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Motivations for and barriers to innovation in non-profit organizations: The case of nursing homes in Northern Portugal

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International Journal of Innovation Studies 2024年第1期8卷 25-44页

作者： ana rita Gonçalves Lopes Aldina Isabel de Azevedo Correia Alexandra Maria da Silva Braga Center for Research and Innovation in Business Sciences and Information Systems School of Management and TechnologyPolitecnico do PortoRua do Curral-Margaride4610-156 FelgueirasPortugal

To contribute to the empirical literature on innovation in non-profit organizations,this study examines innovation in Private Social Solidarity Institutions with social responses for the elderly in Northern *** enriches the literature by clarifying the concept of innovation applied to non-profit organizations,which represents a perspective different from the business ***,it is important to support the innovation decisionmaking process in similar non-profit *** this study,the population was surveyed through questionnaires based on the PUBLIN research project,which has already been applied in different countries,and the targets were employees of organizations with social responses for the *** sample is small,with 28 respondent institutions and 51 employees,but it is representative,as it includes institutions from all districts in Northern *** study employed a quantitative approach,particularly factor analysis,multiple linear regression,and correlation analyses,using scales already applied in other dimensions of the social sector,to understand the effect of each innovation dimension/determinant on creativity and innovation in nonprofit *** results show that in these organizations with social responses for the elderly,learning orientation,risk-taking,and job satisfaction have a positive impact on innovation.

关键词： Determinants of innovation non-profit organizations social responses for the elderly Northern Portugal

Hydrocarbons in particulate samples from wildfire events in central Portugal in summer 2010

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Journal of Environmental Sciences 2017年第3期29卷 122-131页

作者： ana Vicente ana Calvo ana P.Fernandes Teresa Nunes Cristina Monteiro Casimiro Pio Célia alves Centre for Environmental and Marine Studies (CESAM) Department of EnvironmentUniversity of Aveiro Department of Physics IMARENABUniversity of León

In summer 2010, twenty eight （14 PM=2.5 samples plus 14 samples PM2.5-10） smoke samples were collected during wildfires that occurred in central Portugal. A portable high-volume sampler was used to perform the sampling, on quartz fibre filters of coarse （PM=2.5-10） and fine （PM2.5） smoke samples. The carbonaceous content （elemental and organic carbon） of particulate matter was analysed by a thermal-optical technique. Subsequently, the particulate samples were solvent extracted and fractionated by vacuum flash chromatog- raphy into three different classes of organic compounds （aliphatics, polycyclic aromatic hydrocarbons （PAHs） and carbonyl compounds）. The organic speciation was performed by gas chromatography-mass spectrometry （GC-MS）. Emissions were dominated by the fine particles, which represented around 92% of the PM10. A clear predominance of carbonaceous constituents was observed, with organic to elemental carbon （OC/EC） ratios ranging between 1.69 and 245 in both size fractions. The isoprenoid ketone 6,10,14-trimethyl-2-pentadecanone, a tracer for secondary organic aerosol formation, was one of the dominant constituents in both fine and coarse particles. Retene was the most abundant compound in all samples. Good correlations were obtained between OC and both aliphatic and PAH compounds. Pyrogenic processes, thermal release of biogenic com- pounds and secondary processing accounted for 97% of the apportioned PM2.5 levels.

关键词： WildfiresOrganic carbonOrganic compoundsBiomarkersParticulate matterPortugal

Thermal and Mechanical Properties of Thermoplastic Starch and Poly(Vinyl Alcohol-Co-Ethylene)Blends

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Journal of Renewable Materials 2019年第3期7卷 245-252页

作者： ana Clara Lancarovici alves Rafael Grande Antonio José Felix Carvalho Department of Materials Engineering Sao Carlos School of EngineeringUniversity of Sao PauloAv.Joao Dagnone110013563-120Sao Carlos-SP-Brazil

