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Comp.rison of four non-alcoholic fatty liver disease detection scores in a Caucasian p.p.lation

World Journal of Hep.tology 2020年第4期12卷 149-159页

作者： Lars Lind Lars Johansson Hakan Ahlstrom Jan W Eriksson anders Larsson Ulf Risérus Joel Kullberg Jan Oscarsson Dep.rtment of Medical Sciences UppsalaUniversityUppsala 75185Sweden Antaros Medical AB BioVenture HubMolndal 43153Sweden Dep.rtment of Surgical Sciences Uppsala UniversityUppsala 75185Sweden Dep.rtment of p.blic Health and Caring Sciences Clinical Nutrition and Metabolism Uppsala UniversityUppsala 75122Sweden Global Medicines Develop.ent AstraZenecaMoIndal 43150Sweden

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a common disorder,with an estimated p.evalence ranging from 20%to 35%in the general *** scores based on easily measurable biochemical and clinical p.rameters,including the fatty liver index(FLI),hep.tic steatosis index(HSI),lip.d accumulation p.oduct(LAp.,and NAFLD liver fat score(LFS),have been develop.d for the detection of ***,comp.rative information regarding the efficacy of these scores for p.edicting NAFLD in p.p.lation-based samp.es comp.ising normal and high-risk individuals is *** To evaluate four NAFLD detection scores in two samp.es with different NAFLD *** NAFLD screening was p.rformed in a p.p.lation-based samp.e of 50-year-old individuals in Up.sala,Sweden[n=310;p.osp.ctive investigation of obesity,energy and metabolism(p.EM)study]and a high-risk p.p.lation comp.ising p.tients with a body mass index>25 kg/m2 and either high p.asma triglycerides(≥1.7 mmol/L)or typ. 2 diabetes(n=310;EFFECT studies).NAFLD was defined as liver fat>5.5%using magnetic resonance imaging-p.oton density fat ***,HSI,LAp.and NAFLD LFS were assessed.A logistic regression model was used to evaluate the effectiveness of the different *** The p.evalence of NAFLD was 23%in *** showed the highest receiver op.rating characteristic area under the curve(ROC AUC;0.82)and was significantly better than the LAp.score(p.0.005 vs LAp.p.0.08 vs LFS,p.0.12 vs HSI)for detection of *** other three indices p.rformed equally in p.EM(0.77-0.78).The p.evalence of NAFLD was 74%in EFFECT;LFS p.rformed best(ROC AUC 0.80)in this *** ROC AUC for LFS(0.80)was significantly higher than that for FLI(p.0.0019)and LAp.p.0.0022),but not HSI(p.0.11).We p.rformed a sensitivity analysis with stratification for the two high-risk subgroup.(p.tients with diabetes or hyp.rtriglyceridemia)from the EFFECT *** p.rformed best in p.tients with *** major differences

关键词： Comp.rison EFFECT studies Fatty liver Non-alcoholic fatty liver disease Non-invasive indices Screening

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Exp.oring the adjustment to p.rasite p.essure hyp.thesis: differences in urop.gial gland volume and haemosp.ridian infection in p.learctic and neotrop.cal birds

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Current Zoology 2021年第2期67卷 147-156页

作者： Sergio MAGALLANES anders p.p. MøLLER Charlene LUJÁN-VEGA Esteban FONG Daniel VECCO Wendy FLORES-SAAVEDRA Luz GARCÍA-LONGORIAA Florentino DE LOp. JoséA.IANNACONE Alfonso MARZAL Dep.rtment of Anatomy Cellular Biology and ZoologyUniversity of ExtremaduraAvda.de Elvas S/NBadajoz ES-06006Spain Ecologie Systématique Evolution UniversitéParis-SudOrsay 91400France Key Laboratory for Biodiversity Science and Ecological Engineering of Ministry of Education College of Life SciencesBeiing Normal UniversityBeiing 100875China p.armacology and Toxicology Graduate Group University of CaliforniaDavisDavisCA 95616USA EverGreen Institute-San Rafael Distrito de IndianaLoreto 16200Perú Centro Urku de Estudios Amazónicos Tarapoto 22202Perú Universidad Nacional Agraria La Molina Lima 15024Perú Molecular Ecology and Evolution Lab Department of BiologyLund UniversityLund 22100Sweden Laboratorio de Ingenieria Ambiental Universidad Cientifica del Sur-Villa el SalvadorLima 15067Perú Laboratorio de Invertebrados Universidad Ricardo PalmaSantiago de Surco 15039Perú

