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Neutropenic Fever in Lung Cancer:Clinical Aspects Related to Mortality and Antibiotic Failure

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中国肺癌杂志 2021年第11期24卷 764-769页

作者： Inês RODRIGUES Luísa NASCIMENTO ana Cláudia PIMENTA Sara RAIMUNDO Bebiana CONDE ana FERNANDES Pulmonology Department Centro Hospitalar Trás-os-Montes e Alto DouroVila RealPortugal

Background and objectives:Lung cancer(LC)is the leading cause of cancer *** treated with chemotherapy are at risk of developing chemotherapy-induced febrile neutropenia(FN),a potentially life-threatening *** aims of this study were(1)to characterize FN admissions of patients with LC in a pulmonology department,and(2)to determine associations between patient profiles,first-line antibiotic failure(FLAF)and ***:Retrospective observational case-series,based on the analysis of medical records of LC patients that required hospitalization due to chemotherapy-induced ***:A total of 42 cases of FN were revised,corresponding to 36 patients,of which 86.1%were male,with a mean age of 66.71±9.83 *** patients had a performance status(PS)equal or less than 1,and metastatic disease was present in 40.5%(n=17).Respiratory tract infections accounted for 42.9%(n=18)of FN cases,and multidrug-resistant Staphylococcus aureus was the most isolated *** mortality rate was 16.7%(n=7),and the FLAF was 26.2%(n=11).Mortality was associated with a PS≥2(P=0.011),infection by a Gram-negative agent(P=0.001)and severe anemia(P=0.048).FLAF was associated with longer hospitalizations(P=0.020),PS≥2(P=0.049),respiratory infections(P=0.024),and infection by a Gram-negative(P=0.003)or multidrug-resistant agent(P=0.014).Conclusions:Lower PS,severe anemia,and infections by Gram-negative or multi-resistant agents seem to be associated with worse outcomes in FN patients.

关键词： Febrile neutropenia First-line antibiotic failure Lung neoplasms Mortality

Haarlet analysis of Lipschitz regularity in metric measure spaces

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Science China Mathematics 2012年第5期55卷 967-975页

作者： AIMAR Hugo BERNARDIS ana NOWAK Luis Departamento de Matemática Facultad de Ingeniería QuímicaUniversidad Nacional del LitoralSanta FeArgentina Instituto de Matemática Aplicada del Litoral Consejo Nacional de Investigaciones Científicas y TécnicasSanta FeArgentina Departamento de Matemática Facultad de Economía y AdministraciónUniversidad Nacional del ComahueNeuquenArgentina

In this note we shall give a characterization of Lipschitz spaces on spaces of homogeneous type via Haar coefficients.

关键词： Lipschitz spaces Haar basis spaces of homogeneous type

Patient-specific induced pluripotent stem cells as“disease-in-adish”models for inherited cardiomyopathies and channelopathies–15 years of research

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World Journal of Stem Cells 2021年第4期13卷 281-303页

作者： Miruna Mihaela Micheu ana-Maria Rosca Department of Cardiology Clinical Emergency Hospital of BucharestBucharest 014452Romania Cell and Tissue Engineering Laboratory Institute of Cellular Biology and Pathology"Nicolae Simionescu"Bucharest 050568Romania

Among inherited cardiac conditions,a special place is kept by cardiomyopathies(CMPs)and channelopathies(CNPs),which pose a substantial healthcare burden due to the complexity of the therapeutic management and cause early *** other inherited cardiac conditions,genetic CMPs and CNPs exhibit incomplete penetrance and variable expressivity even within carriers of the same pathogenic deoxyribonucleic acid variant,challenging our understanding of the underlying pathogenic *** recently,the lack of accurate physiological preclinical models hindered the investigation of fundamental cellular and molecular *** advent of induced pluripotent stem cell(iPSC)technology,along with advances in gene editing,offered unprecedented opportunities to explore hereditary CMPs and *** features of iPSCs include the ability to differentiate into unlimited numbers of cells from any of the three germ layers,genetic identity with the subject from whom they were derived,and ease of gene editing,all of which were used to generate“disease-in-a-dish”models of monogenic cardiac ***,iPSC-derived cardiomyocytes that faithfully recapitulate the patient-specific phenotype,allowed the study of disease mechanisms in an individual-/allele-specific manner,as well as the customization of therapeutic *** review provides a synopsis of the most important iPSC-based models of CMPs and CNPs and the potential use for modeling disease mechanisms,personalized therapy and deoxyribonucleic acid variant functional annotation.

