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Application of tensor CSAMT with high-power orthogonal signal sources in Jiama porphyry copper deposit,South Tibet

China Geology 2023年第1期6卷 37-49页

作者： Peng-liang Yu Ting Qu Ri-zheng He Jian-li Liu Su-fen Wang xiao-long chen Shaanxi Geology and Mining Geophysical and Geoehemical Prospecting Team Co. Ltd.Xi’an 710043China Chinese Academy of Geological Sciences Beijing 100037China

The Jiama porphyry copper deposit in Tibet is one of the proven supergiant copper deposits in the Qinghai-Tibet Plateau at present,with the reserves of geological resources equivalent to nearly 20×10^(6) ***,it features wavy and steep terrain,leading to extremely difficult field operation and heavy *** study attempts to determine the effects of the tensor controlled-source audiomagnetotellurics(CSAMT)with high-power orthogonal signal sources(also referred to as the high-power tensor CSAMT)when it is applied to the deep geophysical exploration in plateaus with complex terrain and mining areas with strong *** test results show that the high current provided by the highpower tensor CSAMT not only greatly improved the signal-to-noise ratio but also guaranteed that effective signals were received in the case of a long transmitter-receiver ***,the tensor data better described the anisotropy of deep geologic *** addition,the tests also show that when the transmitting current reaches 60 A,it is still guaranteed that strong enough signals can be received in the case of the transmitter-receiver distance of about 25 km,sounding curves show no near field effect,and effective exploration depth can reach 3 *** 2D inversion results are roughly consistent with drilling results,indicating that the high-power tensor CSAMT can be used to achieve nearly actual characteristics of underground electrical ***,this method has great potential for application in deep geophysical exploration in plateaus and mining areas with complex terrain and strong interference,*** study not only serves as important guidance on the prospecting in the Qinghai-Tibet Plateau but also can be used as positive references for deep mineral exploration in other areas.

关键词： Jiama porphyry copper deposit Supergiant copper polymetallic deposit Tensor CSAMT of 150 kw High power 2D inversion Deep prospecting Mineral exploration engineering Xizang(Tibet)

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Role of the gut microbiota in anticancer therapy:from molecular mechanisms to clinical applications

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2687-2713页

作者： Lin-Yong Zhao Jia-Xin Mei Gang Yu Lei Lei Wei-Han Zhang Kai Liu xiao-long chen Damian Kołat Kun Yang Jian-Kun Hu Department of General Surgery&Laboratory of Gastric Cancer State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduChina Gastric Cancer Center West China HospitalSichuan UniversityChengduChina State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan UniversityFrontier Innovation Center for Dental Medicine PlusSichuan UniversityChengduChina Department of Experimental Surgery Medical University of LodzLodzPoland

In the past period,due to the rapid development of next-generation sequencing technology,accumulating evidence has clarified the complex role of the human microbiota in the development of cancer and the therapeutic *** importantly,available evidence seems to indicate that modulating the composition of the gut microbiota to improve the efficacy of anti-cancer drugs may be ***,intricate complexities exist,and a deep and comprehensive understanding of how the human microbiota interacts with cancer is critical to realize its full potential in cancer *** purpose of this review is to summarize the initial clues on molecular mechanisms regarding the mutual effects between the gut microbiota and cancer development,and to highlight the relationship between gut microbes and the efficacy of immunotherapy,chemotherapy,radiation therapy and cancer surgery,which may provide insights into the formulation of individualized therapeutic strategies for cancer *** addition,the current and emerging microbial interventions for cancer therapy as well as their clinical applications are *** many challenges remain for now,the great importance and full potential of the gut microbiota cannot be overstated for the development of individualized anti-cancer strategies,and it is necessary to explore a holistic approach that incorporates microbial modulation therapy in cancer.

