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Expression characteristics of peripheral lymphocyte programmed death 1 and FoxP3+ Tregs in gastric cancer during surgery and chemotherapy

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World Journal of Gastroenterology 2023年第40期29卷 5582-5592页

作者： Hao Li Guan-mei cao Guo-Li Gu Song-Yan Li Yang Yan Ze Fu Xiao-Hui Du Graduate School Medical School of Chinese People’s Liberation ArmyBeijing 100039China Department of General Surgery Air Force Medical CenterAir Force Medical UniversityBeijing 100142China Department of Radiology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of General Surgery Chinese PLA General HospitalBeijing 100039China

BACKGROUND Programmed death 1(PD-1)and CD4^(+)CD25^(+)FoxP3^(+)expression in peripheral blood T-cells has been previously reported in various types of ***,the specific variation tendency during surgery and chemotherapy,as well as their relationship in gastric cancer patients,still remain *** this aspect may provide some novel insights for future studies on tumor recurrence and tumor immune escape,and also serve as a reference for determining the optimal timing and dose of clinical anti-PD-1 *** To observe and analyze the expression characteristics of peripheral lymphocyte PD-1 and FoxP3^(+)regulatory T cells(FoxP3^(+)Tregs)before and after surgery or chemotherapy in gastric cancer *** Twenty-nine stomach cancer patients undergoing chemotherapy after a D2 gastrectomy provided 10 mL peripheral blood samples at each phase of the perioperative period and during *** study also included 29 agematched healthy donors as a control ***-1 expression was detected on lymphocytes,including CD4^(+)CD8^(+)CD45RO^(+),CD4^(+)CD45RO^(+),and CD8^(+)CD45RO^(+)lymphocytes as well as regulatory T *** We observed a significant increase of PD-1 expression on immune subsets and a larger number of FoxP3^(+)Tregs in gastric cancer patients(P<0.05).Following D2 gastrectomy,peripheral lymphocytes PD-1 expression and the number of FoxP3^(+)Tregs notably decrease(P<0.05).However,during postoperative chemotherapy,we only observed a decrease in PD-1 expression on lymphocytes in the CD8^(+)CD45RO^(+)and CD8^(+)CD45RO^(+)***,linear correlation analysis indicated a positive correlation between PD-1 expression and the number of CD4^(+)CD45RO^(+)FoxP3high activated Tregs(aTregs)on the total peripheral lymphocytes(r=0.5622,P<0.0001).CONCLUSION The observed alterations in PD-1 expression and the activation of regulatory T cells during gastric cancer treatment may offer novel insights for future investigat

关键词： Programmed death 1 Active regulatory T cells Stomach cancer Peripheral lymphocyte

Evaluation of Compatibilizers for Improving Compatibility between Waste Vegetable Oil and Aged Asphalt

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1278-1286页

作者： WANG Yanghui DING Yongjie LI Danli cao Zhilong SUN Guoqiang mei Zijun Department of Road and Urban Railway Engineering Beijing University of TechnologyBeijing 100124China School of Civil Engineering Chongqing Jiaotong UniversityChongqing 400074China Shanghai Municipal Engineering Design Instit Shanghai 230031China

Modifying agents 2,2-Bis(4-glycidyloxyphenyl)propane(2BPE)and dibutyl phthalate(DBP)were selected to enhance the *** using molecular simulation software(Materials Studio,MS),nine systems were constructed,including molecular models of aged asphalt and WVO monomers with 2BPE and/or *** solubility parameters,Flory-Huggins parameters,and interaction energies of these systems were calculated to determine the impact of 2BPE and DBP on the compatibility of WVO and aged *** showed that the addition of 2BPE and DBP reduced the difference in the solubility parameters between WVO and aged asphalt,thus improving the compatibility between WVO and aged ***,using a combination of 2BPE and DBP in both aged asphalt and rejuvenator was found to be more effective than using either 2BPE or DBP ***,it was determined that evaluating the compatibility of WVO and aged asphalt using Van der Waals potential and non-bonding energy as evaluation indicators was more accurate than using electrostatic potential energy.

