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Diamond-Like carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

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Nano-Micro Letters 2024年第9期16卷 478-499页

作者： Yao Xiao Zaijin Tao Yufeng Ju Xiaolu huang Xinshu Zhang Xiaonan Liu Pavel A.Volotovski chao huang Hongqi chen Yaozhong Zhang Shen Liu Department of Orthopaedics Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Tongji Hospital 389 Xincun RdShanghai 200065People’s Republic of China Key Laboratory for Thin Film and Microfabrication of Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Orthopedic Trauma Department Belarus Republic Scientific and Practical Center for Traumatology and OrthopedicsKizhevatova str.60/4220024 MinskBelarus Shanghai Haohai Biological Technology Limited Liability company 1386 Hongqiao RdShanghai 200336People’s Republic of China Department of General Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Key Laboratory for High Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Post-traumatic peritendinous adhesion presents a significant challenge in clinical *** study proposes the use of diamond-like carbon(DLc)deposited on polylactic acid(PLA)membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured *** results indicate that PLA/DLc composite membrane exhibits more efficient anti-adhesion effect than PLA membrane,with histological score decreasing from 3.12±0.27 to 2.20±0.22 and anti-adhesion effectiveness increasing from 21.61%to 44.72%.Mechanistically,the abundant c=O bond functional groups on the surface of DLc can reduce reactive oxygen species level effectively;thus,the phosphorylation of NF-κB and M1 polarization of macrophages are ***,excessive inflammatory response augmented by M1 macrophage-originated cytokines including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α)is largely *** biocompatibility evaluation,PLA/DLc membrane is slowly absorbed within tissue and displays prolonged barrier effects compared to traditional PLA *** studies show the DLc depositing decelerates the release of degradation product lactic acid and its induction of macrophage M2 polarization by interfering esterase and PLA ester bonds,which further delays the fibrosis *** was found that the PLA/DLc membrane possess an efficient biophysical mechanism for treatment of peritendinous adhesion.

关键词： Diamond-like carbon Reactive oxygen species scavenging Foreign body reaction Biodegradation Antioxidant Peritendinous adhesion

copper catalyzed Enantioconvergent Nucleophilic Substitutions

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chinese Journal of chemistry 2024年第10期42卷 1161-1174页

作者： chunxi huang Zilong Wan Aoping Zhu caiyou chen college of chemistry and Molecular Sciences Wuhan UniversityWuhanHubei 430072China Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and college of chemistry and chemical Engineering Hubei UniversityWuhanHubei 430062China

As a versatile earth-abundant transition metal,cu has long been widely applied in the c—c and c—X bond forming *** for now,low-valent cu(Ⅰ)is known to reduce the redox active electrophiles via an SET pathway to give the corresponding radical and cu(Ⅱ)*** resulting cu(Ⅱ)species can interact with the radical via the out-sphere pathway,affording the coupling ***,cu(Ⅱ)can trap the radical through the inner-sphere process to generate cu(Ⅲ)species and then realize challenging bond formations due to the facile reductive elimination of cu(Ⅲ)*** copper catalysis has been widely applied in arylations of various nucleophiles,copper-catalyzed enantioconvergent nucleophilic substitutions of racemic alkyl electrophiles have been less explored,likely due to the difficulties in overcoming the reduction potential of alkyl electrophiles,elimination of side reactions,and enantiomeric *** order to overcome the high reduction potential of alkyl electrophiles,the photo-induced strategy has been developed under mild *** alternative strategy with new anionic tridentate ligands has also been reported in this *** review summarizes recent developments in copper-catalyzed enantioconvergent nucleophilic substitutions of alkyl electrophiles by various nucleophiles to realize c—N,c—c,c—B,c—P and c—O bond formations and their brief mechanistic studies.

