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High aluminum concentration and initial establishment of Handroanthus impetiginosus : clues about an Al non-resistant species in Brazilian Cerrado

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Journal of Forestry Research 2020年第6期31卷 2075-2082页

作者： Ane Marcela das Chagas Mendon ca Jean Marcel Sousa Lira ana luiza de oliveira vilela Daniel Amorim Vieira Nayara Cristina de Melo Joao Paulo Rodrigues Alves delfi no Barbosa Programa de Pós-Graduacao em Fisiologia Vegetal Departamento de BiologiaUniversidade Federal de LavrasLavrasMG 37200-000Brazil Programa de Pós-Graduacao em Ciências Ambientais Instituto de Ciências ExatasUniversidade Federal de AlfenasAlfenasMG 37130-001Brazil Programa de Pós-Graduacao em Fitotecnia Departamento de AgriculturaUniversidade Federal de LavrasLavrasMG 37200-000Brazil Instituto Federal de Educacao Ciência e Tecnologia do Pará BelémPA 66093-020Brazil

Cerrado soils are acidic and nutrient-poor,with high content of solubilized Al 3+.Plants growing in these conditions may display adaptations to cope with high aluminum concentrations especially during early developmental *** investigated leaf nutritional status,and photosynthetic and growth characteristics during the initial establishment of Handroanthus impetiginosus(*** Dc.)Mattos,a secondary tree species distributed in the Brazilian *** goal was to understand leaf-level traits related to diff erent aluminum *** plants were cultivated in four diff erent aluminum sulfate concentrations:0,1,2,and 4 mM Al,for 40 *** performed analyses of growth,leaf gas exchange,chloroplast pigment content,and leaf mineral *** observed a linear increase of Al leaf content as a function of Al concentration in the nutrient *** grown in 1 mM Al showed a remarkable increase of K leaf content,net photosynthesis,stomatal conductance,and transpiration,while in 4 mM Al there were reductions of N,P,and K contents,gas exchange characteristics,and *** did not have mechanisms of avoidance,compartmentalization,or resistance to high Al ***,this species showed a hormetic response,with low Al concentrations stimulating and high Al concentrations inhibiting plant responses.

关键词： Hormesis Low Al concentration Al toxicity Cerrado species Carbon assimilation

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development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão Freire Natália Marchesan Bexiga Marco Antonio Stephano João Ezequiel oliveira Carlos Roberto Jorge Soares ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia Luiz Felipe S. Teixeira Maria Helena Marumo Bellini Natanael Gomes da Silva luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

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ID7 Isolated from Bauhinia variegata Stem Inhibits Tumor Progression and Metastatic Mechanisms of Triple Negative Breast Cancer in Vivo

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 368-384页

作者： Kamilla Monteiro dos Santos Izabela Natalia Faria Gomes Renato JoséSilva oliveira Fernanda E.Pinto Bruno oliveira Fabrício P.Batista Rafael Cesar Russo Chagas Hélio B.Santos Ralph G.Thomé Wanderson Romao Rui Manuel Reis Maria luiza vilela Oliva Rosy Iara Maciel de Azambuja Ribeiro Laboratory of Experimental Pathology Federal University of Sao Joao del-Rei(UFSJ)DivinópolisMGBrazil Josédo Rosário Vellano University UnifenasDivinópolisMGBrazil Molecular Oncology Research Center(CPOM) Barretos Cancer HospitalBarretosSPBrazil Petroleomic and Forensic Chemistry Laboratory Department of ChemistryFederal Institute of Espírito Santo(IFES)VitóriaESBrazil Chemistry department Federal University of Sao PauloBrazil Tissue Processing Laboratory Federal University of Sao Joao del-Rei(UFSJ)DivinópolisMGBrazil Life and Health Sciences Research Institute(ICVS) Medical SchoolUniversity of MinhoBragaPortugal 3ICVS/3B’s-PT Government Associate Laboratory GuimaraesBragaPortugal

Background:The breast cancer has been the most common form of cancer among *** triple negative subtype represents 20%of all breast cancer cases in the world and is standing out by affecting young women and being *** main cause of death of patients with cancer is due to metastasis,which can reach the liver and ***:The activities of ID7 fraction of the stems of Bauhinia variegata *** breast cancer,lung metastasis and liver inflammatory process were ***:ID7 was characterized by *** viability of murine mammary cells(4T1)treated with ID7 was assessed by MTT,trypan blue and fluorescence assay and viability of BT-20,MDA-MB-231 and MCF-7 human breast cancer tumor lines by *** cell migration,invasion using matrigel and adhesion were *** expression of cell death proteins was quanitified by western blot and the gelatinases by *** ID7 activity of the tumor(4T1)and metastatic progession in vivo was ***:ID7 reduced the 4T1 and MDA-MB-231viability and increased the late apoptosis,inhibited the 4T1 migration and invasion,increased the 4T1 adhesion and decreased the secreted active ***7 also increased the expression of PARP,caspase-7 and caspase-8,RIP and *** vivo,the ID7 decreased the volume and weight of the tumors and decreased lung metastasis and inflammation in the *** characterization showed mainly the presence of oleic acid,myricetin,quercetin and kaempferol in ***:Thus,it was found that ID7 fraction exhibits selective antitumor and on the mechanisms of breast cancer metastasis activity,preventing lung metastasis and inflammation in the *** is suggested that fatty acids and flavonoids are correlated with such activities.