关键词： road engineering aged asphalt compatibility molecular dynamics solubility parameter Flory-Huggins parameter

CYP2C19基因型对急性心脑血管梗塞患者预后的影响

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医学信息 2024年第3期37卷 109-113页

作者：曹美娜刘小平郑艳安杨飞玉高金亮鄂尔多斯市中心医院分子医学实验室鄂尔多斯市中心医院心血管内科鄂尔多斯市中心医院神经内科鄂尔多斯市中心医院感染管理科

目的探讨急性心脑血管梗塞患者中CYP2C19基因多态性的分布特征及其检测在临床治疗中的指导价值。方法选取2017年12月-2022年12月鄂尔多斯市中心医院收治的225例急性心脑血管梗塞患者作为研究对象，检测CYP2C19基因型，将患者按照对氯... 详细信息

目的探讨急性心脑血管梗塞患者中CYP2C19基因多态性的分布特征及其检测在临床治疗中的指导价值。方法选取2017年12月-2022年12月鄂尔多斯市中心医院收治的225例急性心脑血管梗塞患者作为研究对象，检测CYP2C19基因型，将患者按照对氯吡格雷代谢反应快慢不同分为A组（快代谢型）、B组（中间代谢型）、C组（慢代谢型）。所有患者均接受基础对症治疗、支持治疗及阿司匹林治疗，给予常规剂量硫酸氢硫酸氢氯吡格雷（75 mg/d），比较三组生理生化指标、CYP2C19基因型及术后3个月内不良事件发生情况。结果三组各项生理生化指标比较，差异无统计学意义（P>0.05）;225例患者携带CYP2C19*2和*3突变杂合子的分别为84例和20例，携带CYP2C19*2和*3突变纯合子的分别为13例和0例。A组*1/*1者104例，*1/*17者4例，B组*1/*2者79例，*1/*3者20例，*2/*17者5例，C组*2/*2者13例。B组心源性再住院发生率高于A组和C组，差异有统计学意义（P0.05）。结论急性心脑血管梗塞患者术后应用硫酸氢氯吡格雷抗凝预后一定程度上受CYP2C19基因多态性的影响，CYP2C19基因检测对临床术后抗血小板治疗具有重要的指导价值，需要进一步的研究。

关键词： CYP2C19基因氯吡格雷急性心脑血管梗塞

Validation and Evaluation of a Mechanistic Model of Phasic and Phenological Development in Wheat

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Agricultural Sciences in China 2001年第1期 77-82页

作者： YAN mei-chun cao Wei-xing LI Cun-dong WANG Zhao-long Ministry of Agriculture Key Laboratory of Crop Growth Regulation Nanjing Agricultural University Nanjing 210095 Ministry of Agriculture Key Laboratory of Crop Growth Regulation Nanjing Agricultural University Nanjing 210095 Ministry of Agriculture Key Laboratory of Crop Growth Regulation Nanjing Agricultural University Nanjing 210095 Ministry of Agriculture Key Laboratory of Crop Growth Regulation Nanjing Agricultural University Nanjing 210095

Three sets of data from the field experiments with different wheat( Triticum L. ) varieties and sowing dates in China and USA were used to test the performance of the mechanistic model of wheat development. The results showed that the absolute prediction errors for most phasic and phenological stages ranged within 0 - 5 days, and the root mean square errors were generally less than 5 days. The model was of high accuracy and low error especially for emergence, tillering, stamen and pistil initiation, and heading stages, reflecting an enhanced level of mechanism and prediction.

关键词： Wheat Development stages Mechanistic model Validation

Correlation of preoperative inflammatory factors and emotional disorders with postoperative delirium in patients with craniocerebral trauma

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World Journal of Psychiatry 2024年第7期14卷 1043-1052页

作者： Peng cao Zhe-Yong Jia Tao Zheng Tao mei Department of Neurosurgery Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415003Hunan ProvinceChina

BACKGROUND Traumatic brain injury(TBI)imposes a substantial societal and familial burden due to its high disability and fatality rates,rendering it a serious public health *** patients with TBI have poor treatment outcomes and are prone to postoperative delirium(POD),which affects their quality of *** has been linked to increased POD incidence in some studies,while others have found no *** To investigate the correlation of POD risk factors,preoperative inflammatory factors,and mood disorders in patients with *** We retrospectively collected data on the treatment of 80 patients with TBI from November 2021 to September *** were grouped as POD and non-POD,according to their POD status,and the general data of the two groups were *** factor levels were detected preoperatively,and the Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)were used to investigate the risk factors associated with POD in these *** regression was used to identify the independent risk *** Twenty-one patients(26.25%)developed POD,including 7,10,and 4 cases of the excitatory,inhibitory,and mixed types,*** were 59 cases(73.75%)in the non-POD *** with the non-POD group,the POD group had a significantly higher proportion of patients with low Glasgow Coma Scale(GCS)scores before admission,unilateral mydriasis,preoperative hemorrhagic shock,intraventricular hemorrhage(IVH),and postoperative hyperglycemic hyperosmolar disease(P<0.05).In the POD group,interleukin-6(IL-6),human tumor necrosis factor-α(TNF-α),myeloperoxidase levels,HAMA,and HAMD scores were higher than those in the non-POD group(all P<0.05).Logistic multivariate analysis showed that GCS score at admission,IVH,IL-6,TNF-α,HAMA,and HAMD were independent risk factors for POD in patients with TBI(P<0.05).CONCLUSION Low GCS score at admission,IVH,elevated IL-6 and TNF-α,other inflammatory indicators,anxiety,and depress