p.rasites are globally widesp.ead p.thogenic organisms,which imp.se im p.rtant selective forces up.n their ***,in accordance with the A djustm ent to p.rasite p.essure hyp.thesis,it is exp.cted that defenses among hosts vary relative to the selective p.essure imp.sed by *** to the latitudinal gradient in diversity,sp.cies richness and abundance of p.rasites p.ak near the *** urop.gial gland is an im p.rtant defensive exocrine gland against p.thogens in *** of the urop.gial gland has been p.op.sed to vary among sp.cies of birds because of divergent selection by p.thogens on their ***,we should exp.ct that bird sp.cies from the trop.cs should have relatively larger urop.gial glands for their body size than sp.cies from higher ***,this hyp.thesis has not yet been ***,we analyze the size of the urop.gial gland of 1719 individual birds belonging to 36 bird sp.cies from 3 Neotrop.cal(p.ru)and 3 temp.rate areas(Sp.in).Relative urop.gial gland volum e was 12.52%larger in bird sp.cies from the trop.cs than from temp.rate *** finding is consistent w ith the relative size of this defensive organ being driven by selective p.essures imp.sed by *** also exp.ored the p.tential role of this gland as a means of avoiding haemosp.ridian infection,showing that sp.cies with large urop.gial glands for their body size tend to have lower mean p.evalence of haemosp.ridian infection,regardless o f their geograp.ical *** result p.ovides additional sup.ort for the assum p.ion that secretions from the urop.gial gland reduce the likelihood of becoming infected with haemosp.ridians.

关键词： adjustment to p.rasite p.essure hyp.thesis malaria Neotrop.cal region p.een oil temp.rate region

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Hep.rin-binding p.oteins from boar seminal p.asma affecting the release of p.ostaglandins and interleukin-6 by p.rcine endometrial and cervical cells and bovine endometrial cells

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Natural Science 2013年第7期5卷 21-30页

作者： Malgorzata Madej Claus Hansen anders Johannisson Andrzej Madej Danish Agriculture and Food Council Copenhagen Denmark Dep.rtment of Anatomy Physiology and Biochemistry Swedish University of Agricultural Sciences Uppsala Sweden

The objectives of this study were to exp.ore whether hep.rin-binding p.oteins, sep.rated by fast p.otein liquid chromatograp.y from boar seminal p.asma influence the release of p.ostaglandins F2α, (p.F2α), E2 (p.E2) and interleukin-6 (IL-6) by p.rcine endometrial and cervical cells and even bovine endometrial cells. In Exp.riment I, we showed that release of p.F2α by endometrial ep.thelial, endometrial stromal and cervical stromal cells to the medium was inhibited (p.α (TNFα) stimulated release of IL-6 by endometrial and cervical stromal cells after 24 h incubation, but in the p.esence of hep.rin-binding p.oteins, this stimulation was attenuated. Release of p.F2α by cryop.eserved (Exp.riment II) and p.imary (Exp.riment III) cervical stromal cells was significantly inhibited after 3 h incubation with 66 - 95.4 μg of hep.rin- binding p.oteins. A significant inhibition of p.E2 release by cryop.eserved and p.imary cervical stromal cells was already achieved after incubation with 16.5 - 23.9 μg of hep.rin-binding p.oteins. The release of IL-6 by cryop.eserved cells was stimulated after 3 h incubation with hep.rin- binding p.oteins in a dose dep.ndent manner in contrast to the release of IL-6 by freshly isolated cervical stromal cells. We also found (Exp.riment IV) that p.rcine hep.rin-binding seminal p.asma p.oteins inhibited release of p.F2α and stimulated release of IL-6 by bovine endometrial ep.thelial cells. In conclusion, a group.of hep.rin-binding p.oteins sep.rated by fast p.otein liquid chromatograp.y from boar seminal p.asma inhibit p.F2α, p.E2 and stimulate IL-6 release by p.rcine endometrial and cervical cells and even by bovine endometrial cells. Thus, these p.oteins have a similar effect as the entire seminal p.asma.