关键词： 4T1 cells MDA-MB-231 medicinal plants kaempferol gelatinases apoptosis cell viabilty in vivo

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Quality of Seeds of Upland Rice Lines Adapted to the State of Minas Gerais, Brazil

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American Journal of Plant Sciences 2015年第12期6卷 1920-1927页

作者： Heloisa oliveira dos Santos Flávia Barbosa Silva Botelho ana Cláudia de Amorim Fonseca Ricardo Kenji Uenojo Marcela Pedroso Mendes Edila vilela de Resende Von Pinho department of Agriculture Federal University of Lavras Lavras Brazil

In the final stages of a plant breeding program, a crucial step is the multiplication of seeds in production fields. Besides a solid planning, the seeds multiplication needs a special attention to guarantee seeds with high quality, genetic integrity, high germination and vigor to the farmer. The aim of this study was to evaluate the physiologic quality, enzymatic expression and respiratory activity of seeds of 20 elite upland rice lines adapted to the state of Minas Gerais, Brazil, from the upland rice breeding program from three Brazilians research institutions. The quality parameters evaluated were root protrusion, number of normal seedlings in the germination test, number of normal seedlings in the germination first count, initial stand from emergence test, speed of emergence index, seedlings shoot and root length, percentage of O2 and CO2 from respiratory activity and the expression pattern of the enzymes alcohol dehydrogenase (ADH) and malate dehydrogenase (MDH). The seeds quality varied among lines, allowing the selection of lines with best performance. The respiratory activity was lower in seeds of lines with high quality. The enzyme ADH was an excellent marker to infer about the quality of seeds, and the variation in the expression of MDH did not depend on the quality of rice seeds. The lines BRS Esmeralda, CMG1896 and CMG1509 showed high physiologic quality in their seeds, and therefore, they should receive higher attention in rice breeding programs.

关键词： Oriza sativa Physiologic Quality Enzymatic Expression Respiratory Activity Vigor

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Phenotypic and Enzymatic analyses of Upland Rice Lines Seeds under No-Tillage

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American Journal of Plant Sciences 2015年第12期6卷 1981-1989页

作者： Heloisa oliveira dos Santos Flávia Barbosa Silva Botelho Ricardo Kenji Uenojo ana Cláudia de Amorim Fonseca Marcela Pedroso Mendes Edila vilela de Resende Von Pinho Maria Laene Moreira de Carvalho department of Agriculture Federal University of Lavras Lavras Brazil

Over 40% of the agricultural area in Brazil corresponds to no-tillage farming. Although it is evident the importance of obtaining upland rice cultivars adapted to this cropping system, researches in this sense are still incipient and breeders do not have cultivars available to recommend with enough security. The aim of this study was to evaluate phenotypic characters favorable to the no-tillage system in order to establish the basis for upland rice breeding programs interested in this cropping system. The seeds of twenty elite inbred lines from the Upland Rice Breeding Program from the Brazilian research institutions UFLA, EMBRAPA and EPAMIG were evaluated at the Central Seeds Lab from the Agriculture department of UFLA following a randomized block design with four replicates. The characters evaluated were seedlings emergence (SE), green matter yield (GM), dry matter yield (DM), photosynthetic activity (PA), and superoxide dismutase activity (SOD). The quality parameters evaluated were obtained by a germination test (GT), germination first count (GFC), emergence test (E), initial stand (IS), and alpha-amylase expression. The lines CMG 2074, CMG 1967, CMG 2017, BRSMG Caravera and CMG 2097 showed higher SOD content in the enzymatic analyses, and consequently higher tolerance to abiotic stresses that could be caused by no-tillage. Considering the evaluation of agronomic traits, the line CMG 1967 showed the best performance in no-tillage soil and, therefore, should receive higher attention in Upland Rice Breeding Programs.

