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Action of Gaseous Nitric Oxide on Some Physical and Chemical Parameters of Human blood Samples

Journal of biomedical Science and Engineering 2014年第9期7卷 675-681页

作者： Andrew K. Martusevich Anna G. Soloveva Sergey P. Peretyagin anatoly F. Vanin N.N. Semenov Institute of Chemical Physics of Russian Academy of Science Moscow Russia Nizhny Novgorod Research Institute of Traumatology and Orthopaedics Nizhny Novgorod Russia

We studied the metabolic changes induced by gaseous nitric oxide in whole blood samples in vitro. blood samples were collected from healthy donors (Nizhny Novgorod station of blood transfusion). We carried out the direct bubbling of blood samples (n = 14) with gaseous flow with NO in a special appliance. We modeled standard conditions using the apparatus “Plazon” (concentration NO 800 mcg/l). Middle power of gas flow was used. The blood sparging time was 2 min, and exposition time lasted 3 min. Every blood sample volume was 5 ml. All the parameters were controlled before and after blood processing with NO. We tested lactate dehydrogenase activity in direct and reverse reactions spectrometrically by G. A. Kochetov’s method. Aldehyde dehydrogenase activity was examined by b. M. Kershnhots’s and E. V. Serkina’s methods, superoxide dismutase—by T. V. Sirota’s technology. Total protein level was examined by modified Louri’s method. The concentration of lactate was tested with the automatic analyzer “SuperGL Ambulance”. The indices of acidbase balance and blood gases partial pressure were estimated with special analyzer “AbL-77”. Additional control of energy metabolism changes was accomplished with derivative parameters, such as coefficient of energy reaction balance and coefficient of substrate provision. Different changes of blood physical and chemical parameters are induced by NO-processing which was fixed in our experiments. There is an inhibition of erythrocytes energy metabolism, decreasing of plasma antioxidant reserves, moderate ionic disorders and of acid-base misbalance in blood samples in vitro. besides, according to the indirect signs, the used regimen of NO-processing mainly affected erythrocytes, and stipulated methemoglobin formation. These data testify that the used dose of gaseous nitric oxide is too high for investigated human blood. In our opinion, registered negative effects of free NO may be eliminated by bound nitric oxide use (first of all in its na

关键词： Nitric Oxide blood Lactate Lactate Dehydrogenase Superoxide Dismutase Acid-base balance

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Experimental demonstration of linear and spinning Janus dipoles for polarisation-and wavelength-selective near-field coupling

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Light(Science & Applications) 2019年第1期8卷 732-738页

作者： Michela F.Picardi Martin Neugebauer Jorg S.Eismann Gerd Leuchs Peter banzer Francisco J.Rodriguez-Fortuno anatoly V.Zayats Department of Physics and London Centre for Nanotechnology King’s College LondonStrandLondon WC2R LS UK.2Max Planck Institute for the Science of LightStaudtstr.2D-91058 ErlangenGermany Institute of Optics Information and PhotonicsUniversity Erlangen-NurembergStaudtstr.7/B2D-91058 ErlangenGermany

The electromagnetic field scattered by nano-objects contains a broad range of wavevectors and can be efficiently coupled to waveguided *** dominant contribution to scattering from subwavelength dielectric and plasmonic nanoparticles is determined by electric and magnetic dipolar ***,we experimentally demonstrate spectral and phase selective excitation of Janus dipoles,sources with electric and magnetic dipoles oscillating out of phase,in order to control near-field interference and directional coupling to *** show that by controlling the polarisation state of the dipolar excitations and the excitation wavelength to adjust their relative contributions,directionality and coupling strength can be fully ***,we introduce a novel spinning Janus dipole featuring cylindrical symmetry in the near and far field,which results in either omnidirectional coupling or *** the propagation of guided light waves via fast and robust near-field interference between polarisation components of a source is required in many applications in nanophotonics and quantum optics.