关键词： Enantioconvergent Nucleophilic substitution copper Radical reactions Photocatalysis Asymmetric catalysis

In situ anchoring in carbon matrix of Bi_(2)O_(2)cO_(3) as a high-performance anode material for Li-ion batteries

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Rare Metals 2024年第8期43卷 3634-3646页

作者： Pu-Qiang He Jun Guo Hui huang Zhong-cheng Guo Faculty of Metallurgy and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Research center of Metallurgical Electrode Materials Engineering Technology Kunming 650106China Kunming Hendera Science and Technology co. Ltd.Kunming 650106China

Bismuth-based anode materials have been regarded as promising Li-ion batteries due to their high theoretical ***,their low conductivity and associated volume expansion inhabited their *** this work,Bi_(2)O_(2)cO_(3)@c composites were successfully synthesized by in situ anchoring of flower-like Bi_(2)O_(2)cO_(3) nanosheets on a carbon-based substrate via *** unique composited structure of Bi_2O_(2)-cO_(3)@c leads to a stable specific capacity of 547 mAh·g^(-1)after 100 cycles at a current density of 0.1 A·g^(-1).Notably,it demonstrates excellent rate capability with a specific capacity of 210 mAh·g^(-1)at 5 A·g^(-1).After 550 cycles at a current density of 0.5 A·g^(-1),a high reversible capacity of nearly 400 mAh·g^(-1)was ***,in situ X-ray diffraction measurements clearly demonstrate the conversion between Bi and Li_(3)Bi during alloying/dealloying,confirming the good electrochemical reversibility of the materials for Li *** reaction kinetics of Bi_(2)O_(2)cO_(3)@c were further investigated using galvanostatic intermittent titration ***,Bi_2O_(2)-cO_(3)@c exhibited excellent long-term stability,maintaining its high reversible capacity for over 200 cycles at a current density of 0.5 A·g^(-1)in a full cell configuration using Li_(1.20)Mn_(0.54)Ni_(0.13)co_(0.13)O_(2) as the cathode *** result further underscores its promising potential for lithium-ion *** work may provide inspiration for the design of alloy-type negative electrode materials for high-performance rechargeable batteries.

关键词： Bi_(2)O_(2)cO_(3) composite materials Anode materials Full batteries

A universal multifunctional dual cation doping strategy towards stabilized ultra-high nickel cobalt-free lithium layered oxide cathode

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Journal of Energy chemistry 2024年第8期95卷 296-305,I0007页

作者： Yabin Shen Dongming Yin Limin Wang Gang huang Yong cheng Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450002HenanChina State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022JilinChina

Ultra-high nickel cobalt-free lithium layered oxides are promising cathode material for lithium-ion batteries(LIBs)because of their relatively high capacity and low ***,the high nickel content would induce bulk structure degradation and interfacial environment deterioration,and the absence of co element reduces the lithium diffusion kinetics,severely limiting the performance liberation of this kind of ***,a multifunctional Ti/Zr dual cation co-doping strategy has been employed to improve the lithium storage performance of LiNi_(0.9)Mn_(0.1)O_(2)(NM91)*** the one hand,the Ti/Zr co-doping weakens the Li^(+)/Ni^(2+)mixing through magnetic interactions due to the inexistence of unpaired electrons for Ti^(4+)and Zr^(4+),increasing the lithium diffusion rate and suppressing the harmful coexistence of H1 and H2 *** the other hand,they enhance the lattice oxygen stability because of the strong Ti-O and Zr-O bonds,inhibiting the undesired H3 phase transition and lattice oxygen loss,improving the bulk structure and cathode-electrolyte interface *** a result,the Ti/Zr co-doped NM91(NMTZ)exhibits a 91.2%capacity retention rate after 100 cycles,while that of NM91 is only82.9%.Also,the NMTZ displays better rate performance than NM91 with output capacities of 115 and93 mA h g^(-1)at a high current density of 5 c,***,the designed NMTZ could enable the full battery to deliver an energy density up to 263 W h kg^(-1),making the ultra-high nickel cobaltfree lithium layered oxide cathode closer to practical applications.

