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Taurine: a promising nutraceutic in the prevention of retinal degeneration

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Neural Regeneration Research 2024年第3期19卷 606-610页

作者： Diego García-Ayuso Johnny Di Pierdomenico ana martínez-Vacas Manuel Vidal-Sanz Serge Picaud maría PVillegas-Pérez Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaEspaña Sorbonne Université INSERMCNRSInstitut de la VisionParisFrance

Taurine is considered a non-essential amino acid because it is synthesized by most ***,dietary intake of taurine may be necessary to achieve the physiological levels required for the development,maintenance,and function of certain *** may be especially important for the *** concentration of taurine in the retina is higher than that in any other tissue in the body and taurine deficiency causes retinal oxidative stress,apoptosis,and degeneration of photoreceptors and retinal ganglion *** plasma taurine levels may also underlie retinal degeneration in humans and therefore,taurine administration could exert retinal neuroprotective *** has antioxidant,anti-apoptotic,immunomodulatory,and calcium homeostasis-regulatory *** review summarizes the role of taurine in retinal health and disease,where it appears that taurine may be a promising nutraceutical.

关键词： amino acid anti-inflammatory antioxidant gamma-aminobutyric acid nutraceutical photoreceptor degeneration retina retinitis pigmentosa taurine

Comparation of the eutectic mixture of lidocaine/prilocain versus benzocaine gel in children

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Open Journal of Stomatology 2011年第3期1卷 84-91页

作者： ana maría Leyda Carmen Llena 不详

Objective: To compare the anesthetic effect of a non commercial eutectic mixture of 4% lidocaine/ prilocaine (PLO 4%) and 20% benzocaine gel (Hurricaine?), as topical anesthetic, prior to inferior alveolar nerve block and buccal infiltration anesthe-sia in 5-12 year old children. Study design: Infiltrative anesthesia was applied in 50 children, divided in two groups (n = 25) using PLO 4% and Hurricaine? as topical anesthesia prior to infiltration. Physical reac-tions were registered using the Sound-Eyes- Motor Scale. Physiological changes expressed by ar-terial pressure and heart rate. Subjective pain re-sponse was scored on a Facial Image Scale. Physical physiological and subjective response was related to the type of topical anesthetic, age and sex using χ2 and Mann-Whitney U test. Results: Physical responses to puncture were similar and localized in the state of comfort with both anesthetics. Girls showed more ocular response than boys. Subjective pain perception and physiological reactions showed no anesthetic- or sex-related differences, except for heart rate before and after the procedure which was significantly higher in girls. Conclusions: PLO 4% showed the same capacity as Hurricaine? in reducing pain response to needle puncture. Girls expressed more needle puncture-related pain than boys. The young children showed most prior comfort and less discomfort to the puncture than older children.

关键词： Lidocaine Prilocaine Benzocaine Topical Anesthetics

Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice

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Neural Regeneration Research 2024年第9期19卷 2068-2074页

作者： Carolina Aguado Sara Badesso Josémartínez-Hernández Alejandro martín-Belmonte Rocío Alfaro-Ruiz Miriam Fernández ana Esther Moreno-martínez mar Cuadrado-Tejedor ana García-Osta Rafael Luján Synaptic Structure Laboratory Instituto de Investigación en Discapacidades Neurológicas(IDINE)Department of Medical SciencesFacultad de MedicinaUniversidad de Castilla-La ManchaCampus BiosanitarioAlbaceteSpain Gene Therapy for Neurological Disease Program Center for Applied Medical Research(CIMA)University of NavarraInstituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Pharmacology Unit Department of Pathology and Experimental TherapeuticsFaculty of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaBarcelonaSpain Neuropharmacology and Pain Group Neuroscience ProgramInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatSpain Department of Pathology Anatomy and PhysiologySchool of MedicineUniversity of NavarraPamplonaSpain UniversitéGrenoble Alpes Grenoble Institut des NeurosciencesGrenobleFrance