关键词： coupling spinning excitation

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Molecular Dynamics Simulations of Perovskites: The Effect of Potential Function Representation on Equilibrium Structural Properties

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Open Journal of Physical Chemistry 2015年第4期5卷 110-121页

作者： Kholmirzo T. Kholmurodov Sagille A. Ibragimova Pavel P. Gladishev anatoly V. Vannikov Alexey R. Tameev Tatyana Yu. Zelenyak Frank Laboratory of Neutron Physics JINR Dubna Russia Dubna International University Dubna Russia A.N. Frumkin Institute of Physical Chemistry and Electrochemistry Russian Academy of Sciences Moscow Russia

The perovskites with general formula AbX3 have been widely used as for materials with their unique properties (ferroelectric, piezoelectric, dielectric, catalytic and so on). Hybrid organolead halide perovskites are a class of semiconductors with AbX3 (X = Cl, br, and I) structures consisting of lead cations in 6-fold coordination (b site), surrounded by an octahedron of halide anions (X site, face centered) together with the organic components in 12-fold cub octahedral coordination. These hybrid perovskites have a direct band gap, a large absorption coefficient as well as high charge carrier mobility that represent a very attractive characteristic of cost-effective solar cells. basically, these crystals are inorganic solids of CaTiO3 type held together by bonds that are either ionic or partially ionic and partially covalent. In spite of the partially covalent character of the Ti-O bond, the system is modeled by a two-body central force interatomic potential (the form of the Vashishta and Rahman interatomic potential), which has been used successfully for many materials with a perovskite structure. In the present work using molecular dynamics (MD) simulation method we investigate the dynamical and structural behavior of CaTiO3 perovskite at normal pressure and temperature conditions. The MD calculations were performed on a system of 16,000 particles (3200Ca + 3200Ti + 96,00O), initially in an orthorhombic-Pbnm structure. The orthorhombic MD box had edges Lx = 53.4 Å, Ly = 53.4 Å and Lz = 61.12 Å, which provided a density matching the experimental value of ρ = 4 g/cm3. Starting with this structure and using proposed interatomic potentials the MD system stabilizes at room temperature in its initial configuration. The aim of the present study to explore the effect of potential function representations on structural equilibrium properties for the perovskite models including hybrid halide ones outlined above. Concerning the perovskite equilibrium state we

关键词： Perovskites Halides Potential Functions Structural Properties MD Simulations

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Study of Antimicrobial Activity of Medications for Wound Treatment

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Journal of Pharmacy and Pharmacology 2015年第7期3卷 350-355页

作者： boyko N. Nick Zaytsev I. Alexander Osolodchenko P. Tatyana Melnik L. anatoly Nevmerzhitskiy V.Vitaliy Volkov O. Taras Kazmirchuk V. Victor Department of Processes and Devices of Chemical-Pharmaceutical Industries National Pharmaceutical University Kharkov61140 Ukraine biochemistry and biotechnology Laboratory and Antibacterial Agents Laboratory State Institution LI. Mechnikov Institute ofMicrobiology and Immunology of the National Academy of Medical Sciences of Ukraine Kharkov 6105 7 Ukraine

This paper presents data on the study of antimicrobial activity of 16 medications used for wound treatment. Antimicrobial activity of medications has been studied by well diffusion method on standard microorganism test strains： S. aureus ATCC 25923, E. coli ATCC 25922, P. aeruginosa ATCC 27853, P. vulgaris ATCC 4636, b. subtilis ATCC 6633, and C. albicans ATCC 885/653. Integrated indexes of antimicrobial activity of medications using vector theory have been calculated, which allowed to place most active of them in the order of descending activity： Levomecolum A = 2.73, r2 = 0.82; Levosin A = 2.41, r2 = 0.83; Synthomycinum A = 2.33, r2 = 0.97; Methyluracilum cum myramistino A = 2.31, r2 = 0.83; Oflocainum-Darnitsa A = 2.25, 1-2 = 0.97; and betadine A = 2.03, r2 = 0.97. The mean of integrated indexes of antimicrobial activity and the square of the correlation coefficient for the group of these medications are as follows： A = 2.02, and r2 = 0.91. Comparison of mean values of integrated indexes of antimicrobial activity of medicines for wound treatment with those of water-alcohol extracts from plant raw material containing alkaloids, tannins, hydroquinone, naphthoquinones, anthraquinones, and phenols has shown to be promising of further development of domestic agents having antimicrobial activity based on water-alcohol extracts from plant raw material.

关键词： Antimicrobial activity wound medications well diffusion method.

