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BIOCELL 2019年第1期43卷 13-19页

作者： ana laura cimador Emeli Luciana GALANTE Lucila Ibel MUNOZ Patricia Silvia ROMANO Antonella Denisse LOSINNO Maria Cristina VANRELL Facultad de Farmacia y Bioquimica Universidad Juan Agustin Maza.MendozaArgentina Facultad de Ciencias Medicas Universidad Nacional de Cuyo.MendozaArgentina Laboratorio de Biologia de Trypanosoma cruzi y la celula hospedadora-Instituto de Histologia y Embriologia“Dr.Mario H.Burgos”IHEM-CONICET-Universidad Nacional de Cuyo.Mendoza Argentina

Trypanosoma rangeli and *** are both parasitic unicellular species that infect *** ***,the causative agent of Chagas disease,*** is an infective and non-pathogenic parasite for humans,but pathogenic for vectors from the Rhodnius *** both species can coexist in different hosts and overlap their infective cycles but very little is known about the infection of *** in mammalian cells,we decided to characterize both the development of this parasite in cell culture and the effect of therapeutic agents with potential trypanocidal action on *** found that *** exhibits a cycle of infection in Vero cells similar to that for *** and that the repurposed drug,17-AAG,and the natural extract Artemisia *** oil produce a toxic effect on epimastigotes showing a trypanocidal action from the fifth day of *** treatments also affected the infection of trypomastigotes and reduced the capacity of replication of amastigotes of *** ***/*** coinfection cases have been reported,the finding of drugs with potential activity against both species could be significant in the ***,studies of susceptibility of both species to drugs could also help to know the different mechanisms of pathogenicity in humans displayed by *** that are absent in ***.

关键词： Life-cycle Treatment Trypanosoma rangeli

The Janus face of N-terminal lysines in α-synuclein

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Neural Regeneration Research 2020年第10期15卷 1840-1841页

作者： ana Belén Uceda laura Mari?o Miquel Adrover Institut Universitari d’Investigació en Ciències de la Salut (IUNICS) Institut d’Investigació Sanitària Illes Balears (Id ISBa) Departament de Química Universitat de les Illes Balears

Parkinson’s disease(PD)is the second most prevalent progressive neurodegenerative disorder after Alzheimer’s *** usually starts with a tremor in the extremities(usually in the hands)and gradually evolves with other symptoms such as bradykinesia,muscle stiffness,impaired posture,loss of automatic movements or speech *** symptoms worsen as the condition progresses and eventually lead to death.

关键词： impaired Alzheimer eventually

Cancer stem cells: Involvement in pancreatic cancer pathogenesis and perspectives on cancer therapeutics

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World Journal of Gastroenterology 2014年第31期20卷 10790-10801页

作者： Cristiana Pistol Tanase ana Iulia Neagu laura Georgiana Necula Cristina Mambet ana-Maria Enciu Bogdan Calenic Maria Linda Cruceru Radu Albulescu Department of Biochemistry-Proteomics Victor Babes National Institute of Pathology Stefan S Nicolau Institute of Virology Carol Davila University of Medicine and Pharmacy National Institute for Chemical Pharmaceutical Research and Development

Pancreatic cancer is one of the most aggressive and lethal malignancies. Despite remarkable progress in understanding pancreatic carcinogenesis at the molecular level, as well as progress in new therapeutic approaches, pancreatic cancer remains a disease with a dismal prognosis. Among the mechanisms responsible for drug resistance, the most relevant are changes in individual genes or signaling pathways and the presence of highly resistant cancer stem cells(CSCs). In pancreatic cancer, CSCs represent 0.2%-0.8% of pancreatic cancer cells and are considered to be responsible for tumor growth, invasion, metastasis and recurrence. CSCs have been extensively studied as of late to identify specific surface markers to ensure reliable sorting and for signaling pathways identified to play a pivotal role in CSC self-renewal. Involvement of CSCs in pancreatic cancer pathogenesis has also highlighted these cells as the preferential targets for therapy. The present review is an update of the results in two main fields of research in pancreatic cancer, pathogenesis and therapy, focused on the narrow perspective of CSCs.