关键词： clinical mechanisms stated

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Differences of EEG between Eyes-Open and Eyes-Closed States Based on Autoregressive Method

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Journal of Electronic Science and Technology of China 2009年第2期7卷 175-179页

作者： Ling Li Lei xiao long chen The autho-rs are with School of Biomedical Engineering University of Electronic Science and Technology of China Chengdu 610054 China

Autoregressive （AR） power spectral density estimate method was used to analyze the electroencephalogram （EEG） signals in eyes-open and eyes-closed states. From the topographical distributions of delta, theta, alpha, and beta power spectrum, these two states can be clearly discriminated. In these two states, frontal areas were activated in delta power, both frontal and occipital areas were activated in theta band, and occipital areas were activated in alpha and beta bands. These four bands had significantly higher power in frontal, parietal, and occipital areas when eyes were close. The results also implied that the optimum order of AR model could be more suitable for estimating EEG power spectrum of different states.

关键词： Index Terms-Autoregressive (AR) model electro-encephalogram (EEG) optimum order power spectraldensity,

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Extraction of inclusive photon production at mid-rapidity in p+p and Au+Au collisions at√SNN=200GeV

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Nuclear Science and Techniques 2021年第1期32卷 58-65页

作者： Sheng-Hui Zhang Rong-Rong Ma Yi-Fei Zhang xiao-long chen Xiu-Jun Li Fan Si cheng Li Ming Shao Yong-Jie Sun Ze-Bo Tang Wang-Mei Zha University of Science and Technology of China Hefei 230026China University of Illinois at Chicago ChicagoIL 60607USA Brookhaven National Laboratory UptonNY 11973USA

We present a comprehensive study on the individual sources of an inclusive photon production during high-energy hadronic *** cross section and invariant yields of inclusive photons are obtained as a function of pT at mid-rapidity(|y|<0.5)in p+p and Au+Au collisions at√SNN=*** results provide crucial inputs to separate measurements of open bottom and charm hadron yield suppression in heavyion collisions,which are used to test the mass hierarchy of the parton energy loss in the quark gluon plasma created during these *** procedure developed in this study can also be applied to other measurements of electrons from an open heavy-flavor hadron decay,such as the collective flow in the RHIC beam energy scan program.

关键词： Inclusive photon Cross section Invariant yields Mass hierarchy Technical reference

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Neoadjuvant plus adjuvant chemotherapy benefits overall survival of locally advanced gastric cancer

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World Journal of Gastroenterology 2011年第40期17卷 4542-4544页

作者： Xin-Zu chen Kun Yang Jie Liu xiao-long chen Jian-Kun Hu Department of Gastrointestinal Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Faculty of Medicine West China Medical School Sichuan University Chengdu 610041 Sichuan Province China

Neoadjuvant chemotherapy (NAC) has drawn more attention to the treatment of locally advanced gastric cancer (AGC) in the current multidisciplinary treatment model. EORTC trial 40954 has recently reported that NAC plus surgery without postoperative adjuvant chemotherapy could not benefit the locally AGC patients in their overall survival. We performed a meta-analysis of 10 studies including 1518 gastric cancer patients. Stratified subgroups were NAC plus surgery and NAC plus both surgery and adjuvant chemotherapy (AC), while control was surgery alone. The results showed that NAC plus surgery did not benefit the patients with locally AGC in their overall survival [odds ratio (OR) = 1.20, 95% CI 0.80-1.80, P = 0.37] and the number needed to treat (NNT) was 74. However, the NAC plus both surgery and AC had a slight overall survival benefit (OR = 1.33, 95% CI 1.03-1.71, P = 0.03) and NNT was 14, which is superior to the NAC plus surgery. Therefore, we recommend that combined NAC and AC should be used to improve the overall survival of the locally AGC patients.