Plaques of amyloid-β(Aβ)and neurofibrillary tangles are the main pathological characteristics of Alzheimer’s disease(AD).However,some older adult people with AD pathological hallmarks can retain cognitive *** the factors that lead to this cognitive resilience to AD offers promising prospects for identifying new therapeutic *** hypothesis focuses on the contribution of resilience to changes in excitatory synapses at the structural and molecular levels,which may underlie healthy cognitive performance in aged AD *** the Morris Water Maze test,we selected resilient(asymptomatic)and cognitively impaired aged Tg2576 *** the enzyme-linked immunosorbent assay showed similar levels of Aβ42 in both experimental groups,western blot analysis revealed differences in tau pathology in the pre-synaptic supernatant *** further investigate the density of synapses in the hippocampus of 16-18 month-old Tg2576 mice,we employed stereological and electron microscopic *** findings indicated a decrease in the density of excitatory synapses in the stratum radiatum of the hippocampal CA1 in cognitively impaired Tg2576 mice compared with age-matched resilient Tg2576 and non-transgenic ***,through quantitative immunoelectron microscopy in the hippocampus of impaired and resilient Tg2576 transgenic AD mice,we uncovered differences in the subcellular localization of glutamate ***,the density of GluA1,GluA2/3,and mGlu5 in spines and dendritic shafts of CA1 pyramidal cells in impaired Tg2576 mice was significantly reduced compared with age-matched resilient Tg2576 and non-transgenic ***,the density of GluA2/3 in resilient Tg2576 mice was significantly increased in spines but not in dendritic shafts compared with impaired Tg2576 and non-transgenic *** subcellular findings strongly support the hypothesis that dendritic spine plasticity and synaptic machinery in the hippocampus play cr

关键词： aging Alzheimer´s disease cognitive hippocampus immunoelectron microscopy resilience synapse

SCADA Data-Based Support Vector Machine for False Alarm Identification for Wind Turbine Management

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Intelligent Automation & Soft Computing 2023年第9期37卷 2595-2608页

作者： ana maría Peco Chacón Isaac Segovia Ramírez Fausto Pedro García Márquez Ingenium Research Group Universidad Castilla-La ManchaCiudad Real13071Spain

Maintenance operations have a critical influence on power gen-eration by wind turbines(WT).Advanced algorithms must analyze large volume of data from condition monitoring systems(CMS)to determine the actual working conditions and avoid false *** paper proposes different support vector machine(SVM)algorithms for the prediction and detection of false alarms.K-Fold cross-validation(CV)is applied to evaluate the classification reliability of these *** Control and Data Acquisition(SCADA)data from an operating WT are applied to test the proposed *** results from the quadratic SVM showed an accuracy rate of 98.6%.Misclassifications from the confusion matrix,alarm log and maintenance records are analyzed to obtain quantitative information and determine if it is a false *** classifier reduces the number of false alarms called misclassifications by 25%.These results demonstrate that the proposed approach presents high reliability and accuracy in false alarm identification.

关键词： Machine learning classification support vector machine false alarm wind turbine cross-validation

In-depth analysis of soil management and farmers’perceptions of related risks in two olive grove areas in southern Spain

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International Soil and Water Conservation Research 2021年第3期9卷 461-473页

作者： José A.Gòmez ana Sanchez Montero Gema Guzman marfa-Auxiliadora Soriano a Institute for Sustainable Agriculture CSICCordobaSpain Agronomy Department University of CordobaCordobaSpain

This manuscript presents a questionnaire-based study aimed to provide a detailed analysis on the different soil management carried out by olive farmers in two representative olive-growing areas in southern Spain(Cordoba and Estepa),their perceptions on cover crop use and the possible influence of the different types of farms and farmers’typologies on these *** results show a relatively large variability of soil management,with fourteen options,as a result of a combination of different alternatives for bare soil and cover crops with the use or not of pruning residues,but with a great similarity between both *** results indicate a high adoption of soil conservation measures in the two study areas,with 63%of farmers using cover crops and 80%a mulch of pruning residues,higher than that reported in previous studies in Southern Spain,and a trend of lower use of these techniques by less experienced and younger *** high penetration of soil conservation measures resulted in a significant reduction of soil erosion risk,as indicated by the relatively low values for the cover and management factor(C)of RUSLE,also calculated and presented in this study,but also the possibility of focusing further efforts on fanners with less *** results indicate the persistence of a minor,but relevant,percentage of farmers using bare soil management(37%)and no mulching(20%),with a moderate concern on the impact of soil erosion on soil degradation and provision of ecosystem *** suggests the need to concentrate efforts also on this cluster of farmers to enhance the success of what seems to be a remarkable expansion of the use of soil conservation measures in recent decades in Southern Spain,but also in similar areas in the Mediterranean basin.

