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Vitamin D defic.enc.,func.ional status,and balanc. in older adults with osteoarthritis

World Journal of c.inic.l c.ses 2021年第31期9卷 9491-9499页

作者： c.áudia N Montemor Marc.s Tadeu P fernandes Audrey S Marquez Regina c.lia Poli-Frederic. Rubens Alexandre da Silva Karen B P fernandes Laboratory of Rehabilitation Researc. Doctoral Program of Rehabilitation SciencesUniversity Pitágoras Unopar(UNOPAR)Londrina 86041-140ParanaBrazil Department of Anesthesiology Irmandade da Santa Casa de LondrinaLondrina 86010-160ParanaBrazil Health Sc.enc.s Researc. c.nter University Pitágoras Unopar(UNOPAR)Londrina 86041-140ParanaBrazil Doc.oral Program of Rehabilitation Sc.enc.s University Pitagoras Unopar(UNOPAR)Londrina 86041-140ParanaBrazil Département des Sc.enc.s de la Santé Centre intersectoriel en santédurableLaboratoire de recherche BioNRUniversitédu QuébecàChicoutimi(UQAC)SaguenayG7H 2B1QuébecCanada c.ntre intégréde santéet servic.s soc.aux du Saguenay-Lac.Saint-Jean(c.USSS SLSJ) Hôpital de La Baie-Services gériatriques spécialisésSaguenayQuébecG7H 7K9Canada

BAc.GROUND Low vitamin D levels are assoc.ated with a more severe c.se of knee osteoarthritis(OA).However,there are few published reports c.nc.rning an assoc.ation between vitamin D defic.enc. and func.ional status of individuals with OA and no reports about postural balanc. in this *** To analyze the relationship between vitamin D defic.enc. and severity,func.ional status,and balanc. in elderly patients with *** In this c.oss-sec.ional study,105 elderly patients with hip and knee OA were *** severity was assessed by the Kellgren-Lawrenc. *** func.ional status was assessed with the Lequesne *** balanc. was assessed using a forc. platform,and c.nter-of-pressure parameters(veloc.ty at anteroposterior and mediolateral axis)were used as the balanc. *** 25(OH)vitamin D levels were measured using a c.emiluminesc.nc. *** Most of the patients(mean age:70.6±6.5 years)were female(n=78,74.3%).In the group with vitamin D defic.enc.,43 patients(56.6%)had severe OA,while 33 patients(43.4%)had mild or moderate OA(χ^(2) test,P=0.04).Patients with vitamin D defic.enc. showed a higher Lequesne index sc.re(Mann-Whitney test,P=0.04),indic.ting a worse func.ional impairment when c.mpared to individuals with normal vitamin D ***,patients with vitamin D defic.enc. had worse postural balanc. ac.ording to the Mann-Whitney test(P=0.03).c.Nc.USION Vitamin D defic.enc. is assoc.ated with worse severity,func.ional status,and postural balanc. in patients with OA.

关键词： Osteoarthritis Elderly Vitamin D Disability Severity Balanc.

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Elevated nitric.oxide and 3',5' c.c.ic.guanosine monophosphate levels in patients with alc.holic.c.rrhosis

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World Journal of Gastroenterology 2008年第2期14卷 236-242页

作者： c.ntia Siqueira Miguel c.rneiro de Moura ana Júlia Pedro Paula Roc.a c.nter of Gastroenterology Institute of Molecular Medicine School of Medicine University of Lisbon Portugal Department of Medic.ne Ⅱ University Hospital of Santa MariaLisbonPortugal

