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Giant squamous cell carcinoma of the gallbladder: A case report

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World Journal of Clinical Cases 2019年第18期7卷 2787-2793页

作者： Marcelo AF Ribeiro Junior Murillo de Lima Favaro Stephanie Santin Cintia Magalhaes Silva ana paula Marconi Iamarino Department of Acute Care and Trauma Surgery Hospital MoriahSao Paulo 04081000Brazil Department of Surgery University of Santo AmaroSao Paulo 04829- 300Brazil Department of Surgery Hospital MoriahUniversity of Santo AmaroSao Paulo 04829-300Brazil Medical Student University of Santo AmaroSao Paulo 04829-300Brazil Department of Surgery Hospital MoriahHospital MoriahSao Paulo 04829-300Brazil

BACKGROUND Gallbladder cancer is the most common malignant tumor of the biliary tract. The majority of cases are adenocarcinoma. Squamous cell carcinoma is the histological type present in 12% of all neoplasias accounting for approximately 12% of gallbladder neoplasms. It can occur in its pure form reaching 1%-3% of the tumors. Many patients are at an advanced stage when diagnosed and have bad therapeutic efficacy. CASE SUMMARY A 45-year-old male patient presented with left flank pain for 1 year and irradiated to the mesogastric region. He denied fever, vomiting, and any other intestinal changes. He reported a weight loss of 10 kg in a period of 7 mo. He denied alcoholism, smoking, drug use, or prior illness. Computed tomography of the abdomen showed in the gallbladder fossa a voluminous mesogastric heterogeneous collection that had a thick and irregular capsule with liquid and gaseous contents. A predominantly hypoattenuating rounded material with partially calcified margins measuring about 2.0 cm related to gallstone was also emphasized. No lymphadenomegalies or free fluid was observed in the abdominal cavity. Patient underwent laparotomy where a huge tumor was observed affecting the transverse colon and gallbladder. This mass was resected en bloc removing gallbladder and transverse colon together with corresponding mesocolon and regional lymphadenectomy. There were no complications in the postoperative period. Although oncological treatment was performed, the patient died 6 mo after surgery. CONCLUSION Squamous cell carcinoma represents a rare disease. Patients often present with large, bulky tumors with involvement of adjacent organs. In spite of progress in surgical techniques and adjuvant chemotherapy, the prognosis remains poor.

关键词： Squamous cell Carcinoma Gallbladder neoplasm Treatment Case report

Integrating species and successional classes for wood production in a mixed forest restoration system in a neotropical region

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Journal of Forestry Research 2021年第6期32卷 2313-2321页

作者： ananias Francisco Dias Junior ana Lucia Martins Sodero Pincelli ana paula Camara da Silva Alison Moreira da Silva Natalia Dias de Souza Mario Tommasiello Filho Jose Otavio Brito Wood and Forestry Science Department Federal University of EspIrito Santo(UFES)Av.Governador Lindemberg316JerOnimo Monteiro CityES 29550-000Brazil São Paulo State School of Technology(FATEC/SP) Av.DiacOno Jair de Oliveira651PiracicabaSP 13414-141Brazil Forest Products Department Federal Rural University of Rio de Janeiro(UFRRJ)BR 465km 07SeropEdicaRJ 29890-000Brazil University of SAo Paulo “Luiz de Queiroz”College of Agriculture(USP/ESALQ)Av.PAdua Dias11PiracicabaSP 13418-900Brazil

As forests in neotropical regions,particularly in developing countries,are devastated,interventions to restore biodiversity and its ecological functions are *** producers have thus been encouraged to grow trees for wood production as an economic *** objective of this study was to quantify the increment of wood density of four forest species from different successional classes of a mixed system of restoration in a neotropical forest in *** discs were sampled at breast height and analyzed radially by X-ray densitometry to obtain apparent density and basic *** trees each of a species from the pioneer,early and late secondary successional stages and of the dominant species in the climax *** radial profiles indicated increasing density from the pith to bark of trunks,except for some variations due to wood defects and *** density was 0.576 g cm^(-3),0.655 g cm^(-3),0.706 g cm^(-3)and 0.775 g cm^(-3),respectively,for Peltophorum dubium,Schinus terebinthifolius,Cariniana estrellensis and Hymenaea *** profiles indicated higher amplitudes in the apparent densities for slow-growing species.X-ray densitometry generated parameters such as minimum,average and maximum densities,and radial density *** parameters are important for understanding the ecological functional role of successional classes of the Atlantic Forest from the Neotropical region.

