻性队列研究儿童基因调节子严重度评分动态改变

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巯基苯并噻唑或巯基混合物:何为标准品系?

世界核心医学期刊文摘（皮肤病学分册） 2006年第9期2卷 45-45页

作者： Diepgen T.L. Bruynzeel D.P. andersen k.e. 张路坤 Department of Social Medicine Occupational and Environmental Dermatology University Hospital Heidelberg Thibaut Str. 3 69115 Heidelberg Germany

Mercaptobenzothiazole (MBT) compounds are well known contact allergens. To detect rubber allergic patients we use both MBT (2% in petrolatum) and a mercapto-mix with 4 constituents of 0.5% each in our standard series. In this article the eeCDRG presents data of in total 32 475 consecutive tested patients attending the respective contact dermatitis clinics from 11 centres in europe to determine if the mix and MBT detected the same allergic patients. We found 327 patients positive to the mix or MBT, or to both. 261 were positive to the mix and 254 to MBT. MBT was negative in 73 patients who were positive to the mix. If the mix had not been in the standard series, on average 22% of patients allergic to a mercapto-compound would have been missed, for MBT this would have been on average 20% . All clinics would have missed a significant number of positive reactions if both compounds had not been tested. We conclude, that both the mercapto mix and MBT are required in the standard series.

关键词：巯基混合物品系标准噻唑阳性反应接触性皮炎苯 MBT

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儿童重度染发剂过敏反应8例

世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 45-45页

作者： Sosted H. Johansen J.D. andersen k.e. Menné T. 罗素菊 Department of Dermatology Gentopte Hospital University of Copenhagen2900 HelleupDenmark

Serious adverse skin reactions to permanent hair dyes and temporary black tattoos have been reported. As temporary tattoos have become fashionable among adolescents, the risk profile for p-phenylenediamine (PPD) sensitization of the population has changed simultaneously with an increasing use of hair dyes in this age group. This investigation reports PPD sensitization in children with regard to cause of sensitization, clinical presentation and consequences. Clinical history and patch test results for consecutive children below 16 years of age with suspected hair dye allergic reactions and positive patch tests to PPD were collected over 2 years in 2 Danish dermatology clinics. 8 children aged 12-15 years were collected, and they all reacted to several hair dye ingredients. 5 of the patients were hospitalized, 1 in the intensive care unit. 6 of the patients gave a history of prior reaction to temporary black tattoos. These children showed simultaneous positive patch reactions to N-isopropyl-N-phe-nylp-phenylenediamine and local anaesthetics, while such reaction patterns were not seen in children with hair dye reactions only. The clinical consequences of these reactions are unknown. A re-evaluation of the risk assessment/risk management for hair dyes is required.

关键词：染发剂过敏反应斑贴试验临床病史重症监护住院治疗临床后果对苯二胺对-苯二胺持久性

Interactive effects of reproductive assets and ambient predation risk on the threat-sensitive decisions of Trinidadian guppies

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Current Zoology 2016年第3期62卷 221-226页

作者： Jemma kATWAROO-andersen Chris k. eLVIDGe Indar RAMNARINe Grant e. BROWN Department of Biology Concordia University 7141 Sherbrooke St. West Montreal QC H4B 1R6 Canada Department of Life Sciences University of the West Indies St. Augustine Trinidad and Tobago

Threat-sensitive behavioral trade-offs allow prey animals to balance the conflicting demands of successful predator detection and avoidance and a suite of fitness-related activities such as forag- ing, mating, and territorial defense. Here, we test the hypothesis that background predation level and reproductive status interact to determine the form and intensity of threat-sensitive behavioral decisions of wild-caught female Trinidadian guppies Poecilia reticulata. Gravid and nongravid gup- pies collected from high- and low-predation pressure populations were exposed to serial dilutions of conspecific chemical alarm cues. Our results demonstrate that there was ＇no effect of reproduct- ive status on the response of females originating from a low-predation population, with both gravid and nongravid guppies exhibiting strong anti-predator responses to the lowest concentration of alarm cues tested. Increasing cue concentrations did not result in increases in response intensity. Conversely, we found a significant effect of reproductive status among guppies from a high- predation population. Nongravid females from the high-predation population exhibited a strong graded （proportional） response to increasing concentrations of alarm cue. Gravid females from the same high-predation population, however, shifted to a nongraded response. Together, these re- sults demonstrate that accrued reproductive assets influence the threat-sensitive behavioral deci- sions of prey, but only under conditions of high-ambient predation risk.

关键词： asset protection antipredator behavior fitness trade-offs ecological uncertainty chemical alarm cues.

The Bamble Sector,South Norway:A review

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Geoscience Frontiers 2014年第5期5卷 635-658页

作者： Timo G.Nijland Daniel e.Harlov Tom andersen TNO P.O.Box 49.2600 AA Delft.The Netherlands GeoForschungsZentrum Telegrafenberg14473 Potsdam.Germany Department of Geology.University of Johannesburg P.O.Box 524.Auckland Park 2006.South Africa Department of Geosciences.University of Oslo P.O.Box 1047.Blindern.0316 Oslo Norway

The Proterozoic Bamble Sector, South Norway, is one of the world＇s classic amphiboliteto granulite- facies transition zones. It is characterized by a well-developed isograd sequence, with isolated ＇granulite-facies islands＇ in the amphibolite-facies portion of the transition zone. The area is notable for the discovery of C02-dominated fluid inclusions in the granolite-facies rocks by Jacques Touter in the late 1960＇s, which triggered discussion of the role of carbonic fluids during granulite genesis. The aim of this review is to provide an overview of the current state of knowledge of the Bamble Sector, with an emphasis on the Arendal-Froland-Nelaug-Tvedestrand area and off shore islands （most prominantly Tromay and Hisoy） where the transition zone is best developed. After a brief overview of the history of geological research and mining in the area, aspects of sedimentary, metamorphic and magmatic petrology of the Bamble Sector are discussed, including the role of fluids. Issues relevant to current geotectonic models for SW Scandinavia, directly related to the Bamble Sector, are discussed at the end of the review.

关键词： Bamble SectorSouth NorwayCharnockiteAmphibolire- ro granulire-facies transitionCO2BrinesPrecambrian