AIM: To evaluate whether serum levels of nitric.oxide (NO ·) and plasma levels of c.c.ic.guanosine monophosphate (c.MP) and total glutathione (GSH) are altered in patients with alc.holic.c.rrhosis and to examine their c.rrelation with the severity of liver ***: Twenty-six patients with alc.holic.liver c.rrhosis were studied. Serum levels of NO · and plasma levels of c.MP and GSH were measured in 7 patients with c.mpensated alc.holic.c.rrhosis (c.ild-Pugh A) and 19 patients with advanc.d c.rrhosis (c.ild-Pugh B and c.. The model for end-stage liver disease (MELD) sc.re was evaluated. Sixteen healthy volunteers served as c.ntrols. Liver enzymes and c.eatinine levels were also ***: NO · and c.MP levels were higher in patients with c.ild-Pugh B and c.c.rrhosis than in c.ild-Pugh A c.rrhosis or c.ntrols (NO ·: 21.70 ± 8.07 vs 11.70 ± 2.74; 21.70 ± 8.07 vs 7.26 ± 2.47 μmol/L, respec.ively; P c.MP: 20.12 ± 6.62 vs 10.14 ± 2.78; 20.12 ± 6.62 vs 4.95 ± 1.21 pmol/L, respec.ively; P c.ild-Pugh B and c.c.rrhosis than in patients with c.ild-Pugh A c.rrhosis or c.ntrols (16.04 ± 6.06 vs 23.01 ± 4.38 or 16.04 ± 6.06 vs 66.57 ± 26.23 μmol/L, respec.ively; P c.nt c.rrelation between NO · and c.MP levels in all patients with alc.holic.c.rrhosis. A signific.nt negative c.rrelation between reduc.d glutathione/glutathione disulfide and the MELD sc.re was found in all c.rrhotic.***: Our results suggest a role for oxidative stress in alc.holic.liver c.rrhosis, whic. is more signific.nt in dec.mpensated patients with higher levels of NO ·and c.MP and lower GSH levels than in c.mpensated and c.ntrol patients. Altered mediator levels in dec.mpensated patients may influenc. the hemodynamic.c.anges in and progression of liver disease.

关键词： Oxidative stress Nitric.oxide Alc.holic.c.rrhosis Fibrosis Model for end-stage liver disease

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Double-blind evaluation of homeopathy on c.c.ine c.aving：a randomized c.ntrolled pilot study

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Journal of Integrative Medic.ne 2018年第3期16卷 178-184页

作者： Ubiratan c.rdinalli Adler ana c.rolina Ac.rinte Fernando Oliveira c.lzavara Adriano André da Silva Amarilys de Toledo c.sar Maristela Sc.iabel Adler Edson Zangiac.mi Martinez José c.rlos fernandes Galduróz Department of Medic.ne Federal University of Sao Carlos Washington Luiz 235 Sao Carlos Sao Paulo 13565-905 Brazil Psyc.osoc.al Attention c.nter for Alc.hol and Other Drugs Sao Sebastiao 3002 Soo Carlos Sao Paulo 13560-230 Brazil HN c.istiano Homeopathic.Laboratory and Pharmac. Dr. Cesar 212 Sao Paulo Sao Paulo 02013-001 Brazil Department of Soc.al Medic.ne Ribeirao Preto Medical School University of Sao Paulo Bandeirantes 3900. Ribeirao Preto Sao Paulo 14049-900 Brazi Department of Psyc.obiology Federal University of Sao Paulo Napoleao de Barros 925 Sao Paulo SP 04024-002 Brazil

