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Chemical Research in Chinese Universities 2014年第1期30卷 119-124页

作者： POPESCU ana-Maria CONSTANTIN Virgil Laboratory of Molten Salts llie Murgulescu Institute of Physical Chemistry of the Romanian Academy Bucharest 006021 Romania

The authors prepared,characterized and preliminary studied the properties of some neoteric solvents-ionic liquids based on choline chloride,i.e.,three ionic liquids based on the eutectics of choline chloride（2-hydroxyN,N,N-trimethylethanaminium chloride） with,respectively,urea,malonic acid and citric *** obtained mixtures were clear and colorless ionic liquids at room *** thermophysical properties,namely,density,viscosity,and electrical conductivity of these mixtures were investigated as a function of temperature within a range of 298-353 *** for the temperature dependence of the measured properties were generated and discussed in terms of Arrhenius *** the electrochemical windows of the eutectic liquids were determined.

关键词： Neoteric solvent Ionic liquid Choline chloride Malonic acid Citric acid Density Viscosity Conductivity

Ontogeny of vocal rhythms in harbor seal pups: an exploratory study

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Current Zoology 2019年第1期65卷 107-120页

作者： Andrea RAViGNANi Christopher T. Kello Koen de Reus Sonja A KoTz Simone Dalla BELLA Margarita Mendez-Arostegui Beatriz Rapado-Tamarit ana Rubio-garcia Bart de BoER Research Department Sealcentre Pieterburen Pieterburen The Netherlands Artificial Intelligenee Lab Vrije Universiteit Brussel Brussels Belgium Cognitive and Information Sciences University of California Merced CA USA Basic and Applied NeuroDynamics Lab Faculty of Psychology and Neuroscience Department of Neuropsychology & Psychopharmacology Maastricht University Maastricht The Netherlands Department of Neuropsychology Max-Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany International Laboratory for Brain Music and Sound Research (BRAMS) Montreal QC Canada Department of Psychology University of Montreal Montreal QC Canada Department of Cognitive Psychology WSFiZ in Warsaw Warsaw Poland

Puppyhood is a very active social and vocal period in a harbor seal's life Ph oca vitulina. An important feature of vocalizations is their temporal and rhythmic structure, and understanding vocal timing and rhythms in harbor seals is critical to a cross-species hypothesis in evolutionary neuroscience that links vocal learning, rhythm perception, and synchronization. This study utilized analytical techniques that may best capture rhythmic structure in pup vocalizations with the goal of examining whether (1) harbor seal pups show rhythmic structure in their calls and (2) rhythms evolve over time. Calls of 3 wild-born seal pups were recorded daily over the course of 1-3 weeks;3 temporal features were analyzed using 3 complementary techniques. We identified temporal and rhythmic structure in pup calls across different time windows. The calls of harbor seal pups exhibit some degree of temporal and rhythmic organization, which evolves over puppyhood and resembles that of other species' in teractive comm un icati on. We suggest n ext steps for investigating call structure in harbor seal pups and propose comparative hypotheses to test in other pinniped species.

关键词： bioacoustics pinnipeds rhythm timing vocal development

Evaluation of glial cell proliferation with non-invasive molecular imaging methods after stroke

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Neural Regeneration Research 2021年第11期16卷 2209-2210页

作者： ana Joya Abraham Martín Achucarro Basque Center for Neuroscience LeioaSpain CIC biomaGUNE Basque Research and Technology Alliance(BRTA)PaseoSpain Ikerbasque Basque Foundation for Science BilbaoSpain

