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Hepatoprotective effects of Xiaoyao San formula on hepatic steatosis and inflammation via regulating the sex hormones metabolism

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World Journal of Hepatology 2024年第7期16卷 1051-1066页

作者： Xiao-Li Mei Shu-Yi wu Si-lan wu Xiao-Lin Luo Si-Xing Huang Rui Liu Zhe Qiang Department of Pharmacology and Toxicology Sichuan-Chongqing Joint Key Laboratory of New Chinese Medicine Creation LaboratoryChongqing Academy of Chinese Materia MedicaChongqing 400061China College of Chinese Medicine Chongqing College of Traditional Chinses MedicineChongqing 402760China Department of Oncology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China College of Pharmacy Chongqing Medical UniversityChongqing 400010China

BACKGROUND The modified Xiaoyao San(MXS)formula is an adjuvant drug recommended by the National Health Commission of China for the treatment of liver cancer,which has the effect of preventing postoperative recurrence and metastasis of hepatocellular carcinoma and prolonging patient ***,the molecular mechanisms underlying that remain *** To investigate the role and mechanisms of MXS in ameliorating hepatic injury,steatosis and *** A choline-deficient/high-fat diet-induced rat nonalcoholic steatohepatitis(NASH)model was used to examine the effects of MXS on lipid accumulation in primary *** tissues were collected for western blotting and immunohisto chemistry(IHC)*** accumulation and hepatic fibrosis were detected using oil red staining and Sirius red *** serum samples were collected for biochemical assays and NMR-based metabonomics *** inflammation/lipid metabolism-related signaling and regulators in liver tissues were also detected to reveal the molecular mechanisms of MXS against *** MXS showed a significant decrease in lipid accumulation and inflammatory response in hepatocytes under metabolic *** western blotting and IHC results indicated that MXS activated AMPK pathway but inhibited the expression of key regulators related to lipid accumulation,inflammation and hepatic fibrosis in the pathogenesis of *** metabonomics analysis systemically indicated that the arachidonic acid metabolism and steroid hormone synthesis are the two main target metabolic pathways for MXS to ameliorate liver inflammation and hepatic ***,we found that MXS protected against NASH by attenuating the sex hormone-related metabolism,especially the metabolism of male *** MXS ameliorates inflammation and hepatic steatosis of NASH by inhibiting the metabolism of male *** male hormone related metabolic pathways may be the potential therapeutic app

关键词： Hepatic steatosis Inflammation Sex hormone metabolism Male hormone Phosphatase and tensin homolog deleted on chromosome ten

Preparation of(Lu,Y)_(3)(Al,Sc,Cr)_(2)Al_(3)O_(12)phosphor ceramics with high thermal stability for near-infrared LED/LD

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Journal of Advanced Ceramics 2024年第3期13卷 354-363页

作者： Yuelong Ma Xingcan Li lan wu Chenyang Shao Boqiang Zhang Tao Pang Lili Lu Hui Qiu Ye Tian Guilu Wang Yanbo Hui Qianwen Guo Daqin Chen School of Mechanical and Electrical Engineering Henan University of TechnologyZhengzhou 450001China Huzhou Key Laboratory of Materials for Energy Conversion and Storage College of ScienceHuzhou UniversityHuzhou 313000China College of Physics and Energy Fujian Normal UniversityFuzhou 350117China SongShan Laboratory Zhengzhou 450046China College of Food Science and Engineering Henan University of TechnologyZhengzhou 450046China School of Mechanical Engineering Zhengzhou University of Science and TechnologyZhengzhou 450064China

