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Dexamethasone implant in naive versus refractory patients with diabetic macular edema:a Meta-analysis

International Journal of Ophthalmology(English edition) 2024年第10期17卷 1898-1904页

作者： qian xu Chao Yang Jie Luan Department of Ophthalmology Zhongda HospitalSoutheast UniversityNanjing 210009Jiangsu ProvinceChina School of Medicine Southeast UniversityNanjing 210009Jiangsu ProvinceChina

AIM:To evaluate the efficacy and safety of the intravitreal dexamethasone implant in naive and refractory patients with diabetic macular edema(DME).METHODS:PubMed,Embase,Web of Science,and Medline databases were *** main outcomes were best-corrected visual acuity(BCVA)and central retinal thickness(CRT).The secondary outcomes included mean number of injections,intraoperative or postoperative complications including intraocular pressure(IOP)elevation and ***:Ten comparative studies involving a total of 1000 DME eyes including 402 naive eyes and 598 refractory eyes were *** postoperative BCVA in the naive group was significantly better than in the refractory group[mean difference(MD)-0.11,95%confidence interval(CI)-0.17 to-0.05,P=0.0003;MD 8.69,95%CI 5.08 to 12.30,P<0.00001].Additionally,the naive group got greater improvement of BCVA change as well as more gains of BCVA letters than the refractory group[MD 7.71,95%CI 2.02 to 13.40,P=0.008;odds ratio(OR)2.99,95%CI 2.05 to 4.37,P<0.00001].The subgroup analysis revealed that the naive group had significantly higher BCVA gains of≥5,≥10,and≥15 letters compared to the refractory group(P=0.002,0.0001,0.003,respectively).No significant difference was detected between the two groups in either postoperative CRT(MD-22.36,95%CI-46.39 to 1.66,P=0.07)or the overall mean number of injections(MD-0.08,95%CI-0.38 to 0.22,P=0.61).Intraoperative and postoperative complications including the elevation of IOP(OR 0.47,95%CI 0.20 to 1.13,P=0.09)and cataract(OR 1.78,95%CI 0.97 to 3.24,P=0.06)showed no significant differences between the two groups during the follow-up ***:Intravitreal dexamethasone implants for DME can improve anatomical and functional outcomes in both naive and refractory eyes and have a well-acceptable safety ***,naive eyes maintain better visual outcomes than refractory *** provides further evidence of better visual response when used for naive eyes as firstline t

关键词： diabetic macular edema dexamethasone implant refractory eyes systemic review

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Significantly enhanced performance and conductivity mechanism in Nb/Mn co-doped CaBi_(4)Ti_(4)O_(15)ferroelectrics

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Journal of Materiomics 2024年第3期10卷 652-669页

作者： Jiageng xu Shaoxiong Xie qian xu Jie Xing Qingyuan Wang Jianguo Zhu School of Aeronautics and Astronautics Sichuan UniversityChengdu610000China Institute for Advanced Study Chengdu UniversityChengdu610106China Department of Mechanical Engineering Kyushu UniversityFukuoka819-0395Japan College of Architecture and Environment Sichuan UniversityChengdu610065China College of Material Science and Engineering Sichuan UniversityChengdu610065China

With the rapid development of high-end industries,the demand for high-temperature piezoelectric materials is significantly ***,realizing the ultra-high performance to meet more ap-plications still faces major scientific and engineering challenges of our ***,a new Nb/Mn co-doped CaBi_(4)Ti_(4)O_(15)(CBT)high-temperature piezoelectric material system of CaBi_(4)Ti_(4-x)(Nb_(2/3)Mn_(1/3))_(x)O_(15)was synthesized by the conventional solid-state sintering *** results show that the addition of the dopants tends to break the long-range ferroelectric chain and soften the flexibility of polarization,resulting in more distorted crystal structure and better ferroelectric properties of CBT *** ultra-high piezoelectric constant(d_(33)=26.8 pC/N)is thus attained in CBT-based ceramics with x=0.12,which is about several times larger than that of pure CBT ***,numerous nano-sized layered domain structures that lie on the lateral plane of grains are observed in ceramics,with lower domain wall energy and better dynamic features under electric fields,mainly responsible for the origin of enhanced ***,excess dopants could make the conductivity mechanism of CBT ceramics transform from p-type to n-type,and also result in a shift of conduction relaxation mechanism from defect dipole rotation polarization to electron relaxation *** work not only provides a promising candidate for high-temperature piezoelectric materials,but also opens a window for opti-mizing performance by tailoring domain structures using chemical modification.