The interest in thermoplastic starch(TPS)as a substitute material to replace conventional thermoplastics continues especially due its biodegradability,availability,low cost and because it is obtained from renewable ***,its poor mechanical properties and its high sensitivity to humidity have limited its use in several ***,the copolymer poly(ethylene-co-vinyl alcohol)(EVOH),with two different ethylene contents,27 and 44 mol%were blended with TPS by extrusion in order to overcome these *** obtained blends were characterized by thermogravimetric analysis(TGA),differential scanning calorimetry(DSC),mechanical tensile testing,Scanning Electron Microscopy(SEM)and moisture absorption *** addition of EVOH copolymer did not significantly changed the thermal stability of TPS,however it increased the tensile strength in 65%when compared to *** morphology of the blends did not showed two distinct phases,an indication of miscibility or partial miscibility of the components.A decrease of moisture absorption was obtained by the addition of EVOH and is more pronounced for the EVOH with 44% of ethylene.

关键词： Thermoplastic starch EVOH polymer blends thermal properties of polymers mechanical properties of polymers

Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review

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Journal of Pharmaceutical analysis 2021年第4期11卷 405-421页

作者： Sara Meirinho Marcio Rodrigues ana Fortuna Amílcar Falcao Gilberto alves Faculty of Health Sciences Health Sciences Research CenterUniversity of Beira Interior(CICS UBI)6200-506CovilhaPortugal Research Unit for Inland Development Polytechnic Institute of Guarda(UDI-IPG)6300-654GuardaPortugal Coimbra Institute for Biomedical Imaging and Translational Research(CIBIT) University of Coimbra3000-548CoimbraPortugal Laboratory of Pharmacology Faculty of PharmacyUniversity of Coimbra3000-548CoimbraPortugal

The new antiepileptic drugs perampanel,retigabine,rufinamide and stiripentol have been recently approved for different epilepsy *** them an innovation in the antiepileptics armamentarium,a lot of investigations regarding their pharmacological properties are yet to be ***,considering their broad anticonvulsant activities,an extension of their therapeutic indications may be worthy of investigation,especially regarding other seizure types as well as other central nervous system *** different liquid chromatographic(LC)methods coupled with ultraviolet,fluorescence,mass or tandem-mass spectrometry detection have already been developed for the determination of perampanel,retigabine,rufinamide and stiripentol,new and more cost-effective methods are yet ***,this review summarizes the main analytical aspects regarding the liquid chromatographic methods developed for the analysis of perampanel,retigabine(and its main active metabolite),rufinamide and stiripentol in biological samples and pharmaceutical dosage ***,the physicochemical and stability properties of the target compounds will also be ***,this review gathers,for the first time,important background information on LC methods that have been developed and applied for the determination of perampanel,retigabine,rufinamide and stiripentol,which should be considered as a starting point if new(bio)analytical techniques are aimed to be implemented for these drugs.

关键词： Bioanalysis Liquid chromatography Perampanel Retigabine Rufinamide Stiripentol

Pathophysiology of cystic fibrosis and drugs used in associated digestive tract diseases

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World Journal of Gastroenterology 2013年第46期19卷 8552-8561页

作者： Adriana Haack Giselle Gonalves Arago Maria rita Carvalho Garbi Novaes Department of Health Universidade Paulista (UNIP)

Cystic fibrosis(CF)causes chronic infections in the respiratory tract and alters the digestive *** paper reviews the most important aspects of drug treatment and changes in the digestive tract of patients with *** is a review of the literature,emphasizing the discoveries made within the last 15 years by analyzing scientific papers published in journals indexed in the Scientific Electronic Library Online,Sciences Information,United States National Library of Medicine and Medical Literature analysis and Retrieval System Online databases,both in English and Portuguese,using the key words:cystic fibrosis,medication,therapeutic,absorption,***,observational,experimental,and epidemiological clinical studies were selected,among others,with statistical significance of 5%.This review evaluates the changes found in the digestive tract of CF patients including pancreatic insufficiency,constipation and liver *** in nutritional status are also *** treatment,nutritional supplementation and drug management were classified in this review as essential to the quality of life of CF patients,and became available through public policies for monitoring and treating *** information gathered on CF and a multi professional approach to the disease is essential in the treatment of these patients.