Glial proliferation:For the last decades,glial cells have been wrongly believed to have a mere passive supporting role for ***,this notion has clearly changed and it is now admitted that these cells are essential for the correct development and regulation of the nervous *** cell population are commonly subdivided in astrocytes,oligodendrocytes and *** the development,neural stem cells(NSCs)(called neuroepithelial progenitor cells or NPCs)transform into radial glia,the primary progenitor cells for neurons,astrocytes and oligodendrocytes(Zuchero and Barres,2015).Microglial cells,however,derive from a mesenchymal precursor infiltration,meaning that during brain development,precursors generated in the bone narrow invade the nervous parenchyma and differentiate into microglial cells(Zuchero and Barres,2015).This proliferative capacity is preserved in the adult mammalian brain,and neurogenic NSCs are stored in two restricted regions of the central nervous system(CNS),the forebrain subventricular zone(SVZ)and the hippocampal dentate gyrus(subgranular zone).These cells continue to produce neurons and glial cells during the adulthood,being activated after certain signals and leaving the quiescent state(Urbán et al.,2019).This process,in which glial progenitor cells differentiate into mature glia during development and in the adult brain to maintain and regulate brain function,is called gliogenesis(Ardaya et al.,2020).

关键词： admitted maintain supporting

Co-occurrence of germline pathogenic variants for different hereditary cancer syndromes in patients with Lynch syndrome

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Cancer Communications 2021年第3期41卷 218-228页

作者： Rosario Ferrer-Avargues Maria isabel Castillejo Estela Damaso Virginia Diez-Obrero Noemi Garrigos Tatiana Molina Alan Codoner-Alejos Angel Segura ana Beatriz Sanchez-Heras Adela Castillejo Jose Luis Soto Foundation for the Promotion of Health and Biomedical Research of Valencia Region(FISABIO) FISABIO-Elche Health DepartmentElche 032303Spain Molecular Genetics Unit.Elche University Hospital Elche 032303Spain Department of Molecular Biopathology Immunological Center of AlicanteSan Juan-Alicante 03550Spain Medical Oncology Department Cancer Genetic Counseling Unit.La Fe University HospitalValencia 46026Spain Medical Oncology Department Cancer Genetic Counseling Unit.Elche University HospitalElche 03203Spain

Background:Lynch syndrome(LS)is a hereditary condition characterized by a high risk of colorectal cancer,endometrial cancer,and other neoplasia associated with germline alterations in DNA mismatch repair *** classical genetic diagnostic strategy for LS consists of the Sanger sequencing of genes associated with the suspected ***-generation sequencing(NGS)enables the simultaneous sequencing of a large number of hereditary cancer ***,we aimed to study whether other germline pathogenic variants of hereditary cancer genes are present in patients with ***:A cohort of 84 probands with a previous genetic diagnosis of LS by Sanger sequencing was reanalyzed using NGS via a commercial panel of 94 hereditary cancer genes by hybrid *** American College of Medical Genetics and Genomics criteria were used to classify the clinical significance of the *** findings of NGS were confirmed by Sanger *** possible,genetic analyses of the new findings in the proband’s relativeswere also performed by Sanger ***:We identified five families(6%),out of 84,with at least two germline pathogenic variants conferring to high or moderate risk in different dominant cancer-predisposing genes:[MLH1-BRCA2-NBN],[MLH1-BRCA1],[MSH2-ATM],[MSH6-NF1],and[MLH1-FANCA].Interestingly,only one out of these five families exhibited a clinical phenotype associated with the new pathogenic *** family with three pathogenic variants of the[MLH1-BRCA2-NBN]genes showed a high aggregation of tumors associated with LS and breast and ovarian cancer ***:Our results showed that the co-occurrence of more than one pathogenic variant in cancer-predisposing genes was remarkable among cases of *** cases,no clinicial manifestations were associated with the secondary pathogenic *** studies are needed to confirm these findings and elucidate their clinical *** of LS families should be considered only in fa

关键词： cancer panel hereditary cancer lynch syndrome moderate penetrance genes multilocus inherited neoplasia alleles syndrome next-generation sequencing secondary findings

Clinical characteristics and type of antithrombotic treatment in a Spanish cohort of elderly patients with atrial fibrillation according to dependency, frailty and cognitive impairment

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Journal of Geriatric Cardiology 2018年第4期15卷 268-274页

