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Differentially Expressed Genes in Heads and Tails of Angelica Sinensis diels： Focusing on Ferulic Acid Metabolism

Chinese Journal of Integrative Medicine 2017年第10期23卷 779-785页

作者： YANG Jie LI Wei-hong AN Rong WANG Yi-li XU Yan chen Jie WANG xiao-fang ZHANG xiao-bo LI Jing DING Wei-jun Bijie Medical College Bijie Guizhou Province 551700 China Department of Fundamental Medicine Chengdu University of Traditional Chinese Medicine Chengdu 610075 China

Objective： To explore the scientific connotation of the discrepant pharmaceutical activities between the head and tail of Angelica sinensis diels（AS）, an important herb extensively utilized in Chinese medicine, by the approach of transcriptome sequencing. Methods： Ten samples of AS were randomly collected in Min County, Gansu Province of China. Transcriptome sequencing of AS was accomplished in a commercial ILLumina Hi Seq-2000 platform. The transcriptome of each head and tail of AS were fixed in a gene chip, and detected under the procedure of Illumina Hi Seq-2000. Differentially expressed unigenes between the heads and tails of AS were selected by Shanghai Biotechnology Corporation（SBC） online analysis system, based on Gene Ontology, Kyoto Encyclopedia of Genes and Genomes and relevant bioinformatic database. Results： Totally 63,585 unigenes were obtained from AS by high-throughput sequencing platform. Among which 3359 unigenes were identified as differentially expressed unigenes between the heads and tails of AS by SBC analysis system scanning. Of which 15 differentially expressed unigenes participate in the metabolic regulation of phenylpropanoid biosynthesis（PB） pathway and ferulic acid metabolites, in response to the distinguished pharmaceutical actions of the heads and tails of AS. Conclusion： Different content of ferulic acid in the heads and tails of AS is related to the differentially expressed genes, particularly involved in the PB pathway.

关键词： Angelica sinensis diels transcriptome sequencing ferulic acid phenylpropanoid biosynthesis pathway Chinese medicine

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Effectiveness of Xinglouchengqi decoction on constipation in patients with acute ischemic stroke: a randomized controlled trial

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Journal of Traditional Chinese Medicine 2020年第1期40卷 112-120页

作者： chen Pei Jiang Lan Geng Hualei Han xiao Xu Yinping chen Yan Guo Jinbin Wu Shuang Wang Yahui Yan Ruyu Ren Yi ZouYihuai Department of Neurology Dongzhimen Hospital affiliated to Beijing University of Chinese MedicineBeijing 100700China The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalCapital Medical University&Advanced Innovation Center for Human Brain ProtectionCapital Medical UniversityBeijing 100088China Department of Neurology Beijing Pinggu Hospital of Traditional Chinese MedicineBeijing 101200China Department of Neurology Beijing Changping Hospital of Traditional Chinese MedicineBeijing 102200China Department of Neurology Hospital affiliated to Changzhi Academy of Chinese Medical SciencesChangzhi 046000China Department of Emergency Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China

OBJECTIVE:To evaluate the effectiveness of traditional Chinese herbal Xinglouchengqi(XLCQ)decoction for the treatment of constipation in acute ischemic stroke patients,and figure out the role that bowel movements play in the treatment of acute ischemic ***:A total of 317 eligible patients were recruited and randomized to the XLCQ group(211 patients)or the control group(106 patients).In addition to conventional standard medical care and rehabilitation,participants in the XLCQ group received XLCQ decoction,while the control group received clysis therapy using glycerin enemas or lactulose oral *** groups were given treatment for 3 to 6 d,during which they received daily visits to record defecation features and accompanying *** assessments using the National Institutes of Health Stroke Scale(NIHSS)were conducted before and 1 month after ***:Patients in the XLCQ group had lower aggregate constipation scores compared with the control group on days 3 and 5(P<0.05).Spontaneous bowel movements tended to reappear more rapidly after taking the XLCQ decoction than after conventional laxative *** the average aggregate constipation score and the time taken to achieve spontaneous bowel movements showed positive correlations with NIHSS scores before and1 month after treatment(P<0.01).CONCLUSION:Treatment with XLCQ decoction effectively alleviated the overall symptoms of constipation in acute ischemic stroke *** status of bowel movements in acute ischemic stroke can reflect the severity of neurological impairment and predict neurological outcomes at 1 month.

