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Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA

World Journal of Gastroenterology 2019年第48期25卷 6939-6948页

作者： Lucie Benešová Tereza Hálková Renata Ptáčková anastasiya semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik Centre for Applied Genomics of Solid Tumors Genomac Research InstitutePrague CZ 16100Czech Republic Surgery Department 2nd Faculty of Medicine of Charles University Prague and Military University HospitalPrague CZ 16902Czech Republic Surgery Department 1st Faculty of MedicineCharles University Prague and Thomayer HospitalPrague CZ 14059Czech Republic Surgery Department 2nd Faculty of Medicine of Charles University Prague and Motol University HospitalPrague CZ 15006Czech Republic Institute of Biostatistics and Analyses of the Masaryk University Brno CZ 62500Czech Republic Elphogene Prague CZ 16100Czech Republic

BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative *** referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be *** is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or *** To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal *** total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical *** postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA *** addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month *** presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the *** Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 *** 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive dur

关键词： Circulating tumor DNA Metastatic colorectal cancer Postoperative Radicality of resection Follow-up Recurrence

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