关键词： Cystic fibrosis Medication Therapeutic Absorption digestion

PM_(2.5) chemical composition and health risks by inhalation near a chemical complex

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Journal of Environmental Sciences 2023年第2期124卷 860-874页

作者： Celia alves Margarita Evtyugina Estela Vicente ana Vicente Ismael Casotti Rienda ana Sanchez de la Campa Mario Tome Iola Duarte Department of Environment Centre for Environmental and Marine Studies(CESAM)University of Aveiro3810-193 AveiroPortugal Associate Unit CSIC-University of Huelva“Atmospheric Pollution” Centre for Research in Sustainable Chemistry-CIQSOUniversity of HuelvaE21071 HuelvaSpain Department of Mining MechanicEnergetic and Construction EngineeringETSIUniversity of Huelva21071 HuelvaSpain PROMETHEUS School of Technology and Management(ESTG)Polytechnic Institute of Viana do Castelo4900-348 Viana do CasteloPortugal Department of Chemistry CICECO-Aveiro Institute of MaterialsUniversity of Aveiro3810-193 AveiroPortugal

Particulate matter(PM_(2.5))samples were collected in the vicinity of an industrial chemical pole and analysed for organic and elemental carbon(OC and EC),47 trace elements and around 150 organic *** average,OC and EC accounted for 25.2% and 11.4% of the PM_(2.5) mass,*** compounds comprised polycyclic aromatic hydrocarbons(PAHs),alkylated PAHs,anhydrosugars,phenolics,aromatic ketones,glycerol derivatives,aliphatic alcohols,sterols,and carboxyl groups,including aromatic,carboxylic and dicarboxylic *** factors>100 were obtained for Pb,Cd,Zn,Cu,Sn,B,Se,Bi,Sb and Mo,showing the contribution of industrial emissions and nearby major *** component analysis revealed that vehicle,industrial and biomass burning emissions accounted for 66%,11% and 9%,respectively,of the total PM_(2.5)-bound *** of the detected organic constituents are likely associated with plasticiser ingredients and thermal stabilisers used in the manufacture of PVC and other plastics in the industrial *** products of both anthropogenic(e.g.,toluene)and biogenic(e.g.,isoprene and pinenes)precursors were also *** was estimated that biomass burning accounted for 13.8%of the PM_(2.5) concentrations and that secondary OC represented 37.6% of the total *** lifetime cancer risk from inhalation exposure to PM_(2.5)-bound PAHs was found to be negligible,but it exceeded the threshold of 10−6 for metal(loi)s,mainly due to Cr and As.

关键词： PM_(2.5) OC/EC Organic speciation Trace elements Cancer and non-cancer risks

Impact of the metabolic syndrome on the evolution of neurodegenerative diseases

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Neural Regeneration Research 2021年第4期16卷 688-689页

作者： ana Paula de A.Boleti Jeeser alves Almeida Ludovico Migliolo S-InovaBiotech Programa de Pós-Graduação em BiotecnologiaUniversidade Católica Dom BoscoCampo GrandeMSBrazil Programa de Pós-Graduação em Ciências do Movimento Programa de Pós-Graduação em Saúde e Desenvolvimento na Região Centro OesteUniversidade Federal de Mato Grosso do SulCampo GrandeMSBrazil Programa de Pós-graduação em Biologia Celular e Molecular Programa de Pós-graduação em BioquímicaUniversidade Federal do Rio Grande do NorteNatalBrazil

Metabolic syndrome(MetS)might be defined as the simultaneous accumulation of s everal functional changes that frequently occur in adults over 60 years of age(Gomez et al.,2018).The diagnosis of MetS requires the presence of three or more factors such as high body mass,type-2 diabetes mellitus(T2DM),dyslipidemia,and arterial hypertension,which increase the risk of cardiovascular diseases as well as neurological complications,as stroke and dementia(Dyken and Lacoste,2018).Usually,these functional changes coincide and result in insensitivity for example hormones as leptin,adiponectin,and insulin(Dyken and Lacoste,2018).