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Evaluation of Natural Radioactivity Levels for Structural Material Used in the Construction of the Neutrino Detector

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World Journal of Nuclear Science and Technology 2015年第1期5卷 43-56页

作者： Vladimir G. Zinovyev Anatolii P. Serebrov Ivan A. Mitropolsky Yuriy E. Loginov Georgiy I. Shulyak Tatyana M. Tyukavina Sergey L. Sakharov anatoly V. Chernyj Neutron Research Department National Research Centre “Kurchatov Institute” B.P. Konstantinov Petersburg Nuclear Physics Institute Gatchina Russia

In this work, the evaluation of natural radioactivity and spontaneous fission rates was performed for 8 nuclides from the natural radioactive 238U, 235U and 232Th decay chains. For this purpose, three samples of structural materials of the neutrino detector, i.e. aluminum, titanium and glass were analyzed by gamma spectroscopy and by neutron activation analysis to quantify a specific radioactivity of the samples. According to the results of this investigation, glass and aluminum samples have maximum values of the mean uranium concentrations 7.3(7) × 10-4% and 3.1(6) × 10-5%, respectively, while the lowest value for mean concentration of the uranium was found in titanium samples to be 4.7(3) × 10-6%. Aluminum sample had maximum values of the mean thorium concentrations, 2.5(8) × 10-3%, while the lowest value for mean concentration of the thorium was found in titanium samples to be 6.2(3) × 10-7%.

关键词： Spontaneous Fission Radioactive Decay Chain α-Decay Radionuclide branching Factor

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A Study of Calcifying Nanoparticles Extracted from the Vorotilovskaya Well

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材料科学与工程（中英文b版） 2012年第8期2卷 464-470页

作者： Sergey V. Vasile anatoly b. Churilo Olga Y. Prikhodko Alexander S. Rudy Nina V. Shekhovtsova Anastasiya Y. Yagushkina Facilities Sharing Centre "Micro-and Nanostructures Diagnosis" Yaroslavl State University 14 Sovetskaya street Yaroslavl150000 Russia Yaroslavl branch of Physics and Technology Institute of Russian Academy of Sciences 21 Universitetskaya street Yaroslavl150007 Russia Department of biology Yaroslavl State University 14 Sovetskaya street Yaroslavl 150000 Russia

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Real-Time In Vivo Dose Verification for Serial Tomotherapy of Head and Neck Patients

Real-Time In Vivo Dose Verification for Serial Tomotherapy o...

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中华医学会放射肿瘤治疗学分会六届二次暨中国抗癌协会肿瘤放疗专业委员会二届二次学术会议

作者： Zhen-Yu Qi,Xiao-Wu Deng,Shao-Min Huang,Xiao-Yan Huang,Zhi-Chun He,Almon S Shiu,Michael Lerch,Peter Metcalfe,anatoly Rosenfeld,Tomas Kron a Department of Radiation Oncology,Sun Yat-Sen University Cancer Center and State Key Laboratory of Oncology in Southern China,Guangzhou 510060,China b Centre for Medical Radiation Physics, University of Wollongong,Wollongong,NSW 2522,Australia cRadiation Physics Department,The University of Texas,M.D.Anderson Cancer Center,Houston,Texas 77030,USA dPeter MacCallum Cancer Centre,Melbourne,VIC 3002,Australia

Purpose:The complexity of intensity-modulated radiation therapy(IMRT) has enhanced the need for a rigorous quality assurance program to ensure accurate treatment delivery. Methods and Materials:In this work,a recently designed metal-oxide-semiconductor field effect transistor(MOSFET) dosimetry system that can enable the real-time monitoring of the delivered doses to the patients during serial tomotherapy treatment has been *** key factors that may affect the accuracy of MOSFET measurements such as source-surface distance(SSD),field size,beam incident angles and radiation energy spectrum are *** feasibility of this dosimetry system in IMRT dose verification is evaluated with comparison to ionization chamber measurements in an IMRT QA phantom. Results:The initial results of the real-time in vivo measurements with MOSFTEs during serial tomotherapy treatment of head and neck cancer patients are *** MOSFET sensitivity did not change with *** photon field sizes less than 20×20 cm,the MOFET sensitivity varied with field size within 1.0%.The detector angular response was isotropic within 2%over full 360°,and the observed sensitivity variation with depth due to changes in the radiation energy spectrum waa negligible in high energy photon *** MOSFET measurements agreed with the ionization chamber results in IMRT phantom plan verification at all points to within±5%.The overall deviation of in vivo measurements for head and neck cancer patients undergoing serial tomotherapy treatment was on average 3.33%ranging from -2.20%to 7.89%,compared with doses predicted by a commercial treatment planning system (TPS).Less than 5%deviation from the planned dose was measured in 92%of all cases. Conclusion:The developed real-time in vivo MOSFET dosimetry system has proven to be a useful tool both in evaluating the actual dose within individual patients and in avoiding misadministration in the delivery of serial IMRT treatment.