关键词： Cancer stem cells Pancreatic cancer Cancer stem cells signaling pathways Targeted therapy miRNA

Gastrointestinal cancer stem cells as targets for innovative immunotherapy

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World Journal of Gastroenterology 2020年第14期26卷 1580-1593页

作者： Mihaela Chivu-Economescu laura G Necula Lilia Matei Denisa laura Dragu ana I Neagu Irina Alexiu Coralia Bleotu Carmen Cristina Diaconu Department of Cellular and Molecular Pathology Stefan S.Nicolau Institute of VirologyBucharest 030304Romania Nicolae Cajal Institute Titu Maiorescu UniversityBucharest 040441Romania

The role of cancer stem cells in gastrointestinal cancer-associated death has been widely *** cancer stem cells(GCSCs)are considered to be responsible for tumor initiation,growth,resistance to cytotoxic therapies,recurrence and metastasis due to their unique *** properties make the current therapeutic trials against GCSCs ***,recent studies have shown that targeting stem cell surface markers or stemness associated pathways might have an additional off-target effect on the immune *** advances in oncology and precision medicine have opened alternative therapeutic strategies in the form of cancer *** approach differs from classical anti-cancer therapy through its mechanism of action involving the activation and use of a functional immune system against tumor cells,instead of aiming physically destruction of cancer cells through radio-or *** immunological approaches for GCSCs targeting involve the use of different immune cells and various immune mechanisms like targeting specific surface antigens,using innate immune cells like the natural killer and T cells,T-cell chimeric antigen receptor technology,dendritic cell vaccine,or immune checkpoint *** this respect,better understandings of immune regulatory mechanisms that govern anti-tumor response bring new hope in obtaining long-term remission for cancer therapy.

关键词： Immunotherapy Gastrointestinal cancer Cancer stem cells CAR-T Dendritic cells vaccines Immune checkpoints inhibitors

阿塞洛米塔尔图巴朗钢铁集团火花发射光谱法优化氮的分析

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冶金分析 2012年第7期32卷 25-31页

作者： FAGUNDES laura DIEGUEZ ana Carolina 阿塞洛米塔尔图巴朗钢铁集团

近年来,钢铁行业需求量快速上升,竞争也变得更加激烈。为了得到性能可靠的产品,钢铁车间在生产工艺方面需要进一步严格控制好产品的生产规格。在这种背景下,为了严格控制好生产工艺的密封性并保证产品所期望的特性(尤其是其韧性和机械... 详细信息

近年来,钢铁行业需求量快速上升,竞争也变得更加激烈。为了得到性能可靠的产品,钢铁车间在生产工艺方面需要进一步严格控制好产品的生产规格。在这种背景下,为了严格控制好生产工艺的密封性并保证产品所期望的特性(尤其是其韧性和机械加工性方面),精确地进行氮的分析必不可少。在过去几年中,经典燃烧技术(CC)已广泛应用于鉴定钢中的碳、硫和氮元素。而火花发射法因其性能改进、耗材成本(燃烧技术方面)降低以及在分析时间缩短等方面的优势,也在氮分析方面得到了应用,并且应用越来越广泛。本项研究的目的在于通过火花发射光谱仪(OES)对氮分析进行优化。研究是在巴西塞拉的阿塞洛米塔尔图巴朗钢铁集团的化学分析实验室进行,利用DMAIC方法学(一种用于改进生产工艺质量的研究方法)[1],对潜在的影响因素(包括漂移、样品和周期)进行了分析,并确定和优化了影响氮分析精度的根本原因。在实施该计划后,对结果的精度(基于内标物的标准偏差)和准确性(通过与OE认证的参考物质和力可交叉核验结果进行比较)进行了评估。在本研究项目之前,通过光发射法测得的氮元素的标准偏差高达0.004 0%。阿塞洛米塔尔图巴朗钢铁集团利用光谱仪完成所有的研究计划后,试验表明,其测定标准偏差低达0.000 5%,充分展现了该技术的潜力。本研究对这一标准偏差进行了监测,频率为每周一次,监测期为3个月。结果发现,该标准偏差在0.000 3%到0.000 5%之间波动,表明稳定性较好。由此可见,火花发射光谱技术是氮分析的一种较有前途的方法。

关键词：光发射氮分析钢铁经典燃烧

Influence of surface roughness on the color of dental-resin composites

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第7期12卷 552-562页

作者： Razvan GHINEA laura UGARTE-ALVAN ana YEBRA Oscar E.PECHO Rade D.PARAVINA Maria del Mar PEREZ Department of Optics Faculty of ScienceUniversity of Granada Department of Stomatology Faculty of OdontologyUniversity of Granada Houston Center for Biomaterials and Biomimetics & Department of Restorative Dentistry and Biomaterials University of Texas Dental Branch at Houston