关键词： Stroke Constipation Xinglouchengqi decoction Randomized controlled trial

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An Empirical Study on the Coupling and Coordination of Health Investment, Resident Health and Economic Growth in Sichuan Province —Based on a Modified Coupling Model

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Open Journal of Applied Sciences 2023年第3期13卷 355-365页

作者： long Qian Fei chen Development Research Center of Medical Science and Society Chongqing Medical University of Public Health and Management Chongqing China

We should calculate the coupling degree of medical investment, resident health and economic growth in Sichuan Province, and make clear the coordinated development of the aforementioned three factors. In that, the government was able to formulate policies that feature the positive interaction and coordinated development of regional medical investment, health and economy. Methods on index system for the evaluation of health investment, resident health and economic growth were constructed, and the coupling and coordination degree of the three systems were empirically studied based on the entropy weight method, the coupling coordination model and the gray correlation method. From the perspective of time series, the overall coupling and coordination level of Sichuan Province is relatively low, and the comprehensive development level of health investment and economic growth system has lagged behind the resident health system;from the perspective of spatial distribution characteristics, in 2019, the coordinated development level of health investment resident health and economic growth coupling in western Sichuan, southern Sichuan, northern Sichuan, eastern Sichuan and northern Sichuan is in the primary coordination stage, but there is a lag in the development of the health investment system between western Sichuan and southern Sichuan, and there is a lag in the development of the economic growth system between northern Sichuan and eastern Sichuan. From the analysis of gray correlation degree, the main correlation factors are diverse. All in all, the overall coordination level of health investment, resident health and economic growth in Sichuan Province is relatively low, and in order to achieve its coordinated development, it is necessary to narrow regional differences, formulate coordinated development strategies according to local conditions, and improve the overall coordination level.

关键词： Health Investment Resident Health Economic Growth Coupling Model

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Process and Mechanism of Controlling Outburst Floods of Landslide Dams through Artificial Structures: Physical Experiments

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Journal of Earth Science 2024年

作者： Hechun Ruan Huayong chen xiaoqing chen Wanyu Zhao xiao Li Key Laboratory of Mountain Hazards and Surface Processes， Institute of Mountain Hazards and Environment， Chinese Academy of Sciences University of Chinese Academy of Sciences

The scale of the outburst flood resulting from a landslide dam failure significantly influences the extent of the disaster and losses downstream. This study proposes a method for controlling the discharge of landslide dam failure using the artificial structure (AS). The primary approach involves strategically arranging the designed AS on both sides of the excavated spillway. As the breach is eroded， ASs gradually falls into the breach， serving to control the discharge. Fourteen sets of flume experiments were conducted to investigate the impact of various factors， including AS types， distances from the breach boundary， arrangements， columns， numbers， on the discharge control effectiveness. The mechanism how AS controls outburst discharge was revealed. Results indicate a pronounced control effect of AS on landslide dam-break discharge， with the maximum reducing rate of the peak discharge in the experiment reaching 47.4%. In controlling outburst discharge， four-sided framed structures demonstrate superior performance compared to four-sided solid structures， and serial structures outperform discrete structures. When arranging ASs， it is essential to ensure that the structure initiates its descent into the breach at the onset of the rapid increase in outburst discharge and continues until the peak discharge occurs. Building upon this foundation， augmenting the number of ASs and columns significantly enhances the efficacy of discharge control. The fundamental rationale for this discharge control lies in the AS’s capacity to reduce the headward scarp height， constrain sediment transport， and diminish the erosion capacity of the outburst flood， ultimately lowering the breach erosion rate. Lastly， a calculation method for the size design of the AS is established based on mechanical analysis. The research findings offer a new technological option for the emergency disposal of landslide dams.