关键词： CaBi_(4)Ti_(4)O_(15) Lattice distortion Electrical performance Domain structure Conductivity mechanism

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Effectiveness of intravitreal ranibizumab for diabetic macular edema in vitrectomized versus non-vitrectomized eyes:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 729-735页

作者： Yi-Heng Wang qian xu Jie Luan Department of Ophthalmology Zhongda HospitalSoutheast UniversityNanjing 210009Jiangsu ProvinceChina School of Medicine Southeast UniversityNanjing 210009Jiangsu ProvinceChina

AIM:To evaluate the effectiveness and safety of intravitreal ranibizumab(IVR)for diabetic macular edema(DME)in vitrectomized versus non-vitrectomized ***:The PubMed,EMBASE,Web of Science,Cochrane,EBSCO were comprehensively searched for studies comparing vitrectomized and non-vitrectomized eyes with *** outcomes of best-corrected visual acuity(BCVA),central macular thickness(CMT),the mean number of intravitreal injection and adverse events were extracted and ***:Six studies involving 641 eyes were *** visual gain significantly improved and CMT significantly reduced in vitrectomized eyes at 6mo and 12mo visits(P<0.05).Although the mean reduction in CMT among non-vitrectomized eyes was significantly greater than in vitrectomized eyes at the 6mo[mean difference(MD)=53.57,95%confidence interval(CI):28.03 to 78.72,P<0.0001]and 12mo(MD=49.65,95%CI:19.58 to 79.72,P=0.01),no significant difference was detected in improvement in BCVA at either 6mo(MD=0.05,95%CI:-0.02 to 0.13,P=0.14)or 12mo(MD=0.03,95%CI:-0.04 to 0.09,P=0.43).Injection number of ranibizumab in non-vitrectomized eyes was significantly less than that in vitrectomized eyes during 6-month period(MD=0.60,95%CI:0.16 to 1.04,P=0.008),while there was no statistically significant difference between the two groups during 12mo of ***:Evidence from current study suggests that IVR was useful for both vitrectomized group and nonvitrectomized group with *** less reduction in macular thickness is found in vitrectomized group,visual improvement between two groups is similar.

关键词： diabetic macular edema ranibizumab vitrectomized eye

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The Adjustment Analysis Method of the Active Surface Antenna Based on Convolutional Neural Network

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Research in Astronomy and Astrophysics 2024年第6期24卷 294-306页

作者： You Ban Shang Shi Na Wang qian xu Shufei Feng School of Mechanical Engineering Xinjiang UniversityUrumqi 830017China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808China

Active surface technique is one of the key technologies to ensure the reflector accuracy of the millimeter/submillimeter wave large reflector *** antenna is complex,large-scale,and high-precision equipment,and its active surfaces are affected by various factors that are difficult to comprehensively deal *** this paper,based on the advantage of the deep learning method that can be improved through data learning,we propose the active adjustment value analysis method of large reflector antenna based on deep *** method constructs a neural network model for antenna active adjustment analysis in view of the fact that a large reflector antenna consists of multiple panels spliced *** on the constraint that a single actuator has to support multiple panels(usually 4),an autonomously learned neural network emphasis layer module is designed to enhance the adaptability of the active adjustment neural network *** classical 8-meter antenna is used as a case study,the actuators have a mean adjustment error of 0.00252 mm,and the corresponding antenna surface error is0.00523 *** active adjustment result shows the effectiveness of the method in this paper.

关键词： techniques:radar astronomy telescopes methods:analytical methods:numerical

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Systematic review and network meta-analysis of different nonsteroidal anti-inflammatory drugs for juvenile idiopathic arthritis

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World Journal of Clinical Cases 2024年第12期12卷 2056-2064页

作者： Tao Zeng Jian-Zhong Ye Hui Qin qian-qian xu College of Medicine Jingchu University of Technology JingmenJingmen 448000Hubei ProvinceChina