关键词： MOSFET in vivo dosimetry real time dosimetry intensity modulated radiation therapy quality assurance

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非ST段抬高急性冠脉综合征患者随机应用依诺肝素或普通肝素抗凝治疗的疗效和出血并发症：系统综述

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美国医学会杂志（中文版） 2005年第4期24卷 209-216页

作者： John L. Petersen Kenneth W. Mahaffey Vic Hasselblad Elliott M. Antman Marc Cohen Shaun G. Goodman anatoly Langer Michael A. blazing Anne Le-Moigne-Amrani James A. de Lemos Christopher C. Nessel Robert A. Harrington James J. Ferguson Eugene braunwald Robert M. Califf 徐成斌（译） Duke Clinical Research Institute Durham NC Cardiovascular Division Department of Medicine Brigham and Women＇s Hospital Boston Mass Division of Cardiology Newark Beth Israel Medical Center. Newark. NJ Canadian Heart Research Centre and Terrence Donnelly Heart Centre Division of Cardiology St Michael＇s Hospital University of TorontoToronto Ontario Division of Cardiology University of Texas Southwestem Dallas Aventis Inc BridgewaterNJ St Luke＇s-Episcopal Hospital Texas Heart InstituteHouston

背景：抗凝疗法已成为急性冠脉综合征（acute coronary syndrome，ACS）治疗指南推荐的标准疗法。但是，最近某些试验在ACS患者中对依诺肝素（enoxaparin）与普通肝素（unfractionated heparin）的应用进行了比较，发现这些抗凝疗法的... 详细信息

背景：抗凝疗法已成为急性冠脉综合征（acute coronary syndrome，ACS）治疗指南推荐的标准疗法。但是，最近某些试验在ACS患者中对依诺肝素（enoxaparin）与普通肝素（unfractionated heparin）的应用进行了比较，发现这些抗凝疗法的疗效及安全性并不及既往试验结果。目的：有6项随机对照试验对依诺肝素与普通肝素治疗ACS患者进行了比较，对其终点（即全因死亡及非致死性心肌梗死）、输血与大出血进行系统评估。资料来源：从杜克临床研究所（Duke Clinical Research Institute）获取ESSENCE、A to Z及SYNERGY试验的原始数据。由TIMI 11b、ACUTEⅡ及INTERACT研究的主要研究人员提供各自的基线特征和事件发生频率。研究选取：在非ST段抬高ACS患者中比较依诺肝素与普通肝素的6项随机对照试验均人选进行分析。数据提取：从全部试验人群和随机分组前未接受抗凝治疗的亚人群中获取疗效终点和安全性终点。数据综合：应用随机效应经验性贝叶斯模型（random—effects empirical bayes model），系统评估21946例患者的结果。依诺肝素与普通肝素30天死亡率无显著差异（3．0％比3．0％，优势比[odds ratio，OR]，1．00；95％可信区间[confidence interval，CI]，0．85～1．17）。在所有试验人群中，依诺肝素与普通肝素相比，30天死亡或非致死性心肌梗死（myocardial infarction，MI）联合终点显著下降，具有统计学差异（10．1％比11．0％；OR，0．91；95％CI，0．83～0．99；所需治疗例数107）。随机分组前未接受抗凝治疗的依诺肝素组患者30天死亡或MI联合终点亦显著下降，具有统计学差异（8．0％比9．4％；OR，0．81；95％CI，0．70～0．94；所需治疗例数72）。随机分组后第7天，总体安全人群或者随机分组前未接受抗凝治疗的人群输血（OR，1．01；95％CI，0．89～1．14）或大出血的发生率（OR，1．04；95％CI，0．83～1．30）无显著差异。结论：对近22000例各类ACS患者进行系统回顾发现，在预防死亡或MI联合终点方面依诺肝素较普通肝素更有效。

关键词：非ST段抬高急性冠脉综合征随机对照试验依诺肝素普通肝素抗凝治疗出血并发症患者系统综述疗效

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