Near-infrared(NIR)phosphor-converted light-emitting diodes/laser diodes(LEDs/LDs)are prospective lighting sources for NIR ***,developing NIR phosphor materials with desired thermal robustness and high photoelectric efficiency is a crucial challenge for their *** this work,based on the cationic radius matching effect,a series of(Lu,Y)_(3)(Al,Sc,Cr)_(2)Al_(3)O_(12)NIR phosphor ceramics(LuYScCr NIR-PCs)were fabricated by vacuum *** thermal stability(95%@150℃)was obtained in the prepared NIR-PCs,owing to their weak electron-phonon coupling effect(small Huang-Rhys factor).Being excited at 460 nm,NIR-PCs realized a broadband emission(650-850 nm)with internal quantum efficiency(IQE)of 60.68%.Combining NIR-PCs with LED/LD chips,the maximum output power of the encapsulated LED prototype was 447 mW@300 mA with photoelectric efficiency of as high as 18.6%@180 mA,and the maximum output power of the LD prototype was 814 mW@2.5 *** working temperatures of NIR-PCs were 70.8℃@300 mA(LED)and 102.8℃@3 A(LD).Finally,the prepared NIR-PCs applied in food detection were verified in this study,demonstrating their anticipated application prospects in the future.

关键词： thermal stability electron phonon coupling effect photoelectric efficiency near-infrared phosphor ceramics(NIR-PCs) NIR light-emitting diode/laser diode(LED/LD)prototype

Comprehensive,Continuous,and Vertical Measurements of Seawater Constituents with Triple-Field-of-View High-Spectral-Resolution Lidar

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Research 2024年第2期2023卷 191-201页

作者： Kai Zhang Yatong Chen Hongkai Zhao Zhongping Lee Emmanuel Boss Iwona Stachlewska Davide Dionisi Cedric Jamet Paolo D.Girolamo Aleksey Malinka Chengchong Jiang Hongda wu Lingyun wu Feitong Chen Xiaolei Zhu Nanchao Wang Chuxiao Chen Qun Liu lan wu Yudi Zhou Weibiao Chen Dong Liu Ningbo Research Institute State Key Laboratory of Modern Optical InstrumentationCollege of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological lnnovation Center Zhejang UniversityHangzhou 311200China Donghai Laboratory.Zhoushan 316021 China State Key Lab of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China School of Marine Sciences University of MaineOronoME 04469-5741USA Faculty of Physics University of WarsawWarsaw 02093Poland institute of Marine Sciences Italian National Research CouncilRome 00133Italy Universitédu Littoral Cote d'Opale CNRSUniv.LilleIRDUMR 8187-LOG-Laboratoire d'Oceanologie et de GéosciencesWimereux F-6293 Francen Institute Scuola di Ingegneria Universita della BasilicataPotenza 85100Italy Institute of Physics National Academy of Sciences of BelarusMinsk 220072Belarus Key Laboratory of Space Laser Communication and Detection Technology Shanghai lnstitute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Inteligent Optics&Photonics Research Center Jiaxing Research Institute Zhejiang UniversityJiaxing 314000China Jiaxing Key Laboratory of Photonic Sensing&Intelligent Imaging Jiaxing 314000China

Measuring the characteristics of seawater constituent is in great demand for studies of marine ecosystems and ***,existing techniques based on remote sensing or in situ samplings present various tradeoffs with regard to the diversity,synchronism,temporal-spatial resolution,and depth-resolved capacity of their data ***,we demonstrate a novel oceanic triple-field-of-view(FOV)high-spectral-resolution lidar(HSRL)with an iterative retrieval *** technique provides,for the first time,comprehensive,continuous,and vertical measurements of seawater absorption coefficient,scattering coefficient,and slope of particle size distribution,which are validated by simulations and field ***,it depicts valuable application potentials in the accuracy improvement of seawater classification and the continuous estimation of depth-resolved particulate organic carbon *** triple-FOV HSRL with high performance could greatly increase the knowledge of seawater constituents and promote the understanding of marine ecosystems and biogeochemistry.