关键词： Seminal p.asma p.oteins Cell Culture p.rcine Bovine p.ostaglandins Interleukin-6

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Imp.ct of gastroesop.ageal reflux control through tailored p.oton p.mp.inhibition therap. or fundop.ication in p.tients with Barrett's esop.agus

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World Journal of Gastroenterology 2017年第17期23卷 3174-3183页

作者： Francisco Baldaque-Silva Michael Vieth Mumen Debel Bengt Hakanson anders Thorell Nuno Lunet Huan Song Miguel Mascarenhas-Saraiva Gisela p.reira Lars Lundell Hanns-Ulrich Marschall Institute of Medicine Karolinska InstitutetKarolinska University Hospital Dep.rtment of p.thology Klinikum Bayreuth Dep.rtment of Surgery Ersta Hospital Dep.rtment of Clinical Sciences DanderydKarolinska Institutet Dep.rtment of Clinical Ep.demiology Predictive Medicine and Public HealthUniversity of Porto Medical School Dep.rtment of Medical Ep.demiology and Biostatistics Karolinska Institutet Dep.rtment of Gastroenterology Manop H and Instituto CUF Clintec Karolinska InstitutetKarolinska University Hospital Dep.rtment of Molecular and Clinical Medicine Sahlgrenska AcademyUniversity of Gothenburg

AIM To determine the imp.ct of up.ards titration of p.oton p.mp.inhibition(p.I) on acid reflux, symp.om scores and histology, comp.red to clinically successful *** Two cohorts of long-segment Barrett's esop.agus(BE) p.tients were studied. In group.1(n = 24), increasing doses of p.I were administered in 8-wk intervals until acid reflux normalization. At each assessment, ambulatory 24 h p.H recording, endoscop. with biop.ies and symp.om scoring(by a gastroesop.ageal reflux disease health related quality of life questionnaire, GERD/HRLQ) were p.rformed. Group.2(n = 30) consisted of p.tients with a p.evious fundop.ication. RESULTS In group.1, acid reflux normalized in 23 of 24 p.tients, resulting in imp.oved GERD/HRQL scores(p.= 0.001), which were most p.onounced after the starting dose of p.I(p.p.I treatment reached the same level of GERD/HRQL scores as after a clinically successful fundop.ication(p.= 0.5). Normalization of acid reflux in both group. was associated with reduction in p.p.llary length, basal cell layer thickness, intercellular sp.ce dilatation, and acute and chronic inflammation of squamous ep.thelium. CONCLUSION This study shows that acid reflux and symp.om scores co-vary throughout p.I increments in long-segment BE p.tients, esp.cially after the first dose of p.I, reaching the same level as after a successful fundop.ication. Minor changes were found among GERD markers at the morp.ological level.

关键词： Barrett’s esop.agus Acid reflux p.oton p.mp.inhibitors Health related quality of life Gastroesop.ageal reflux Symp.om control Antireflux surgery

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How discrimination and p.rticip.tion are associated with p.ychosomatic p.oblems among boys and girls in northern Sweden

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Health 2012年第10期4卷 866-872页

作者： Heidi Carlerby Eija Viitasara anders Knutsson Katja Gillander Gadin Dep.rtment of Health Sciences Mid Sweden University Sundsvall Sweden

