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Computer Systems Science & Engineering 2023年第10期47卷 699-720页

作者： krishna Santosh Naidana Soubhagya Sankar Barpanda School of Computer Science and Engineering VIT-AP UniversityInavoluBeside AP SecretariatAmaravati-522237APIndia

Glaucoma is a group of ocular atrophy diseases that cause progressive vision loss by affecting the optic *** of its asymptomatic nature,glaucoma has become the leading cause of human blindness *** this paper,a novel computer-aided diagnosis(CAD)approach for glaucomatous retinal image classification has been *** extracts graph-based texture features from structurally improved fundus images using discrete wavelet-transformation(DWT)and deterministic tree-walk(DTW)*** images are considered from both public repositories and eye *** are enhanced with image-specific luminance and gradient transitions for both contrast and texture *** enhanced images are mapped into undirected graphs using DTW trajectories formed by the image’s wavelet ***-based features are extracted fromthese graphs to capture image texture *** learning(ML)classifiers use these features to label retinal *** approach has attained an accuracy range of 93.5%to 100%,82.1%to 99.3%,95.4%to 100%,83.3%to 96.6%,77.7%to 88.8%,and 91.4%to 100%on the ACRIMA,ORIGA,RIM-ONE,Drishti,HRF,and HOSPITAL datasets,*** major strength of this approach is texture pattern identification using various topological *** has achieved optimal performance with SVM and RF classifiers using biorthogonal DWT combinations on both public and patients’fundus *** classification performance of the DWT-DTW approach is on par with the contemporary state-of-the-art methods,which can be helpful for ophthalmologists in glaucoma screening.

关键词： Wavelet-transformation glaucoma classification deterministic tree walk graph-based features

A novel GPCR mediates pancreatic cancer associated fibroblast-cancer cell interaction

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中国药理学与毒理学杂志 2017年第10期31卷 953-953页

作者： Shu Z WILEY krishna SRIRAM Wen-jing LIANG Sarah E CHANG Randall FRENCH Thalia MCCANN Hiroshi NISHIHARA Andrew M LOWY Paul A INSEL Departments of Pharmacology Medicine and Surgery and Moores Cancer CenterUniversity of California Division of Clinical Cancer Genomics Hokkaido Cancer Center

OBJECTIVE Pancreatic ductal adenocarcinoma(PDAC),a lethal cancer in need of new,effective therapies,has a unique tumor microenvironment characterized by a dense fibrotic stroma(desmoplasia)that is generated by pancreatic cancer-associated fibroblasts(PCAFs)derived from pancreatic stellate cells(PSCs)and pancreatic fibroblasts(PFs).METHEDS and RESULTS Hypothesizing that G protein-coupled receptors(GPCRs)may regulate PCAFs,we used an unbiased GPCRomic array approach to compare GPCR expression in PCAFs,PFs and PSCs and identified 82 GPCRs commonly expressed by PCAFs derived from primary tumors of five PDAC *** discovered that PCAFs have increased expression of numerous GPCRs,in particular a GPCR with much higher expression in PCAFs compared to both PFs and *** revealed increased expression of this GPCR in PDAC ***-culture of PSCs with PDAC cells or incubation with TNFαinduced its *** of the GPCR in PCAF sincreased expression of interleukin-6(IL-6)via a cA MP/PKA/CREB signaling *** knockdown with siR NA diminished IL-6 production and secretionby PCAFs and ability of PCAF conditioned media to enhance proliferation of PDAC *** We conclude that PDAC cells induce expression by PCAFs of a novel GPCR,resulting in increased IL-6 production by PCAFs and promotion of PDAC cell *** PCAF-expressed GPCR thus contributes to PDAC cell-PCAF interaction and as such,may be a novel therapeutic target for PDAC tumors.