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Study on Detection of Fluorescence Ion Based on V-B-O Cluster Compounds

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光谱学与光谱分析 2018年第S1期38卷 259-260页

作者： gao xiao-mei pan ying-min chen yi-ping college of chemistry fuzhou university，Ｆｕｚｈｏｕ　３５０１０８，Ｃｈｉｎａ

In this paper,the synthesis of a novel polyoxovanadiumborate Cd_(0.75) Na_2 Ni_(0.5) [V_(12) B_(18) O_(50.5)(OH)_(9.5)]·27.5 H_2 O by hydrothermal *** compound consists of metal M(Cd,Na,Ni)and V_(12) B_(18) O_(60) cluster units connected through the M-O bond to form a three-dimensional *** performed a series of characterizations of Compound 1 of our team and tested its fluorescence properties at the same *** luminescence investigations show that the compound 1 displays an interesting luminescence *** compound 1 exhibits a good potential as a luminescent multi-responsive sensing material for Fe^(3+)ions.

关键词： Vanadium oxygen cluster Hydrothermal synthesis Crystal structure Fluorescence spectral

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20C,a new bibenzyl compound,plays a significant role in rotenone-induced oxidative insult

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中国药理学与毒理学杂志 2017年第10期31卷 1008-1009页

作者： xiao-ling ZHANG Yu-he YUAN Nai-hong chen State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica & Neuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical College College of Pharmacy Hunan University of Chinese Medicine

20C,a bibenzyl compound isolated from Gastrodia elata,possesses antioxidative properties in PC12 cells,but its in-depth molecular mechanisms against rotenone-induced neurotoxicity remains *** studies indicate that without intact DJ-1,nuclear factor erythroid 2-related factor(Nrf2)protein becomes unstable,and the activity of Nrf2-mediated downstream antioxidant enzymes are thereby ***,increasing the nuclear translocation of Nrf2 by DJ-1 may present a helpful means for the prevention and treatment of chronic diseases related to oxidative *** results showed that 20C clearly protected PC12 and SH-SY5Y cells against rotenone-induced oxidative injury in a concentration-dependent ***,20C markedly up-regulated the levels of DJ-1,which in turn activated phosphoinositide-3-kinase(PI3K)/Akt signaling and inhibited glycogen synthase kinase 3β(GSK3β)activation,eventually promoting Nrf2 nuclear translocation and inducing the expression of Nrf2-mediated downstream antioxidative enzymes such as *** antioxidative effects of 20C could be partially blocked by ShR NA-mediated knockdown of DJ-1 and inhibition of the PI3K/Akt pathways with Akt1/2 kinase inhibitor in PC12 and SH-SY5Y cells,***,our findings confirm that DJ-1 is necessary for 20C-mediated protection against rotenone-induced oxidative damage,at least in part,by activating PI3K/Akt signaling,and subsequently enhancing the nuclear accumulation of *** findings from our investigation suggest that 20C should be developed as a novel candidate for preventing or alleviating the consequences of PD in the future.

关键词： 20C Parkinson disease DJ-1 Akt oxidative stress nuclear factor erythroid 2-related factor(Nrf2)

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600MPa级高能量输入焊接压力钢管用钢的研制

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钢铁 2007年第6期42卷 38-41页

作者：陈颜堂芮晓龙武汉钢铁集团公司技术中心湖北武汉430080

经过系列技术攻关,改进了武钢专用钢板冶炼及连铸过程中一些工艺,形成了一套自主操作技术模式,生产的微合金化低合金高强钢中杂质含量显著降低,钢板性能稳定性明显提高。利用武钢新改进的冶炼技术研制了一种600 MPa级低焊接裂纹敏感性... 详细信息

经过系列技术攻关,改进了武钢专用钢板冶炼及连铸过程中一些工艺,形成了一套自主操作技术模式,生产的微合金化低合金高强钢中杂质含量显著降低,钢板性能稳定性明显提高。利用武钢新改进的冶炼技术研制了一种600 MPa级低焊接裂纹敏感性高能量输入焊接水电站压力钢管用钢,研究了该钢的力学性能、微观组织结构以及焊接粗晶热影响区(CGHAZ)的组织特征及力学性能。结果表明,研制的新钢种集高强度、高韧性、优异的焊接性能于一体,且能承受大线能量焊接,焊前不预热,焊后不热处理。CGHAZ中弥散分布的复合氧化物夹杂促使针状铁素体的形成,提高了CGHAZ的力学性能。