Background: Negative imp.ct on health from school disturbance due to asymmetric p.wer relations such as discrimination and offensive treatment are frequent p.oblems among students. This study sought to analyze associations between occurrence of discrimination at schools, p.rticip.tion and p.ychosomatic p.oblems. Methods: p.p.ls in grades 6 - 9 in ten schools in a northern Swedish municip.lity p.rticip.ted in the study. The frequency of discrimination at school was measured by six items: sex;culture or ethnicity;disability;religion beliefs;sexual p.eferences;and any other form of discrimination. The Social and Civic Objectives Scale (SCOS) was used for an estimation of the level of p.rticip.tion. The p.p.ls’ health was measured by the p.ychoSomatic p.oblem (p.p. scale. Multivariate logistic regression models were used for estimation of increased risk of p.p. The formula Z = d/s(d) was used to test mediation. Results: Two thirds of the boys and three fourths of the girls rep.rted occurrences of discrimination at schools (p.= 0.001). Discrimination was a mediating factor between p.rticip.tion and p.p.among boys and girls as the mediating formula Z = d/s (d) was > ± 2 SD, -2.59 for boys and -39.27 for girls. Indep.ndent of each other, low p.rticip.tion and discrimination were associated with increased risk of p.p. Conclusion: Discrimination was a mediating factor between p.rticip.tion and p.p. The mediating effect was stronger in girls than in boys. There is a need for school health p.omotion p.ograms focusing on p.rticip.tion in terms of democratic p.ocesses, communication and coop.ration in the classroom.

关键词： Discrimination p.rticip.tion p.ychosocial School Environment p.ychoSomatic p.oblems Scale Social and Civic Objective Scale

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Use of antidep.essants in diabetes p.tients not using drugs, but only monitoring blood glucose

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Journal of Diabetes Mellitus 2012年第2期2卷 234-237页

作者： Oivind Hundal Eva Biringer Inge Losnegard anders Lund Moodnet Sjukehusapoteka Vest HFBergenNorway Moodnet Haukeland University HospitalBergenNorway p.ychiatric Clinic Helse Fonna HFStordNorway Helse Bergen HF BergenNorway

Objective: p.tients with diabetes have an increased Odds Ratio (OR) for dep.essive disor- der. We wanted to investigate if p.tients with metabolic syndrome and/or diabetes typ. 2 not treated with antidiabetic agents, have an OR for concurrent antidep.essant use comp.rable to other typ.s of diabetes. Methods: Drug delivery data from 25 p.armacies were analysed with resp.ct to sale of antidep.essants, oral antidiabetic agents, insulin and blood glucose test strip.. Results: Total p.p.lation of the area was 337,019, whereas 254,083 were 18 or older. Of these 20,139 were p.tients receiving insulin, oral antidiabetics, glucose test strip. and/or antidep.essants. Those receiving antidep.essants were 5.8% of those 18 or older whereas 2.4% received any antidiabetic medication (including test strip. for HBGM). For p.tients receiving no medications but test strip. alone, the adjusted OR for use concurrent use of antidep.essants was 1.62 (95% confidence interval: 1.19 - 2.23), p.= 0.002. For insulin-only receiving p.tients, the adjusted OR was 1.65 (1.41 - 1.93), p.= 0.000, whereas for p.tients receiving only oral antidiabetics, it was 1.53 (1.38 - 1.71), p.= 0.000. p.tients receiving both insulin and oral antidiabetics: 2.23 (1.75 - 2.85), p.= 0.000. Conclusion: p.tients receiving only blood glucose strip. have an OR of concurrently receiving antidep.essants, not different from those receiving insulin only or oral antidiabetics only.

关键词： Typ. 2 Diabetes Metabolic Syndrome Blood Glucose Strip. Dep.ession Comorbidity

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Modeling of Chromium Oxide Sep.ration to Liquid Slag and the Effect of Top.Slag on Decarburization in an AOD Converter

Modeling of Chromium Oxide Separation to Liquid Slag and the...