关键词： Oriza sativa Physiologic Quality Enzymatic Expression Cropping System Vigor

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Hospitalizations and in-hospital mortality for inflammatory bowel disease in Brazil

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2022年第1期13卷 1-10页

作者： ana luiza Vilar Guedes Amanda Lopes Lorentz Larissa Fernandes de Almeida Rios Rios Beatriz Camara Freitas Adriano Gutemberg Neves Dias ana Luísa Eckhard Uhlein Felipe oliveira Vieira Neto Jobson Felipe Soares Jesus Túlio de SáNovaes Torres Raquel Rocha Vitor D Andrade Genoile oliveira Santana Life Sciences department State University of BahiaSalvador 41150-000BahiaBrazil Sciences of Nutrition Federal University of BahiaSalvador 40110-060BahiaBrazil Medicine department Universidade Salvador(UNIFACS)Salvador 41820-021BahiaBrazil Medicine and Health Postgraduate Program Federal University of BahiaSalvador 40110-060BahiaBrazil

BACKGROUND Inflammatory bowel disease(IBD)is associated with complications,frequent hospitalizations,surgery and *** introduction of biologic drugs into the therapeutic arsenal in the last two decades,combined with an expansion of immunosuppressant therapy,has changed IBD management and may have altered the profile of hospitalizations and in-hospital mortality(IHM)due to *** To describe hospitalizations from 2008 to 2018 and to analyze IHM from 1998 to 2017 for IBD in *** This observational,retrospective,ecological study used secondary data on hospitalizations for IBD in Brazil for 2008-2018 to describe hospitalizations and for 1998-2017 to analyze *** data were obtained from the Hospital Information System of the Brazilian Unified Health System and population data from demographic *** following variables were analyzed:Number of deaths and hospitalizations,length of hospital stay,financial costs of hospitalization,sex,age,ethnicity and type of hospital *** There was a reduction in the number of IBD hospitalizations,from 6975 admissions in 1998 to 4113 in 2017(trend:y=-0.1682x+342.8;R^(2)=0.8197;Pdecreased,from 3.60/100000 in 2000 to 2.17 in *** rates varied during the 20-year period,between 2.06 in 2017 and 3.64 in 2007,and did not follow a linear trend(y=-0.0005049x+2.617;R^(2)=0,00006;P=0.9741).IHM rates also varied between regions,increasing in all but the southeast,which showed a decreasing trend(y=-0.1122x+4.427;R^(2)=0,728;Pdeaths/100 admissions),with an increasing trend(y=0.1105x+1.110;R^(2)=0.6265;P<0.0001),but the lowest hospitalization rate(1.15).The Midwest and South regions had the highest hospitalization rates(3.27 and 3.17,respectively).A higher IHM rate was observed for nonelective admissions(2.88),which accounted for 81%of IB

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Hospitalization Hospital mortality Hospital information systems Epidemiology

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Stability of the Antioxidant Activity of Flavonoids after Gamma Irradiation

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Food and Nutrition Sciences 2011年第5期2卷 490-493页

作者： Antonio Fernando de Melo Vaz Marthyna Pessoa de Souza Adriana Carla Cavalcante Malta Argolo ana Maria Mendonca de Albuquerque Melo Maria luiza vilela Oliva Haroldo Sátiro Xavier Luana Cassandra Breitenbach Barroso Coelho Maria Tereza dos Santos Correia department of Biochemistry Federal University of PernambucoRecifeBrazil department of Biophysics and Radiobiology Fed-eral University of PernambucoRecifeBrazil department of Biochemistry Federal University of Sao PauloSao PauloBrazil department of Pharmaceutical Science Federal University of PernambucoRecifeBrazil

Food irradiation has the purpose of destroying insects or microorganisms, thereby increasing the safety and shelf life of foods. Flavonoids are ubiquitous plant secondary products with radical scavenger ability. In the present study their antioxidant stability after gamma irradiation was evaluated. The flavonoids showed fast scavenger ability measured with the 2.2-diphenyl-1-picrylhydrazyl radical (DPPH) after high doses of radiation. The low damage caused by irra- diation on antioxidant capacity of the flavonoids shows their potential use in combating chemical oxidation of bio- molecules in irradiated foods.

关键词： Flavonoid Food Irradiation Scavenger Capacity Gamma Irradiation

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Physical Exercise and Gene p53—A Mini Review

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Journal of Cancer Therapy 2020年第8期11卷 463-469页

作者： Tayane Horstmann Cabral ana luiza Lozinski Gabriel Massao Tanaka Marco André Cardoso Rossana Baggio Simeoni Péricles Varella Gomes Zair Candido oliveira Netto Luiz Cesar Guarita-Souza Julio Cesar Francisco Ricardo Correa Cunha School of Health Sciences Positivo University Curitiba Brazil School of Medical Sciences Pontifical Catholic University of Paraná Curitiba Brazil School of Medical Sciences Pontifical Catholic University of Paraná Curitiba Brazil GEL LAB Michigan State University East Lansing East Lansing USA