BACKGROUND Various non-steroidal anti-inflammatory drugs(NSAIDs)have been used for juvenile idiopathic arthritis(JIA).However,the optimal method for JIA has not yet been *** To perform a systematic review and network meta-analysis to determine the optimal *** We searched for randomized controlled trials(RCTs)from PubMed,EMBASE,Google Scholar,CNKI,and Wanfang without restriction for publication date or language at August,*** RCTs that comparing the effectiveness of NSAIDs with each other or placebo for JIA were included in this network *** surface under the cumulative ranking curve(SUCRA)analysis was used to rank the treatments.P value less than 0.05 was identified as statistically *** We included 8 RCTs(1127 patients)comparing 8 different instructions including meloxicam(0.125 qd and 0.250 qd),Celecoxib(3 mg/kg bid and 6 mg/kg bid),piroxicam,Naproxen(5.0 mg/kg/d,7.5 mg/kg/d and 12.5 mg/kg/d),inuprofen(30-40 mg/kg/d),Aspirin(60-80 mg/kg/d,75 mg/kg/d,and 55 mg/kg/d),Tolmetin(15 mg/kg/d),Rofecoxib,and *** were no significant differences between any two NSAIDs regarding ACR Pedi 30 *** SUCRA shows that celecoxib(6 mg/kg bid)ranked first(SUCRA,88.9%),rofecoxib ranked second(SUCRA,68.1%),Celecoxib(3 mg/kg bid)ranked third(SUCRA,51.0%).There were no significant differences between any two NSAIDs regarding adverse *** SUCRA shows that placebo ranked first(SUCRA,88.2%),piroxicam ranked second(SUCRA,60.5%),rofecoxib(0.6 mg/kg qd)ranked third(SUCRA,56.1%),meloxicam(0.125 mg/kg qd)ranked fourth(SUCRA,56.1%),and rofecoxib(0.3 mg/kg qd)ranked fifth(SUCRA,56.1%).CONCLUSION In summary,celecoxib(6 mg/kg bid)was found to be the most effective NSAID for treating ***,piroxicam,and meloxicam may be safer options,but further research is needed to confirm these findings in larger trials with higher quality studies.

关键词： Non-steroidal anti-inflammatory drugs Juvenile idiopathic arthritis Network meta-analysis Systematic review

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Nonlinear Impact Damage Evolution of Charpy Type and Analysis of Its Key Influencing Factors

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 254-264页

作者： Jianfeng Mao qian xu Jiadong Yang Chi Cao Dasheng Wang Fengping Zhong Mingya Chen Institute of Process Equipment and Control Engineering Zhejiang University of TechnologyHangzhou 310032China Taizhou Key Laboratory of Advanced Manufacturing Technology Taizhou InstituteZhejiang University of TechnologyTaizhou 318014China State Key Laboratory of Nuclear Power Safety Monitoring Technology and Equipment Shenzhen 518172China Zhejiang Academy of Special Equipment Science Hangzhou 310020China Suzhou Nuclear Power Research Institute Suzhou 215004China

The current research of Charpy impact mainly focuses on obtaining the ductile brittle transition temperature of materials by *** with experiments,numerical simulation can study many problems with harsh ***,there are still few studies on the influence of geometric factors such as side *** this paper,the geometry of standard Charpy impact test is *** with different widths and side grooves are *** finite element model of Charpy impact was established by ABAQUS *** test results and simulation results to verify each *** effects of sample width,side groove depth and side groove bottom fillet on the impact fracture resistance of the sample were *** results show that the specimen width is positively correlated with the impact toughness of the *** side groove greatly reduces the impact toughness of the material;the toughness of side groove decreases with the increase of depth;the fracture toughness of side groove decreases with the increase of fillet at the bottom of side *** proportion of toughness energy to impact energy of samples was *** results show that the toughness energy accounts for about 70%of the impact energy of the sample,which has little to do with the geometric characteristics of the *** study presents a reliable method for studying Charpy impact *** influence of geometric parameters is obtained,which provides a reference method for the study of impact toughness of high toughness materials.

关键词： Johnson-Cook model Impact toughness Charpy impact

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Current trends and hotspots of depressive disorders with colorectal cancer:A bibliometric and visual study

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3687-3704页

作者： Zi-Wei Yan Ying-Nan Liu qian xu Yuan Yuan Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Laboratory of GI Cancer Etiology and Prevention in Liaoning Province The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Depression is strongly associated with colorectal cancer(CRC).Few bibliometric analyses have systematically summarized the research focus and recent progress in this *** To determine the research status and hotspots by bibliometric analysis of relevant publications on the relationship between CRC and *** Articles on depression in CRC patients were collected from the Web of Science Core *** and VOSviewer software were used to visualize bibliometric *** From 2001 to 2022,Supportive Care in Cancer,the United States,Tilburg University,and Mols were the most productive and influential journal,country,institution,and author ***-occurrence cluster analysis of keywords placed quality of life,anxiety,and psychological stress in the center of the visual network *** clustering was performed for the clusters with studies of the relevant mechanism of action,which showed that:(1)Cytokines have a role essential for the occurrence and development of depressive disorders in CRC;(2)MicroRNAs have a role essential for the development of depressive disorders in CRC;(3)Some anticancer drugs have pro-depressant activity;and(4)Selective serotonin reuptake inhibitors have both antitumor and antidepressant *** Life quality and psychological nursing of the cancer population were key *** roles of cytokines and microRNAs,the pro-depression activity of anticancer drugs and their antitumor properties deserve in-depth study.

