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Haploidentical hematopoietic stem cell transplantation as promising therapy in the improved survival of pediatric patients with leukemias and myelodysplasias

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World Journal of Meta-analysis 2023年第5期11卷 181-195页

作者： ana clara carvalho cardoso brito Everton Oliveira Carneiro Ribeiro Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

BACKGROUND Haploidentical hematopoietic stem cell transplantation(Haplo-HSCT)is often performed in children with hematologic *** with the gap in the literature regarding the approach to experiences related to Haplo-HSCT with pediatric patients with leukemias and myelodysplasias aged up to 18 years,there was an interest in exploring the clinical outcomes of patients undergoing this *** To identify and summarize the scientific contributions available on Haplo-HSCT performed in the last 10 years in children and adolescents with myeloid and lymphoid leukemias and myelodysplasias,aged up to 18 *** This is a descriptive systematic *** extracted data including characteristics of participants,health condition,characteristics of the donation,conditioning regimen,recurrent clinical complications and clinical *** Virtual Health Library Brazil,PubMed,EMBASE,and SciELO platforms were used,finding a total of 1052 *** the eligibility criteria and complete reading of the texts,18 articles were included for *** The total sample of all study cohorts was 1825 patients,mostly male,the highest reported median age was 15.0 years and the lowest was 1.2 *** graftversus-host disease and chronic graft-versus-host disease were observed in almost all ***,graft rejection and delayed immune recovery were identified as major clinical ***-transplant minimal positive residual disease was identified in 288 *** are also among the main clinical complications,viral,bacterial and fungal infections being *** is observed that in the 5-year interval,the lowest rates of EFS and overall survival(OS)were 29.5%and 68.0%,***,the highest rates of EFS and OS,in the same interval,were 80.1%and 81.0%.CONCLUSION Haplo-HSCT represents a promising therapy,considering the potential number of possible donors and the conditioning and treatment platforms that can be *** res

关键词： Haploidentical Stem cell transplantation Children Cancer Treatment outcome Prognosis

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Hypertension Associated with Atherosclerosis Risk Factors in Patients of Family Health Strategy Highlighting the Framingham Risk Score

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Open Journal of Preventive Medicine 2018年第8期8卷 229-247页

作者： Bruna Lais da Silva Coutinho Rosana Andrade brito ana Isabel Cezario de carvalho Conceicao Fabiola de Jesus cardoso Andreza Silva dos Santos Bruno Felipe Ferreira Lopes Rubson Dantas da Silva Polyane Medeiros Alves Raiane dos Santos Pereira Alvaro Luis Muller da Fonseca Department of Education(DEDC7) Universidade do Estado da Bahia(UNEB)Senhor do BonfimBrazil Immunology Laboratory(LAIM) Department of Education(DEDC7)Universidade do Estado da Bahia(UNEB)Senhor do BonfimBrazil

The Systemic Arterial Hypertension (SAH) stands out among the chronic non-transmissible pathologies that impact the cause and/or aggravation of cardiovascular diseases (CVD) on a global level, as the disease is an underestimated disorder due to non-perceptive symptoms and associated with factors and risk markers of another CVD. Therefore, establishing the risk of progression and aggravation of the SAH, according the Framingham Risk Score (FRS), allows to reducing morbidity and improving preventative measures for DCVs. This observational and transversal study approaches the data collection of patient records at the Health Family Strategy of Senhor do Bonfim, BA, which established differences by descriptive and inferential statistical analysis (correlation and regression). The aspects of hypertension associated with risk factors for atherosclerosis were analyzed, determining the risk of developing cardiovascular events in 10 years by FRS. From 432 families, 746 patients were selected, of which 340 are hypertensive individuals (SAH = 45.57%) and 406 (NSAH = 54.42%) non-hypertensives. Among the SAH the majority (31.17%) was in the age range of 63 - 77, but, in both groups, women were in stronger number. There was greater prevalence in SAH for all the characteristics analyzed, smoking (13.20%), sedentary (29.41%) and cardiovascular accident (22.60%). The SAH group is more susceptive to the CVD progress in 10 years by FRS (P analyzed as was expected, without differences between the linear correlation and regression, indicating the physio-metabolic equilibrium of the factors and markers evaluated by FRS. Already in SAH group, despite the correlations have been significant too, the regression analysis revealed that only Total Cholesterol (P = 0.0086);LDL (P < 0.0001), Glucose (P < 0.0006) and Age (P < 0.0001) have significative association with FRS. So, these factors and markers

关键词： Hypertension Risk Factors Atherosclerosis Cardiovascular Diseases Framingham Risk Score Family Health Strategy

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