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Science China(Technological Sciences) 2009年第11期52卷 3335-3347页

作者： KRONVANG Brian WINDOLF JФrgen GRANT Ruth andersen hans e THODSeN hans OVeSeN Niels B LARSeN SФren e National environmental Research Institute Aarhus University VejlsФvej 25 DK-8600 Silkeborg Denmark

Nationwide monitoring of the aquatic environment was initiated in 1988 in Denmark as a means to follow the outcome of the Action Plans for nutrient pollution of the aquatic environment. Five Action Plans have been adopted by the Danish Parliament since 1985 and the nationwide monitoring programme can be used to quantify the outcome as shown by reductions in nutrient discharges from both point and non-point sources. Moreover, the empirical experience gathered from nearly 20 years of monitoring is assisting the development and calibration of models for simulation of nitrogen leaching, nitrogen removal in groundwater and surface waters and the establishment of a P-index all covering the entire land area of Denmark.

关键词： nitrogen phosphorus monitoring data point sources non-point sources models Action Plans Danish experience

effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al Kabbani Christoph Köhler hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Severe chronic diarrhea and weight loss in cholesteryl ester storage disease: A case report

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World Journal of Gastroenterology 2005年第15期11卷 2364-2366页

作者： Uta Drebber Matthias andersen hans U Kasper Peter Lohse Manfred Stolte hans P Dienes Institute of Pathology Department of Internal Medicine Department of Clinical Chemistry-Grosshadern

AIM: An inherited deficiency of human lysosomal acid lipase (LAL)results in the rare conditions of Wolman disease and cholesteryl ester storage disease (CeSD). We want to present the rare case of CeSD in an ***: We report about an adult female patient with severe chronic diarrhea and weight loss as a consequence of CeSD. Clinical examination revealed signs of malabsorption and slightly elevated liver ***: Histopathologic changes in the liver tissue and DNA sequence analysis confirmed the diagnosis of CeSD due to homozygosity for the most common CeSD mutation,a G934A splice site defect encoded by exon 8 of the lysosomal acid lipase (LIPA) ***: It is the first case in the literature with diarrhea as a putative symptom of CeSD in adult patients.

关键词： CeSD Acid esterase Hydrolase Liver biopsy Pathology Diarrhea

The emperor''s new clothes

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Safety and efficacy of Profermin~to induce remission in ulcerative colitis

丛书名：津津有味·读经典

2012年

作者： (丹麦) hans Chridstian andersen原

本书收录了安徒生的四个故事, 分别是《老头子总是对的》、《海的女儿》、《拇指姑娘》和《皇帝的新装》。

ISBN: (纸本)9787544728263;9787895006157

本书收录了安徒生的四个故事, 分别是《老头子总是对的》、《海的女儿》、《拇指姑娘》和《皇帝的新装》。

关键词：童话

来源：畅想之星图书光盘版（南... 评论

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World Journal of Gastroenterology 2012年第15期18卷 1773-1780页

作者： Aleksander Krag hans Israelsen Bjrn von Ryberg Klaus K andersen Flemming Bendtsen Gastrounit Medical Devision 360Copenhagen University Hospital Hvidovre Faculty of Health Sciences Copenhagen UniversityDK-2650 HvidovreDenmark Nordisk Rebalance A/S M.D.Madsensvej 14-16DK-3450 AllerdDenmark Statistics Section Informatics and Mathematical ModellingTechnical University of DenmarkDK-2800 LyngbyDenmark

AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).MeTHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 andedian:7.5),who were treated open-label with Profermintwice daily for 24 *** SCCAI was reported observer blinded via the ***:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in *** secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,Pe estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(Aes)or withdrawals due to *** was generally well ***:Profermin is safe and may be effective in inducing remission of active UC.

关键词： Ulcerative colitis Diet Probiotic Profermin Inflammatory bowel disease Dietary management Medical foods

The Bamble Sector,South Norway:A review

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Geoscience Frontiers 2014年第5期5卷 635-658页

作者： Timo G.Nijland Daniel e.Harlov Tom andersen TNO P.O.Box 49.2600 AA Delft.The Netherlands GeoForschungsZentrum Telegrafenberg14473 Potsdam.Germany Department of Geology.University of Johannesburg P.O.Box 524.Auckland Park 2006.South Africa Department of Geosciences.University of Oslo P.O.Box 1047.Blindern.0316 Oslo Norway

The Proterozoic Bamble Sector, South Norway, is one of the world＇s classic amphiboliteto granulite- facies transition zones. It is characterized by a well-developed isograd sequence, with isolated ＇granulite-facies islands＇ in the amphibolite-facies portion of the transition zone. The area is notable for the discovery of C02-dominated fluid inclusions in the granolite-facies rocks by Jacques Touter in the late 1960＇s, which triggered discussion of the role of carbonic fluids during granulite genesis. The aim of this review is to provide an overview of the current state of knowledge of the Bamble Sector, with an emphasis on the Arendal-Froland-Nelaug-Tvedestrand area and off shore islands （most prominantly Tromay and Hisoy） where the transition zone is best developed. After a brief overview of the history of geological research and mining in the area, aspects of sedimentary, metamorphic and magmatic petrology of the Bamble Sector are discussed, including the role of fluids. Issues relevant to current geotectonic models for SW Scandinavia, directly related to the Bamble Sector, are discussed at the end of the review.

