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珠江口盆地珠一坳陷西部中新世早-中期沉积特征及控制因素

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古地理学报 2022年第1期24卷 99-111页

作者：李智高丁琳李小平吴宇翔李潇郭伟向巧维中海石油(中国)有限公司深圳分公司广东深圳518054

大型海相三角洲分布范围广,沉积动力复杂,其精细层序—沉积构型和演化规律是沉积学领域长期研究的热点。综合岩矿、测井和三维地震资料,充分结合高精度层序地层学和三维地震沉积学分析方法,对古珠江三角洲西侧的恩平地区中新世早-中期... 详细信息

大型海相三角洲分布范围广,沉积动力复杂,其精细层序—沉积构型和演化规律是沉积学领域长期研究的热点。综合岩矿、测井和三维地震资料,充分结合高精度层序地层学和三维地震沉积学分析方法,对古珠江三角洲西侧的恩平地区中新世早-中期沉积特征进行了精细研究,识别出了辫状河道、曲流河道等河控三角洲的主要微相单元,同时也揭示出海岸砂脊等浪控三角洲中发育的典型微相类型。在高精度层序格架约束下,揭示出单一典型层序内古珠江三角洲的演化特征:低位体系域以河控三角洲为主,发育大型交切状辫状水道;海侵和高位体系域河道规模明显减小,以小规模曲流河道为主,且易于见到海岸砂脊等波浪作用的典型特征。此外,针对恩平地区中新世早-中期沉积相带的系统编图和演化分析,在大约6 Ma时间内识别出6次河道大规模改道现象,推测恩平地区沉积演化明显受到自旋回沉积过程的影响。

关键词：珠江三角洲恩平凹陷沉积演化中新世控制因素

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天福庙水库坝肩稳定分析及加固设计

人民长江 2006年第11期37卷 16-18页

作者：肖桃先莫珍李志高长江水利委员会设计院湖北武汉430010

天福庙浆砌石双曲拱坝最大坝高63.3 m,工程于1978年1月基本建成蓄水,但坝体渗漏严重,后虽多次进行坝体防渗及右岸F15断层灌浆处理,但水库一直只能限制蓄水运行。用刚体极限平衡法分析了两岸拱座的抗滑稳定,分析结果表明左坝肩抗滑稳定... 详细信息

天福庙浆砌石双曲拱坝最大坝高63.3 m,工程于1978年1月基本建成蓄水,但坝体渗漏严重,后虽多次进行坝体防渗及右岸F15断层灌浆处理,但水库一直只能限制蓄水运行。用刚体极限平衡法分析了两岸拱座的抗滑稳定,分析结果表明左坝肩抗滑稳定安全系数不满足现行规范要求,右坝肩抗滑稳定安全系数满足现行规范要求;据此提出了在左坝肩设置阻滑键等加固处理措施,加固后左坝肩抗滑稳定安全系数满足现行规范要求。

关键词：坝肩抗滑稳定加固设计刚体极限平衡法天福庙水库

含银杏叶提取物的肺保护液对心内直视术患者肺的保护作用

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中国现代医学杂志 2008年第14期18卷 1987-1990页

作者：李志高贺大璞王元星南华大学附属第一医院湖南衡阳421001

目的探讨体外循环(CPB)期间肺动脉灌注低温含银杏叶提取物的肺保护液对MDA、IL-6和TNF-α的影响,观察其对肺脏的保护作用。方法30例二尖瓣置换术患者随机等分为保护组和对照组,均在CPB下行心内直视术,保护组CPB期间经肺动脉灌注低温含... 详细信息

目的探讨体外循环(CPB)期间肺动脉灌注低温含银杏叶提取物的肺保护液对MDA、IL-6和TNF-α的影响,观察其对肺脏的保护作用。方法30例二尖瓣置换术患者随机等分为保护组和对照组,均在CPB下行心内直视术,保护组CPB期间经肺动脉灌注低温含银杏叶提取物的保护液,对照组灌注等量生理盐水,其他处理与保护组相同。监测CPB前和CPB后0、6、12和24h患者的血氧指数、血浆丙二醛(MDA)、肿瘤坏死因子α(TNF-α)及白细胞介素6(IL-6)的变化,并观察肺组织形态学改变。结果保护组各时点血氧指数均高于对照组(P<0.05),CPB后血浆MDA、IL-6和TNF-α水平较术前升高(P<0.05);在CPB后各时间点,肺保护组患者血浆IL-6、TNF-α和MDA均低于对照组(P<0.05);对照组肺组织可见中性粒细胞浸润、肺间质水肿、肺泡壁小血管扩张、充血,保护组肺组织炎性反应较轻微。结论CPB可引起患者术后血浆MDA、IL-6和TNF-α水平升高;经肺动脉灌注低温含银杏叶提取物的肺保护液可抑制心内直视术后患者血浆MDA、IL-6以及TNF-α的表达,减轻肺组织的炎性损伤。