关键词： pancreatic ductal adenocarcinoma pancreatic cancer-associated fibroblasts G proteincoupled receptors

New frontiers for the materials genome initiative

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npj Computational Materials 2019年第1期5卷 776-798页

作者： Juan J.de Pablo Nicholas E.Jackson Michael A.Webb Long-Qing Chen Joel E.Moore Dane Morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo krishna Rajan Evan J.Reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao Institute for Molecular Engineering University of ChicagoChicagoIL 60615USA Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Physics University of CaliforniaBerkeleyBerkeleyCA 94720USA Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWI 53706USA Materials Department and Materials Research Laboratory University of CaliforniaSanta BarbaraCA 93106USA Department of Materials Science and Engineering Cornell UniversityIthacaNY 14853USA Department of Physics Colorado School of MinesGoldenCO 80401USA Materials Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Department of Physics University of Texas at AustinAustinTX 78712USA Department of Polymer Science and Engineering University of MassachusettsAmherstMA 01003USA Institute of Condensed Matter and Nanosciences UniversitéCatholique de Louvain1348 Louvain-la-NeuveBelgium Department of Materials Science and Engineering University of MarylandCollege ParkMD 20742USA Department of Materials Design and Innovation University of Buffalo–The State University of New YorkBuffaloNY 14260-5030USA Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA Department of Chemistry and Biochemistry University of MarylandCollege ParkMD 20742USA Department of Metallurgical and Materials Engineering Colorado School of MinesGoldenCO 80401USA Department of Materials Science and Engineering University of MichiganAnn ArborMI 48109USA Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA

The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and *** with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the *** May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and *** article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts.

关键词： utilize frontier accomplishment

Open Space Implications in Urban Development: Reflections in Recent Urban Planning Practices in Nepal

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Journal of Geographical Research 2022年第2期5卷 69-81页

作者： krishna Prasad Timalsina Bhim Prasad Subedi Central Department of Geography Tribhuvan UniversityKathmanduNepal University Grants Commission Tribhuvan UniversityNepal

Open space has various implications in urban development planning and has been integrated in recent urban planning approaches and practices in *** open spaces are not only important for(re)shaping the urban form but are also important for enhancing urban social life and disaster risk management,particularly for dense *** most of the cities in Nepal have been growing haphazardly,the cities lack sufficient open ***,the value of open space in dense cities like Kathmandu has been recognized more after the Gorkha Earthquake 2015 as the open spaces were extensively used for risk relief,treatment,recovery,and rehabilitation during and after the *** this background,this paper presents the major planning initiatives in Nepal and discusses how recent urban plans have provisioned and initiated open spaces development by reviewing concurrent urban planning practices,particularly reviewing Periodic Plans,Integrated Urban Development Plan,Smart City Plan,and Land Development *** development of open areas has not been given much attention in the earlier urban planning practice but recent urban development planning has emphasized with a special focus which is very important for sustainable and safer city development and is expected to address the current bulging urban issues of spatiality and ***,it is very important for integrating open space implications in city planning and such open space should be conceptualized according to the city’s geography,landscape as well as socio-cultural contexts.

关键词： Open space Urban development Planning practices Land development

Glimpses of the Lichen Flora of Achanakmar-Amarkantak Biosphere Reserve in Central India

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Reduction of Systematic Error in Radiopharmaceutical Activity by Entropy Based Mutual Information

American Journal of Plant Sciences（美国植物学期刊） 2012年第6期

作者： Achuta Nand Shukla krishna Pal Singh

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Carbon Dioxide Emissions from the Tropical Dowleiswaram Reservoir on the Godavari River, Southeast of India

World Journal of Nuclear Science and Technology（核科学与技术国际期刊） 2012年第1期

作者： Palliyakarany Thirumani krishna Kumar Toshikazu Takeda

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Journal of Water Resource and Protection 2013年第5期5卷 534-545页

作者： M. H. K. Prasad V. V. S. S. Sarma V. V. Sarma M. S. krishna N. P. C. Reddy National Institute of Oceanography Council of Scientific and Industrial Research (CSIR) Regional Centre Visakhapatnam India