关键词： diagnosis arterial hypertension

The brain as a source and a target of prolactin in mammals

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Neural Regeneration Research 2022年第8期17卷 1695-1702页

作者： ana R.Costa-Brito Isabel Gonçalves Cecília R.A.Santos CICS-UBI-Health Sciences Research Centre Universidade da Beira InteriorCovilhãPortugal C4-UBI-Cloud Computing Competence Centre Universidade da Beira InteriorCovilhãPortugal

Prolactin is a polypeptide hormone associated with an extensive variety of biological *** the roles of prolactin in vertebrates,some were preserved throughout *** is the case of its function in the brain,where prolactin receptors,are expressed in different structures of the central nervous *** the brain,prolactin actions are principally associated with reproduction and parental behavior,and involves the modulation of adult neurogenesis,neuroprotection,and neuroplasticity,especially during pregnancy,thereby preparing the brain to *** is mainly produced by specialized cells in the anterior pituitary ***,during vertebrate evolution many other extrapituitary tissues do also produce prolactin,like the immune system,endothelial cells,reproductive structures and in several regions of the *** review summarizes the relevance of prolactin for brain function,the sources of prolactin in the central nervous system,as well as its local production and secretion.A highlight on the impact of prolactin in human neurological diseases is also provided.

关键词： brain brain disease choroid plexus neurogenesis neuroplasticity neuroprotection prolactin prolactin receptor

Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages

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World Journal of Stem Cells 2021年第9期13卷 1160-1176页

作者： Alexia Nedel Sant'ana Anelise Bergmann Araújo Fabiany da Costa Gonçalves ana Helena Paz Laboratório de Células Tecidos e Genes Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903RSBrazil Centro de Processamento Celular Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903RSBrazil Department of Internal Medicine Erasmus Medical CenterRotterdam 3015 GDNetherlands Departamento de Ciências Morfológicas Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto Alegre 90035-903RSBrazil

Mesenchymal stromal cells (MSCs) are multipotent and self-renewing stem cellsthat have great potential as cell therapy for autoimmune and inflammatorydisorders, as well as for other clinical conditions, due to their immunoregulatoryand regenerative properties. MSCs modulate the inflammatory milieu by releasingsoluble factors and acting through cell-to-cell mechanisms. MSCs switch theclassical inflammatory status of monocytes and macrophages towards a nonclassicaland anti-inflammatory phenotype. This is characterized by an increasedsecretion of anti-inflammatory cytokines, a decreased release of pro-inflammatorycytokines, and changes in the expression of cell membrane molecules and inmetabolic pathways. The MSC modulation of monocyte and macrophage phenotypesseems to be critical for therapy effectiveness in several disease models, sincewhen these cells are depleted, no immunoregulatory effects are observed. Here,we review the effects of living MSCs (metabolically active cells) and metabolicallyinactive MSCs (dead cells that lost metabolic activity by induced inactivation) andtheir derivatives (extracellular vesicles, soluble factors, extracts, and microparticles)on the profile of macrophages and monocytes and the implications forimmunoregulatory and reparative processes. This review includes mechanisms ofaction exhibited in these different therapeutic appro-aches, which induce the antiinflammatoryproperties of monocytes and macrophages. Finally, we overviewseveral possibilities of therapeutic applications of these cells and their derivatives,with results regarding monocytes and macrophages in animal model studies andsome clinical trials.

关键词： Mesenchymal stromal cells Macrophage Monocyte Immunomodulation Cell therapy Immunoregulation