关键词：体外循环肺灌注低温银杏叶提取物

Pulsed dynamic electrolysis enhanced PEMWE hydrogen production:Revealing the effects of pulsed electric fields on protons mass transport and hydrogen bubble escape

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Journal of Energy Chemistry 2025年第1期100卷 201-214页

作者： Xuewei Zhang Wei Zhou Yuming Huang liang Xie Tonghui li Huimin Kang lijie Wang Yang Yu Yani Ding Junfeng li Jiaxiang Chen Miaoting Sun Shuo Cheng Xiaoxiao Meng Jihui gao Guangbo Zhao School of Energy Science and Engineering Harbin Institute of Technology China Datang Technology Innovation Co. Ltd

The transition of hydrogen sourcing from carbon-intensive to water-based methodologies is underway,with renewable energy-powered proton exchange membrane water electrolysis （PEMWE） emerging as the preeminent pathway for hydrogen *** remarkable advancements in this field,confronting the sluggish electrochemical kinetics and inherent high-energy consumption arising from deteriorated mass transport within PEMWE systems remains a formidable *** impediment stems primarily from the hindered protons mass transfer and the untimely hydrogen bubbles *** address these challenges,we harness the inherent variability of electrical energy and introduce an innovative pulsed dynamic water electrolysis *** to constant voltage electrolysis (hydrogen production rate:51.6 m L h-1,energy consumption:5.37 kWh Nm-3H2),this strategy (hydrogen production rate:66 m L h-1,energy consumption:3.83 kWh Nm-3H2) increases the hydrogen production rate by approximately 27%and reduces the energy consumption by about 28%.Furthermore,we demonstrate the practicality of this system by integrating it with an off-grid photovoltaic （PV） system designed for outdoor operation,successfully driving a hydrogen production current of up to 500 mA under an average voltage of approximately 2 *** combined results of in-situ characterization and finite element analysis reveal the performance enhancement mechanism:pulsed dynamic electrolysis （PDE） dramatically accelerates the enrichment of protons at the electrode/solution interface and facilitates the release of bubbles on the electrode *** such,PDE-enhanced PEMWE represents a synergistic advancement,concurrently enhancing both the hydrogen generation reaction and associated transport *** promising technology not only redefines the landscape of electrolysis-based hydrogen production but also holds immense potential for broadening its application across a diverse spectrum of electrocatalytic endeavors.

关键词： Electrolysis

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu liu Xu gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

心内直视手术中应用小剂量鱼精蛋白的临床效果

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中国现代医学杂志 2008年第15期18卷 2185-2187页

作者：贺大璞李志高王元星南华大学附属第一医院心胸外科湖南衡阳421001

目的探讨心内直视手术中小剂量(0.33～0.67∶1)鱼精蛋白中和肝素的临床结果。方法361例心内直视手术使用小剂量鱼精蛋白中和肝素为实验组,87例心内直视手术使用鱼精蛋白1.5∶1的比例中和肝素为对照组,比较两组鱼精蛋白用量、术后引流量... 详细信息

目的探讨心内直视手术中小剂量(0.33～0.67∶1)鱼精蛋白中和肝素的临床结果。方法361例心内直视手术使用小剂量鱼精蛋白中和肝素为实验组,87例心内直视手术使用鱼精蛋白1.5∶1的比例中和肝素为对照组,比较两组鱼精蛋白用量、术后引流量、中和后的ACT值、鱼精蛋白毒性反应发生率。结果小剂量组术后引流量及二次开胸的发生率均低于对照组(P0.05),但实验组鱼精蛋白的用量、鱼精蛋白毒性反应发生率均低于对照组(P<0.01)。结论小剂量鱼精蛋白0.33～0.67∶1(鱼精蛋白/肝素)可有效地中和肝素,防止术后引流量增多,降低鱼精蛋白毒性反应的发生。

关键词：剂量鱼精蛋白体外循环心内直视手术

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin li Ting Zhang Yanlin Fu Peiyan Long Xiao gao Zhengwei Wang zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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河大水库除险加固设计

广西水利水电 2016年第3期 63-66,73页

作者：李智高陈耿广西水利科学研究院南宁530023 广西水利电力勘测设计研究院南宁530023

针对河大水库工程存在的主要问题,结合工程地质条件,采用坝基固结灌浆、防渗帷幕灌浆、封堵旧放水涵洞,新建放水隧洞、溢洪道加固衬砌等设计措施。实施后水库大坝防渗效果显著,安全度汛,达到预期效果。

关键词：水库除险加固设计

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： ling-Xiao Yi Hui Ren Woon Genevieve Saw li Zeng Eng King Tan zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches