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The Association between Mutations Detected in Tissue and Plasma from Patients with Colorectal Adenoma and Adenocarcinoma

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Journal of Cancer Therapy 2014年第14期5卷 1399-1401页

作者： Caroline Brenner Larsen Jan Lindebjerg Rikke Fredslund andersen Niels Pallisgaard Susanne Holck Anders Jakobsen hans Jorgen Nielsen Department of Oncology Vejle HospitalVejleDenmark Department of Pathology Vejle HospitalVejleDenmark Department of Biochemistry Vejle HospitalVejleDenmark Department of Pathology Copenhagen University HospitalCopenhagenDenmark Department of Surgical Gastroenterology Copenhagen University HospitalCopenhagenDenmark

Most colorectal cancers evolve through an adenoma-carcinoma sequence with mutations in the KRAS/BRAF pathway as an early event. Mutation analyses are usually performed on tissue samples, but during the last couple of years the same analysis in blood has been facilitated. Our aim was to investigate the correlation between BRAF/KRAS mutations in tissue and plasma from colorectal adenomas and adenocarcinomas. Out of 22 patients with adenomas 10 had a mutation in the tissue, but no mutations were detected in the plasma. In 10 of 26 adenocarcinomas a mutation was found in the tumor and in four of these, the mutation was also detected in the plasma. Our results confirm previous findings that mutated DNA in plasma can be detected in approximately 50%?of non-metastasized adenocarcinomas. The difference between adenomas and adenocarcinomas suggests that appearance of mutated DNA in plasma associates with invasion.

关键词： KRAS BRAF Adenomas Adenocarcinomas Carcinogenic Development

Modeling slow deformation of polygonal particles using DeM

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Particuology 2008年第6期6卷 506-514页

作者： Andrés A. Pea Pedro G. Lind hans J. Herrmann Institute for Computational Physics Universitt Stuttgart Computational Physics IfB HIF E12 ETH Hnggerberg CH-8093 Zrich Switzerland Departamento de Física Universidade Federal do Ceará

We introduce two improvements in the numerical scheme to simulate collision and slow shearing of irregular particles. First, we propose an alternative approach based on simple relations to compute the frictional contact forces. The approach improves efficiency and accuracy of the Discrete element Method （DeM） when modeling the dynamics of the granular packing. We determine the proper upper limit for the integration step in the standard numerical scheme using a wide range of material parameters. To this end, we study the kinetic energy decay in a stress controlled test between two particles. Second, we show that the usual way of defining the contact plane between two polygonal particles is, in general, not unique which leads to discontinuities in the direction of the contact plane while particles move. To solve this drawback, we introduce an accurate definition for the contact plane based on the shape of the overlap area between touching particles, which evolves continuously in time.

关键词： Granular media Discrete element method Slow deformation Contact forces

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Seasonal changes on two different spatial scales： response of aquatic invertebrates to water body and microhabitat

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Insect Science 2005年第4期12卷 263-280页

作者： WILCO C.e.P. VeRBeRK HeIN H. VAN KLeeF MARTIJN DIJKMAN PAUL VAN HOeK PeTeR SPIeReNBURG hans eSSeLINK Bargerveen Foundation Radboud University Nijmegen Department of environmental Studies Institute for Wetland and Water Research Radboud University Nijmegen Department of Animal ecology and ecophysiology Radboud University NijmegenNijmegen the Netherlands

Knowledge about the spatial and temporal scales of both habitat use and the functional significance of different adaptations is essential for an understanding of the population dynamics of invertebrate assemblages. This fundamental knowledge is not only interesting from an academic point of view, but is sorely lacking and needed in the field of restoration ecology. Many species are threatened due to degradation. Knowing what environmental conditions are needed dtLring the life cycle of these species is important in the design of restoration measures which aim to lift existing bottlenecks for threatened species. To assess the relative importance of water type and microhabitat in structuring the invertebrate assemblage during different seasons, invertebrates were sampled in three water bodies differing in trophic level and acidity. Different parts within a water body （microhabitats） were sampled separately and each water body was sampled in all four seasons. Results show that water body is an important factor structuring the invertebrate assemblage early in the season, whereas microhabitat became more important later in the season. Structural complexity of microhabitats was related to the type of locomotion employed by invertebrates. Seasonal differences could be related to population dynamics （reproduction, mortality）. Moreover, fluctuations in resource availability were expected to differ between the water bodies, with highest fluctuations in the eutrophic water body and with fluctuations becoming less predictable later in the season. This was confirmed by the data： species synchronization to pulses in food availability was strongest in the eutrophic water body. Moreover, synchronization was strongest in summer, while in autumn waters were invaded by dispersive species. Based on these results a synthesis is presented on the functioning of the different waters during the different seasons.