关键词： lidar Vertical seawater

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基于方差异质性随机参数模型的汇合行为分析

吉林大学学报（工学版） 2024年第4期54卷 883-889页

作者：邬岚赵乐李根南京林业大学汽车与交通工程学院南京210037

为研究高速公路交织区入口匝道车辆汇入主线的换道行为,基于方差异质性随机参数模型构建了车辆汇入换道模型,先从NGSIM数据集中提取7个在统计上显著且对换道行为有影响的解释变量,然后将其引入方差异质性随机参数模型探索潜在异质性,计... 详细信息

为研究高速公路交织区入口匝道车辆汇入主线的换道行为,基于方差异质性随机参数模型构建了车辆汇入换道模型,先从NGSIM数据集中提取7个在统计上显著且对换道行为有影响的解释变量,然后将其引入方差异质性随机参数模型探索潜在异质性,计算各变量平均边际效应量化对换道行为的影响,最后提出了“个体样本精度”指标对模型进行比较。研究结果表明:汇入车辆与目标车道领车的车头间距、目标车道领车宽度、辅助车道领车速度对换道行为产生了显著的影响,且汇入车辆在辅助车道上的纵向位置显著影响汇入车辆与目标车道领车的车头间距,方差异质性随机参数模型比未考虑方差异质性的随机参数模型和二元Logit模型具有更高的拟合优度和模型精度,能够更好地解释车辆汇入行为中的潜在异质性。本文的研究成果可应用于自动驾驶辅助系统和交通流仿真软件中,对阐明车道变换行为的机理有一定的参考价值。

关键词：交通运输安全工程方差异质性随机参数模型汇合行为高速公路交织区

Non-contact wide-field viewing system-assisted scleral buckling surgery for retinal detachment in silicone oilfilled eyes

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 761-766页

作者： Su-lan wu Yi-Qi Chen Li-Jun Shen Jian-Bo Mao Li Lin Ji-Wei Tao Huan Chen Shi-An Zhang Jia-Feng Yu Chen-Xi Wang Center for Rehabilitation Medicine Department of OphthalmologyZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina The Affiliated Eye Hospital of Wenzhou Medical University in Hangzhou Hangzhou 310000Zhejiang ProvinceChina

AIM:To evaluate scleral buckling(SB)surgery using a noncontact wide-field viewing system and 23-gauge intraocular illumination for the treatment of rhegmatogenous retinal detachment in silicone oil(SO)-filled ***:Totally 9 patients(9 eyes)with retinal detachment in SO-filled eyes were retrospectively *** patients underwent non-contact wide-field viewing system-assisted buckling surgery with 23-gauge intraocular *** was removed at an appropriate time based on *** patients were followed up for at least 3mo after SO *** reattachment,complications,visual acuity and intraocular pressure(IOP)before and after surgery were ***:Patients were followed up for a mean of 8.22mo(3-22mo)after SO *** patients had retinal *** the final follow-up,visual acuity showed improvement for 8 patients,and no change for 1 *** IOP was high in 3 patients before surgery,but it stabilized after treatment;it was not affected in the other *** of the patients had infections,hemorrhage,anterior ischemia,or any other ***:This new non-contact wide-field viewing system-assisted SB surgery with 23-gauge intraocular illumination is effective and safe for retinal detachment in SO-filled eyes.

关键词： non-contact wide-field viewing system scleral buckling silicone oil-filled retinal detachment

土司文化赋能广西乡村文化振兴的实践路径研究

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贺州学院学报 2024年第1期40卷 29-35页

作者：蓝武广西师范大学历史文化与旅游学院广西桂林541001

广西壮族土司文化历史悠久、底蕴深厚,内涵丰富、类型多样,是广西少数民族文化的突出特色之一,具有较高的历史价值。优秀土司文化资源独特的历史价值、政治价值、经济价值、教育价值与实践价值,在全面推进乡村文化振兴的时代背景下亦大... 详细信息