作者： Jose Maria Mostaza Manuel Jesús Romero Jiménez Fernando José ruiz Laiglesia José Antonio Díaz Peromingo Manuel Beltrán Robles Ernesto Guevara Sierra ana Santander Bilbao Carmen Suárez Hospital Carlos III Madrid Spain Hospital Infanta Elena Huelva Spain Hospital Clínico Universitario Lozano Blesa Zaragoza Spain Complejo Hospitalario Universitario de Santiago Santiago de Compostela Spain Hospital Virgen del Camino Sanlucar-Cádiz Spain Centro Socio-Sanitario Vallparadís Terrassa Spain Hospital de Basurto Bilbao Spain Hospital Universitario de La Princesa Madrid Spain

Background Available data regarding clinical profile and management of elderly patients with atrial fibrillation （AF） according to dependency, fragility and cognitive impairment are scarce. The objective of the study was to analyze the biodemographic data, clinical profile and antithrombotic treatment according to dependency, fragility and cognitive impairment in elderly AF patients. Methods Cross- sectional and multi-center study performed in consecutive AF patients ≥ 75 years treated with oral anticoagulants ≥ 3 months attended in Internal Medicine Departments in Spain. Results A total of 837 patients （83.0 ± 5.0 years; CHA2DS2-VASc： 5.0 ± 1.4; HAS-BLED： 2.1 ± 0.9） were included. 44.4% of patients had some degree of dependency, 43.3% were fragile, and 32.3% had cognitive impairment. Patients with any of these conditions were older, had a worse clinical profile, with more comorbidities and higher risks of thromboembolic and bleeding events. All these conditions were independently associated among them. Overall, 70.8% of patients were taking vitamin K antagonists, the remaining 29.2% direct oral anticoagulants and 9.7% oral antiplatelets. This distribution was independent of the presence of dependency or fragility, but there was a trend to a higher prescription of vitamin K antagonists in those patients with cognitive impairment （75.2% vs. 68.8%; P = 0.05）. Conclusions Approximately 32%-44% of elderly anticoagulated AF patients attended have some degree of dependency, fragility and/or cognitive impairment. Patients with any of these conditions are older and have a worse clinical profile. Ap？proximately 71% of patients are taking vitamin K antagonists, regardless dependency or frailty, but with a trend to higher prescription in patients with cognitive impairment.

关键词： Atrial fibrillation Cognitive impairment Dependency Fragility Oral anticoagulants

Electrochemical studies on cerium(Ⅲ) in molten fluoride mixtures

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Journal of Rare Earths 2010年第3期28卷 428-434页

作者： VIRGIL CONSTANTIN ana-MARIA POPESCU MIRCEA OLTEANU Romanian Academy Institute of Physical Chemistry "Ilie Murgulescu"Department of Molten Salts Splaiul Independentei 202Bucharest-Romania

This study aims to determine the principal electrochemical characteristics of the electrodeposition of cerium metal from molten fluoride *** cathodic process of Ce3+ ions in LiF-NaF and LiF-NaF-CaF2 molten salts was studied using electrochemical techniques as steady state and cyclic voltammetry *** decomposition potential(Ed) and the overvoltage(η) were determined for NaCeF4 using current-potential curves under galvanostatic *** Ed was found to be 2.025 V in LiF-NaF and 2.045 V in...

关键词： cerium molten salts lanthanides NaCeF4 electrolysis cyclic voltammetry

Mobile Interaction Capturing System in Real Environments

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Computer Technology and Application 2012年第8期3卷 533-543页

作者： Ivan Pretel garcia ana B. Lago Vilarino Deusto Institute of Technology (DeustoTech) University of Deusto Bilbao 48007 Spain

Mobile applications are being used in a great range of fields and application areas. As a result, many research fields have focused on the study and improvement of such devices. The current Smartphones are the best example of the research and the evolution of these technologies. Moreover, the software design and development is progressively more focused on the user; finding and developing new mobile interaction models. In order to do so, knowing what kind of problems the users could have is vital to enhance a bad interaction design. Unfortunately, a good software quality evaluation takes more time than the companies can invest. The contribution revealed in this work is a new approach to quality testing methodology focused on mobile interactions and their context in use where external capturing tools, such as cameras, are suppressed and the evaluation environments are the same as the user will use the application. By this approach, the interactions can be captured without changing the context and consequently, the data will be more accurate, enabling the evaluation of the quality-in-use in real environments.