This study deals with the influence of surface roughness on the color of resin *** resin composites (microfilled,hybrid,and microhybrid) were each polished with 500-grit,1 200-grit,2 000-grit,and 4 000-grit SiC *** roughness parameter (Ra) was measured using a Plμ confocal microscope,and field-emission scanning electron microscope (Fe-SEM) images were used to investigate filler *** was measured using a spectroradiometer and a D65 standard illuminant (geometry diffuse/0° specular component excluded (SCE) mode).Surface roughness decreased with grit number and was not influenced by filler size or size distribution.A significant influence of Ra on lightness (L*) was *** increased with decreases in roughness,except for specimens that underwent polishing procedure 4 (PP4;500-grit,1 200-grit,2 000-grit,and 4 000-grit SiC papers consecutively).Generally,it was found that surface roughness influenced the color of resin *** composites that underwent PP1 (500-grit SiC paper) exhibited significant differences in chroma (C*),hue (h°),and lightness (L*) compared to composites that underwent PP3 (500-grit,1 200-grit,and 2 000-grit SiC papers consecutively) and *** difference (E*) between the polishing procedures was within acceptability thresholds in dentistry.

关键词： Color measurement Dental resin composites Roughness

Systemic epigallocatechin gallate protects against retinal degeneration and hepatic oxidative stress in the P23H-1 rat

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Neural Regeneration Research 2022年第3期17卷 625-631页

作者： Lorena Perdices Lorena Fuentes-Broto Francisco Segura ana Cavero Elvira Orduna-Hospital Gema Insa-Sánchez ana Isabel Sánchez-Cano laura Fernández-Sánchez Nicolás Cuenca Isabel Pinilla Aragón Institute for Health Research(IIS Aragón) ZaragozaSpain Pharmacology Physiology&Legal and Forensic MedicineUniversity of ZaragozaZaragozaSpain Department of Applied Physics University of ZaragozaZaragozaSpain Health Sciences Faculty San Jorge UniversityVillanueva de GállegoSpain Department of Ophthalmology Miguel Servet University HospitalZaragozaSpain Department of Physiology Genetics and MicrobiologyUniversity of AlicanteAlicanteSpain Department of Surgery Gynecology and ObstetricsUniversity of ZaragozaZaragozaSpain/Department of OphthalmologyLozano Blesa University HospitalZaragozaSpain

Retinitis pigmentosa(RP) is a group of inherited retinal disorders that lead to photoreceptor *** has been reported to be related to oxidative stress,autophagy,and inflammation.(-)-Epigallocatechin gallate(EGCG),the most abundant catechin-based flavonoid in green tea leaves,has significant antioxidant,anti-carcinogenic,antimicrobial,and neuroprotective ***,given its low molecular weight and hydrophilic properties,can cross the blood-retinal barrier and is able to reach different ocular tissues such as the lens,cornea,and *** has been shown to provide retinal protection against ischemia;sodium nitroprusside-,N-methyl-D-aspartate-,lipopolysaccharide-,light-,sodium iodate-,or H2 O2-induced damage and diabetic *** suggests that systemic EGCG administration has the potential to protect against retinal degenerative or neurodegenerative diseases such as *** aim of this work was to investigate whether EGCG can protect against RP progression in the animal P23 H line 1,the model of *** P23 H rats were crossed with pigmented Long Evans rats to produce offspring exhibiting the clinical features of *** P23 H rats were treated via intraperitoneal injection with saline or EGCG at a dose of 25 mg/kg every week from P100 to P160 and then compared to wild-type Long Evans *** treated with EGCG showed better visual and retinal electrical function with increased contrast sensitivity and b-wave values compared with those observed in P23 H rats treated with *** reduced lipid peroxidation and increased total antioxidant capacity and catalase and superoxide dismutase *** differences were observed in visual acuity,nitrate levels,nitrite levels or glutathione S-transferase *** conclusion,EGCG not only reduced the loss of visual function in P23 H rats but also improved the levels of antioxidant enzymes and reduced oxidative *** study was approved by the Institutional Animal Care and Use Committee(CE

关键词： antioxidants contrast sensitivity electroretinogram green tea neurodegeneration oxidative stress retinal degeneration retinitis pigmentosa systemic visual acuity

Lecithin-Bifidobacterium probiotics interactions:a case study

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Food Bioscience 2023年第1期51卷 589-597页