Cancer is a global problem that in addition to physical, emotional and physiological causes economic and social impacts. The p53 gene is a tumor suppressor gene found in many malignant and benign tumors;this has the primary function of keeping cells at rest after damaging to DNA. The p53 acts in the maintenance of cellular homeostasis, mainly through autophagy, playing a role in cell cycle arrest, when necessary, thus avoiding mutated DNA replication. When in the oncogenic environment in many cases it is mutated, losing much of its efficiency allowing tumor development. Studies show that exercise can in the regular part of its pro-autophagic function even in the oncology setting. Stimuli of moderate-intensity aerobic and predominance of submaximal seem to trigger the protective function of p53 in various cancer settings. Among the many changes that these pathology triggers were the objective of this mini review is to relate the changes that exercise generates in p53 protein functions and their possible influence on tumor cells.

关键词： p53 Physical Exercise Gene Mutations Autophagy

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Role of Cognitive Behavioral Therapy in Fibromyalgia: A Systematic Review

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Open Journal of Rheumatology and Autoimmune Diseases 2021年第4期11卷 169-187页

作者： Heloisa Lima Heller Aline Rizzo Borges Luís Otávio Amarante Franco João Pedro de oliveira Aucelio Marcos Igor Albanaz Vargas Rebeca Naoum Lorga Mirella Bastos Sales Natália Vargas Do Nascimento Gabriela Furlan Ribeiro Barbosa Netto Beatriz Carneiro Passos Beatriz Pires Paes Beatriz Toledo Mendes Bruna de Paula Gonçalves Sousa Lyra Ciro Moisés oliveira Vieira Dos Santos Gustavo Araújo Do Nascimento Santos Maria luiza Pimentel de oliveira Matheus Macêdo Da Silva Maurício Silva de Jesus Paulo Ricardo Guimaraes Rocha Storni Tamires Martinelli de oliveira Ferraz Viviane Cristina Uliana Peterle ana Paula Monteiro Gomides Reis Centro Universitário de Brasília Brasília Brazil Universidade Católica de Brasília Brasília Brazil Centro Universitário Euro Americano Brasília Brazil

A literature search of articles from 2002-2019 was performed using Medline, Embase, Cochrane, LILACS, IBECS, CRD, and Epistemonikos databases, to analyze the effects of Cognitive-Behavioral Therapy (CBT) in the treatment of fibromyalgia. Twenty-seven articles were selected in which CBT was performed exclusively by specialist physicians, associated or not with conventional pharmacological treatment and/or physical exercise. In most articles, CBT worked with self-knowledge and cognitive restructuring, attempting to reduce pain perception, and it showed a general improvement in daily activities by decreasing patient’s limitations, such as morning stiffness. The literature showed significant correlations of CBT in pain processing over time. When CBT was compared to conventional pharmacological therapy, a certain superiority of CBT could be observed concerning the quality of life, catastrophizing, and acceptance of pain. However, when they were simultaneously applied, this improvement in quality of life was not observed.

关键词： Cognitive Behavioral Therapy Fibromyalgia Pain

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The Trade Relationship Between Brazil and Algeria in the Import of Oil and Its derivatives in the Period 2010-2016

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Chinese Business Review 2018年第5期17卷 247-251页

作者： Fabiana Lucena oliveira Milena Vilena ana luiza Silveira Amazonas State University ManausBrazil University of Pittsburgh PittsburghUSA

The Brazilian choice on the energy matrix,which established as a priority the exploitation of oil and consequently its derivatives for energy generation,had consequences for its foreign trade *** is important to clarify that the choice of the energy matrix involves strategic variables and decisions about investment,consumption,and demand projected for the next 30 years,for ***,this paper intends to analyze the trade balance between Brazil and Algeria(Country of North Africa,with a strong movement of oil and its derivatives),in the period 2010-2016,focusing even on the period in which Brazil began its periods of recession(2015).The research problem is,therefore,“during the period of 2010-2016,what is the situation of the trade balance between Brazil and Algeria?”.Therefore,the hypothesis formulated is that,because it does not have enough to supply Brazilian domestic demand for oil and,consequently,derivatives,Brazil has imported these products from other *** the period analyzed,Brazil did not have a favorable *** reason why Algeria was chosen for analysis and not another country since Brazil has trade relations with more than 70 countries is that the African continent is the main supplier surpassing the percentage of 71%,and Algeria has significant *** methodology used was a bibliographical research,based on the analysis of recent data from the Brazilian trade balance,including in the context of recession,starting in *** results obtained are:(1)The Brazilian energy matrix is diversified,but still shows a majority of non-renewable energies,different from what happens with other emerging countries;(2)it is necessary to revise the demand for oil and its derivatives for the next 30 years,as a matter of urgency;and(3)the investment volume defined by the Brazilian government for the energy matrix is not sufficient for the established demand.

关键词： foreign trade exploitation of oil energy matrix

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