关键词： X-ray densitometry Timber species of neotropical forest Successional classes of forest species Maintenance of forest restoration

Marginal Architecture[How Will We Live Together?]-A Process under Construction

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Journal of Civil Engineering and Architecture 2021年第11期15卷 586-589页

作者： ana paula Rainha ana Bordalo Instituto Superior Manuel Teixiera Gomes ArchitectueArts and Design DepartmentPortimão 8500-724Portugal CIAUD Lisbon School of ArchitectureUniversidade de LisboaLisbon 1349-063Portugal

The organization of territory and cities is a structuring element for the management of epidemic *** existence of basic sanitary structures is,nowadays,an acquired and determined factor for the healthiness of territories,as well as for the structural contribution to the well-being of the *** the 19th century epidemic crises established health parameters for Architecture and Urbanism,which are still a reference *** after one hundred years,where the questions of salubrity were supposed to be consolidated,we find that,suddenly,without advice,new alarm bells ring:we found that the world was not prepared to be closed in its“housing units”.Assuming Portimão as an urban laboratory and as a waterfront city,we will present the studies that were developed by students in workshops context,searching for contemporary solutions,considering nowadays ecological and Architectural concerns,having in mind concepts of sustainability,reuse and recycling.

关键词： Waterfront city architectonic mentality urban laboratory

Synthesis and applications of lanthanoid complexes of pentadentate and hexadentate N_(5) and N_(6) macrocycles:A review

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Journal of Rare Earths 2024年第1期42卷 1-15,I0001页

作者： Julio Corredoira-Vázquez Cristina González-Barreira paula Oreiro-Martínez ana M.García-Deibe Jesús Sanmartín-Matalobos Matilde Fondo Departamento de Química Inorganica Facultade de QuímicaUniversidade de Santiago de CompostelaCampus Vida15782Santiago de CompostelaSpain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of Aveiro3810-193AveiroPortugal Institute of Materials(iMATUS) Universidade de Santiago de Compostela15782Santiago de CompostelaSpain

In this paper,the lanthanoid complexes of N_(5) and N_(6) macrocycle ligands,without pendant arms or additional heteroatoms,are *** review covers the period from 2015 to the current date,since in 2014 Schiff base macrocyclic ligands incorporating the pyridine moiety,and their complexes,were revised,and in 2015 the chemistry of pentaaza macrocycle ligands with rare earth metals was also *** and phthalocyanine ligands are not included in this review,which primarily focuses on complexes with Schiff bases and amines without pendant arms or any additional donor other than *** synthetic methods,structural characterization,based on single X-ray crystal data,and properties of the lanthanoid complexes,with special attention to magneto-structural correlations,are presented herein.

关键词： Lanthanoid N_(5),N_(6)macrocycle Coordination chemistry Chirality Biological activity Molecule magnet

Tracking leaf area index and coefficient of light extinction over the harvesting cycle of black wattle

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Journal of Forestry Research 2016年第6期27卷 1211-1217页

作者： Aiexandre Behling Carlos Roberto Sanquetta ana paula Dalla Corte Sylvio Pellico Netto Aurelio Lourenco Rodrigues Braulio Otomar Caron Augusto Arlindo Simon Federal University of Parana 900Lothario Meissner AvCuritibaParana 80210-170Brazil Federal University of Santa Maria 1000 Roraima AvSanta MariaRio Grande do SulBrazil TanaC SA 199 Torbjom Weibull StMontenegroRio Grande do SulBrazil