作者： laura García Plaza Panagiota Dima Elisa Audin Bernadeta Stancikaite Ioannis S.Chronakis ana C.Mendes Technical University of Denmark(DTU)-Food Research Group for Food Production EngineeringLaboratory of Nano-BioScienceKemitorvet B2022800 Kgs.LyngbyDenmark

Probiotic formulations containing lecithin phospholipids have been shown to extend their ***,the protective effect of lecithin and the properties of the mixtures of lecithin and probiotic cells in aqueous media have not been fully *** aim of this study was to investigate the interactions between Bifidobacterium animalis ***(Bifido)probiotics and *** lecithin-Bifido interactions were dependent on lecithin *** and Raman spectroscopy suggested that Bifido cells interacted with lecithin molecules,mainly through hydrophobic *** the lecithin concentration of 0.1%.w/v,Bifido lost only about 17%of their viability over 56 days,while free Bifido probiotics(without lecithin)lost about 66%of their viability in the same time ***,flow cytometer side scatter plots also showed that Bifido-lecithin samples at 0.1.%w/v lecithin,showed the lowest side scatter,which is indicative of lower cellular stress and a more stable environment to preserve Bifido cells viability over time.

关键词： Probiotics Phospholipids FTIR spectroscopy Raman spectroscopy Bacteria stability

Thermodynamics of clayedrug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography

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Journal of Pharmaceutical analysis 2020年第1期10卷 78-85页

作者： ana-Maria Totea Juan Sabin Irina Dorin Karl Hemming Peter R.Laity Barbara R.Conway laura Waters Kofi Asare-Addo School of Applied Sciences Department of PharmacyUniversity of HuddersfieldQueensgateHuddersfieldHD13DHUK AFFINImeter Edificio EmprendiaCampus VidaSantiago de CompostelaSpain Malvern Panalytical Ltd. MalvernUK School of Applied Sciences Department of ChemistryUniversity of HuddersfieldQueensgateHuddersfieldHD13DHUK Department of Materials Science and Engineering University of SheffieldSir Robert Hadfield BuildingMappin StreetSheffieldS13JDUK

An understanding of the thermodynamics of the complexation process utilized in sustaining drug release in clay matrices is of great *** characterisation techniques as well as isothermal calorimetry were utilized in investigating the adsorption process of a model cationic drug(diltiazem hydrochloride,DIL)onto a pharmaceutical clay system(magnesium aluminium silicate,MAS).X-ray powder diffraction(XRPD),attenuated total reflectance Fourier transform infrared spectroscopy(ATRFTIR)and optical microscopy confirmed the successful formation of the DIL-MAS *** quantification from the complexes demonstrated variable behaviour in the differing media used with DIL degrading to desacetyl diltiazem hydrochloride(DC-DIL)in the 2 M HCl *** also,the authors report for the first time two binding processes that occurred for DIL and MAS.A competitor binding model was thus proposed and the thermodynamics obtained suggested their binding processes to be enthalpy driven and entropically *** information is of great importance for a formulator as care and consideration should be given with appropriate media selection as well as the nature of binding in complexes.

关键词： Clay-drug complex dispersions Magnesium aluminium silicate Diltiazem hydrochloride Isothermal titration calorimetry High performance liquid chromatography

Hepatocellular carcinoma after direct-acting antiviral hepatitis C virus therapy:A debate near the end

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World Journal of Gastroenterology 2020年第43期26卷 6770-6781页

作者： Cristina Maria Muzica Carol Stanciu laura Huiban ana-Maria Singeap Catalin Sfarti Sebastian Zenovia Camelia Cojocariu Anca Trifan Department of Gastroenterology Grigore T.Popa University of Medicine and PharmacySt.Spiridon Emergency HospitalIasi 700115Romania

Direct acting antivirals(DAAs)have revolutionized the treatment of hepatitis C virus(HCV)infection,achieving high rates(≥95%)of sustained virological response,with a good safety profile and high compliance ***,it had been expected that viral clearance will reduce morbidity and mortality rates,as well as the risk of hepatocellular carcinoma(HCC).However,since 2016,concerns have been raised over an unexpected high rate of HCC occurrence and recurrence after DAA therapy,which led to an avalanche of studies with contradictory *** aimed to review the most recent and relevant articles regarding the risk of HCC after DAA treatment and identify the associated risk factors.

关键词： Hepatocellular carcinoma Direct acting antivirals therapy Hepatitis C virus infection Sustained virological response Risk factors of hepatocellular carcinoma Review