关键词： Bamble SectorSouth NorwayCharnockiteAmphibolire- ro granulire-facies transitionCO2BrinesPrecambrian

The Dream of Little Tuk

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英语画刊（初三版） 2011年第9期 1-4页

作者： hans Christian andersen

《小杜克》是丹麦著名童话作家安徒生的作品。安徒生1805年出生于丹麦欧登塞的贫民区，父亲是个鞋匠，母亲是洗衣妇。安徒生在他的《童话全椠》的手记中写道：“这篇故事中有些情节牵涉到我儿时的记忆。”

关键词：英语学习中学英语课外读物英语阅读

Interactive effects of reproductive assets and ambient predation risk on the threat-sensitive decisions of Trinidadian guppies

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Current Zoology 2016年第3期62卷 221-226页

作者： Jemma KATWAROO-andersen Chris K. eLVIDGe Indar RAMNARINe Grant e. BROWN Department of Biology Concordia University 7141 Sherbrooke St. West Montreal QC H4B 1R6 Canada Department of Life Sciences University of the West Indies St. Augustine Trinidad and Tobago

Threat-sensitive behavioral trade-offs allow prey animals to balance the conflicting demands of successful predator detection and avoidance and a suite of fitness-related activities such as forag- ing, mating, and territorial defense. Here, we test the hypothesis that background predation level and reproductive status interact to determine the form and intensity of threat-sensitive behavioral decisions of wild-caught female Trinidadian guppies Poecilia reticulata. Gravid and nongravid gup- pies collected from high- and low-predation pressure populations were exposed to serial dilutions of conspecific chemical alarm cues. Our results demonstrate that there was ＇no effect of reproduct- ive status on the response of females originating from a low-predation population, with both gravid and nongravid guppies exhibiting strong anti-predator responses to the lowest concentration of alarm cues tested. Increasing cue concentrations did not result in increases in response intensity. Conversely, we found a significant effect of reproductive status among guppies from a high- predation population. Nongravid females from the high-predation population exhibited a strong graded （proportional） response to increasing concentrations of alarm cue. Gravid females from the same high-predation population, however, shifted to a nongraded response. Together, these re- sults demonstrate that accrued reproductive assets influence the threat-sensitive behavioral deci- sions of prey, but only under conditions of high-ambient predation risk.

关键词： asset protection antipredator behavior fitness trade-offs ecological uncertainty chemical alarm cues.

On the development of optical peripheral nerve interfaces

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Neural Regeneration Research 2019年第3期14卷 425-436页

作者： hans e.Anderson Richard F.ff.Weir Department of Bioengineering University of Colorado Denver|Anschutz Medical Campus

Limb loss and spinal cord injury are two debilitating conditions that continue to grow in prevalence. Prosthetic limbs and limb reanimation present two ways of providing affected individuals with means to interact in the world. These techniques are both dependent on a robust interface with the peripheral nerve. Current methods for interfacing with the peripheral nerve tend to suffer from low specificity, high latency and insufficient robustness for a chronic implant. An optical peripheral nerve interface may solve some of these problems by decreasing invasiveness and providing single axon specificity. In order to implement such an interface three elements are required:(1) a transducer capable of translating light into a neural stimulus or translating neural activity into changes in fluorescence,(2) a means for delivering said transducer and(3) a microscope for providing the stimulus light and detecting the fluorescence change. There are continued improvements in both genetically encoded calcium and voltage indicators as well as new optogenetic actuators for stimulation. Similarly, improvements in specificity of viral vectors continue to improve expression in the axons of the peripheral nerve. Our work has recently shown that it is possible to virally transduce axons of the peripheral nerve for recording from small fibers. The improvements of these components make an optical peripheral nerve interface a rapidly approaching alternative to current methods.

关键词： peripheral nerve interfaces optogenetics optical neural interface optical peripheral nerve interface GCaMP ArcLight adenoassociated viral vector lentiviral vectors viral vectors implantable microscopy

Intestinal organoids as tools for enriching and studying specific and rare cell types:advances and future directions

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Journal of Molecular Cell Biology 2020年第8期12卷 562-568页

作者： Kim e.Boonekamp Talya L.Dayton hans Clevers Oncode Institute Hubrecht InstituteRoyal Netherlands Academy of Arts and Sciences(KNAW)and University Medical Centre(UMC)Utrecht358A CT UtrechtThe Netherlands Princess Maxima Centre for Paediatric Oncology 358A CS UtrechtThe Netherlands

Adult tissue-derived organoids allow for the expansion and maintenance of primary epithelial cells in a near-native *** 3D and self-organizing organotypic cultures derived from adult tissues have been increasingly used in fundamental and translational research.A key feature of this organoid system is that it recapitulates the stem cell lineage and thus,the differentiated cell-type heterogeneity of the in vivo tissue of origin.

关键词： directions organo rare