关键词： Tillage Cover crops Olive yield Erosion risk Irrigation Questionnaire

Effect of dichloromethylene diphosphonate on liver regeneration following thioacetamide-induced necrosis in rats

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World Journal of Hepatology 2013年第7期5卷 379-386页

作者： Mirandeli Bautista maría ngeles Gómez del Rio Juana Benedí maría Isabel Sánchez-Reus José A Morales-González ana maría Téllez-López maricela López-Orozco rea Académica de Farmacia Instituto de Ciencias de la Salud Universidad Autónoma del Estado de Hidalgo Departamento de Bioquímica y Biología Molecular Facultad de Farmacia Ciudad Universitaria Departamento de Farmacología Facultad de Farmacia Ciudad Universitaria Escuela Superior de Medicina Instituto Politécnico Nacional

AIM: To study the effect of dichloromethylene diphos-phonate (DMDP), a selective Kupffer cell toxicant in reference to liver damage and postnecrotic liver regeneration in rats induced by sublethal dose thioacetamide (TA). METHODS: Rats, intravenously (iv ) pre-treated with a single dose of DMDP (10 mg/kg), were intraperitoneally (ip ) injected with TA 6.6 mmol/kg (per 500 mg/kg body weight). Hepatocytes were isolated from rats at 0, 24, 48 and 72 h following TA intoxication and blood and liver samples were obtained. To evaluate the mecha-nisms involved in the postnecrotic regenerative state, DNA distribution and ploidy time course were assayed in isolated hepatocytes. Circulating cytokine tumor necrosis factor-alpha (TNF-α) was assayed in serum and determined by reverse transcriptase-polymerase chain reaction in liver extract. RESULTS: The effect of DMDP induced noticeable changes in postnecrotic regeneration, causing an increased percentage of hepatocytes in the cell cycle S phase. The increase at 24 h in S1 population in rats pretreated with DMDP + TA was significantly (P < 0.05) different compared with that of the TA group (18.07% vs 8.57%). Hepatocytes increased their proliferation as a result of these changes. Also, TNF-α expression and serum level were increased in rats pre-treated with DMDP. Thus, DMDP pre-treatment reduced TA-induced liver injury and accelerated postnecrotic liver regeneration. CONCLUSION: These results demonstrate that Kupffer cells are involved in TA-induced liver, as well as in post-necrotic proliferative liver states.

关键词： Dichloromethylene diphosphonate Kupffer cells Thioacetamide Hepatotoxicity Cell cycle

Responsible research and innovation training programmes:implementation and evaluation of the HEIRRI project

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Forensic Sciences Research 2021年第3期6卷 320-330页

作者： Ružica Tokalić Ivan Buljan Niels Mejlgaard mar Carrió Alexander Lang Gema Revuelta ana marušić HEIRRI Consortium Department of research in Biomedicine and health University of split school of Medicinesplitcroatia Danish centre for studies in research and research Policy Department of Political scienceaarhus UniversityaarhusDenmark health sciences education research Group Department of experimental and health sciencesPompeu Fabra UniversityBarcelonaspain Techno-science&societal Transformation research Group institut für höhere studien-institute for advanced studies(i)Viennaaustria estudies centre on science communication and societyDepartment of experimental and health sciencesPompeu Fabra UniversityBarcelonaspain

Responsible research and innovation,or RRI,is a concept that aims to bring together society and science for a better *** are six key elements of RRI:public engagement,gender equality,science education,open access,ethics and *** Education Institutions and Responsible Research and Innovation(HEIRRI)project aimed to bring the concept of RRI into the educational *** state-of-the-art review of good practices,HEIRRI team developed 10 training programmes on RRI for different higher education institution educational levels,including a summer school and a massive open online course(MOOC).We conducted pilot of the trainings and evaluated participants’*** with HEIRRI training programmes on responsible research and innovation was high,both for participants and for the trainers,and trainings raised awareness of ***’feedback was used to identify areas that need improvement and provided for recommendations for final versions of the HEIRRI training *** order to equip researchers with skills to recognize and apply RRI values,RRI should be included in their *** training is suitable for a range of different disciplines,including forensic science,and is free to use and adjust for specific contexts(available from:https://***/heirri-training-programmes).