关键词：压力钢管低焊接裂纹敏感性高能量焊接

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The 10^th National Congress of Genetic Society of China:Celebrating its 40^th anniversary in Nanjing

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Journal of Genetics and Genomics 2018年第12期45卷 688-689页

作者： Ying Zhang Chi Xu Yubo Han xiaofang chen Yan Zhang Mingjie xiao Editorial Office of Journal of Genetics and Genomics China Editorial Office of Heriditas (Beijing) China Genetics Society of China China

The 10National Congress of Genetic Society of China(GSC)was held on November 26th?29th,2018 in Nanjing,where GSC was established and the First National Congress of GSC was held in *** congress was sponsored by GSC,co-sponsored by Genetics Society of Jiangsu Province,Nanjing Agricultural University,State Key Laboratory of Crop Genetics and Germplasm

关键词： National Congress of Genetic Society of China The 10 th GSC Celebrating its 40

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Case Report:Adenoma of nonpigmented epithelium in ciliary body:literature review and case report

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第9期8卷 612-615页

作者： chen Zhi-qing FANG xiao-yun Department of Ophthalmology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Adenomas of the nonpigmented ciliary epithelium (NPCE) are often clinically indistinguishable from amelanotic malignant melanomas of the ciliary body or metastatic carcinomas. This paper reports a case study of a distinctive variant of adenoma of the NPCE, which clinically appears as epiretinal membrane in the macular region. Histopathologic studies have revealed this is an adenoma of the NPCE. Identification of this clinic feature is important because it will miss the diagnosis of the adenoma of the NPCE. In this case study, B-scan ultrasonography as well as computerized tomography (CT) has been used to provide help in diagnosing the ciliary body tumor. Because of their anterior location in the ciliary body, partial lamellar sclerou-vectomy is an effective method of treatment.

关键词： Epiretinal membrane Ciliary body Uveal tumor Adenoma

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Night Sleep Duration and Risk of Cognitive Impairment in a Chinese Population： A Cross-sectional Study

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Biomedical and Environmental Sciences 2017年第10期30卷 749-757页

作者： SONG Qiao Feng LIU xiao Xue HU Wan Ning HAN xiao chen ZHOU Wen Hua LU Ai Dong WANG Xi Zhu WU Shou Ling Department of Cardiology Tangshan People's HospitalNorth China University of Science and TechnologyTangshan 063000HebeiChina The Cancer Institute Tangshan People's HospitalTangshan 063000HebeiChina Department of Head and Neck Surgery Tangshan People's HospitalTangshan 063000HebeiChina Department of Ophthalmology Kailuan HospitalNorth China University of Science and TechnologyTangshan 063000HebeiChina Department of Cardiology Kailuan HospitalNorth China University of Science and TechnologyTangshan 063000HebeiChina

Objective Although sleep is one of the most important health-related behavioral factors, the association between night sleep duration and cognitive impairment has not been fully understood. A cross-sectional study was conducted with a random sample of 2,514 participants （≥ 40 years of age; 46.6% women） in China to examine the association between night sleep duration and cognitive impairment. Methods Night sleep duration was categorized as ≤ 5, 6, 7, 8, or ≥ 9 h per night. Cognitive function was measured using the Mini-Mental State Examination. A multivariate regression analysis was used to analyze the association of night sleep duration with cognitive impairment. A total of 122 participants were diagnosed with cognitive impairment. Results A U-shaped association between night sleep duration and cognitive impairment was found. The odds ratios （95% confidence intervals） of cognitive impairment （with 7 h of daily sleep being considered as the reference） for individuals reporting ≤ 5, 6, 8, and ≥ 9 h were 2.14 （1.20-3.83）, 1.13 （0.67-1.89）, 1.51 （0.82-2.79）, and 5.37 （1.62-17.80）, respectively （P ≤ 0.01）. Conclusion Short or long night sleep duration was an important sleep-related factor independently associated with cognitive impairment and may be a useful marker for increased risk of cognitive impairment.

关键词： Night sleep duration Cognitive Impairment Cross-sectional

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