关键词： Gastric cancer Adjuvant chemotherapy Neoadjuvant chemotherapy Surgery Survival

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Research on a New Type of Diamond Saw Plate

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厦门大学学报（自然科学版） 2002年第S1期41卷 294-295页

作者： SHI xiao-liang, DUAN long-chen, TANG Feng-lin, YANG Kai- hua (Engineering Faculty, China University of Geosciences, Wuhan 430074, Ch ina)

With the developing of stone material, diamond saw pl ate is used widely, and in order to increase cutting efficiency and life-span o f diamond saw plate, there are a lot of research jobs of segment for diamond saw plate. Layered segment for diamond saw plate is to divide single segment into s everal cutting tools by its structure, then increases rock-cutting faces. For i mpregnated man-made diamond saw plate, the bonding strength of diamonds with ma trix material has great effect on its life and service. Diamond is a kind of non metal and there is such high interface energy between diamond and common metals or alloys that diamond surface can’t be soaked by low melt-point metal or allo y. Diamonds are hold in metal matrix of working layer only mechanically, rather than bonded chemically, so the usage rate of diamonds in working layer is very l ow. Weakly impregnated method refers to covering diamonds with a thin layer of tu ngsten carbide mechanically by physical method, and chemical plating membrane re fers to coating a layer of carbide, which can react with the carbon atoms on the surface of diamond by chemical method and be soaked by matrix metal. In this pa per it analyses working mechanism and sintering process of layered segment of di amond saw plate by means of resistor hot-pressing sintering, it points out shor tages of layered structure, and raises using weakly impregnated layer instead of pure matrix layer, then overcomes the pure matrix layer slipping by pulling out diamonds earlier to improve cutting efficiency of saw plate, in the same time u ses diamond grains of chemical plating membrane proposed then preventing the hea t-hurting to diamond grains in working layer during the process of welding and sintering and improving the bonding strength of diamond with matrix, then improv ing life-span and aging of diamond saw. The theory of the design of mixed holding of diamonds by matrix of saw plate assures that chemical plating diamonds in working layer cut

关键词： diamond saw plate layered segment weakly impre gnated plating membrane slipping

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美国先前学习评价的个案研究——以俄克拉荷马州立大学技术学院为例

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职业技术教育 2016年第35期37卷 72-77页

作者：肖龙陈鹏江苏师范大学教育科学学院

美国作为最早实行先前学习评价的国家之一,形成了其独具特色的一套评价制度与方法。美国俄克拉荷马州立大学技术学院(OUSIT)采用多元化的评价方式,为在生涯与技术培训、产业经验以及军队服务等领域获得知识和技能的学生提供先前学习评... 详细信息

美国作为最早实行先前学习评价的国家之一,形成了其独具特色的一套评价制度与方法。美国俄克拉荷马州立大学技术学院(OUSIT)采用多元化的评价方式,为在生涯与技术培训、产业经验以及军队服务等领域获得知识和技能的学生提供先前学习评价服务,并通过标准的申请程序、严格的审核流程、多级的监管制度以及开放的公示制度为通过先前学习评价的学生授予一定的学术学分,帮助他们节省学费与时间,促进他们的"生长"。

关键词：先前学习评价俄克拉荷马州立大学技术学院(OUSIT) 职业教育美国

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Amidohydrolase and amidase from Diaphorobacter sp. LR2014-1 complementally hydrolyzes various herbicides

Amidohydrolase and amidase from Diaphorobacter sp. LR2014-1 ...

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中国生物工程学会第十届学术年会暨2016年全国生物技术大会

作者： long Zhang xiao-long chen Qiang Hu Kai chen Xin Yan Shun-Peng Li Jian-Dong Jiang Department of Microbiology Key Lab of Microbiological Engineering of Agricultural Environment Ministry of Agriculture College of Life Sciences Nanjing Agricultural University