The amount of photosynthetic radiation inter- cepted by a crop is a function of the incident solar radiation on the plants, the leaf area index （LAI）, and the light extinction coefficient （k）. We quantified LAI and k in stands of black wattle （Acacia mearnsii De Wild.） over a 7-year growth cycle at two locations in the state of Rio Grande do Sul, Brazil. Our study was conducted in commercial stands in agroecological regions with high densities of black wattle plantations. LAI was calculated as the ratio between the leaf area of a tree and its planting space, and k was derived from Beer＇s law. LAI depends on the planting site and stand age. Between the two sites, the LAI was similar over time, the amount of variation differed. Values of k depended only on stand age, with the highest average observed for stands up to 5 years old. The trend of k during the plantation cycle was inversely proportional to LAI and was correlated with LAI, leaf area, leaf dry mass, canopy volume, height, branches dry mass, total dry mass, and crown diameter.

关键词： Leaf area - Light attenuation Tree canopy Biomass Photosynthetic radiation intercepted

In vitro antileishmanial effects of Physalis angulata root extract on Leishmania infantum

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Journal of Integrative Medicine 2018年第6期16卷 404-410页

作者： Bruno Jose Martins Da Silva Sandro Wilson Gomes Pereira ana paula Drummond Rodrigues Jose Luiz Martins Do Nascimento Edilene Oliveira Silva Laboratory of Structural Biology Institute of Biological SciencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Structural Biology and Bioimaging(INCT-INBEB) Rio de Janeiro 21941-901Brazil Laboratory of Electron Microscopy Department of Health SurveillanceMinistry of HealthEvandro Chagas InstituteBelemPard 66087-082Brazil Laboratory of Molecular and Cellular Neurochemistry Institute of Biological SciencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Neuroimmunomodulation(INCT-NIM) Rio de Janeiro 21040-360Brazil

Objective： In the present study, we evaluated the effects of the aqueous extract of Physalis angulata root （AEPa） on Leishmania infanturn proliferation, morphology, and the driving mechanism in leishmanicidal activity and modulatory action on macrophages. Methods： I., infantum promastigotes were treated with 50 and 100 μg/mL AEPa for 72 h and then antipro- mastigote assay was performed by counts in a Newbauer chamber, morphological changes were analyzed by transmission electron microscopy and the mechanism of the leishmanicidal activity was detected. In addition, macrophages were infected with L. infantum and were used to evaluate anti-amastigote activity of AEPa and effects of AEPa on cytokine secretion after 72-hour treatment. Results： Treatment with AEPa reduced the numbers ofL infantum promastigotes （50% inhibitory concen- tration （ICso） = 65.9μg/mL; selectivity index （SI）= 22.1） and amastigotes （ICso = 37.9 μg/mL; SI = 38.5） compared with the untreated control. Amphotericin B reduced 100% of the promastigote numbers after 72 h of treatment （IC50 = 0.2μg/mL）. AEPa induced several morphological changes and increased the production of reactive oxygen species and apoptotic death in promastigotes after treating for 72 h. AEPa （100 μg/mL） promoted tumor necrosis factor-α secretion in macrophages infected with L. infantum after 72 h of treatment, but did not induce an increase in this cytokine in noninfected macrophages. In addition, AEPa showed no cytotoxic effect on J774-A1 cells （50% cytotoxic concentration 〉1000μg/mL）. Conclusion： AEPa presented antileishmanial activity against the promastigotes and amastigotes of I.. infantum without macrophage cytotoxicity; these results show that natural products such as P. angulata have leishmanicidal potential and in the future may be an alternative treatment for leishmaniasis.