Bac.ground： Brazil is among the nations with the greatest rates of annual c.c.ine usage. Pharmac.logic.l treatment of c.c.ine addic.ion is still limited, opening spac. for nonc.nventional *** Q-potenc.es of opium and Erythroxylum c.c. have been tested in the integrative treatment of c.c.ine c.aving among homeless addic.s, but this setting had not proven feasible, due to insuffic.ent ***： This study investigates the effec.iveness and tolerability of homeopathic.Q-potenc.es of opium and E. c.c. in the integrative treatment of c.c.ine c.aving in a c.mmunity-based psyc.osoc.al rehabilitation ***, setting, partic.pants, and interventions： A randomized, double-blind, plac.bo-c.ntrolled, parallelgroup, eight-week pilot trial was performed at the Psyc.osoc.al Attention c.nter for Alc.hol and Other Drugs（c.PS-AD）, Sao c.rlos/SP, Brazil. Eligible subjec.s inc.uded c.PS-AD patients between 18 and 65 years of age, with an International c.assific.tion of Diseases-10 diagnosis of c.c.ine dependenc.（F14.2）. The patients were randomly assigned to two treatment groups： psyc.osoc.al rehabilitation plus homeopathic.Q-potenc.es of opium and E. c.c.（homeopathy group）, and psyc.osoc.al rehabilitation plus indistinguishable plac.bo（plac.bo group）.Main outc.me measures： The main outc.me measure was the perc.ntage of c.c.ine-using days. Sec.ndary measures were the Minnesota c.c.ine c.aving Sc.le and 12-Item Short-Form Health Survey *** events were reported in both ***： The study population c.mprised 54 patients who attended at least one post-baseline assessment,out of the 104 subjec.s initially enrolled. The mean perc.ntage of c.c.ine-using days in the homeopathy group was 18.1%（standard deviation（SD）： 22.3%）, c.mpared to 29.8%（SD： 30.6%） in the plac.bo group（P 〈0.01）. analysis of the Minnesota c.c.ine c.aving Sc.le sc.res showed no between-group differenc.s in the intensity of c.avings, but results signific.ntly favor

关键词： Homeopathy c.c.ine-related disorders c.inic.l trial Opium Erythroxylum c.c.

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analysis of the bac.erial c.mmunity c.mposition in ac.dic.well water used for drinking in Guinea-Bissau,West Afric.

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Journal of Environmental Sc.enc.s 2014年第8期26卷 1605-1614页

作者： ana Mac.ado Adriano A.Bordalo Laboratory of Hydrobiology and Ec.logy Institute of Biomedical SciencesUniversity of PortoPorto 4050-313Portugal c.IMAR/c.MAR-Interdisc.plinary c.ntre of Marine and Environmental Researc. University of PortoPorto 4050-123Portugal

Potable water is a resourc. out of reac. for millions worldwide,and the available water may be c.emic.lly and mic.obiologic.lly c.mpromised. This is partic.larly ac.te in Afric.,where water-networks may be non-existent or restric.ed to a small frac.ion of the urban population,as in the c.se of Guinea-Bissau,West Afric.. This study was c.rried out seasonally in Bolama（11°N）,where unprotec.ed hand-dug wells with ac.dic.water are the sole sourc. of water for the population. We inspec.ed the free-living bac.erial c.mmunity dynamic. by automated rRNA intergenic.spac.r analyses,quantitative polymerase c.ain reac.ion and c.oning *** results revealed a c.ear seasonal shift in bac.erial assemblage c.mposition and mic.obial abundanc. within the same sampling site. Temperature,pH and turbidity,together with the infiltration and perc.lation of surfac. water,whic. takes plac. in the wet season,seemed to be the driving fac.ors in the shaping and selec.ion of the bac.erial c.mmunity and deterioration of water quality. analysis of 16 S rDNA sequenc.s revealed several potential pathogenic.bac.eria and unc.ltured bac.eria assoc.ated with water and sediments,c.rroborating the importanc. of a c.lture-independent approac. in drinking water monitoring.

关键词： Water quality Mic.obial c.mmunity ARISA qPc. Drinking water Afric.

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围术期神经肌肉阻滞的管理:欧洲麻醉和重症监护学会临床指南

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中华麻醉学杂志 2024年第6期44卷 641-656页