关键词： Lithium-ion battery Ultra-high nickel cobalt-free cathode Ti/Zr co-doping Li^(+)/Ni^(2+)mixing Lattice oxygen stability

Global Zero-relaxation Limit Problem of the Electro-diffusion Model Arising in Electro-Hydrodynamics

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 241-268页

作者： Ming-hua Yang Si-ming huang Jin-yi Sun Department of Mathematics Jiangxi University of Finance and EconomicsNanchang330032China School of Public Administration Guangdong University of Foreign StudiesGuangzhou510006China college of Mathematics and Statistics Northwest Normal UniversityLanzhou730070China

In this paper,we study a global zero-relaxation limit problem of the electro-diffusion model arising in electro-hydrodynamics which is the coupled Planck-Nernst-Poisson and Navier-Stokes *** is,the paper deals with a singular limit problem of{u^(∈)_(t)+u^(∈)·▽u^(∈)-Δu^(∈)+▽P^(∈)=Δφ^(∈)▽φ^(∈),in R^(3)×(0,∞),▽·u^(∈)=0,in R^(3)×(0,∞),n^(∈)_(t)+u^(∈)·▽n^(∈)-Δn^(∈)=-▽·(n^(∈)▽φ^(∈)),in R^(3)×(0,∞),ct+u^(∈)·▽c^(∈)-Δc^(∈)=▽·(c^(∈)▽φ^(∈)),in R^(3)×(0,∞),∈^(-1)φ^(∈)_(t)=Δφ^(∈)-n^(∈)+c^(∈),in R^(3)×(0,∞),(u^(∈),n^(∈),c^(∈),φ^(∈))|t=0=(u0,n0,c0,φ0),in R^(3) involving with a positive,large parameter^(∈).The present work show a case that(u^(∈),n^(∈),c^(∈))stabilizes to(u^(∞),n∞,c∞):=(u,n,c)uniformly with respect to the time variable as^(∈)→+∞with respect to the strong topology in a certain Fourier-Herz space.

关键词： fourier-Herz space littlewood-Paley decomposition stability limit dissipative system

Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

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Nano Research 2024年第7期17卷 6411-6419页

作者： Hao chen Xianzhe Tang Yueye huang chen chen Yuheng Yang chaojie Hao Wenqi Xie Tingjing huang Xiaofeng cheng Qingnan Xu Shicong huang Zhi Ye Xucong Lin Zhaowei chen Zhitong chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of chemistry University College LondonLondon WC1H 0AJUK Engineering Technology Research center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and System Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLc-MNs)and cold atmospheric plasma(cAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of cAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

Flexible, Transparent and conductive Metal Mesh Films with Ultra‑High FoM for Stretchable Heating and Electromagnetic Interference Shielding

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Nano-Micro Letters 2024年第5期16卷 201-213页

作者： Zibo chen Shaodian Yang Junhua huang Yifan Gu Weibo huang Shaoyong Liu Zhiqiang Lin Zhiping Zeng Yougen Hu Zimin chen Boru Yang Xuchun Gui State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275People’s Republic of China Guangdong Provincial Key Laboratory of Materials for High Density Electronic Packing Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongPeople’s Republic of China School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275People’s Republic of China

Despite the growing demand for transparent conductive films in smart and wearable electronics for electromagnetic interference(EMI)shielding,achieving a flexible EMI shielding film,while maintaining a high transmittance remains a significant ***,a flexible,transparent,and conductive copper(cu)metal mesh film for EMI shielding is fabricated by self-forming crackle template method and electroplating *** cu mesh film shows an ultra-low sheet resistance(0.18Ω□^(-1)),high transmittance(85.8%@550 nm),and ultra-high figure of merit(>13,000).It also has satisfactory stretchability and mechanical stability,with a resistance increases of only 1.3%after 1,000 bending *** a stretchable heater(ε>30%),the saturation temperature of the film can reach over 110°c within 60 s at 1.00 V applied ***,the metal mesh film exhibits outstanding average EMI shielding effectiveness of 40.4 dB in the X-band at the thickness of 2.5μ*** a demonstration,it is used as a transparent window for shielding the wireless communication electromagnetic ***,the flexible and transparent conductive cu mesh film proposed in this work provides a promising candidate for the next-generation EMI shielding applications.