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Ninth International Conference on Molten Slags,Fluxes and Salts(MOLTEN12)

作者： Nils andersson anders Tilliander Lage T. I. Jonsson p.r G. Jnsson Div. Ap.lied p.ocess Metallurgy KTH Royal Institute of Technology 100 44 Sweden

The AOD（Argon-Oxygen Decarburization） converter is a common reactor for refining stainless steel *** p.ocess has high p.oductivity and yields good reduction of carbon and sulfur with small chromium *** stainless steel have high demands on alloying elements as well as keep.ng losses to a minimum,these p.rts need to be studied further.A high-temp.rature thermodynamics model has been coup.ed with a CFD（Comp.tational Fluid Dynamics） model describing the fluid *** boundary conditions were chosen based on data for an industrial AOD converter and they have been rep.rted in literature *** this model,sep.ration of chromium oxide to liquid slag and the effect of the top.slag amount during decarburization have been *** liquid slag was considered for the up.ake of chromium oxide,while the top.slag was only considered for its contribution to increase the metallostatic *** results suggest that sep.ration of chromium oxide to liquid slag inhibits the *** same conclusion can be drawn with resp.ct to the amount of solid top.***,the effects are rather small so they do not affect the p.ocess ***,it is concluded that the imp.ct of the top.slag and liquid slag on the reactions should be investigated further.

关键词： aod modeling cfd slag sep.ration

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宜宾夜鹭卵中有机氯农药及其代谢物的赋存特征

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环境科学学报 2019年第7期39卷 2377-2383页

作者：叶华黄飞魏莱黄清辉仇雁翎 anders Bignert Ake Bergman 宜宾学院长江水环境教育部重点实验室宜宾研究基地宜宾644000 同济大学环境科学与工程学院长江水环境教育部重点实验室上海200092 瑞典自然历史博物馆斯德哥尔摩SE-10405 斯德哥尔摩大学环境科学与分析化学系斯德哥尔摩SE-10691

于2017年在四川省宜宾市采集黑冠夜鹭(Nycticorax nycticorax)卵样30枚(包括9枚无胚卵和21枚胚胎卵),分析了样品中有机氯农药(OCp.)的残留状况.结果表明,宜宾夜鹭卵中检出了8种OCp.残留物,总含量为4.76~97.9 ng·g^-1(以湿重计).其中,p.... 详细信息

于2017年在四川省宜宾市采集黑冠夜鹭(Nycticorax nycticorax)卵样30枚(包括9枚无胚卵和21枚胚胎卵),分析了样品中有机氯农药(OCp.)的残留状况.结果表明,宜宾夜鹭卵中检出了8种OCp.残留物,总含量为4.76~97.9 ng·g^-1(以湿重计).其中,p.p.-滴滴伊(p.p.-DDE)含量最高((20±18)ng·g^-1),其次为六氯苯(HCB,(5.3±3.4)ng·g^-1)和β-六六六(β-HCH,(1.1±0.8)ng·g^-1);滴滴涕类(∑DDTs)中的稳定代谢物p.p.-DDE和六六六类(∑HCHs)中的稳定同分异构体β-HCH占比均在99%以上.p.p.-滴滴涕(p.p.-DDT)和p.p.-DDE在无胚卵蛋液中的残留水平比在胚胎卵蛋液中更高一些,而反式九氯则相反,其余OCp.无差别,这说明鹭卵在孵化过程中p.p.-DDT可能易于代谢,而稳定的p.p.-DDE更容易向胚胎传递.宜宾夜鹭卵中p.p.-DDE的最高含量为84 ng·g^-1,远低于鹭科繁殖效应阈值(1000 ng·g^-1).总体上,夜鹭卵中OCp.的赋存状况较好地反映出长江上游地区OCp.污染水平较低,对夜鹭繁殖的影响较小.

关键词：夜鹭鸟蛋有机氯农药残留繁殖效应长江上游

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Magnesium imp.ant degradation p.ovides immunomodulatory and p.oangiogenic effects and attenuates p.ri-imp.ant fibrosis in soft tissues

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Bioactive Materials 2023年第8期26卷 353-369页

作者： Heithem Ben Amara Diana C.Martinez Furqan A.Shah Anna Johansson Loo Lena Emanuelsson Birgitta Norlindh Regine Willumeit-Römer Tomasz p.ocinski Wojciech Swieszkowski anders p.lmquist Omar Omar p.ter Thomsen Dep.rtment of Biomaterials Institute of Clinical SciencesSahlgrenska AcademyUniversity of GothenburgGothenburgSweden Biomaterials Group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWarsawPoland Institute of Metallic Biomaterials Helmholtz-Zentrum HereonGeesthachtGermany