关键词： Inflammatory factors Mood disorders Traumatic brain injury Postoperative delirium Relevance Risk factor

An AIEgen nano-assembly for simultaneous detection of ATP and H_(2)S

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Chinese Chemical Letters 2024年第6期35卷 376-379页

作者： Jia-mei Qin Xue Li Wei Lang Fu-Hao Zhang Qian-Yong cao School of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China

A new aggregation-induced emission(AIE)-based fluorescence sensor,TPEPy-SS-C14,for simultaneous recognition of adenosine triphosphate(ATP)and hydrogen sulfide(H_(2)S)has been reported via the aggregation-disaggregation *** probe self-assembles nano-structure aggregations in aqueous *** shows fluorescence turn-on response toward ATP for the complexation-enhanced aggregation,but leads to fluorescence quenching of H_(2)S for cleavage the aggregations.

关键词： AIE-based ATP detection H_(2)S detection Fluorescent sensor Cell imaging

打开课堂合作学习的黑箱:来自CSCL的经验

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教育发展研究 2018年第20期38卷 68-74页

作者：曹梅南京师范大学教育科学学院南京210097

课堂合作学习广受诟病,如何在技术层面上推动课堂合作学习策略的理解和开发值得探索。本文比较了课堂合作学习与计算机支持合作学习(CSCL),发现两者的作用方式截然不同,前者侧重于教学组织层面的设计,它以"教"为中心的策略设计视课堂合... 详细信息

课堂合作学习广受诟病,如何在技术层面上推动课堂合作学习策略的理解和开发值得探索。本文比较了课堂合作学习与计算机支持合作学习(CSCL),发现两者的作用方式截然不同,前者侧重于教学组织层面的设计,它以"教"为中心的策略设计视课堂合作学习过程如"黑箱";而后者则指向合作学习过程中的认知交互,它以"学"为中心的策略导向明显。为此,课堂合作学习策略有必要借鉴CSCL的经验,从组织形式转向合作学习过程,对课堂合作学习的认知过程进行建模,同时移植CSCL中的干预策略,培养学生的合作技能,强化教师的导学者、观察者和评价者角色。

关键词：课堂合作学习组织形式计算机支持的协作学习认知过程学习策略

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数据驱动的学生核心素养发展

电化教育研究 2023年第9期44卷 86-92页

作者：曹梅南京师范大学教育科学学院江苏南京210097

当前核心素养的数字化测评面临挑战,且综合素质评价重“评”而轻“育”、发展性薄弱。与数据赋能精准教学类似,学生核心素养发展也有必要基于数据驱动形成闭环,从而彰显评价的发展性功能。通过对数据驱动教学决策与学习决策的原理阐述... 详细信息

当前核心素养的数字化测评面临挑战,且综合素质评价重“评”而轻“育”、发展性薄弱。与数据赋能精准教学类似,学生核心素养发展也有必要基于数据驱动形成闭环,从而彰显评价的发展性功能。通过对数据驱动教学决策与学习决策的原理阐述、对现代学习评价三个维度的学理分析,研究主张从面向核心素养的教学到评测诊断、积极反馈等环节构建核心素养发展的闭环,并提出了具体的数据驱动路径,包括:整合表现性评价与伴随性数据采集技术而获得更全面、动态的核心素养数据;从学科贯通横轴、纵轴两个方向上构建核心素养的评价指标;基于证据的积极反馈与决策机制等。研究为中小学核心素养测评与发展提供了直接建议。

关键词：数据驱动核心素养伴随性数据采集学习决策学习评价

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基于本体的业务流程管理系统技术的研究

通信学报 2006年第11期27卷 67-72页

作者：曹美荣姚青山东大学计算机科学与技术学院山东济南250061

在业务流程管理领域引入了本体思想,探讨了业务流程本体的构建。具体介绍了对业务流程基本概念模型的构造,并以电子图档借阅管理流程为例,用OWL语言对流程本体进行形式化描述。还提出了一种基于Jena的信息检索方法,介绍了Jena的推理机... 详细信息

在业务流程管理领域引入了本体思想,探讨了业务流程本体的构建。具体介绍了对业务流程基本概念模型的构造,并以电子图档借阅管理流程为例,用OWL语言对流程本体进行形式化描述。还提出了一种基于Jena的信息检索方法,介绍了Jena的推理机制以及推理规则构造语法,并通过实例来说明Jena在本体的信息检索中的应用。

关键词：本体业务流程 OWL