广西壮族土司文化历史悠久、底蕴深厚,内涵丰富、类型多样,是广西少数民族文化的突出特色之一,具有较高的历史价值。优秀土司文化资源独特的历史价值、政治价值、经济价值、教育价值与实践价值,在全面推进乡村文化振兴的时代背景下亦大有可为。迄今为止,广西壮族土司文化资源的保护、开发与利用程度尚显偏低,其应有的时代价值与社会功能没有得到充分发挥。广西各地土司文化富集地应切实提高历史文化遗产保护、开发与利用的意识,深入挖掘土司文化的内在价值及社会功能,统筹推进土司文化与基层社会治理、乡土历史教育、乡村旅游产业及现代新技术的耦合,使土司文化在新时代背景下有效赋能乡村文化振兴、推进乡村现代化建设的进程。

关键词：土司文化历史文化遗产乡村振兴

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城市出入口连接段处货车专用道研究

重庆交通大学学报（自然科学版） 2024年第4期43卷 74-79页

作者：邬岚梁栋朱兴贝南京林业大学汽车与交通工程学院江苏南京210037

为缓解物流业迅速发展导致的大型物流园区与高速公路的国道连接路段客货拥堵问题,从城市出入口连接段的交通流特性出发,根据连接段交叉口货车与客车的转向数量及比例,建立货车专用道交织区长度计算模型,并且对不同车道数的交叉口进口道... 详细信息

为缓解物流业迅速发展导致的大型物流园区与高速公路的国道连接路段客货拥堵问题,从城市出入口连接段的交通流特性出发,根据连接段交叉口货车与客车的转向数量及比例,建立货车专用道交织区长度计算模型,并且对不同车道数的交叉口进口道进行渠化,将专用道交织区长度计算模型和进口道渠化方案进行了仿真,验证了交织区长度计算模型与交叉口渠化方案的可行性。

关键词：交通运输工程连接段交通组织货车专用道国道

高等职业教育与百县千村共振发展的路径探索研究

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对外经贸 2024年第7期 153-156页

作者：吴岚汕头职业技术学院广东汕头515071

通过阐述高等职业教育与百县千村共振发展的背景,分析高等职业教育与百县千村之间的内在联系。在此基础上,深入探讨高等职业教育与百县千村共振发展的路径,建立高等职业教育与百县千村合作机制;优化专业设置,对接乡村产业需求;加强实践... 详细信息

通过阐述高等职业教育与百县千村共振发展的背景,分析高等职业教育与百县千村之间的内在联系。在此基础上,深入探讨高等职业教育与百县千村共振发展的路径,建立高等职业教育与百县千村合作机制;优化专业设置,对接乡村产业需求;加强实践教学,提升学生服务乡村能力。提出相应的对策建议,政府部门应增强对高等职业教育的投入与支持,完善相关政策,鼓励高等职业院校与县级政府、企事业单位开展合作,共同培育符合地方经济发展需求的高素质技能人才。

关键词：高等职业教育乡村振兴乡村经济共振发展

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客家服饰在赣南旅游业发展中的价值研究

西部皮革 2024年第7期46卷 37-39页

作者：吴岚赣南师范大学

文章通过对客家服饰独特文化符号及其历史和艺术价值的分析，探讨了赣南客家服饰在旅游业发展中的价值与意义。研究得出，在赣南旅游业发展中，客家服饰在提升游客体验、促进文化传承与创新、塑造景区形象等方面具有显著作用。同时指出... 详细信息

文章通过对客家服饰独特文化符号及其历史和艺术价值的分析，探讨了赣南客家服饰在旅游业发展中的价值与意义。研究得出，在赣南旅游业发展中，客家服饰在提升游客体验、促进文化传承与创新、塑造景区形象等方面具有显著作用。同时指出，为应对文化同质化和资源保护的挑战，亟待加强服饰文化传承与创新，并结合现代审美观念与市场需求进行创新性创作，在加强服饰品牌建设和市场推广的基础上，充分发挥赣南客家服饰在旅游发展中的作用，推动服饰与旅游业的融合发展，促进文化传承与创新，以助于推动当地经济和社会发展。

关键词：客家服饰旅游发展文化传承