关键词： Induced pluripotent stem cells Cardiomyopathy Channelopathy Genes Mutation Deoxyribonucleic acid variants

An MAP Kinase Cascade Downstream of RGF/GLV Peptides and Their RGI Receptors Regulates Root Development

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Molecular Plant 2020年第11期13卷 1542-1544页

作者： ana I.Fernandez Tom Beeckman Department of Plant Biotechnology and Bioinformatics Ghent UniversityGhentBelgium VIB Center for Plant Systems Biology GhentBelgium

Plant developmental processes require active cell-cell *** peptides are now recognized as major players involved in many plant developmental and immunity ***,the cognate receptors for many signaling peptides have also been *** we are starting to gain insights into some of the molecular components,the downstream pathway after ligand perception is in most cases unknown(Oh et al.,2018).

关键词： starting insight hough

Data-Fusion for Epidemiological analysis of Covid-19 Variants in UAE

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Computers, Materials & Continua 2021年第9期68卷 3895-3913页

作者： Anoud Bani-Hani anaïs Lavorel Newel Bessadet Zayed University DubaiUnited Arab Emirates Staffordshire University Stoke-on-TrentST42DEUnited Kingdom Keele University NewcastleST55BGUnited Kingdom

Since December 2019,a new pandemic has appeared causing a considerable negative global *** SARS-CoV-2 first emerged from China and transformed to a global pandemic within a short *** virus was further observed to be spreading rapidly and mutating at a fast pace,with over 5,775 distinct variations of the virus observed globally(at the time of submitting this paper).Extensive research has been ongoing worldwide in order to get a better understanding of its behaviour,influence and more importantly,ways for reducing its *** analytics has been playing a pivotal role in this research to obtain valuable insights into understanding and fighting against the spread of ***,this is time and resource intensive,making it difficult to observe and quickly identify the impact of *** such as the spread or virulence could explain the three months delay in revealing the new virus variant in the *** paper presents an extensive correlation analysis of the effect caused by the different SARS-CoV-2 strains,and their influence on the population across diverse factors,such as propagation and fatality rates,during the peak of the pandemic,with a focus on two major countries in the Middle East,the United Arab Emirate(UAE)and the Kingdom of Saudi Arabia(KSA).This research aims to investigate the epidemiological behaviour of the Coronavirus’genomic variants over time in the UAE,compared with the KSA,where correlation analysis is carried out for a number of cases,deaths and their statistical *** results of the analysis highlight very interesting insights into the epidemiological impact of the Covid-19 genomic behaviour in both countries,which could lead to important actions taken to minimize the impact on wider public health,possibly saving lives,and the *** instance,our method identifies a potential correlation between a spike in the number of deaths per case of 5.5 observed in the UAE by March 24th,with the emergence of new

关键词： SARS-CoV-2 genome covid-19 public health pandemic epidemiology case study United Arab Emirates UAE Kingdom of Saudi Arabia KSA

Symmetry and Transitive Properties of Monohedral f-triangulations of the Riemannian Sphere

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Acta Mathematica Sinica,English Series 2009年第10期25卷 1609-1616页

作者： ana M.BREDA J.M.SIGARRETA Department of Mathematics University of Aveiro Facultad de Matematicas Universidad Autonoma de Guerrero

Here we give the complete description of the symmetry group and transitive properties of the set of all of monohedral triangulations of the Riemannian sphere by f-tilings. We shall also show that each monohedral f-tiling of the Riemannian sphere can be seen, up to a spherical isometry, as the singular set of a spherical isometric folding.