Time-series observations were conducted in the Dowleiswaram dam reservoir that was constructed on the largest monsoonal river in India to understand the source of inorganic carbon, and fluxes to the atmosphere. The reservoir stores water during dry period of six months and water increases during the period when Indian subcontinent receives significant rainfall. Significant modification of organic matter was noticed during storage period indicated by decrease in pH from 7.5 to 6.4 and oxygen saturation from ~95% to 65%. The relationship of dissolved inorganic carbon (DIC) with oxygen saturation, dissolved organic carbon (DOC) and isotopic ratios of DIC suggests that heterotrophic activities are the major source of inorganic carbon to the reservoir. In addition to this, ground water exchange also contributes significantly to the inorganic carbon pool in the reservoir. Nutrients released due to decomposition of organic matter in the reservoir supports both autotrophic and heterotrophic activities. The pCO2 levels in the reservoir varied between 3944 and 16,042 μatm and higher pCO2 levels were noticed during peak discharge period. The annual mean CO2 fluxes from the reservoir amounted to 112 ± 126 mmolC m-2·d-1 and ~6 times higher fluxes were noticed during discharge period compared to dry period and such high fluxes during discharge period were contributed by both high pCO2 levels and winds. It was further noticed that dam reservoir is a strong source of pCO2 to the estuary wherein 2 during dry period and >15,000 μatm during discharge period were observed. Our study also indicates that Dowleiswaram dam reservoir is a strong source of CO2 to atmosphere, even though it is much smaller than Brazilian (tropical) reservoir but higher than European reservoirs.

关键词： Inorganic Carbon System CO2 Flux Heterotrophic Activity Ground Water Exchange Reservoir

P53-MDM2在普萘洛尔诱导血管瘤内皮细胞凋亡中的作用

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现代口腔医学杂志 2018年第1期32卷 6-10页

作者：姚天华李全雁李立峰杜婧婷 krishna Regmi 葛苏蒙屠军波西安交通大学口腔医院.陕西省颅颌面精准医学研究重点实验室陕西710004 山东省泰安市口腔医院牙周粘膜科西安交通大学口腔医院口腔颌面外科陕西710004

目的初步研究P53、MDM2与普萘洛尔诱导血管瘤内皮细胞凋亡的关系,为血管瘤的治疗提供新的思路和靶点。方法体外培养血管瘤内皮细胞,实验设计为2组,加药组和空白对照组,加药组以100umol/L的普萘洛尔处理细胞,空白对照组不予以特殊处理。... 详细信息

目的初步研究P53、MDM2与普萘洛尔诱导血管瘤内皮细胞凋亡的关系,为血管瘤的治疗提供新的思路和靶点。方法体外培养血管瘤内皮细胞,实验设计为2组,加药组和空白对照组,加药组以100umol/L的普萘洛尔处理细胞,空白对照组不予以特殊处理。倒置显微镜、电镜下观察形态学变化,流式细胞术检测细胞凋亡率,RTPCR、Western-blot检测MDM2、P53 mRNA水平和蛋白水平上的变化。结果用普萘洛尔处理后,大部分细胞形态有紧密排列的"铺路石"形态逐渐变圆。透射电镜观察到细胞呈现凋亡相,对照组无明显变化;加药组细胞凋亡率为14.67%,空白对照组4.87%,具有统计学差异。RT-PCR、Western-blot结果一致,与空白对照组相比,P53、MDM2均升高,具有统计学差异。结论 100umol/L普萘洛尔能够诱发体外培养的血管瘤内皮细胞凋亡,能促使体外培养的血管瘤内皮细胞中P53与MDM2呈现高表达。

关键词：普萘洛尔血管瘤内皮细胞细胞凋亡 P53/MDM2

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安达曼盆地-未来的勘探目标

海洋地质 2010年第2期26卷 64-69页

作者： krishna MOHAN S.G. VINOD DANGWAL SOMA SENGUPTA A.G. DESAI 李学杰（译） Keshava Deva Malaviya .石油勘探研究院 ONGC Dehradun 广州市海洋地质调查局海洋地质科学发展战略研究所

安达曼盆地，位于孟加拉东南，以安达曼-尼科巴岛链为界，是从南部印度尼西亚群岛至北部缅甸的大型构造单元的一部分。盆地长约1200km，从缅甸至苏门答腊；宽650km，从马来半岛至安达曼群岛-尼科巴群岛。

关键词：勘探目标盆地印度尼西亚构造单元苏门答腊孟加拉群岛缅甸

地下实验室用右旋盐酸伪麻黄碱通过伯歧还原合成右旋甲基安非他明过程中反应条件的影响

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地下实验室用右旋盐酸伪麻黄碱通过伯歧还原合成右旋甲基安非他明...