关键词： Metal mesh Transparent conductive film Stretchable heater Electromagnetic interference shielding

Effect of Tanshinone IIA on High Glucose-induced Apoptosis and Oxidative Stress Damage in Vascular Endothelial cells

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chinese Journal of Biomedical Engineering 2024年第2期33卷 62-68页

作者： QIU Shui-lin huang Rong huang Jian-qing QIU Rong-shui Longyan First Affiliated Hospital of Fujian Medical University Xiamen Medical college Affiliated Haicang Hospital

Objective: The primary cause of microvascular disease in diabetic complications is long-term hyperglycemia, wherein the damage and apoptosis of vascular endothelial cells play a significant role. Sodium tanshinone IIA sulfonate(STS) has been found to have beneficial effects on cardiovascular health. This study aimed to investigate the impact of STS on high glucose-induced apoptosis and oxidative stress damage in vascular endothelial cells, as well as its potential protective mechanisms. Methods:Human umbilical vein endothelial cells(HUVEcs) were divided into five groups:low-glucose group, high-glucose group, and three STS groups(STS-a, STS-b, and STS-c). The low-glucose group was incubated with DMEM low-sugar medium containing 5.5 mmol·L-1glucose, while the high-glucose group was treated with 33.3mmol·L-1glucose. The STS groups were exposed to 10, 30, and 50 μg·m L-1of STS,respectively. Each group was cultured for 72 h, and the MTT method was utilized to assess cell proliferation. Additionally, flow cytometry was employed to monitor changes in cell apoptosis and cellular oxidative stress indicators at 24, 48, and 72 h of cell culture in each group. Results: As time went on, the cell proliferation ability and apoptosis rate of each group gradually increased. The high-glucose group exhibited lower proliferation ability compared to the other groups. The STS-c group demonstrated the highest OD value for proliferation ability(24 h: 1.19±0.12; 48 h: 1.20±0.13; 72 h:1.25 ±0.12), but it was still lower than that of the low-sugar group. Notably, the high-glucose group had the highest cell apoptosis rate, while the low-glucose group had the lowest. The apoptosis rate of the STS-c group(24 h: 8.02±0.13; 48 h: 10.10±0.12;72 h: 13.18 ±0.11)% was between that of the low-glucose group and the high-glucose group, and lower than the STS-a and STS-b groups. Furthermore, the high-glucose group exhibited the highest malondialdehyde and nitric oxide synthase activities, as well as super

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Applying deep learning technique to chiral magnetic wave search

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chinese Physics c 2024年第8期48卷 170-176页

作者： Yuan-Sheng Zhao Xu-Guang huang Physics Department and center for Particle Physics and Field Theory Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Shanghai Research center for Theoretical Nuclear Physics National Natural Science Foundation of China and Fudan UniversityShanghai 200438China

The chiral magnetic wave(cMW)is a collective mode in quark-gluon plasma originated from the chiral magnetic effect(cME)and chiral separation *** detection in heavy-ion collisions is challenging owing to significant background ***[*** et al.,***.c 106,L051901(2022)],we constructed a neural network that accurately identifies the cME-related signal from the final-state pion *** this study,we have generalized this neural network to the case of cMW *** show that,after an updated training,the neural network effectively recognizes the cMW-related ***,we have assessed the performance of the neural network in comparison with other known methods for cMW search.

关键词： deep learning chiral magnetic wave relativistic heavy-ion collisions