Herbicides including phenylurea herbicides(PHs) are widely used and frequently detected as contaminants in ecosystems. Microbial or enzymatic technology is considered as the effective method to clean up herbicide-residues in environment. Though several amidohydrolases or amidases capable of breaking the urea or amide bonds of different herbicides have been characterized, different hydrolases from one strain that are capable of complementally catabolizing various herbicides and especially PH amidohydrolases with broad-substrate-spectrum from Gram-negative strains have not been reported. In this study, an amidohydrolase gene phh as well as an amidase gene mhh were cloned from the Gram-negative strain of Diaphorobacter sp. LR2014-1 based on analysis of the draft genome sequences and subsequent function expression. Phh converted both N,N-dimethyl-substituted PHs(diuron, K = 235.4 ± 37 μM;chlorotoluron, K = 110.1 ± 12 μM and fluometuron, K = 275.1 ± 46 μM) and N-methoxy-N-methyl-substituted PH(linuron, K = 19.9 ± 2.3 μM) to their corresponding aniline derivatives. Mhh not only showed activities toward the PHs(linuron, K = 33.4 ± 1.9 μM and siduron, K =23.0 ± 4.3 μM) but also demonstrated activities toward the herbicides of propanil(K = 31.0 ± 2.7 μM) and swep(K = 37.8 ± 2.0 μM). Phh shows relative low homologies to previously reported amidohydrolases such as the thiocarbamate herbicide molinate hydrolase MolA(53%) and the phenylurea hydrolases Puh A(51%) and Puh B(50%), which were all identified from Gram-positive bacteria. While Mhh shows low homologies with previously identified amidases(27-38%), except the newly reported triclocarban amidase TccA(100%). This is the first report of two independent hydrolases including a broad-substrate-spectrum PH-amidohydrolase derived from one Gram-negative strain, which are functional complementation in the hydrolysis of a variety of herbicides.

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糖尿病视网膜病变的激光治疗进展

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国际眼科杂志 2017年第5期17卷 891-893页

作者：王光陈晓隆中国医科大学附属盛京医院眼科中国辽宁省沈阳市110001

糖尿病视网膜病变(diabetic retinopathy,DR)是工作年龄人群第一位的致盲性疾病,其视力损害和失明的主要原因是增生性糖尿病视网膜病变和糖尿病黄斑水肿,视网膜激光光凝是目前治疗DR的最主要方法,但传统激光存在诸多副作用及并发症,为... 详细信息

糖尿病视网膜病变(diabetic retinopathy,DR)是工作年龄人群第一位的致盲性疾病,其视力损害和失明的主要原因是增生性糖尿病视网膜病变和糖尿病黄斑水肿,视网膜激光光凝是目前治疗DR的最主要方法,但传统激光存在诸多副作用及并发症,为减少这些副作用并提高疗效,很多新的视网膜激光治疗系统随之出现,本文就近几年来有关DR的激光治疗进展进行综述。

关键词：糖尿病视网膜病变激光凝固术治疗进展

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Captopril抑制鼠视网膜新生血管的形成(英文)

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国际眼科杂志 2009年第8期9卷 1448-1450页

作者：底煜陈晓隆中国医科大学盛京医院眼科中国辽宁省沈阳市110004

目的:探讨Captopril对鼠视网膜新生血管形成的抑制作用。方法:将60只7d龄小鼠随机分为对照组(30只)和治疗组(30只),置于体积分数750±50mL/L高氧环境下饲养5d后回到正常空气环境中饲养,出氧箱后治疗组每天1次玻璃体腔内注射2.7mL/kg Cap... 详细信息

目的:探讨Captopril对鼠视网膜新生血管形成的抑制作用。方法:将60只7d龄小鼠随机分为对照组(30只)和治疗组(30只),置于体积分数750±50mL/L高氧环境下饲养5d后回到正常空气环境中饲养,出氧箱后治疗组每天1次玻璃体腔内注射2.7mL/kg Captopril,对照组注射9g/L的氯化钠注射液2.7mL/kg,连续5d。两组小鼠均于17d处死并摘除眼球,采用ADP酶视网膜铺片、HE染色及免疫组织化学法分别观察视网膜血管的改变、计数视网膜新生血管内皮细胞核数及检测MMP-2、PEDF蛋白的表达。结果:治疗组与对照组相比视网膜血管分布规则、分支良好、新生血管密度减少,且突破视网膜内界膜的血管内皮细胞核数目明显减少(P<0.05);治疗组MMP-2染色较对照组减弱,PEDF染色较对照组增强。结论:玻璃体腔内注射2.7mL/kg Captopril能够有效抑制高氧诱导下的小鼠视网膜新生血管形成, Captopril有望成为防治血管增生性视网膜病变的一种有效的方法。

关键词：视网膜新生血管 Captopril 玻璃体腔注射

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