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Changes of Serum Follicular Stimulating Hormone,Luteinizing Hormone and Follicular Sizes duringElectroacupuncture for Induction of Ovulation

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Chinese Journal of Integrative Medicine 1995年第2期1卷 13-16页

作者： Yu Jin (俞瑾) Zheng Huai-mei (郑怀美) and bing sheng-min (邴圣民)(Obstetrical and Gynecological Hospital, Shanghai Medical UniversityShanghai) (200011) Obstetrical and Gynecological Hospital Shanghai Medical University Shanghai

Changes in follicular stimulating hormone (FSH) . luteinizing hormone (LH) and follicularsizes were observed in 10 patients with chronic anovulation during electroacupuncture treatment. Sevencases were diagnosed as suffering from polycystic ovary syndrome, 2 from dysfunctional uterine bleeding,and 1 from hypogonadotropic amenorrhea. Among them 8 cases complained of infertility for an average of2. 7years. Ovulation was confirmed by pregnancy or the combination of biphasic basal body temperatureand ultrasonographic signs. During one course of 3 consecutive days of electroacupuncture treatment onacupoints Guanyuan (Ren 4), Zhongji (Ren 3), Zigong (Extra 16) and Sanyingjiao (SP 6). ovulation re-sulted in 5 patients (ovulating group) and 3 of the 4 infertile women became pregnant. Five cases failed toovulate (non-ovulating group) , 3 of them reached a biphasic basal body temperature without ovulatorysigns on ultrasonograph. Serum FSH, LH values and FSH pulse frequency increased significantly during-electroacupuncture treatment in the ovulating group (from 2. 10±0. 42 pulses/4h to 3. 70±1. 64 pulses/4h), but not in the non-ovulating group. No apparent change was found in LH pulse frequency, or in pulseamplitudes for FSH and LH. In the ovulating group, diameters of ovarian follicules markedly increased,but their growth was limited in the non-ovulation group. The results suggest ovulation may be induced byelectroacupuncture via a regulation on the hypothalamic-pituitary function, leading to normal secretion ofFSH and LH.

关键词： electroacupuncture treatment. pulsatile secretion ovarian follicle follicular stimulatinghormone. Iuteinizing hormone ovufation

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-min Xing Hai-Dong Qian Qiao Gao sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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手足综合征大鼠模型血浆细胞因子的变化

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中国皮肤性病学杂志 2017年第1期31卷 24-26,30页

作者：黎鹏王炳胜李永民河北北方学院研究生院河北张家口075000 解放军第251医院河北张家口075000 河北北方学院河北张家口075000

目的建立大鼠手足综合征模型,探讨手足综合征发病过程中相关炎性因子的水平及发病机制。方法运用卡培他滨制作手足综合征大鼠模型,分为给药1周期的A组和给药两周期的B组(连续给药7d,间隔3d,10d为一个周期),分别模拟不同给药剂量下发生... 详细信息

目的建立大鼠手足综合征模型,探讨手足综合征发病过程中相关炎性因子的水平及发病机制。方法运用卡培他滨制作手足综合征大鼠模型,分为给药1周期的A组和给药两周期的B组(连续给药7d,间隔3d,10d为一个周期),分别模拟不同给药剂量下发生的手足综合征,留取大鼠足跖部图像资料及血浆标本,检测血浆中亲胆碱能神经元因子(CNTF)、血小板衍生的内皮细胞生长因子(PD-ECGF)、白介素β(IL-β)、白介素10(IL-10)、中性粒细胞趋化因子(CINC-3)水平。结果与正常大鼠相比,1周期模型大鼠PD-ECGF,CINC-3,CNTF,IL-10,IL-β水平均升高(P0.05)。与正常大鼠相比,2周期模型大鼠及模型大鼠停药1周后CINC-3,CNTF水平明显升高(P0.05)。结论在短期给药过程中,HFS的发生主要与广泛发生的炎性损伤有关,而在较长时间的给药后,广泛的炎性反应趋于控制,而主要反应为相关炎性细胞的趋化及神经元的损伤。

关键词：卡培他滨手足综合征发病机制动物模型

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Extramedullary plasmacytoma with the uvula as first affected site:A case report

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World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： Jing Yang Hui Peng sheng-Ke Tu min Li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin Qi bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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Water environmental planning considering the influence of non-linear characteristics

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Journal of Environmental Sciences 2003年第6期15卷 800-807页

作者： ZENGGuang-min$ QINXiao-sheng WANGWei HUANGGuo-he LIJian-bing B.Statzner DepartmentofEnvironmentalScienceandEngineering HunanUniversityChangsha410082China. URACNRS1451EcologiedesEauxDoucesetdesGrandsFleuves UniversityLyonFrance

In practical water environmental planning, the influence of the non-linear characteristics on the benefit of environmental investment was seldom taken into consideration. This paper demonstrates that there exist a lot of non-linear behaviors in water environment by emphatically analyzing the influence of the non-linear characteristics of the economic scale, the meandering river and the model on water environmental planning, which will make a certain impact on the water environmental planning that sometimes cannot be neglected. This paper also preliminarily explores how to integrate the non-linear characteristics into water environmental planning. The results showed that compared with traditional methods, water environmental planning considering non-linear characteristics has its prevalence and it is necessary to develop the relevant planning theories and methods.