关键词： Leishmanicidal activity Leishmania infantum Reactive oxygen species Apoptosis Physalis angulata

Ginger infusion increases diet-induced thermogenesis in healthy individuals:A randomized crossover trial

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Food Bioscience 2022年第6期50卷 314-319页

作者： ana paula da Costa Soares Natália Cristina de Faria Guilherme Fonseca Graciano James Almada da Silva Vitoria Shievila dos Santos Gonçalves Virginia del Carmen Trancoso Valenzuela Maria Isabel Toulson Davisson Correia Lucilene Rezende anastácio Post-Graduate Program in Food Science Pharmacy SchoolUniversidade Federal de Minas GeraisBrazil Surgical Post-Graduate Program Alfa Institute of GastroenterologyHospital das ClínicasUniversidade Federal de Minas GeraisBrazil Pharmacy Department Universidade Federal de SergipeBrazil Fundação Ezequiel Dias Brazil

The purpose of this study is to evaluate the acute effect of ingesting ginger infusion on energy metabolism,appetite responses,and food intake in healthy *** is a clinical(RBR-9ZJGQM),randomized,open,and crossover study with a minimum interval of seven days between *** drinks,ginger infusion(2 g)and water(control)were served with a standard *** has 21 volunteers of both sexes(18–40 years old,18.5–26 kg/m2).Consumption of ginger tea increased on average 95.5±27.4 kcal/day the non-nitrogen energy expenditure after 240 min of ingestion(p=0.002).There was a significant effect of ginger on diet-induced thermogenesis(difference between ginger tea treatment ***:113.0±43.0 kcal/day,p=0.016).However,appetitive responses and prospective food intake did not differ between ginger tea and water intake.

关键词： Zingiber officinale Ginger Indirect calorimetry Energy metabolism

Multi-target prediction of wheat flour quality parameters with near infrared spectroscopy

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Information Processing in Agriculture 2020年第2期7卷 342-354页

作者： Sylvio Barbon Junior Saulo Martielo Mastelini ana paula ACBarbon Douglas Fernandes Barbin Rosalba Calvini Jessica Fernandes Lopes Alessandro Ulrici Computer Science Department Londrina State University(UEL)Londrina 86057-970Brazil Animal Science Department Londrina State University(UEL)Londrina 86057-970Brazil Department of Food Engineering Campinas State University(UNICAMP)Campinas 13083-862Brazil Department of Life Science University of Modena and Reggio Emilia(UNIMORE)42122 Reggio EmiliaItaly

Near Infrared(NIR)spectroscopy is an analytical technology widely used for the nondestructive characterisation of organic samples,considering both qualitative and quantitative *** the present study,the combination of Multi-target(MT)prediction approaches and Machine Learning algorithms has been evaluated as an effective strategy to improve prediction performances of NIR data from wheat flour *** different Multi-target approaches have been tested:Multi-target Regressor Stacking(MTRS),Ensemble of Regressor Chains(ERC)and Deep Structure for Tracking Asynchronous Regressor Stack(DSTARS).Each one of these techniques has been tested with different regression methods:Support Vector Machine(SVM),Random Forest(RF)and Linear Regression(LR),on a dataset composed of NIR spectra of bread wheat flours for the prediction of qualityrelated *** combining all MT techniques and predictors,we obtained an improvement up to 7%in predictive performance,compared with the corresponding Single-target(ST)*** results support the potential advantage of MT techniques over ST techniques for analysing NIR spectra.

关键词： Random forest Support Vector Machine Near-infrared spectroscopy Machine learning MTRS DSTARS Partial Least Squares ERC

Heat Conduction analytical Solutions to be Applied in Boundary Conditions Obtained from Discrete Data

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Journal of Energy and Power Engineering 2013年第8期7卷 1527-1532页

作者： ana paula Femandes Gilmar Guimaraes School of Mechanical Engineering Federal University of Uberldndia Minas Gerais 38408-100 Brazil

analytical solutions have varied uses. One is to provide solutions that can be used in verification of numerical methods. Another is to provide relatively simple forms of exact solutions that can be used in estimating parameters, thus, it is possible to reduce computation time in comparison with numerical methods. In this paper, an alternative procedure is presented. Here is used a hybrid solution based on Green＇s function and real characteristics （discrete data） of the boundary conditions.

关键词： Heat conduction analytical solutions discrete data.