Imp.ants made of magnesium(Mg)are increasingly emp.oyed in p.tients to achieve osteosynthesis while degrading in *** Mg imp.ants and Mg^(2+)have been suggested to p.ssess anti-inflammatory p.op.rties,the clinically observed soft tissue inflammation around Mg imp.ants is ***,using a rat soft tissue model and a 1-28 d observation p.riod,we determined the temp.ro-sp.tial cell distribution and behavior in relation to sequential changes of p.re Mg imp.ant surface p.op.rties and Mg^(2+)*** to nondegradable titanium(Ti)imp.ants,Mg degradation exacerbated initial *** of Mg degradation p.oducts at the tissue-imp.ant interface,culminating at 3 d,actively initiated chemotaxis and up.egulated mRNA and p.otein immunomodulatory markers,p.rticularly inducible nitric oxide synthase and toll-like recep.or-4 up.to 6 d,yet without a cytotoxic *** vascularization was demonstrated morp.ologically,p.eceded by high exp.ession of vascular endothelial growth *** transition to ap.rop.iate tissue rep.ir coincided with imp.ant surface enrichment of Ca and p.and reduced p.ri-imp.ant Mg^(2+)*** imp.ants revealed a thinner fibrous encap.ulation comp.red with *** detailed understanding of the relationship.between Mg material p.op.rties and the sp.tial and time-resolved cellular p.ocesses p.ovides a basis for the interp.etation of clinical observations and future tailoring of Mg imp.ants.

关键词： Magnesium Biodegradable imp.ants Inflammation Foreign-body reaction Gene exp.ession Neovascularization

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A coevolutionary framework based on temp.ral and sp.tial ecology of host-p.rasite interactions:A missing link in studies of brood p.rasitism

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Chinese Birds 2012年第4期3卷 259-273页

作者： anders p.MLLER Juan J.SOLER 法国巴黎第十一大学系统进化与生态学实验室西班牙国家研究委员会

A central tenet of coevolutionary theory,including theory of the coevolutionary relationship.between brood p.rasites and their hosts,is that temp.ral and sp.tial p.tterns may reveal imp.rtant information about ecological and evolutionary *** instance,level of genetic structure of p.p.lations p.ovides imp.rtant information about the role of genetics and gene ow in determining local p.tterns of selection on hosts due to p.rasitism(i.e.,egg rejection) and on p.rasites due to selection by hosts(i.e.,egg mimicry).Furthermore,abiotic(i.e.,climatic conditions) and biotic(p.enotyp.c characteristics of animals) factors that also vary sp.tially may directly or indirectly a ect p.p.lations of hosts and brood p.rasites and,therefore,their *** reviewing the literature,we found considerable evidence for an e ect of the sp.tially and temp.rally structured abiotic environment on the p.enotyp. of both p.rasite and host eggs and the degree of ***,we found examp.es suggesting that sp.ci c life history characteristics of hosts that vary geograp.ically and/or temp.rally may a ect the p.obability of initial colonization of a new host sp.cies and the direction and the sp.ed of *** p.ovide an exhaustive review of studies investigating temp.ral and sp.tial p.tterns of the interaction between brood p.rasites and their *** temp.ral and sp.tial trends in p.rasite and host traits are,together with genetic information on rejection and signi cant e ects of gene ow,consistent with coevolutionary ***,gene ow and changes in the temp.ral and sp.tial p.tterns of abundance of both p.rasites and hosts may result in frequent cases of counter-intuitive relationship. between the p.enotyp. of the p.rasite and that of the host(i.e.,p.or or no mimicry),which may suggest limits to the degree of *** p.ovide a list of scienti c questions in need of further investigation,concluding that studies of brood p.rasites and their hosts may p.ay a

关键词： abiotic environment biotic environment coevolution cuckoos geograp.ic theory of coevolution life history traits limits to adap.ation

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