关键词： dispersal fluctuations in resource availability food substrate synchronization

efficient multi-level fault simulation of HW/SW systems for structural faults

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Science China(Information Sciences) 2011年第9期54卷 1784-1796页

作者： BARANOWSKI Rafal DI CARLO Stefano HATAMI Nadereh IMHOF Michael e. KOCHTe Michael A. PRINeTTO Paolo WUNDeRLICH hans-Joachim ZOeLLIN Christian G. University of Stuttgart Institute of Computer Architecture and Computer Engineering Politecnico di Torino Dipartimento di Automatica e Informatica

In recent technology nodes,reliability is increasingly considered a part of the standard design flow to be taken into account at all levels of embedded systems *** traditional fault simulation techniques based on low-level models at gate-and register transfer-level offer high accuracy,they are too inefficient to properly cope with the complexity of modern embedded ***,they do not allow for early exploration of design alternatives when a detailed model of the whole system is not yet available,which is highly required to increase the efficiency and quality of the design ***-level models that combine the simulation efficiency of high abstraction models with the accuracy of low-level models are therefore essential to efficiently evaluate the impact of physical defects on the *** paper proposes a methodology to efficiently implement concurrent multi-level fault simulation across gate-and transaction-level models in an integrated simulation *** leverages state-of-the-art techniques for efficient fault simulation of structural faults together with transaction-level *** combination of different models allows to accurately evaluate the impact of faults on the entire hardware/software system while keeping the computational effort ***,since only selected portions of the system require low-level models,early exploration of different design alternatives is efficiently *** results obtained from three case studies are presented to demonstrate the high accuracy of the proposed method when compared with a standard gate/RT mixed-level approach and the strong improvement of simulation time which is reduced by four orders of magnitude in average.

关键词： fault simulation multi-level transaction-level modeling

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一个豆荚里的五粒豆

新东方英语(中学生) 2009年第11期 60-63页

作者： hans Christian andersen 张玲贾臻臻

不论卑微还是高贵,不论身处何处,只要你能尽力去帮助别人,就有了存在的价值。从前,在一个豆荚里有五粒豌豆。这些豌豆是绿色的,豆荚也是绿色的,于是它们就认为整个世界都是绿色的。

关键词：豌豆花安徒生

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小驴儿

长喜欢乐英语

长喜欢乐英语 2005年第10期 32-35页

作者： hans Christian andersen 陈秀丽

A SIMPLe PROOF OF THe INeQUALITY R_M(MF(κ))≤1.2+(1/2~κ) IN MULTIPROCeSSOR SCHeDULING

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Acta Mathematicae Applicatae Sinica 1992年第3期8卷 245-251页

作者：越民义 hans KeLLeReR 俞忠良 Institute of Applied Mathematics Academia Sinica Beijing 100080 China Institut fur Mathematik Technische Universitat GrazA-8010 GrazAustria. Mathematics Section Nanjing Forestry UniversityNanjing 200028China Institut fur MathematikTechnische Universitat GrazA-8010 GrazAustria.e consider the well-known problem of scheduling n independent tasks nonpreemptivelyon m identical processors with the objective of minimizing the makespan. Coffman Garey andJohnson described an algorithm MULTIFIT based on bin-packing with a worst case performancebetter than the LPT-algorithm. The bound 1.22 obtained by them was claimed by Friesen in1984 that it can be improved to 1.2. In this paper we give a simp1e proof for this bound.

We consider the well-known problem of scheduling n independent tasks nonpreemptivelyon m identical processors with the objective of minimizing the makespan. Coffman, Garey andJohnson described an algorithm MULTIFIT, based on bin-packing, with a worst case performancebetter than the LPT-algorithm. The bound 1.22 obtained by them was claimed by Friesen in1984 that it can be improved to 1.2. In this paper we give a simp1e proof for this bound.

关键词： FFD IN MULTIPROCeSSOR SCHeDULING A SIMPLe PROOF OF THe INeQUALITY R_M MF

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安徒生童话精选

Sealing of the hepatic resection area using fibrin glue reduces significant amount of postoperative drain fluid

2014年

作者： (丹)H.C. 安徒生(hans Christian andersen)

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World Journal of Gastroenterology 2005年第38期11卷 5984-5987页

作者： Frank eder Frank Meyer Gerd Nestler Zuhir Halloul hans Lippert Department of Surgery

AIM: To investigate whether the routine use of fibrin glue applied onto the hepatic resection area can diminish postoperative volume of bloody or biliary fluids drained via intraoperatively placed perihepatic tubes and can thus lower the complication ***: Two groups of consecutive patients with a comparable spectrum of recent hepatic resections were compared: (1) 13 patients who underwent application of fibrin glue immediately after resection of liver parenchyma;(2) 12 patients who did not. Volumes of postoperative drainage fluid were determined in 4-h intervals through 24 h indicating the intervention caused bloody and biliary ***: Through the first 8 h postoperatively, there was a tendency of higher amounts of fluids in patients with no additional application of fibrin glue while through the following intervals, a significant increase of drainage volumes was documented in comparison with the first two 4-h intervals, e.g., after 12 h, 149.6 mL +/-110 mL vs 63.2 mL +/-78 mL. Using fibrin glue, postoperative fluid amounts were significantly lower through the postoperative observation period of 24 h (851 mL +/-715 mL vs 315 mL +/-305 mL).CONCLUSION: For hepatic resections, the use of fibrin glue appears to be advantageous in terms of a significant decrease of surgically associated segregation of blood or bile out of the resection area. This might result in a better outcome.

关键词： Fibrin glue Hepatic resection