关键词： Research integrity research ethics responsible research and innovation responsibility societal inclusion higher education institutions RRI teaching

Specific primers design based on the superoxide dismutase b gene for Trypanosoma cruzi as a screening tool:Validation method using strains from Colombia classified according to their discrete typing unit

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Asian Pacific Journal of Tropical Medicine 2014年第11期7卷 854-859页

作者： Francisco Olmo Javier Escobedo-Ortegón Patricia Palma Manuel Sánchez-Moreno ana Mejía-Jaramillo Omar Triana Clotilde marín Grupo de Parasitologia Molecular Departmento de Parasitologia Universidad de Granada Laboratorio de Zoonosis y ETV's C.I.R.Dr.Hideyo NoguchiUniversidad Autonoma de YucatanAve.Itzaes #490 x 5997000 MeridaYucatan(Mexico) Grupo Biologiay Control de Enfermedades Infecciosas BCEI-SIU Instituto de BiologiaUniversidad de Antioquia

Objective:To classify 21 new isolates of Trypanosoma cruai(***) according to the Discrete Typing Unit(DTU) which they belong to,as well as tune up a new pair of primers designed to detect the parasite in biological ***:Strains were isolated,DNA extracted,and classified by using three Polymerase Chain Reactions(PCR).Subsequently this DNA was used along with other isolates of various biological samples,for a new PCR using primers ***,the amplified fragments were ***:It was observed the predominance of DTU i in Colombia,as well as the specificity of our primers for detection of ***,while no band was obtained when other species were ***:This work reveals the genetic variability of 21 new isolates of *** in *** primers confirmed their specificity for detecting the presence of ***.

关键词： Trypanosoma cruzi Polymerase chain reaction Colombia Superoxide dismutase gene b-based primers Discrete typing unit

The role of clinical diagnosis criteria on the frequency of accommodative insufficiency

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 647-653页

作者： maría García-Montero Beatriz Antona ana Rosa Barrio Carmen Nieto-Zayas Irene martínez-Alberquilla José Luis Hernández-Verdejo Department of Optometry and Vision Faculty of Optics and Optometry Complutense University of Madrid Department of Statistics and Operations Research Ⅲ Faculty of Statistical Studies Complutense University of Madrid

AIM: To estimate and compare the frequency of accommodative insufficiency(AI) within the same clinical population sample depending on the type of clinical criteria used for diagnosis. Comparing the frequency within the same population would help to minimize bias due to sampling or methodological variability. METHODS: Retrospective study of 205 medical records of symptomatic subjects free of any organic cause and symptoms persisting despite optical compensation evaluated. Based on the most commonly clinical diagnostics criteria found in the literature, four diagnostics criteria were established for AI(Ⅰ, Ⅱ, Ⅲ and Ⅳ) based on subjective accommodative tests: monocular accommodative amplitude two or more diopters below Hofstetter's minimum value [15-(0.25×age)](Ⅰ, Ⅱ, Ⅲ, Ⅳ); failing monocular accommodative facility with minus lens, establishing the cut-off in 0 cycles per minute(cpm)(Ⅰ) and in 6 cpm(Ⅱ, Ⅲ); failing binocular accommodative facility with minus lens, establishing the cut-off in 0 cpm(Ⅰ) and in 3 cpm(Ⅱ).RESULTS: The proportion of AI(95%CⅠ) for criteria Ⅰ, Ⅱ, Ⅲ and Ⅳ were 1.95%(0.04%-3.86%), 2.93%(0.31%-4.57%), 6.34%(1.90%-7.85%) and 41.95%(35.14%-48.76%) respectively, with a statistically significant difference shown between these values(χ2=226.7, P<0.001). A pairwise multiple comparison revealed that the proportion of AI detected for criterion Ⅳ was significantly greater than the proportion for the rest of the criteria(P-adjusted<0.05 in all cases).CONCLUSION: The prevalence of cases of AI within the same clinical population varies with the clinical diagnostic criteria selected. The variation is statistically significant when considering the monocular accommodative amplitude as the only clinical diagnostic sign.

关键词： epidemiology amplitude of accommodation accommodative facility