关键词： water environment non-linear characteristics planning

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我国农产品流通效率时空演变、地区差异与收敛性

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经济问题 2025年第1期 100-112页

作者：高国生叶林祥支海兵南京财经大学粮食和物资学院江苏南京210003 南京审计大学金审学院管理学院江苏南京210023 南京财经大学经济学院江苏南京210003

农产品流通效率事关我国粮食安全和全国统一大市场的建成。运用熵值法测度了2011—2022年我国31个省级行政区的农产品流通效率,并使用Moran’s I、Kernel核密度估计、Markov链、Dagum基尼系数和β收敛模型分别分析了我国农产品流通效率... 详细信息

农产品流通效率事关我国粮食安全和全国统一大市场的建成。运用熵值法测度了2011—2022年我国31个省级行政区的农产品流通效率,并使用Moran’s I、Kernel核密度估计、Markov链、Dagum基尼系数和β收敛模型分别分析了我国农产品流通效率的时空演变、地区差异与收敛性情况。结果显示:研究期内我国农产品流通效率存在显著正向空间相关性,“高—高”集聚和“低—低”集聚特征明显;核密度曲线宽度变大呈现右拖尾和高度差明显的双峰形态,表明农产品流通效率逐渐提升,地区内部存在极化趋势;相邻省区市空间滞后水平对本省区市农产品流通效率维持原有状态或向更高水平发展均有较大影响;地区间差异是造成农产品流通效率总体差异显著的主要原因;农产品流通效率存在显著绝对β收敛和条件β收敛。据此,对如何提高农产品流通效率和缩小地区间差距提出了相关政策建议。

关键词：农产品流通效率时空演变空间分布地区差异

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Experimental Study on the Interactions for Bluff-body and Swirl in Stabilized Flame Process

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Journal of Thermal Science 2012年第1期21卷 88-96页

作者： bing Ge Shu-sheng Zang School of Mechanical Engineering Shanghai Jiao Tong University Shanghai 200240 China

This paper focuses on investigating the interaction effects for swirl and bluff-body in stabilized flame process. Particle image velocimetry was used to measure velocity fields in three burners. First, the comparison of flames in bluff-body stabilized burners with and without swirl is presented. The results of the experiments present the variations of bluff-body stabilized flame when swirl is added into burner: the maximum reverse flow velocity and the maximum mean average radial velocity decrease; the maximum radial rootmean squared fluctuating (rms) velocity increases; the values of the axial velocity peak on the side of nozzle axis are lower, and the distance between the peak and centerline is bigger; the location of the maximum radial rms velocity moves to the outlet of annular air-flow from central recirculation zone (CRZ). Then, the comparison of flames in swirl burners with and without bluff-body is provided. The results of the experiments show the changes of swirling flame when bluff-body is added into swirl burner: the air vortex in the CRZ moves to the burner; the peak values of axial mean and rms velocity decrease; the distance between centerline and the mean axial and rms velocity peak increase; the peak of mean radial velocity decreases, and the peak of rms raidial velocity increase. The data from this experiment can also be established as benchmarks for the development and validation of combustion numerical simulations.

关键词： Swirl burners bluff-body turbulent non-premixed flames PIV

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Extraction of vanadium from high calcium vanadium slag using direct roasting and soda leaching

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International Journal of minerals,Metallurgy and Materials 2012年第7期19卷 595-601页

作者： Xin-sheng Li bing Xie College of Materials Science and Engineering Chongqing University Chongqing 400044 China

The extraction of vanadium from high calcium vanadium slag was attempted by direct roasting and soda leaching. The oxidation process of the vanadium slag at different temperatures was investigated by X-ray diffraction （XRD）, scanning electron microscopy （SEM）, and energy dispersive spectroscopy （EDS）. The effects of roasting temperature, roasting time, Na2CO3 concentration, leaching tem- perature, leaching time, and liquid to solid ratio on the extraction of vanadium were studied. The results showed that olivine phases and spinel phases in the vanadium slag were completely decomposed at 500 and 800℃, respectively. Vanadium-rich phases were formed at above 850℃. The leaching rate of vanadium reached above 90% under the optimum conditions： roasting temperature of 850℃, roasting time of 60 min, Na2CO3 concentration of 160 g/L, leaching temperature of 95℃, leaching time of 150 min, and liquid to solid ratio of 10：1 mL/g. The main impurities were Si and P in the leach liquor.

关键词： vanadium metallurgy extraction slag roasting leaching

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Region-dependent micro damage of enamel under indentation

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Acta Mechanica Sinica 2012年第6期28卷 1651-1658页

作者： bing-bing An Rao-Rao Wang .Dong-sheng Zhang Rao-Rao Wang Dong-sheng Zhang Shanghai Institute of Applied Mathematics and Mechanics 200072 Shanghai China The Tenth People's Hospital of Tongji University 200072 Shanghai China Department of Mechanics Shanghai University200444 Shanghai China Shanghai Key Laboratory of Mechanics in Energy Engineering 200072 Shanghai China

The objective of this investigation is to explore the region-dependent damage behavior of enamel, as well as to develop a good understanding of the deformation mech- anisms of enamel with numerical modeling. Nanoinden- tation experiments have been performed to investigate the load-penetration depth responses for outer and inner enamel. Results show that the unloading curve does not follow the loading curve, and degradation of stiffness in the unloading curve is observed. Based on the experimental data, a physi- cal quantity, the chain density in protein, has been introduced to the Drucker-Prager plastic model. Numerical simulations show that the simulated load-penetration depth curves agree with the experiments, and the stiffness degradation behav- iors of outer and inner enamel are captured by the numerical model. The region-dependent damage behavior of enamel could be revealed by the numerical model. The micro dam- age affected area at inner enamel is larger than that at outer enamel, indicating that the inner enamel experiences more micro damage than the outer one. Compared with its outer counterpart, the inner enamel which is rich in organic protein could break more internal protein chains to dissipate energy and to enhance its resistance to fracture accordingly.

关键词： Enamel. Nanoindentation Damage. Numerical simulation

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