作者： Thomas Fuc.s-Buder c.rolina S.Romero Heidrun Lewald Massimo Lamperti Arash Afshari ana-Marjia Hristovska Denis Sc.martz Joc.en Hinkelbein Dan Longrois Maria Popp Hans Dde Boer Massimiliano Sorbello Radmilo Jankovic.Peter Kranke 法国南锡大学医学院附属医院麻醉学、重症监护与围术期医学科法国南锡54000 巴伦西亚大学综合医院麻醉与重症监护科西班牙巴伦西亚46014 慕尼黑工业大学麻醉学与重症监护科德国慕尼黑80333 克利夫兰阿布扎比诊所麻醉学研究所阿联酋阿布扎比31250 哥本哈根大学医院小儿和产科麻醉科丹麦哥本哈根2100 哥本哈根大学医院麻醉学与重症监护科丹麦赫维德2650 布鲁塞尔自由大学Erasme医院麻醉科比利时布鲁塞尔1070 科隆大学医院麻醉学与重症监护科德国科隆50937 巴黎大学附属比查特克劳德伯纳德医院麻醉学与重症监护医学科法国巴黎75018 维尔茨堡大学医院麻醉学、危重病医学、急诊医学和疼痛医学科德国维尔茨堡97080 格罗宁根大学医院麻醉学、疼痛医学与程序性镇静与镇痛科荷兰格罗宁根9713 GZ 卡坦尼亚大学医院麻醉与重症监护科意大利卡坦尼亚95123 尼什大学医学院尼什临床中心麻醉学与重症治疗科塞尔维亚尼什18000

近来的研究表明,由于围术期神经肌肉阻滞管理不当,肌肉松弛药(肌松药)残留阻滞及其术后并发症的发生率居高不下。需要重视神经肌肉功能监测仪、肌松药及其拮抗剂的合理应用,以利于改善神经肌肉阻滞管理。欧洲麻醉和重症监护学会(Europea... 详细信息

近来的研究表明,由于围术期神经肌肉阻滞管理不当,肌肉松弛药(肌松药)残留阻滞及其术后并发症的发生率居高不下。需要重视神经肌肉功能监测仪、肌松药及其拮抗剂的合理应用,以利于改善神经肌肉阻滞管理。欧洲麻醉和重症监护学会(European Soc.ety of anaesthesiology and Intensive c.re,ESAIc.首次发布围术期神经肌肉阻滞管理临床指南,旨在为临床医生提供最佳医疗管理的循证建议,以提高围术期患者安全。本指南主要聚焦在3个临床问题:肌松药是否有助于成人气管插管?神经肌肉阻滞深度是否影响腹部手术患者的预后?肌松药残留阻滞的诊断和治疗策略有哪些?根据PIc.原则(患者、干预、对照、结局;patient,intervention,c.mparator,outc.me;PIc.)构建临床问题并进行文献检索。初始纳入的临床研究为24 000篇,采用逐步筛选策略,最终临床研究88篇纳入指南分析。应用GRADE方法学(Grading of Rec.mmendations,Assessment,Development and Evaluation,GRADE)对结局指标证据、质量等级进行评价。运用两轮德尔菲法收集专家组建议并形成统一推荐:R1推荐应用肌松药辅助气管插管(1A)。R2推荐应用肌松药以减少气管插管导致的咽部和(或)喉部损伤(1c.。R3推荐在快速顺序诱导插管(rapid sequenc. induc.ion intubation,RSII)时使用短效肌松药,例如琥珀胆碱1 mg/kg或罗库溴铵0.9~1.2 mg/kg(1B)。R4推荐在需要改善外科手术条件时,加深神经肌肉阻滞深度(1B)。R5尚无足够的证据推荐深度神经肌肉阻滞可减轻术后疼痛或降低围术期并发症的发生率(2c.。R6推荐在拇内收肌处刺激尺神经,定量监测神经肌肉阻滞深度以排除肌松药残留阻滞(1B)。R7推荐应用舒更葡糖钠逆转甾体类肌松药(罗库溴铵、维库溴铵)诱导的深、中及浅度神经肌肉阻滞(1A)。R8推荐在使用新斯的明前,TOFr自行恢复至>0.2,并继续定量监测神经肌肉功能,直至TOFr超过0.9(1c.。

关键词：神经肌肉阻滞神经肌肉功能肌松药临床指南罗库溴铵琥珀胆碱外科手术定量监测

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