关键词： Human computer interaction quality in use mobile services context-awareness.

Performance and potential of porous carbons derived of electrospun metal-organic frameworks for supercapacitor applications

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Journal of Energy Chemistry 2022年第10期31卷 348-353,I0008页

作者： Petra Agota Szilagyi ana Jorge Sobrido School of Engineering and Materials Science Queen Mary University of LondonLondon E14NSUK

Supercapacitors(SCs) are energy storage devices with the ability to charge and discharge at very high rates. The fast accumulation and release of charges occurs either electrostatically or electrochemically. There are two types of capacitors: electric double layer capacitors(EDLCs) and pseudocapacitors. EDLCs are the most commercially available.

关键词： Electrospinning MOFs Porous carbons Supercapacitors Electrodes Energy storage

Sexual function in women after delivery:Does episiotomy matter?

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Health 2014年第5期6卷 356-363页

作者： isabel Leal Sílvia Lourenco Raquel Oliveira ana Carvalheira Joao Maroco Unidade de Investigacao em Psicologia e Saúde(UIPES) LisboaPortugal ISPA Instituto UniversitárioLisboaPortugal

Objective: Despite the fact that a restrictive use of episiotomy has proven to be beneficial, it continues to be widely used in vaginal births. Our aim was to compare women with episiotomy, to women with an intact perineum, 3 months after delivery, regarding several sexual variables, namely: sexual desire, arousal, orgasm, pain, sexual satisfaction and sexual function. Methods: An exploratory, descriptive and quantitative study using a non-probabilistic, convenience sample of 147 Portuguese women, of which 54 belonged to a control group, was performed. The groups were not significantly different regarding socio-demographic aspects. Three instruments were used: the Female Sexual Function Index, a Socio-demographic and Clinical Questionnaire and the Female Sexual Function Questionnaire. Results: Most women mentioned a moderate level of sexual interest. Women with episiotomy present higher pain intensity, less sexual satisfaction, greater changes regarding the orgasm’s duration and intensity, lower levels of sexual arousal and total sexual function, than women with intact perineum. Discussion: We found no significant differences between women with episiotomy and women with an intact perineum in most variables. However, women with episiotomy presented higher levels of pain and a lower sexual satisfaction, being these significant differences.

关键词： Episiotomy Episiorrhaphy Intact Perineum Sexual Function Post-Partum

Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia

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Food Science and Human Wellness 2024年第6期13卷 3083-3094页

作者： Guillermo Santos-Sánchez ana isabelÁlvarez-López Eduardo Ponce-España Patricia Judith Lardone Antonio Carrillo-Vico Ivan Cruz-Chamorro Instituto de Biomedicina de Sevilla Instituto de Biomedicina de Sevilla(IbiS)Hospital Universitario Virgen del RocíoConsejo Superior de Investigaciones Científi cas(CSIC)Universidad de SevillaSeville 41013Spain Departamento de Bioquímica Médica y Biología Molecular e Inmunología Facultad de MedicinaUniversidad de SevillaSeville 41009Spain

Cardiovascular diseases(CVDs)are the leading global cause of mortality and disease *** are the most prescribed lipid-lowering drugs to treat hypercholesterolemia and prevent *** biochemical mechanism of statins consists of competitive inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase enzyme(HMG-CoAR),the limiting enzyme in cholesterol *** to statin intolerance in some patient groups,the search for new inhibitors is a field of great *** review focusses on the studies reporting the inhibitory effect of protein hydrolysates and biopeptides on the HMG-CoAR enzyme *** analysis of the action mechanism and physicochemical characteristics of the HMG-CoAR inhibitory peptides revealed that the molecular weight,amino acid composition,charge,and polarity are key aspects of the interaction with the HMG-CoAR *** conclusion,this review reveals the potential of using food peptides as new cholesterol-lowering agents and opens a new interesting field of ***,clinical approaches are mandatory to confirm their therapeutic hypercholesterolemic effect.

关键词： Functional foods Cholesterol Cardiovascular diseases Statins 3-Hydroxy-3-methylglutaryl-coenzyme A