关键词： Depression Colorectal cancer Bibliometric analysis Cytokines Drugs Mechanism

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Heteroatom doping regulates the catalytic performance of singleatom catalyst supported on graphene for ORR

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Nano Research 2024年第3期17卷 1086-1093页

作者： Ji-Kai Sun Yu-Wei Pan Meng-qian xu Lei Sun Shaolong Zhang Wei-Qiao Deng Dong Zhai Institute of Molecular Sciences and Engineering Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

Replacing fossil fuels with fuel cells is a feasible way to reduce global energy shortages and environmental ***,the oxygen reduction reaction(ORR)at the cathode has sluggish kinetics,which limits the development of fuel *** is significant to develop catalysts with high catalytic activity of *** single-atom catalysts(SACs)of Pt supported on heteroatom-doped graphene are potential candidates for *** we studied the SACs of Pt with different heteroatoms doping and screened out Pt-C_(4) and Pt-C_(3)O_(1) structures with only 0.13 V overpotential for ***,it is found that B atoms doping could weaken the adsorption capacity of Pt,while N or O atoms doping could enhance *** regularity was verified on Fe *** the electronic interaction analysis between Pt and adsorbate,we explained the mechanism of this regularity and further proposed a new descriptor named corrected d-band center(ε_(d-corr))to describe *** descriptor is an appropriate reflection of the number of free electrons of the SACs,which could evaluate its adsorption *** work provides a purposeful regulatory strategy for the design of ORR catalysts.

关键词： single-atom catalyst(SAC) oxygen reduction reaction(ORR) heteroatom doping corrected d-band center descriptor

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No tillage increases soil microarthropod(Acari and Collembola)abundance at the global scale

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Soil Ecology Letters 2024年第2期6卷 5-19页

作者： Yulin Liu Lihong Song Donghui Wu Zihan Ai qian xu Xin Sun Liang Chang State Key Laboratory of Black Soil Conservation and Utilization Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun130102China University of Chinese Academy of Sciences Beijing100049China College of Agriculture Guizhou UniversityGuiyang550025China Key Laboratory of Urban Environment and Health Ningbo Observation and Research StationFujian Key Laboratory of Watershed EcologyInstitute of Urban EnvironmentChinese Academy of SciencesXiamen361021China Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control CAS Haixi Industrial Technology Innovation Center in BeilunNingbo315830China

Conservation tillage increases soil microarthropod abundance at the global *** effect of conservative tillage on microarthropods is soil *** positive effect of conservation tillage is particularly evident in nutrient-poor soil *** temperate humid regions,however,this positive effect of conservation tillage is *** effect of conservative tillage on microarthropods varies with fauna group and climate regions.

关键词： no tillage soil microarthropod Acari Collembola meta-analysis

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Recent Advances in Electrochemical-Based Silicon Production Technologies with Reduced Carbon Emission

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Research 2024年第1期2023卷 209-236页

作者： Feng Tian Zhongya Pang Shen Hu xueqiang Zhang Fei Wang Wei Nie xuewen Xia Guangshi Li Hsien-Yi Hsu qian xu Xingli Zou Li Ji Xionggang Lu State Key Laboratory of Advanced Special Steel&Shanghai Key Laboratory of Advanced Ferrometallurgy&School of Materials Science and Engineering Shanghai University99#Shangda RoadShanghai 200444China Center for Hydrogen Metallurgy Technology Shanghai UniversityShanghai 200444China State Key Laboratory of ASIC and System School of MicroelectronicsFudan University220#Handan RoadShanghai 200433China School of Energy and Environment Department of Materials Science and EngineeringCity University of Hong KongKowloon TongHong KongChina

Sustainable and low-carbon-emission silicon production is currently one of the main focuses for the metallurgical and materials science ***,considered a promising strategy,has been explored to produce silicon due to prominent advantages:(a)high electricity utilization efficiency;(b)low-cost silica as a raw material;and(c)tunable morphologies and structures,including films,nanowires,and *** review begins with a summary of early research on the extraction of silicon by *** has been placed on the electro-deoxidation and dissolution–electrodeposition of silica in chloride molten salts since the 21st century,including the basic reaction mechanisms,the fabrication of photoactive Si films for solar cells,the design and production of nanoSi and various silicon components for energy conversion,as well as storage ***,the feasibility of silicon electrodeposition in room-temperature ionic liquids and its unique opportunities are *** this basis,the challenges and future research directions for silicon electrochemical production strategies are proposed and discussed,which are essential to achieve large-scale sustainable production of silicon by electrochemistry.

关键词： directions electrodeposition electricity

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