关键词： isometric folding monohedral tiling graphs combinatoric

Interpreting Morphologically Homogeneous(Paleo-)Populations as Ecological Species Enables Comparison of Living and Fossil Organism Groups,Exemplified by Nummulitid Foraminifera

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Journal of Earth Science 2022年第6期33卷 1362-1377页

作者： Johann Hohenegger ana Ivis Torres-Silva Wolfgang Eder Institute for Paleontology University of Vienna1090ViennaAustria

Morphologically homogeneous groups,either living populations or fossil paleo-populations,must be regarded as ecological species,independent of their molecular genetic resemblance in living *** is always expressed during development by structure genes initiated from a network of regulator genes acting at different times and intensities,additionally being subjected to epigenetic ***,homogeneous populations influenced by the environment represent species better than the reproduction(biological species)or molecular-genetic approach using ancestral sequences like *** and fossil representatives of nummulitid foraminifera were chosen to demonstrate complete reconstruction of morphology using metrical growth-invariant and growth-independent *** these characters,6 models were established to define ecological species in living and fossil ***,a distinction between evolutionary and environmental effects in fossil forms was possible using discriminant analysis showing characters that are responsible for differentiating between evolutionary and environmental trends.

关键词： ecological species growth-invariant metrical characters morphology homogeneity nummulitids

Modern Built Heritage Conservation Policies: How to Keep Authenticity and Emotion in the Age of Digital Culture

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Built Heritage 2018年第2期2卷 17-34页

作者： ana Tostões Instituto Superior Técnico Universidade de LisboaLisbonPortugal

The Modern Movement has demonstrated its long-term legitimacy as a lasting concept endowed with *** technology,spatial form and social commitment to one another,through an optimistic faith in progress,modern architects sought to attain new heights of functionality and flexibility in *** current challenge is to find ways to deal with the conservation of this recent legacy in the continuously changing context of current times,including physical,economic,functional,and fast-moving socio-cultural and political *** address these questions,‘Modern built heritage conservation policies’explores the restoration and renovation processes undertaken in some paradigmatic case studies:the Tugendhat House(Mies van der Rohe and Lilly Reich,Brno,Czech Republic,1929-1930),the Crown Hall(Mies van der Rohe,Chicago,USA,1950-1956),the National Museum of Western Art(Le Corbusier,Tokyo,Japan,1959)and the Gulbenkian Foundation(Alberto Pessoa,Pedro Cid e Ruy d’Athouguia,Lisbon,Portugal,1959-1969).

关键词： restoration renovation conservation Modern Movement architecture authenticity materiality adaptive reuse

Taking a Knee in American Football:A Semiotic Case Study

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Language and Semiotic Studies 2018年第1期4卷 40-49页

作者： ana-Maria Jerca York University Canada

As an athlete whose actions receive enormous amounts of media attention, Colin Kaepernick chose to use his powerful position to bring worldwide attention to the unjust murders of innocent black men at the hands of American police officers by kneeling silently during the national anthem before football *** was soon joined by other players in the NFL who shared his view that the anthem and the flag, both symbols of the nation, do not represent Americans as they should(Miller, 2017, para.3), since the police officers who killed Alton Sterling and Philando Castile—to name a couple—were given paid leave instead of being found guilty of *** movement, "taking a knee", is an example of how nonverbal communication can have indexical meanings founded in cultural *** Silverstein(2003), this paper traces the semiotic trajectory of kneeling, from its traditional, first-order index of respect and humility, to its second-order index of protesting police brutality, its third-order index of disrespect for the nation, and, finally its fourth-order index of solidarity and retaliation to insult, ending with a discussion of the role of patriotism in the ordered *** aim is to show that even gestures can have indexical ordering.

关键词： non-verbal language semiotics indexicality ideology American football